BR0208596A - Variante de polipeptìdeo com gama interferon (ifng), seqência de nucleotìdeos, vetor de expressão, célula hospedeira de glicosilação, população de variantes de polipeptìdeo com ifng ou de uma composição, composição farmacêutica, uso de uma variante de polipeptìdeo, e, métodos para o tratamento de doenças pulmonares intersticiais, para aumentar o grau de n-glicosilação in vivo de um polipeptìdeo com ifng parental, e para a produção de uma variante de polipeptìdeo com ifng - Google Patents
Variante de polipeptìdeo com gama interferon (ifng), seqência de nucleotìdeos, vetor de expressão, célula hospedeira de glicosilação, população de variantes de polipeptìdeo com ifng ou de uma composição, composição farmacêutica, uso de uma variante de polipeptìdeo, e, métodos para o tratamento de doenças pulmonares intersticiais, para aumentar o grau de n-glicosilação in vivo de um polipeptìdeo com ifng parental, e para a produção de uma variante de polipeptìdeo com ifngInfo
- Publication number
- BR0208596A BR0208596A BR0208596-8A BR0208596A BR0208596A BR 0208596 A BR0208596 A BR 0208596A BR 0208596 A BR0208596 A BR 0208596A BR 0208596 A BR0208596 A BR 0208596A
- Authority
- BR
- Brazil
- Prior art keywords
- ifng
- polypeptide
- glycosylation
- polypeptide variant
- variant
- Prior art date
Links
- 102000008070 Interferon-gamma Human genes 0.000 title abstract 9
- 108010074328 Interferon-gamma Proteins 0.000 title abstract 9
- 229920001184 polypeptide Polymers 0.000 title abstract 9
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 9
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 9
- 229960003130 interferon gamma Drugs 0.000 title abstract 5
- 230000004988 N-glycosylation Effects 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 208000029523 Interstitial Lung disease Diseases 0.000 title abstract 2
- 239000013604 expression vector Substances 0.000 title abstract 2
- 230000013595 glycosylation Effects 0.000 title abstract 2
- 238000006206 glycosylation reaction Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000002773 nucleotide Substances 0.000 title abstract 2
- 101150106931 IFNG gene Proteins 0.000 title 4
- 238000001727 in vivo Methods 0.000 title 1
- 125000003729 nucleotide group Chemical group 0.000 title 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 abstract 1
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 102220360521 c.295T>A Human genes 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 208000036971 interstitial lung disease 2 Diseases 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200100579 | 2001-04-06 | ||
| DKPA200100714 | 2001-05-07 | ||
| DKPA200200198 | 2002-02-11 | ||
| PCT/DK2002/000226 WO2002081507A2 (en) | 2001-04-06 | 2002-04-04 | Interferon gamma polypeptide variants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0208596A true BR0208596A (pt) | 2004-03-09 |
Family
ID=27222504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0208596-8A BR0208596A (pt) | 2001-04-06 | 2002-04-04 | Variante de polipeptìdeo com gama interferon (ifng), seqência de nucleotìdeos, vetor de expressão, célula hospedeira de glicosilação, população de variantes de polipeptìdeo com ifng ou de uma composição, composição farmacêutica, uso de uma variante de polipeptìdeo, e, métodos para o tratamento de doenças pulmonares intersticiais, para aumentar o grau de n-glicosilação in vivo de um polipeptìdeo com ifng parental, e para a produção de uma variante de polipeptìdeo com ifng |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1412382A2 (https=) |
| JP (1) | JP2005518183A (https=) |
| KR (1) | KR20030094336A (https=) |
| CN (1) | CN1257186C (https=) |
| BG (1) | BG108256A (https=) |
| BR (1) | BR0208596A (https=) |
| CA (1) | CA2443277A1 (https=) |
| HU (1) | HUP0303645A3 (https=) |
| IL (1) | IL157896A0 (https=) |
| MX (1) | MXPA03009082A (https=) |
| NO (1) | NO20034432L (https=) |
| NZ (1) | NZ528651A (https=) |
| PL (1) | PL366705A1 (https=) |
| WO (1) | WO2002081507A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101039957A (zh) | 2003-05-16 | 2007-09-19 | 因特缪恩公司 | 合成的趋化因子受体配体及其使用方法 |
| JP4707327B2 (ja) * | 2004-01-27 | 2011-06-22 | 旭化成ファーマ株式会社 | ポリペプタイド類の吸着防止剤 |
| CA2576030A1 (en) * | 2004-08-09 | 2006-02-23 | Alios Biopharma Inc. | Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same |
| US7597884B2 (en) | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
| CN103550757A (zh) * | 2005-09-20 | 2014-02-05 | 纽约大学 | 用干扰素治疗肺病的方法 |
| US7625555B2 (en) | 2007-06-18 | 2009-12-01 | Novagen Holding Corporation | Recombinant human interferon-like proteins |
| JP5769142B2 (ja) * | 2007-09-04 | 2015-08-26 | 独立行政法人酒類総合研究所 | ピヒア属酵母において異種タンパク質を高分泌させる方法 |
| EP2039764A1 (en) * | 2007-09-19 | 2009-03-25 | Pevion Biotech AG | Truncated secretory aspartyl proteinase 2 |
| BG66517B1 (bg) | 2008-04-08 | 2016-02-29 | Tigo Gmbh | Супресор на ендогенния човешки гама - интерферон |
| RU2446821C2 (ru) * | 2010-07-15 | 2012-04-10 | Олег Ильич Эпштейн | Лекарственное средство для лечения инфекционных заболеваний, сопровождающихся нейротоксическими нарушениями, и способ лечения инфекционных заболеваний, сопровождающихся нейротоксическими нарушениями |
| GB201621728D0 (en) | 2016-12-20 | 2017-02-01 | Ucb Biopharma Sprl | Methods |
| BG67190B1 (bg) | 2017-03-29 | 2020-11-16 | Tigo Gmbh | Анти-гама мутантен протеин срещу ендогенния човешки гама интерферон |
| WO2023182947A1 (en) * | 2022-03-22 | 2023-09-28 | Chiang Mai University | A modified protein of interferon gamma and its use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9203641A (es) * | 1983-12-16 | 1992-07-01 | Genentech Inc | Interferones gamma recombinantes que poseen estabilidad mejorada y metodos biotecnologicos para su obtencion. |
| BG52073B2 (en) * | 1990-01-24 | 1996-04-30 | Inst Molekuljarna Biolog | Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine |
| DE4036856C1 (https=) * | 1990-11-19 | 1992-05-27 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De |
-
2002
- 2002-04-04 WO PCT/DK2002/000226 patent/WO2002081507A2/en not_active Ceased
- 2002-04-04 CN CNB028078918A patent/CN1257186C/zh not_active Expired - Fee Related
- 2002-04-04 EP EP02722021A patent/EP1412382A2/en not_active Withdrawn
- 2002-04-04 PL PL02366705A patent/PL366705A1/xx not_active Application Discontinuation
- 2002-04-04 NZ NZ528651A patent/NZ528651A/en unknown
- 2002-04-04 HU HU0303645A patent/HUP0303645A3/hu unknown
- 2002-04-04 KR KR10-2003-7013263A patent/KR20030094336A/ko not_active Ceased
- 2002-04-04 CA CA002443277A patent/CA2443277A1/en not_active Abandoned
- 2002-04-04 JP JP2002579493A patent/JP2005518183A/ja active Pending
- 2002-04-04 BR BR0208596-8A patent/BR0208596A/pt not_active IP Right Cessation
- 2002-04-04 MX MXPA03009082A patent/MXPA03009082A/es not_active Application Discontinuation
- 2002-04-04 IL IL15789602A patent/IL157896A0/xx unknown
-
2003
- 2003-10-03 NO NO20034432A patent/NO20034432L/no not_active Application Discontinuation
- 2003-10-10 BG BG108256A patent/BG108256A/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005518183A (ja) | 2005-06-23 |
| NO20034432D0 (no) | 2003-10-03 |
| CN1537117A (zh) | 2004-10-13 |
| IL157896A0 (en) | 2004-03-28 |
| HUP0303645A2 (hu) | 2004-01-28 |
| CN1257186C (zh) | 2006-05-24 |
| EP1412382A2 (en) | 2004-04-28 |
| WO2002081507A2 (en) | 2002-10-17 |
| NZ528651A (en) | 2006-06-30 |
| HK1069834A1 (en) | 2005-06-03 |
| WO2002081507A3 (en) | 2004-02-12 |
| MXPA03009082A (es) | 2004-11-22 |
| CA2443277A1 (en) | 2002-10-17 |
| PL366705A1 (en) | 2005-02-07 |
| KR20030094336A (ko) | 2003-12-11 |
| HUP0303645A3 (en) | 2005-12-28 |
| BG108256A (bg) | 2004-12-30 |
| NO20034432L (no) | 2003-10-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A(S) 8A E 9A ANUIDADE(S) |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2103 DE 26/04/2011. |