CN1257186C - 干扰素γ多肽变体 - Google Patents

干扰素γ多肽变体 Download PDF

Info

Publication number
CN1257186C
CN1257186C CNB028078918A CN02807891A CN1257186C CN 1257186 C CN1257186 C CN 1257186C CN B028078918 A CNB028078918 A CN B028078918A CN 02807891 A CN02807891 A CN 02807891A CN 1257186 C CN1257186 C CN 1257186C
Authority
CN
China
Prior art keywords
polypeptide variant
lys
seq
polypeptide
ifng
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB028078918A
Other languages
English (en)
Chinese (zh)
Other versions
CN1537117A (zh
Inventor
安妮·D·詹森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maxygen Holdings Ltd
Original Assignee
Maxygen Holdings Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maxygen Holdings Ltd filed Critical Maxygen Holdings Ltd
Publication of CN1537117A publication Critical patent/CN1537117A/zh
Application granted granted Critical
Publication of CN1257186C publication Critical patent/CN1257186C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
CNB028078918A 2001-04-06 2002-04-04 干扰素γ多肽变体 Expired - Fee Related CN1257186C (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DKPA200100579 2001-04-06
DKPA200100579 2001-04-06
DKPA200100714 2001-05-07
DKPA200100714 2001-05-07
DKPA200200198 2002-02-11
DKPA200200198 2002-02-11

Publications (2)

Publication Number Publication Date
CN1537117A CN1537117A (zh) 2004-10-13
CN1257186C true CN1257186C (zh) 2006-05-24

Family

ID=27222504

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028078918A Expired - Fee Related CN1257186C (zh) 2001-04-06 2002-04-04 干扰素γ多肽变体

Country Status (14)

Country Link
EP (1) EP1412382A2 (https=)
JP (1) JP2005518183A (https=)
KR (1) KR20030094336A (https=)
CN (1) CN1257186C (https=)
BG (1) BG108256A (https=)
BR (1) BR0208596A (https=)
CA (1) CA2443277A1 (https=)
HU (1) HUP0303645A3 (https=)
IL (1) IL157896A0 (https=)
MX (1) MXPA03009082A (https=)
NO (1) NO20034432L (https=)
NZ (1) NZ528651A (https=)
PL (1) PL366705A1 (https=)
WO (1) WO2002081507A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101039957A (zh) 2003-05-16 2007-09-19 因特缪恩公司 合成的趋化因子受体配体及其使用方法
JP4707327B2 (ja) * 2004-01-27 2011-06-22 旭化成ファーマ株式会社 ポリペプタイド類の吸着防止剤
CA2576030A1 (en) * 2004-08-09 2006-02-23 Alios Biopharma Inc. Synthetic hyperglycosylated, protease-resistant polypeptide variants, oral formulations and methods of using the same
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
CN103550757A (zh) * 2005-09-20 2014-02-05 纽约大学 用干扰素治疗肺病的方法
US7625555B2 (en) 2007-06-18 2009-12-01 Novagen Holding Corporation Recombinant human interferon-like proteins
JP5769142B2 (ja) * 2007-09-04 2015-08-26 独立行政法人酒類総合研究所 ピヒア属酵母において異種タンパク質を高分泌させる方法
EP2039764A1 (en) * 2007-09-19 2009-03-25 Pevion Biotech AG Truncated secretory aspartyl proteinase 2
BG66517B1 (bg) 2008-04-08 2016-02-29 Tigo Gmbh Супресор на ендогенния човешки гама - интерферон
RU2446821C2 (ru) * 2010-07-15 2012-04-10 Олег Ильич Эпштейн Лекарственное средство для лечения инфекционных заболеваний, сопровождающихся нейротоксическими нарушениями, и способ лечения инфекционных заболеваний, сопровождающихся нейротоксическими нарушениями
GB201621728D0 (en) 2016-12-20 2017-02-01 Ucb Biopharma Sprl Methods
BG67190B1 (bg) 2017-03-29 2020-11-16 Tigo Gmbh Анти-гама мутантен протеин срещу ендогенния човешки гама интерферон
WO2023182947A1 (en) * 2022-03-22 2023-09-28 Chiang Mai University A modified protein of interferon gamma and its use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9203641A (es) * 1983-12-16 1992-07-01 Genentech Inc Interferones gamma recombinantes que poseen estabilidad mejorada y metodos biotecnologicos para su obtencion.
BG52073B2 (en) * 1990-01-24 1996-04-30 Inst Molekuljarna Biolog Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine
DE4036856C1 (https=) * 1990-11-19 1992-05-27 Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De

Also Published As

Publication number Publication date
JP2005518183A (ja) 2005-06-23
NO20034432D0 (no) 2003-10-03
CN1537117A (zh) 2004-10-13
IL157896A0 (en) 2004-03-28
HUP0303645A2 (hu) 2004-01-28
EP1412382A2 (en) 2004-04-28
WO2002081507A2 (en) 2002-10-17
NZ528651A (en) 2006-06-30
HK1069834A1 (en) 2005-06-03
WO2002081507A3 (en) 2004-02-12
BR0208596A (pt) 2004-03-09
MXPA03009082A (es) 2004-11-22
CA2443277A1 (en) 2002-10-17
PL366705A1 (en) 2005-02-07
KR20030094336A (ko) 2003-12-11
HUP0303645A3 (en) 2005-12-28
BG108256A (bg) 2004-12-30
NO20034432L (no) 2003-10-29

Similar Documents

Publication Publication Date Title
CN1188172C (zh) G－csf偶联物
US7232562B2 (en) E38N interferon gamma polypeptide variants
CN1522159A (zh) 干扰素配制品
CN1729018A (zh) G－csf偶联物
CN1257186C (zh) 干扰素γ多肽变体
CN1531545A (zh) 降低融合蛋白的免疫原性
CN1309423C (zh) 干扰素γ偶联物
US7038015B2 (en) Interferon gamma polypeptide variants
CN1241638C (zh) Ifnar2/ifn复合物
CN1501815A (zh) 新的干扰素β-样分子
CN1161468C (zh) Mpl配体类似物
US7390638B2 (en) S99T C-11 Truncated polynucleotides encoding interferon gamma polypeptide variants
CN1187447C (zh) Mpl配体类似物
EP1539814A2 (en) Full-length interferon gamma polypeptide variants
HK1069834B (en) Interferon gamma polypeptide variants
RU2296130C2 (ru) Варианты полипептида гамма-интерферона
AU2002252971B2 (en) Interferon gamma polypeptide variants
HK1087927A (en) Interferon-alpha polypeptides and conjugates
HK1009151B (en) Mpl ligand analogs
HK1085670A (en) G-csf conjugates
AU2002252971A1 (en) Interferon gamma polypeptide variants
HK1031397B (en) Mpl ligand analogs
CZ20033016A3 (cs) Varianty polpeptidu interferonu gamma
HK1032914B (en) Ifnar2/ifn complex
HK1102967A (en) N-terminally chemically modified protein compositions and methods

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1069834

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20060524