HUP0303645A2 - Gamma-interferon-polipeptid változatai - Google Patents
Gamma-interferon-polipeptid változataiInfo
- Publication number
- HUP0303645A2 HUP0303645A2 HU0303645A HUP0303645A HUP0303645A2 HU P0303645 A2 HUP0303645 A2 HU P0303645A2 HU 0303645 A HU0303645 A HU 0303645A HU P0303645 A HUP0303645 A HU P0303645A HU P0303645 A2 HUP0303645 A2 HU P0303645A2
- Authority
- HU
- Hungary
- Prior art keywords
- variants
- polypeptide variants
- interferon
- interferon gamma
- diseases
- Prior art date
Links
- 102000008070 Interferon-gamma Human genes 0.000 title 1
- 108010074328 Interferon-gamma Proteins 0.000 title 1
- 229940079322 interferon Drugs 0.000 abstract 2
- 230000035772 mutation Effects 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 101000599940 Homo sapiens Interferon gamma Proteins 0.000 abstract 1
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 abstract 1
- 102100037850 Interferon gamma Human genes 0.000 abstract 1
- 208000029523 Interstitial Lung disease Diseases 0.000 abstract 1
- 230000004988 N-glycosylation Effects 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 208000036971 interstitial lung disease 2 Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000007920 subcutaneous administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
A találmány tárgyát a g-interferon (IFNG) új, g-interferon aktivitásúpolipeptidváltozatai, ezek előállítására szolgáló eljárások, apolipeptid-változatokat tartalmazó gyógyászati készítmények és ezekalkalmazása betegségek, előnyösen szövetközti tüdőbetegségek, mintpéldául idiopátiás tüdőfibrózis, kezelésére képezi. A huIFNG vagyannak fragmentumainak aminosav-szekvenciájával összehasonlítva, ezenúj polipeptid-változatok mindegyike tartalmazza az S99Tszubsztitúciót. E mutációval a természetes körülmények között a 97.helyen lévő N-glikozilációs hely lényegesen jobban hasznosul. Előnyös,ha például szubkután beadás esetén, az ilyen változatok az AUCértékének növelése céljából a változatok további mutációkat istartalmaznak. Ó
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200100579 | 2001-04-06 | ||
| DKPA200100714 | 2001-05-07 | ||
| DKPA200200198 | 2002-02-11 | ||
| PCT/DK2002/000226 WO2002081507A2 (en) | 2001-04-06 | 2002-04-04 | Interferon gamma polypeptide variants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0303645A2 true HUP0303645A2 (hu) | 2004-01-28 |
| HUP0303645A3 HUP0303645A3 (en) | 2005-12-28 |
Family
ID=27222504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0303645A HUP0303645A3 (en) | 2001-04-06 | 2002-04-04 | Interferon gamma polypeptide variants |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP1412382A2 (hu) |
| JP (1) | JP2005518183A (hu) |
| KR (1) | KR20030094336A (hu) |
| CN (1) | CN1257186C (hu) |
| BG (1) | BG108256A (hu) |
| BR (1) | BR0208596A (hu) |
| CA (1) | CA2443277A1 (hu) |
| HK (1) | HK1069834A1 (hu) |
| HU (1) | HUP0303645A3 (hu) |
| IL (1) | IL157896A0 (hu) |
| MX (1) | MXPA03009082A (hu) |
| NO (1) | NO20034432L (hu) |
| NZ (1) | NZ528651A (hu) |
| PL (1) | PL366705A1 (hu) |
| WO (1) | WO2002081507A2 (hu) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2390262A1 (en) | 2003-05-16 | 2011-11-30 | Intermune, Inc. | Synthetic chemokine receptor ligands and methods of use thereof |
| JP4707327B2 (ja) * | 2004-01-27 | 2011-06-22 | 旭化成ファーマ株式会社 | ポリペプタイド類の吸着防止剤 |
| KR20070085227A (ko) * | 2004-08-09 | 2007-08-27 | 앨리오스 바이오파마 인크. | 합성 초글리코실화, 프로테아제 저항성 폴리펩티드 변이체,경구 제제 및 이를 이용한 방법 |
| US7597884B2 (en) * | 2004-08-09 | 2009-10-06 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
| CN103550757A (zh) * | 2005-09-20 | 2014-02-05 | 纽约大学 | 用干扰素治疗肺病的方法 |
| US7625555B2 (en) | 2007-06-18 | 2009-12-01 | Novagen Holding Corporation | Recombinant human interferon-like proteins |
| JP5769142B2 (ja) * | 2007-09-04 | 2015-08-26 | 独立行政法人酒類総合研究所 | ピヒア属酵母において異種タンパク質を高分泌させる方法 |
| EP2039764A1 (en) * | 2007-09-19 | 2009-03-25 | Pevion Biotech AG | Truncated secretory aspartyl proteinase 2 |
| BG66517B1 (bg) | 2008-04-08 | 2016-02-29 | Tigo Gmbh | Супресор на ендогенния човешки гама - интерферон |
| RU2446821C2 (ru) * | 2010-07-15 | 2012-04-10 | Олег Ильич Эпштейн | Лекарственное средство для лечения инфекционных заболеваний, сопровождающихся нейротоксическими нарушениями, и способ лечения инфекционных заболеваний, сопровождающихся нейротоксическими нарушениями |
| GB201621728D0 (en) | 2016-12-20 | 2017-02-01 | Ucb Biopharma Sprl | Methods |
| BG67190B1 (bg) | 2017-03-29 | 2020-11-16 | Tigo Gmbh | Анти-гама мутантен протеин срещу ендогенния човешки гама интерферон |
| WO2023182947A1 (en) * | 2022-03-22 | 2023-09-28 | Chiang Mai University | A modified protein of interferon gamma and its use thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9203641A (es) * | 1983-12-16 | 1992-07-01 | Genentech Inc | Interferones gamma recombinantes que poseen estabilidad mejorada y metodos biotecnologicos para su obtencion. |
| BG52073B2 (en) * | 1990-01-24 | 1996-04-30 | Inst Molekuljarna Biolog | Method for the preparation of recombinant human noncystein -interferon, free of n-end methionine |
| DE4036856C1 (hu) * | 1990-11-19 | 1992-05-27 | Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung Ev, 8000 Muenchen, De |
-
2002
- 2002-04-04 CN CNB028078918A patent/CN1257186C/zh not_active Expired - Fee Related
- 2002-04-04 CA CA002443277A patent/CA2443277A1/en not_active Abandoned
- 2002-04-04 WO PCT/DK2002/000226 patent/WO2002081507A2/en active Application Filing
- 2002-04-04 HU HU0303645A patent/HUP0303645A3/hu unknown
- 2002-04-04 MX MXPA03009082A patent/MXPA03009082A/es not_active Application Discontinuation
- 2002-04-04 NZ NZ528651A patent/NZ528651A/en unknown
- 2002-04-04 EP EP02722021A patent/EP1412382A2/en not_active Withdrawn
- 2002-04-04 BR BR0208596-8A patent/BR0208596A/pt not_active IP Right Cessation
- 2002-04-04 JP JP2002579493A patent/JP2005518183A/ja active Pending
- 2002-04-04 PL PL02366705A patent/PL366705A1/xx not_active Application Discontinuation
- 2002-04-04 KR KR10-2003-7013263A patent/KR20030094336A/ko not_active Application Discontinuation
- 2002-04-04 IL IL15789602A patent/IL157896A0/xx unknown
-
2003
- 2003-10-03 NO NO20034432A patent/NO20034432L/no not_active Application Discontinuation
- 2003-10-10 BG BG108256A patent/BG108256A/bg unknown
-
2005
- 2005-03-15 HK HK05102256A patent/HK1069834A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1257186C (zh) | 2006-05-24 |
| NO20034432L (no) | 2003-10-29 |
| CA2443277A1 (en) | 2002-10-17 |
| JP2005518183A (ja) | 2005-06-23 |
| BG108256A (bg) | 2004-12-30 |
| HK1069834A1 (en) | 2005-06-03 |
| HUP0303645A3 (en) | 2005-12-28 |
| MXPA03009082A (es) | 2004-11-22 |
| WO2002081507A2 (en) | 2002-10-17 |
| BR0208596A (pt) | 2004-03-09 |
| PL366705A1 (en) | 2005-02-07 |
| IL157896A0 (en) | 2004-03-28 |
| NO20034432D0 (no) | 2003-10-03 |
| WO2002081507A3 (en) | 2004-02-12 |
| EP1412382A2 (en) | 2004-04-28 |
| NZ528651A (en) | 2006-06-30 |
| CN1537117A (zh) | 2004-10-13 |
| KR20030094336A (ko) | 2003-12-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0303645A2 (hu) | Gamma-interferon-polipeptid változatai | |
| HUP0100928A2 (hu) | Humán inzulin B láncának részletét tartalmazó peptidanalógok, ezeket tartalmazó gyógyászati készítmények és alkalmazásuk | |
| HUP9901674A2 (hu) | Új gyógyszerkombináció | |
| GB2282140B (en) | Purified forms of dnase | |
| HUP0101734A2 (hu) | Béta-amiloid prekurzor protein és ubiquitin-B kereteltolódásos mutánsok és alkalmazásuk | |
| HUP0000299A1 (hu) | Késleltetett hatóanyag-leadású gyógyszerkészítmények | |
| HUP0400466A2 (hu) | G-CSF konjugátumok | |
| HUP0402217A2 (hu) | Platinaszármazékot tartalmazó gyógyászati készítmények | |
| SG131109A1 (en) | Muteins of tear lipocalin | |
| HUP0004560A2 (hu) | Törést gyógyító PTHrP analógok | |
| HUP9603237A2 (hu) | (R)-(-)-2-{N-[4-(1,1-dioxido-3-oxo-2,3-dihidro-benzizotiazol-2-il)-butil]-amino-metil}-kromán kristályos hidrokloridja, eljárás előállítására és a vegyületeket tartalmazó gyógyszerkészítmények | |
| WO2002088100A3 (de) | Deuterierte 3-piperidinopropiophenone sowie diese verbindungen enthaltende arzneimittel | |
| UA91820C2 (ru) | Терапевтическое применение вариантов хемокинов | |
| HK1079549A1 (en) | Muteins of placental growth factor type 1, preparation method and application thereof | |
| HUP0003428A2 (hu) | Leptin antagonisták alkalmazása diabetes kezelésére | |
| FI912240A0 (fi) | Antitrombiner. | |
| KR20070012801A (ko) | 인터페론-타우에 의한 치료를 최적화하는 방법 | |
| EP1281763A3 (en) | Early growth response-1 (EGR-1) transcription factor | |
| ATE332379T1 (de) | Menschliche dnase resistent gegen actininhibitoren | |
| HUP0400698A2 (hu) | Csökkentett immunogenitású módosított interleukin-1-receptor-antagonista (IL-1RA) | |
| WO2004043373A3 (en) | Precursor n-acetylgalactosamine-4-sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme | |
| HUP0400340A2 (hu) | Polipeptidek immunogenitásának csökkentésére szolgáló eljárások | |
| WO2004005341A3 (en) | Full-length interferon gamma polypeptide variants | |
| HUP0102306A1 (hu) | A csonka kolinkötő protein A N-terminális aminosavait tartalmazó polipeptid, ebből származó vakcina és ezek alkalmazása | |
| HUP0400204A2 (hu) | A Leishmania parazita virulenciájával kapcsolatos gének |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |