KR20230059121A - 보툴리눔 유래 펩타이드를 포함하는 통증개선용 조성물 - Google Patents
보툴리눔 유래 펩타이드를 포함하는 통증개선용 조성물 Download PDFInfo
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
보툴리눔 유래 펩타이드를 포함하는 통증개선용 조성물에 관한 것으로, 본 발명에 따른 보툴리눔 독소 재조합 단백질을 포함하는 조성물은 근육 마비 효과를 가지는 보툴리눔 독소 경쇄를 통증 부위에 빠르게 전달함으로써 효과적으로 근육 긴장을 완화시켜 통증을 감소시킬 수 있으므로 통증 예방, 개선, 또는 치료 물질로 유용하게 이용될 수 있다.
Description
본 발명은 보툴리눔 유래 펩타이드를 포함하는 통증개선용 조성물에 관한 것이다.
일반적으로 통증은 위험에서 신체를 보호하고 손상받은 조직의 회복에 중요한 역할을 하는 것으로 알려져 있다. 그러나 바이러스나 박테리아의 감염, 말초신경 주변의 심각한 염증 반응, 또는 말초신경의 직접적인 손상 등에 의해서 발생하는 병증성 통증은 인체에 유해하며, 환자의 생활의 질에 지대한 영향을 미친다.
인류의 역사를 통틀어 오래 전부터 통증을 완화하거나 무감각하게 하기 위한 진통제가 개발되어 이용되어 왔는데, 이러한 진통제는 구강 투여가 일반적이다. 그러나, 구강 투여는 간손상, 신장손상 등의 문제점을 유발하는 경향이 있으며, 혈류에 진입하기 전에 소화계를 통하여 흡수되어야 하기 때문에, 효능을 발휘하는데 시간 지체가 발생한다.
이러한 구강 투여의 문제점을 해결하기 위해, 비경구 투여방법, 예를 들어, 혈관 내 주입 또는 근육 내 주입 방식들이 제안되었으나, 이들 방법은 편리하지 않고 비용이 많이 소요되는 문제점이 있으며, 병원 외에서는 실시하기가 매우 불편한 문제점이 있다.
따라서, 국소(topical) 투여, 특히, 경피(transdermal) 투여 방식으로 투여하려는 시도들이 이루어지고 있다.
한편, 보툴리눔 독소는 클로스트리디움 보툴리늄(Clostridium botulinum)에 의해 생성되는 신경독소 단백질이며, 신경세포의 신경전달물질인 아세트콜린 및 카테콜아민의 분비를 억제하는 것으로 보고 되고 있다. 보툴리늄 독소는 A, B, C, D, E, F, G 및 H 타입의 8종류가 있으며, A 및 B 타입이 상업적으로 이용된다.
보툴리눔 독소는 신경독 단백질로 인간의 반수 치사량은 정맥주사나 근육 주사 시 1.3 ∼2.1 ng/kg, 흡입할 경우 10 ∼13 ng/kg 로 독성이 매우 높은 물질이나, 적정한 양으로 조절 시 신경장애, 근육 질환, 다한증, 사각턱 등을 치료하는 약물로 사용될 수 있고, 주름, 종아리 근육 축소 등 미용 용도로 가장 많이 사용되고 있다.
이러한 보툴리눔 독소는 경쇄와 중쇄를 합쳐 150 kDa으로 매우 큰 분자이기 때문에 피부를 투과하기 어려워 주사제를 통해서만 활용되고 있으며, 독소 지속 시간은 3~6개월 이내로 정기적인 처치가 필요하므로, 이용 대상자에 대한 편의성을 제공할 수 있는 다른 효과적인 전달 수단을 찾기 위해 많은 연구가 이루어지고 있으나, 아직 미비한 실정이다.
본 발명자들은 본 발명에 따른 보툴리눔 독소 재조합 단백질(피부 투과형 보툴리눔 유래 성분 펩타이드)의 통증 개선 효과를 확인한 결과, 두통, 만성 통증 등의 통증 환자에 대하여 우수한 통증 감소 효과를 나타냄을 확인하여 본 발명을 완성하였다.
따라서, 본 발명의 목적은 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 통증개선용 약학적 조성물로서, 상기 보툴리눔 독소 재조합 단백질은 보툴리눔 독소 경쇄의 일측 말단 또는 양측 말단에 서열번호 1의 아미노산 서열로 이루어진 세포투과성 펩타이드가 융합된 것을 특징으로 하는, 통증개선용 약학적 조성물을 제공하는 것이다.
본 발명의 다른 목적은 상기 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 통증개선용 의약외품 조성물을 제공하는 것이다.
본 발명의 또 다른 목적은 상기 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 통증개선용 피부외용제 조성물을 제공하는 것이다.
본 발명의 또 다른 목적은 상기 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 통증개선용 화장료 조성물을 제공하는 것이다.
그러나, 본 발명이 이루고자 하는 기술적 과제는 이상에서 언급한 과제에 제한되지 않으며, 언급되지 않은 또 다른 과제들은 아래의 기재로부터 본 발명이 속하는 기술 분야의 통상의 지식을 가진 자에게 명확하게 이해될 수 있을 것이다.
상기의 목적을 달성하기 위하여, 본 발명은 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 통증개선용 약학적 조성물로서, 상기 보툴리눔 독소 재조합 단백질은 보툴리눔 독소 경쇄의 일측 말단 또는 양측 말단에 서열번호 1의 아미노산 서열로 이루어진 세포투과성 펩타이드가 융합된 것을 특징으로 하는, 통증개선용 약학적 조성물을 제공한다.
또한, 본 발명은 상기 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 통증개선용 의약외품 조성물을 제공한다.
또한, 본 발명은 상기 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 통증개선용 피부외용제 조성물을 제공한다.
또한, 본 발명은 상기 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 통증개선용 화장료 조성물을 제공한다.
본 발명의 일 구현예로, 상기 보툴리눔 독소 재조합 단백질은 서열번호 31 내지 서열번호 58로 이루어진 군으로부터 선택되는 하나 이상의 아미노산 서열로 이루어질 수 있으나, 이에 제한되지 않는다.
본 발명의 다른 구현예로, 상기 보툴리눔 독소 경쇄는 서열번호 3 내지 서열번호 9로 이루어진 군으로부터 선택되는 하나 이상의 아미노산 서열로 이루어질 수 있으나, 이에 제한되지 않는다.
본 발명의 또 다른 구현예로, 상기 보툴리눔 독소 경쇄는 일측 말단에 헥사히스티딘(hexahistidine) 태그(tag)를 더 포함할 수 있으나, 이에 제한되지 않는다.
본 발명의 또 다른 구현예로, 상기 보툴리눔 독소 경쇄는 보툴리눔 독소 혈청형(serotype) A, B, C, D, E, F 및 G로 이루어진 군으로부터 선택될 수 있으나, 이에 제한되지 않는다.
본 발명의 또 다른 구현예로, 상기 융합은 상기 보툴리눔 독소 경쇄의 카복시 말단, 아미노 말단 또는 이들 모두에 상기 세포투과성 펩타이드가 융합되는 것일 수 있으나, 이에 제한되지 않는다.
본 발명의 또 다른 구현예로, 상기 융합은 펩타이드 결합 또는 공유결합에 의해 이루어질 수 있으나, 이에 제한되지 않는다.
본 발명의 또 다른 구현예로, 상기 보툴리눔 독소 재조합 단백질은 근육 긴장을 완화시킬 수 있으나, 이에 제한되지 않는다.
본 발명의 또 다른 구현예로, 상기 기계적 통증, 열 통증, 만성 통증, 급성 통증, 통각과민 통증, 체인성 통증, 신경병성 통증, 심인성 통증, 열 유도된 통증, 물리적 통증, 통각수용, 통각과민, 류마티스성 통증, 두통, 요통, 골반통, 근막통, 혈관성 통증, 편두통, 상처 연계된 통증, 염증성 통증, 관절염 통증, 당뇨병성 통증, 암 유래의 통증, 신체 내장 통증, 섬유근통, 수술 후 통증, 환상통, 삼차신경통, 포진 후 신경통, 통증이 있는 당뇨병성 신경병증, 통증이 있는 당뇨병성 말초 신경병증, 당뇨병성 다발성 신경증, 좌골 통증, 신경근병증, 척수 신경근통, 근육통, 및 요추 통증으로 이루어진 군으로부터 선택될 수 있으나, 이에 제한되지 않는다.
본 발명의 또 다른 구현예로, 본 발명에 따른 조성물은 경피 투여용일 수 있으나, 이에 제한되지 않는다.
또한, 본 발명은 상기 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 조성물을 이를 필요로 하는 개체에 투여하는 단계를 포함하는 통증개선 방법을 제공한다.
또한, 본 발명은 상기 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 조성물의 통증개선 용도를 제공한다.
또한, 본 발명은 상기 보툴리눔 독소 재조합 단백질의 통증개선용 약제 제조를 위한 용도를 제공한다.
본 발명에 따른 보툴리눔 독소 재조합 단백질은 세포투과성 펩타이드와의 융합을 통해 근육 마비 효과를 가지는 보툴리눔 독소 경쇄를 경피로 전달할 수 있는바, 간편하게 보툴리눔 독소 경쇄를 통증 부위에 빠르게 전달함으로써 효과적으로 근육 긴장을 완화시켜 통증을 감소시킬 수 있으므로 통증 예방, 개선, 또는 치료 물질로 유용하게 이용될 수 있다.
도 1은 보툴리눔 독소 재조합 단백질을 포함하는 조성물 사용 후 피험자별/기간별 두통발생횟수를 비교한 결과를 나타낸 도면이다.
도 2는 보툴리눔 독소 재조합 단백질을 포함하는 조성물 사용 후 기간별 두통횟수 감소율을 비교한 결과를 나타낸 도면이다.
도 3은 보툴리눔 독소 재조합 단백질을 포함하는 조성물 사용 후 기간별 진통제 복용횟수를 비교한 결과를 나타낸 도면이다.
도 4는 보툴리눔 독소 재조합 단백질의 통증 개선 효과를 확인하기 위하여 만성 통증 환자를 대상으로 보툴리눔 로션 적용 후 6일 동안 통증 변화를 확인한 결과를 나타낸 도면이다 (NRS: 숫자 통증 등급, 1-4점: 경도 통증, 5-6점: 중등도 통증, 7-10점: 중증 통증, 이하 동일).
도 5는 보툴리눔 독소 재조합 단백질의 통증 개선 효과를 확인하기 위하여 섬유근통, 및 근육통 환자를 대상으로 보툴리눔 로션 적용 후 6 일동안 통증 감소 지속 여부를 확인한 결과를 나타낸 도면이다.
도 6은 보툴리눔 독소 재조합 단백질의 통증 개선 효과를 확인하기 위하여 마약성 진통제를 이용하는 환자를 대상으로 보툴리눔 로션 적용 후 6일 동안 통증 감소 지속 여부를 확인한 결과를 나타낸 도면이다.
도 7은 보툴리눔 독소 재조합 단백질의 피부 투과 과정을 개략적으로 나타낸 도면이다.
도 2는 보툴리눔 독소 재조합 단백질을 포함하는 조성물 사용 후 기간별 두통횟수 감소율을 비교한 결과를 나타낸 도면이다.
도 3은 보툴리눔 독소 재조합 단백질을 포함하는 조성물 사용 후 기간별 진통제 복용횟수를 비교한 결과를 나타낸 도면이다.
도 4는 보툴리눔 독소 재조합 단백질의 통증 개선 효과를 확인하기 위하여 만성 통증 환자를 대상으로 보툴리눔 로션 적용 후 6일 동안 통증 변화를 확인한 결과를 나타낸 도면이다 (NRS: 숫자 통증 등급, 1-4점: 경도 통증, 5-6점: 중등도 통증, 7-10점: 중증 통증, 이하 동일).
도 5는 보툴리눔 독소 재조합 단백질의 통증 개선 효과를 확인하기 위하여 섬유근통, 및 근육통 환자를 대상으로 보툴리눔 로션 적용 후 6 일동안 통증 감소 지속 여부를 확인한 결과를 나타낸 도면이다.
도 6은 보툴리눔 독소 재조합 단백질의 통증 개선 효과를 확인하기 위하여 마약성 진통제를 이용하는 환자를 대상으로 보툴리눔 로션 적용 후 6일 동안 통증 감소 지속 여부를 확인한 결과를 나타낸 도면이다.
도 7은 보툴리눔 독소 재조합 단백질의 피부 투과 과정을 개략적으로 나타낸 도면이다.
본 발명자들은 보툴리눔 독소 경쇄에 세포투과성 펩타이드를 융합시킨 보툴리눔 독소 재조합 단백질(피부 투과형 보툴리눔 유래 성분 펩타이드)의 통증 개선 효과를 확인한 결과, 두통, 만성 통증 등의 통증 환자에 대하여 우수한 통증 감소 효과를 나타냄을 확인하여 본 발명을 완성하였다.
이하, 본 발명을 상세히 설명한다.
보툴리눔 독소는 하나의 폴리펩타이드로 발현이 되지만 발현 후 재구성 과정에 의해 약 100 kDa의 중쇄(Heavy chain; H 사슬)와 약 50 kDa의 경쇄(Light chain; L 사슬)로 나뉘어 지게 되며 H 사슬과 L 사슬은 디설파이드 결합으로 연결되어 있다. H 사슬은 신경세포의 수용체와 결합하여 내포작용(endocytosis)을 통해 보툴리눔 독소가 내부로 들어갈 수 있도록 한다. 보툴리눔 독소의 L 사슬은 세포 안으로 들어간 후 엔도좀을 빠져나와 세포질로 들어가고, 세포질 내의 스네어 단백질(SNARE protein)을 절단하여 아세틸콜린 분비를 억제시켜 근육 마비 효과를 나타낸다. 따라서, 신경세포의 아세틸콜린 분비 억제는 L 사슬 단독으로도 가능하며 H 사슬과 L 사슬은 각각 독립적으로 기능할 수 있다.
그러나, 분리된 분자량 50 kDa의 보툴리눔 독소 경쇄는 세포막을 투과할 수 없어 그 자체로는 기능을 할 수 없다. 일반적으로 보툴리눔 독소 경쇄가 신경세포 내 세포질로 전달되어 보툴리눔 독소 특유의 활성을 나타내기 위해서는 약 100 kDa의 보툴리눔 독소 중쇄의 도움이 반드시 필요하다.
이에, 본 발명의 일 실시예에서는, 보툴리눔 독소 경쇄를 피부 내부 및 신경세포에 효율적으로 전달할 수 있도록 보툴리눔 독소 경쇄와 세포투과성 펩타이드(MTD; Macromolecule Transduction Domain)가 융합된 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 조성물을 두통, 만성통증, 근육통, 섬유근통, 또는 근막통이 있는 환자의 통증이 있는 부위에 도포한 결과, 우수한 통증 감소 효과를 나타내는 것을 확인하였다.
따라서, 본 발명은 세포 내로의 도입이 용이하지 않은 보툴리눔 독소 경쇄에 세포투과성 펩타이드를 융합시켜 세포투과성을 부여함으로써 보툴리눔 독소 경쇄가 세포 내로 고효율로 전달될 수 있는 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 통증개선용 약학적 조성물로서,
상기 보툴리눔 독소 재조합 단백질은 보툴리눔 독소 경쇄의 일측 말단 또는 양측 말단에 서열번호 1의 아미노산 서열로 이루어진 세포투과성 펩타이드가 융합된 것을 특징으로 하는, 통증개선용 약학적 조성물을 제공한다.
본 발명에서 “보툴리눔 독소 재조합 단백질”이란 세포투과성 펩타이드와 보툴리눔 독소 경쇄(light chain)를 포함하며, 이들의 펩타이드 결합이나 공유결합과 같은 화학적 결합으로 형성된 결합체를 의미한다. 구체적으로, 본 발명에 따른 보툴리눔 독소 재조합 단백질은 세포 내로의 도입이 용이하지 않은 거대분자인 보툴리눔 독소 경쇄에 특정한 세포투과성 펩타이드를 융합시켜 세포투과성을 부여함으로써 보툴리눔 독소 경쇄를 세포 내로 고효율로 전달할 수 있으며, 이때 상기 융합은 상기 보툴리눔 독소 경쇄의 카복시 말단, 아미노 말단 또는 이들 모두에 상기 세포투과성 펩타이드가 융합될 수 있다.
본 발명에 따른 보툴리눔 독소 재조합 단백질은 보툴리눔 독소 경쇄와 세포투과성 펩타이드의 융합을 통해 세포 내로 고효율로 전달될 수 있으며, 보툴리눔 독소 경쇄의 활성 및 안정성이 향상되어 생체 내에서 보툴리눔 독소의 고유의 효능이 극대화되는 것을 특징으로한다.
본 발명에서의 보툴리눔 독소 재조합 단백질(피부투과형 보툴리눔 유래 성분 펩타이드)의 구성은 대한민국 등록특허 제10-1882461호와 동일하며, 상기 문헌에 개시된 모든 내용은 본 출원에 참조로 원용된다.
본 발명에 있어서, 상기 보툴리눔 독소 재조합 단백질은 근육 마비 효과가 있는 보툴리눔 독소 경쇄가 세포 내로 고효율로 전달됨으로써 근육 긴장을 완화하고 근육 회복을 촉진시킴으로써 통증을 감소시킬 수 있다.
본 발명에 있어서, 상기 보툴리눔 독소 재조합 단백질은 피부를 투과하여 SNARE complex의 구성요소인 SNAP-25에 접근하고, 보툴리눔 독소 경쇄는 SNAP-25를 절단함으로써 아세틸콜린(acetylcholine)의 분비를 차단함으로써 통증을 개선할 수 있다.
본 발명에서, "보툴리눔 독소"는 세균에 의해 또는 재조합 기술에 의해 생성되거나 조작된 변이체들 또는 융합 단백질을 포함하여 뒤이어 발견될 수 있는 것인지 여부에 관계없이 임의의 공지된 종류의 보툴리눔 독소를 의미한다.
본 발명에서, 보툴리눔 독소 경쇄는 보툴리눔 독소 혈청형(serotype) A, B, C, D, E, F 및 G로 이루어진 군으로부터 선택될 수 있으며, 이때, 상기 보툴리눔 독소 경쇄는 서열번호 3 내지 서열번호 9으로 이루어진 군으로부터 선택되는 하나 이상의 아미노산 서열로 이루어질 수 있다.
또한, 상기 보툴리눔 독소 경쇄는 서열번호 3 내지 서열번호 9으로 이루어진 군으로부터 선택되는 하나의 아미노산 서열로 이루어질 수 있다.
또한, 일측 말단에 헥사히스티딘(hexahistidine) 태그(tag)를 더 포함할 수 있다. 또한, 상기 보툴리눔 독소 경쇄는 서열번호 10 내지 16으로 이루어진 군으로부터 선택되는 염기서열로 이루어진 폴리뉴클레오티드에 의해 인코딩될 수 있으나, 이에 제한되지 않는다.
본 발명에서, 상기 보툴리눔 독소 경쇄의 일측 말단에 헥사히스티딘 태그를 더 포함한 형태는 서열번호 17 내지 서열번호 23으로 이루어진 군으로부터 선택되는 아미노산 서열로 이루어질 수 있으며, 서열번호 24 내지 서열번호 30으로 이루어진 군으로부터 선택되는 염기서열에 의해 인코딩될 수 있으나, 이에 제한되지 않는다.
본 발명에서, 보툴리눔 독소 경쇄는 대안적으로 보툴리눔 독소 유도체, 즉, 보툴리눔 독소 활성을 가지나 임의로 부분 또는 서열 상에 하나 이상의 변형을 갖는 화합물일 수 있다. 예를 들어, 7종의 혈청형의 보툴리눔 독소 경쇄 단백질에 대비해, 아미노산 서열 상의 결실(deletion), 수정(modification), 치환(replacement) 또는 키메라 융합(chimeric fusion) 등의 방법을 적용하여 경쇄의 endopeptidase의 활성이 유지됨과 동시에 특성을 강화하거나 부작용을 감소시키는 방법으로 변형된 형태일 수 있다. 또는 재조합 또는 화학적인 합성으로 제조된 보툴리눔 독소 경쇄 또는 보툴리눔 독소 경쇄의 일부분이 이용될 수 있다.
본 발명에서, 상기 보툴리눔 독소 재조합 단백질은 서열번호 31 내지 서열번호 58로 구성된 군으로부터 선택되는 하나 이상의 아미노산 서열로 이루어질 수 있으며, 이들을 인코딩하는 폴리뉴클레오티드는 서열번호 59 내지 서열번호 86으로 구성된 군으로부터 선택되는 염기서열로 이루어질 수 있으나, 이에 한정되는 것은 아니다.
또한, 본 발명에서 상기 보툴리눔 독소 재조합 단백질은 서열번호 31 내지 서열번호 58로 구성된 군으로부터 선택되는 하나의 아미노산 서열로 이루어질 수 있다.
본 발명의 일 실시예에 따르면, 상기 보툴리눔 독소 재조합 단백질은 바람직하게는 서열번호 45로 표시되는 아미노산 서열로 이루어질 수 있으며, 이들을 인코딩하는 폴리뉴클레오티드는 서열번호 73로 표시되는 염기서열일 수 있으나, 이에 제한되지 않는다.
본 발명에 있어서, 상기 서열번호 1의 아미노산 서열로 이루어진 세포투과성 펩타이드(MTD; Macromolecule Transduction Domain)는 생물학적 활성 분자의 세포 내 운반을 매개할 수 있는 펩타이드로서, 인간 피부 각질 형성 세포와 신경세포에 대한 투과성을 동시에 보유하고 있을 수 있으나, 이에 제한되지 않는다.
상기 세포투과성 펩타이드는 바람직하게는 정의된 효소 또는 치료적 생물학적 활성을 갖지 않으나, 세포막을 통해 세포 내 전송을 가능하게 하는 전송체(carrier)로써 역할을 한다. 이는 세포 내로 전송하고자 하는 cargo의 N-말단 또는 C-말단 그리고, 양말단에 부착될 수 있으며, 각각의 말단에서 정방향 또는 역방향으로 부착될 수 있다. 또한, 본 발명에 따른 펩타이드는 바람직하게는 단위체(monomer)로 적용될 것이나, 이에 제한되지 않으며, 이합체(dimer) 또는 중합체(polymer) 형태의 구성으로도 이용될 수 있다. 더욱이, 본 발명에 따른 펩타이드는 서열번호 1의 아미노산 서열을 최소의 단위로 포함하는 펩타이드일 수 있다.
본 발명에 있어서, 상기 세포투과성 펩타이드는 서열번호 2의 염기서열로 이루어진 폴리뉴클레오티드에 의해 인코딩될 수 있으나, 이에 제한되지 않는다.
본 명세서에서 “유효성분”은 단독으로 목적으로 하는 활성을 나타내거나 또는 그 자체는 활성이 없는 담체 등과 함께 목적으로 하는 활성을 나타낼 수 있는 성분을 의미한다.
본 발명의 일 실시예에 따르면, 본 발명에 따른 조성물이 통증개선 효과를 내기 위한 가장 적절한 투여 경로는 피부를 통해 흡수되는 것이므로, 바람직하게는 본 발명에 따른 조성물은 경피 투여용일 수 있으나, 이에 제한되지 않는다.
본 발명에 있어서, 본 발명에 따른 조성물은 경피흡수촉진제를 더 포함할 수 있으나, 이에 제한되지 않는다.
상기 "경피흡수촉진제"는 유화제 중에서 피부투과에 영향을 주는 성분들로 통상적으로 경피 패치제에 사용되는 성분이다. 본 발명에서는 보툴리눔 독소 재조합 단백질의의 피부 투과 및 세포 침투를 증대시키는 역할을 하는 것으로, 레시틴(Lecithin), 라우릴 피롤리돈(Lauryl Pyrrolidone), 글리세롤 모노올리에이트(Glycerol Monooleate), 글리세롤 모노라우레이트(Glycerol Monolaurate), 프로필렌 글리콜 모노라우레이트(Propylene Glycol Monolaurate), 폴리옥시에틸렌 소르비탄 모노올리에이트(Polyoxyethylene Sorbitan Monooleate), 폴리옥시에틸렌 소르비탄 모노스테아레이트(Polyoxyethylene Sorbitan Monostearate), 폴리옥시에틸렌 소르비탄 모노라우레이트(Polyoxyethylene Sorbitan Monolaurate), 소르비탄 모노올리에이트(Sorbitan Monooleate), 소르비탄 모노스테아레이트(Sorbitan Monostearate), 소르비탄 모노라우레이트(Sorbitan Monolaurate)일 수 있으나, 이에 제한되지 않는다.
본 발명에서, "통증"은 강한 자극이나 신체 손상으로 인하여 불쾌한 감정을 느끼는 것을 총칭하는 개념이다. 본 발명의 목적상 상기 통증은 신체적인 통증을 의미할 수 있다. 구체적으로, 상기 통증은 기계적 통증, 열 통증, 만성 통증, 급성 통증, 통각과민 통증, 체인성 통증, 신경병성 통증, 심인성 통증, 열 유도된 통증, 물리적 통증, 통각수용, 통각과민, 류마티스성 통증, 두통, 요통, 골반통, 근막통, 혈관성 통증, 편두통, 상처 연계된 통증, 염증성 통증, 관절염 통증, 당뇨병성 통증, 암 유래의 통증, 신체 내장 통증, 섬유근통, 수술 후 통증, 환상통, 삼차신경통, 포진 후 신경통, 통증이 있는 당뇨병성 신경병증, 통증이 있는 당뇨병성 말초 신경병증, 당뇨병성 다발성 신경증, 좌골 통증, 신경근병증, 척수 신경근통, 근육통, 및 요추 통증으로 이루어진 군으로부터 선택될 수 있으나, 이에 제한되지 않는다, 본 발명의 일 실시예에 따르면, 상기 통증은 두통, 만성 통증, 근육통, 섬유근통, 또는 근막통일 수 있다.
본 발명에서 사용되는 용어, “만성 통증”은 통증의 기간과 강도가 환자의 기능이나 생활에 유해한 효과를 일으키거나 또는 정상적인 조직 치유기간, 보통 3개월을 넘어서 지속되는 경우를 의미한다.
본 발명에서 사용되는 용어, “섬유근통(fibromyalgia)”은 만성적으로 전신의 근골격계 통증, 뻣뻣함, 감각 이상, 수면 장애, 피로감을 일으키고, 신체 곳곳에 압통점(누르면 아픈 부분)이 나타나는 힘줄 및 인대 근막과 근육, 지방조직 등 연부조직의 통증 증후군을 의미한다.
본 발명에서 사용되는 용어 “근막통(myofascial pain syndrome)”은 근육이 딱딱하게 뭉쳐지면서 통증을 유발하는 질환으로 잘못된 자세와 스트레스에 의해 어깨나 뒷목 주변 근육이 쉬지 못하고 장시간 긴장함에 따라 근육에 영양분과 산소가 부족해져 발생하는 것을 의미한다.
본 발명에 있어서, 특정 서열번호로 표시되는 아미노산 서열로 이루어진 단백질(펩타이드)에만 제한되지 않으며, 상기 특정 서열번호로 표시되는 아미노산 서열로 이루어진 단백질들의 기능적 동등물도 포함한다. "기능적 동등물"이란 아미노산의 부가, 치환 또는 결실의 결과, 상기 특정 서열번호로 표시되는 아미노산 서열과 적어도 70% 이상, 바람직하게는 80% 이상, 더욱 바람직하게는 90% 이상, 더 더욱 바람직하게는 95% 이상의 서열 상동성을 갖는 것으로, 특정 서열번호로 표시되는 단백질과 실질적으로 동질의 생리활성을 나타내는 단백질을 말한다.
본 명세서에 기재된 특정 아미노산 서열은 기능적 동등성을 유지하는 한 특정 아미노산 서열번호로 표시되는 단백질(펩타이드)에 제한되지 않으며, 상기 아미노산 서열의 변이체가 본 발명의 범위 내에 포함된다. 구체적으로, 특정 서열번호의 아미노산 서열과 80% 이상, 더욱 바람직하게는 90% 이상, 더욱 바람직하게는 95% 이상의 서열 상동성을 가지는 아미노산 서열을 포함할 수 있다. 예를 들면, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, 100%의 서열 상동성을 갖는 단백질(펩타이드)를 포함한다. 특정 아미노산 서열에 대한 “서열 상동성의 %”는 최적으로 배열된 서열과 비교 영역을 비교함으로써 확인되며, 비교 영역에서 아미노산 서열의 일부는 서열의 최적 배열에 대한 참고 서열(추가 또는 삭제를 포함하지 않음)에 비해 추가 또는 삭제(즉, 갭)를 포함할 수 있다.
본 명세서에 기재된 특정 서열번호로 표시되는 염기서열로 이루어진 폴리뉴클레오티드는 해당 염기서열에만 제한되지 않으며, 상기 염기서열의 변이체가 본 발명의 범위 내에 포함된다. 본 발명의 염기서열의 핵산분자는 이를 구성하는 핵산 분자의 작용성 등가물, 예를 들어, 핵산 분자의 일부 염기서열이 결실 (deletion), 치환 (substitution) 또는 삽입 (insertion)에 의해 변형되었지만, 핵산 분자와 기능적으로 동일한 작용을 할 수 있는 변이체 (variants)를 포함하는 개념이다. 구체적으로, 본 발명에 개시된 폴리뉴클레오티드는 특정 서열번호로 표시되는 염기서열과 각각 70% 이상, 더욱 바람직하게는 80% 이상, 더 더욱 바람직하게는 90% 이상, 가장 바람직하게는 95% 이상의 서열 상동성을 가지는 염기서열을 포함할 수 있다. 예를 들면, 70%, 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, 100%의 서열 상동성을 갖는 폴리뉴클레오티드를 포함한다. 폴리뉴클레오티드에 대한 “서열 상동성의 %”는 두 개의 최적으로 배열된 서열과 비교 영역을 비교함으로써 확인되며, 비교 영역에서의 폴리뉴클레오티드 서열의 일부는 두 서열의 최적 배열에 대한 참고 서열(추가 또는 삭제를 포함하지 않음)에 비해 추가 또는 삭제(즉, 갭)를 포함할 수 있다..
본 발명에서 “약학적 조성물”은 질병의 예방 또는 치료를 목적으로 제조된 것을 의미하며, 각각 통상의 방법에 따라 다양한 형태로 제형화하여 사용될 수 있다. 예컨데, 산제, 과립제, 정제, 캡슐제, 현탁액, 에멀젼, 시럽 등의 경구형 제형으로 제형화활 수 있고, 외용제, 좌제 및 멸균 주사용액의 형태로 제형화하여 사용할 수 있다.
본 발명에 따른 약학적 조성물은 약학적 조성물의 제조에 통상적으로 사용하는 적절한 담체, 부형제 및 희석제를 더 포함할 수 있다. 상기 부형제는 예를 들어, 희석제, 결합제, 붕해제, 활택제, 흡착제, 보습제, 필름-코팅 물질, 및 제어방출첨가제로 이루어진 군으로부터 선택된 하나 이상일 수 있다.
본 발명에 따른 약학적 조성물은, 각각 통상의 방법에 따라 산제, 과립제, 서방형 과립제, 장용과립제, 액제, 점안제, 엘실릭제, 유제, 현탁액제, 주정제, 트로키제, 방향수제, 리모나아데제, 정제, 서방형정제, 장용정제, 설하정, 경질캅셀제, 연질캅셀제, 서방캅셀제, 장용캅셀제, 환제, 틴크제, 연조엑스제, 건조엑스제, 유동엑스제, 주사제, 캡슐제, 관류액, 경고제, 로션제, 파스타제, 분무제, 흡입제, 패취제, 멸균주사용액, 또는 에어로졸 등의 외용제 등의 형태로 제형화하여 사용될 수 있으며, 상기 외용제는 크림, 젤, 패치, 분무제, 연고제, 경고제, 로션제, 리니멘트제, 파스타제 또는 카타플라스마제 등의 제형을 가질 수 있다.
본 발명에 따른 약학적 조성물에 포함될 수 있는 담체, 부형제 및 희석제로는 락토즈, 덱스트로즈, 수크로스, 올리고당, 솔비톨, 만니톨, 자일리톨, 에리스리톨, 말티톨, 전분, 아카시아 고무, 알지네이트, 젤라틴, 칼슘 포스페이트, 칼슘 실리케이트, 셀룰로즈, 메틸 셀룰로오스, 미정질 셀룰로오스, 폴리비닐 피롤리돈, 물, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 탈크, 마그네슘 스테아레이트 및 광물유를 들 수 있다.
제제화할 경우에는 보통 사용하는 충진제, 증량제, 결합제, 습윤제, 붕해제, 계면활성제 등의 희석제 또는 부형제를 사용하여 조제된다.
본 발명에 따른 정제, 산제, 과립제, 캡슐제, 환제, 트로키제의 첨가제로 옥수수전분, 감자전분, 밀전분, 유당, 백당, 포도당, 과당, 디-만니톨, 침강탄산칼슘, 합성규산알루미늄, 인산일수소칼슘, 황산칼슘, 염화나트륨, 탄산수소나트륨, 정제 라놀린, 미결정셀룰로오스, 덱스트린, 알긴산나트륨, 메칠셀룰로오스, 카르복시메칠셀룰로오스나트륨, 카올린, 요소, 콜로이드성실리카겔, 히드록시프로필스타치, 히드록시프로필메칠셀룰로오스(HPMC) 1928, HPMC 2208, HPMC 2906, HPMC 2910, 프로필렌글리콜, 카제인, 젖산칼슘, 프리모젤 등 부형제; 젤라틴, 아라비아고무, 에탄올, 한천가루, 초산프탈산셀룰로오스, 카르복시메칠셀룰로오스, 카르복시메칠셀룰로오스칼슘, 포도당, 정제수, 카제인나트륨, 글리세린, 스테아린산, 카르복시메칠셀룰로오스나트륨, 메칠셀룰로오스나트륨, 메칠셀룰로오스, 미결정셀룰로오스, 덱스트린, 히드록시셀룰로오스, 히드록시프로필스타치, 히드록시메칠셀룰로오스, 정제쉘락, 전분호, 히드록시프로필셀룰로오스, 히드록시프로필메칠셀룰로오스, 폴리비닐알코올, 폴리비닐피롤리돈 등의 결합제가 사용될 수 있으며, 히드록시프로필메칠셀룰로오스, 옥수수전분, 한천가루, 메칠셀룰로오스, 벤토나이트, 히드록시프로필스타치, 카르복시메칠셀룰로오스나트륨, 알긴산나트륨, 카르복시메칠셀룰로오스칼슘, 구연산칼슘, 라우릴황산나트륨, 무수규산, 1-히드록시프로필셀룰로오스, 덱스트란, 이온교환수지, 초산폴리비닐, 포름알데히드처리 카제인 및 젤라틴, 알긴산, 아밀로오스, 구아르고무(Guar gum), 중조, 폴리비닐피롤리돈, 인산칼슘, 겔화전분, 아라비아고무, 아밀로펙틴, 펙틴, 폴리인산나트륨, 에칠셀룰로오스, 백당, 규산마그네슘알루미늄, 디-소르비톨액, 경질무수규산 등 붕해제; 스테아린산칼슘, 스테아린산마그네슘, 스테아린산, 수소화식물유(Hydrogenated vegetable oil), 탈크, 석송자, 카올린, 바셀린, 스테아린산나트륨, 카카오지, 살리실산나트륨, 살리실산마그네슘, 폴리에칠렌글리콜(PEG) 4000, PEG 6000, 유동파라핀, 수소첨가대두유(Lubri wax), 스테아린산알루미늄, 스테아린산아연, 라우릴황산나트륨, 산화마그네슘, 마크로골(Macrogol), 합성규산알루미늄, 무수규산, 고급지방산, 고급알코올, 실리콘유, 파라핀유, 폴리에칠렌글리콜지방산에테르, 전분, 염화나트륨, 초산나트륨, 올레인산나트륨, dl-로이신, 경질무수규산 등의 활택제;가 사용될 수 있다.
본 발명에 따른 액제의 첨가제로는 물, 묽은 염산, 묽은 황산, 구연산나트륨, 모노스테아린산슈크로스류, 폴리옥시에칠렌소르비톨지방산에스텔류(트윈에스텔), 폴리옥시에칠렌모노알킬에텔류, 라놀린에텔류, 라놀린에스텔류, 초산, 염산, 암모니아수, 탄산암모늄, 수산화칼륨, 수산화나트륨, 프롤아민, 폴리비닐피롤리돈, 에칠셀룰로오스, 카르복시메칠셀룰로오스나트륨 등이 사용될 수 있다.
본 발명에 따른 시럽제에는 백당의 용액, 다른 당류 혹은 감미제 등이 사용될 수 있으며, 필요에 따라 방향제, 착색제, 보존제, 안정제, 현탁화제, 유화제, 점조제 등이 사용될 수 있다.
본 발명에 따른 유제에는 정제수가 사용될 수 있으며, 필요에 따라 유화제, 보존제, 안정제, 방향제 등이 사용될 수 있다.
본 발명에 따른 현탁제에는 아카시아, 트라가칸타, 메칠셀룰로오스, 카르복시메칠셀룰로오스, 카르복시메칠셀룰로오스나트륨, 미결정셀룰로오스, 알긴산나트륨, 히드록시프로필메칠셀룰로오스(HPMC), HPMC 1828, HPMC 2906, HPMC 2910 등 현탁화제가 사용될 수 있으며, 필요에 따라 계면활성제, 보존제, 안정제, 착색제, 방향제가 사용될 수 있다.
본 발명에 따른 주사제에는 주사용 증류수, 0.9%염화나트륨주사액, 링겔주사액, 덱스트로스주사액, 덱스트로스+염화나트륨주사액, 피이지(PEG), 락테이티드 링겔주사액, 에탄올, 프로필렌글리콜, 비휘발성유-참기름, 면실유, 낙화생유, 콩기름, 옥수수기름, 올레인산에칠, 미리스트산 이소프로필, 안식향산벤젠과 같은 용제; 안식향산나트륨, 살리실산나트륨, 초산나트륨, 요소, 우레탄, 모노에칠아세트아마이드, 부타졸리딘, 프로필렌글리콜, 트윈류, 니정틴산아미드, 헥사민, 디메칠아세트아마이드와 같은 용해보조제; 약산 및 그 염(초산과 초산나트륨), 약염기 및 그 염(암모니아 및 초산암모니움), 유기화합물, 단백질, 알부민, 펩톤, 검류와 같은 완충제; 염화나트륨과 같은 등장화제; 아황산수소나트륨(NaHSO3) 이산화탄소가스, 메타중아황산나트륨(Na2S2O5), 아황산나트륨(Na2SO3), 질소가스(N2), 에칠렌디아민테트라초산과 같은 안정제; 소디움비설파이드 0.1%, 소디움포름알데히드 설폭실레이트, 치오우레아, 에칠렌디아민테트라초산디나트륨, 아세톤소디움비설파이트와 같은 황산화제; 벤질알코올, 클로로부탄올, 염산프로카인, 포도당, 글루콘산칼슘과 같은 무통화제; 시엠시나트륨, 알긴산나트륨, 트윈 80, 모노스테아린산알루미늄과 같은 현탁화제를 포함할 수 있다.
본 발명에 따른 좌제에는 카카오지, 라놀린, 위텝솔, 폴리에틸렌글리콜, 글리세로젤라틴, 메칠셀룰로오스, 카르복시메칠셀룰로오스, 스테아린산과 올레인산의 혼합물, 수바날(Subanal), 면실유, 낙화생유, 야자유, 카카오버터+콜레스테롤, 레시틴, 라네트왁스, 모노스테아린산글리세롤, 트윈 또는 스판, 임하우젠(Imhausen), 모놀렌(모노스테아린산프로필렌글리콜), 글리세린, 아뎁스솔리두스(Adeps solidus), 부티룸 태고-G(Buytyrum Tego-G), 세베스파마 16 (Cebes Pharma 16), 헥사라이드베이스 95, 코토마(Cotomar), 히드록코테 SP, S-70-XXA, S-70-XX75(S-70-XX95), 히드록코테(Hydrokote) 25, 히드록코테 711, 이드로포스탈 (Idropostal), 마사에스트라리움(Massa estrarium, A, AS, B, C, D, E, I, T), 마사-MF, 마수폴, 마수폴-15, 네오수포스탈-엔, 파라마운드-B, 수포시로(OSI, OSIX, A, B, C, D, H, L), 좌제기제 IV 타입 (AB, B, A, BC, BBG, E, BGF, C, D, 299), 수포스탈 (N, Es), 웨코비 (W, R, S, M ,Fs), 테제스터 트리글리세라이드 기제 (TG-95, MA, 57)와 같은 기제가 사용될 수 있다.
경구 투여를 위한 고형제제에는 정제, 환제, 산제, 과립제, 캡슐제 등이 포함되며, 이러한 고형제제는 상기 추출물에 적어도 하나 이상의 부형제 예를 들면, 전분, 칼슘카보네이트(calcium carbonate), 수크로스(sucrose) 또는 락토오스(lactose), 젤라틴 등을 섞어 조제된다. 또한 단순한 부형제 이외에 마그네슘 스티레이트 탈크 같은 윤활제들도 사용된다.
경구 투여를 위한 액상제제로는 현탁제, 내용액제, 유제, 시럽제 등이 해당되는데 흔히 사용되는 단순희석제인 물, 리퀴드 파라핀 이외에 여러 가지 부형제, 예를 들면 습윤제, 감미제, 방향제, 보존제 등이 포함될 수 있다. 비경구 투여를 위한 제제에는 멸균된 수용액, 비수성용제, 현탁제, 유제, 동결건조제제, 좌제가 포함된다. 비수성용제, 현탁제로는 프로필렌글리콜 (propylene glycol), 폴리에틸렌 글리콜, 올리브 오일과 같은 식물성 기름, 에틸올레이트와 같은 주사 가능한 에스테르 등이 사용될 수 있다.
본 발명에 따른 약학적 조성물은 약학적으로 유효한 양으로 투여한다. 본 발명에 있어서, "약학적으로 유효한 양"은 의학적 치료에 적용 가능한 합리적인 수혜/위험 비율로 질환을 치료하기에 충분한 양을 의미하며, 유효용량 수준은 환자 질환의 종류, 중증도, 약물의 활성, 약물에 대한 민감도, 투여 시간, 투여 경로 및 배출비율, 치료기간, 동시 사용되는 약물을 포함한 요소 및 기타 의학 분야에 잘 알려진 요소에 따라 결정될 수 있다.
본 발명에 따른 약학적 조성물은 개별 치료제로 투여하거나 다른 치료제와 병용하여 투여될 수 있고 종래의 치료제와는 순차적 또는 동시에 투여될 수 있으며, 단일 또는 다중 투여될 수 있다. 상기한 요소들을 모두 고려하여 부작용 없이 최소한의 양으로 최대 효과를 얻을 수 있는 양을 투여하는 것이 중요하며, 이는 본 발명이 속하는 기술분야에 통상의 기술자에 의해 용이하게 결정될 수 있다.
본 발명의 약학적 조성물은 개체에게 다양한 경로로 투여될 수 있다. 투여의 모든 방식은 예상될 수 있는데, 예를 들면, 경구 복용, 피하 주사, 복강 투여, 정맥 주사, 근육 주사, 척수 주위 공간(경막내) 주사, 설하 투여, 볼점막 투여, 직장 내 삽입, 질 내 삽입, 안구 투여, 귀 투여, 비강 투여, 흡입, 입 또는 코를 통한 분무, 피부 투여, 경피 투여 등에 따라 투여될 수 있다.
본 발명의 약학적 조성물은 치료할 질환, 투여 경로, 환자의 연령, 성별, 체중 및 질환의 중등도 등의 여러 관련 인자와 함께 활성성분인 약물의 종류에 따라 결정된다.
또한, 본 발명은 상기 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 조성물을 이를 필요로 하는 개체에 투여하는 단계를 포함하는 통증개선 방법을 제공한다.
또한, 본 발명은 상기 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 조성물의 통증개선 용도를 제공한다.
또한, 본 발명은 상기 보툴리눔 독소 재조합 단백질의 통증개선용 약제를 제조를 위한 용도를 제공한다.
본 발명에서 “개체”란 질병의 치료를 필요로 하는 대상을 의미하고, 보다 구체적으로는 인간 또는 비-인간인 영장류, 생쥐 (mouse), 쥐 (rat), 개, 고양이, 말, 및 소 등의 포유류를 의미한다.
본 발명에서 “투여”란 임의의 적절한 방법으로 개체에게 소정의 본 발명의 조성물을 제공하는 것을 의미한다.
본 발명에서 “개선”이란 본 발명에 따른 조성물의 투여로 통증의 증상이 호전되거나 이롭게 변경되는 모든 행위를 의미할 수 있으며, 예방 또는 치료 행위도 포함될 수 있다.
본 발명에서 “예방”이란 목적하는 질환의 발병을 억제하거나 지연시키는 모든 행위를 의미하고, “치료”란 본 발명에 따른 약학적 조성물의 투여에 의해 목적하는 질환과 그에 따른 대사 이상 증세가 호전되거나 이롭게 변경되는 모든 행위를 의미한다.
또한, 본 발명은 본 발명의 다른 양태로 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 통증개선용 의약외품 조성물로서, 상기 보툴리눔 독소 재조합 단백질은 보툴리눔 독소 경쇄의 일측 또는 양말단에 서열번호 1의 아미노산 서열로 이루어진 세포투과성 펩타이드가 융합된 것을 특징으로 하는, 통증개선용 의약외품 조성물을 제공한다.
본 발명의 용어, "의약외품"은 사람이나 동물의 질병을 진단, 치료, 개선, 경감, 처치 또는 예방할 목적으로 사용되는 물품들 중 의약품보다 작용이 경미한 물품들을 의미하는 것으로, 예를 들어 약사법에 따르면 의약외품이란 의약품의 용도로 사용되는 물품을 제외한 것으로, 사람/동물의 질병 치료나 예방에 쓰이는 제품, 인체에 대한 작용이 경미하거나 직접 작용하지 않는 제품 등이 포함된다.
본 발명의 의약외품 조성물은 바디 클렌저, 폼, 비누, 마스크, 연고제, 크림, 로션, 에센스 및 스프레이로 이루어진 군에서 선택되는 하나 이상으로 제조할 수 있으나, 이에 제한되는 것은 아니다. 또한, 상기 조성물은 밴드, 생리대 등의 형태로 제조될 수 있으나, 이에 제한되지 않는다.
본 발명에 따른 보툴리눔 독소 재조합 단백질을 의약외품 첨가물로 사용할 경우, 상기 조성물을 그대로 첨가하거나 다른 의약외품 또는 의약외품 성분과 함께 사용할 수 있고, 통상적인 방법에 따라 적절하게 사용할 수 있다. 유효성분의 혼합량은 사용 목적에 따라 적합하게 결정될 수 있다.
또한, 본 발명은 본 발명의 다른 양태로 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 통증개선용 피부외용제 조성물로서, 상기 보툴리눔 독소 재조합 단백질은 보툴리눔 독소 경쇄의 일측 또는 양말단에 서열번호 1의 아미노산 서열로 이루어진 세포투과성 펩타이드가 융합된 것을 특징으로 하는, 통증개선용 피부외용제 조성물을 제공한다.
본 발명의 피부외용제 조성물은 유효성분으로서 보툴리눔 독소 재조합 단백질을 포함하며 약제학적으로 허용 가능한 담체를 포함할 수 있다. 이외에도, 추가적으로 지방 물질, 유기 용매, 용해제, 농축제 및 겔화제, 연화제, 항산화제, 현탁화제, 안정화제, 발포제(foaming agent), 방향제, 계면활성제, 물, 이온형 또는 비이온형 유화제, 충전제, 금속이온봉쇄제 및 킬레이트화제, 보존제, 비타민, 차단제, 습윤화제, 필수 오일, 염료, 안료, 친수성 또는 친유성 활성제, 지질 소낭 또는 피부용 외용제에 통상적으로 사용되는 임의의 다른 성분과 같은 피부 과학분야에서 통상적으로 사용되는 보조제를 함유할 수 있다. 또한, 상기 성분들은 피부 과학분야에서 일반적으로 사용되는 양으로 도입될 수 있다.
상기 피부외용제 조성물의 투여량은 투여 대상의 체중, 연령, 성별, 건강 상태, 투여 기간, 제거율, 질환의 중증도 등에 따라 변화될 수 있다.
상기 피부외용제 조성물의 제제 형태로는 이에 한정되지는 않으나 예를 들면, 액상도포제, 분무제, 로션제, 겔제, 파스타제, 연고제, 에어로졸, 분말제, 패취, 크림, 롤온, 경피흡수제 등이 있다.
본 발명의 피부외용제 조성물에서 약학적으로 허용되는 담체로는 그의 제형에 따라 다르나, 바셀린, 유동 파라핀, 겔화 탄화수소(플라스티베이스) 등의 탄화수소류; 중쇄지방산트리글리세라이드, 돈지, 하드 팻, 카카오지 등의 동식물성 오일; 세탄올, 스테아릴알코올, 스테아린산, 팔미틴산이소프로필 등의 고급지방산 알코올 및 지방산 및 그의 에스테르류; 폴리에틸렌글리콜, 1,3-부틸렌글리콜, 글리세롤, 젤라틴, 백당, 당알코올 등의 수용성 기제; 글리세린 지방산 에스테르, 스테아린산폴리옥실, 폴리옥시에틸렌경화 피마자유 등의 유화제; 아크릴산에스테르, 알긴산나트륨 등의 점착제; 액화석유가스, 이산화탄소 등의 분사제; 파라옥시벤조산에스테르류 등의 방부제 등을 들 수 있다. 또한, 이들 외에도 안정제, 향료, 착색제, pH 조정제, 희석제, 계면활성제, 보존제, 항산화제 등을 필요에 따라 배합할 수 있다. 본 발명의 피부외용제 조성물의 사용은 통상의 방법에 의해 환부 또는 통증이 발현하는 부위의 피부에 도포하는 것이 바람직하다.
또한, 본 발명에 따른 피부외용제 조성물은 통상적인 반창고의 창상 박리 커버 등과 같은 고체 지지체 상에 점착되어 사용될 수 있다. 점착은 본 발명의 조성물을 고체 지지체에 포화시킨 후 탈수시켜 달성할 수 있다. 바람직하게는 고체 지지체를 먼저 점착제로 피복하여 고체 지지체에 본 발명의 조성물의 부착을 향상시킬 수 있다. 점착제의 예로는 폴리아크릴레이트 및 시아노아크릴레이트 등이 있다.
또한, 본 발명은 본 발명의 다른 양태로 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 통증개선용 화장료 조성물로서, 상기 보툴리눔 독소 재조합 단백질은 보툴리눔 독소 경쇄의 일측 또는 양말단에 서열번호 1의 아미노산 서열로 이루어진 세포투과성 펩타이드가 융합된 것을 특징으로 하는, 통증개선용 화장료 조성물을 제공한다.
본 발명에 따른 화장료 조성물은 당업계에서 통상적으로 제조되는 어떠한 제형으로도 제조될 수 있으며, 본 발명에 따른 조성물 이외에 피부과학적으로 허용 가능한 매질, 기제, 보조제, 부형제 등과 함께 피부과학 분야에서 통상적으로 제조되는 국소 적용 또는 전신 적용할 수 있는 보조제 형태로 제조될 수 있다. 예를 들어, 기초 화장품 조성물(화장수, 크림, 에센스, 클렌징폼 및 클렌징 워터와 같은 세안제, 팩, 보디오일), 색조 화장품 조성물(화운데이션, 립스틱, 마스카라, 메이크업 베이스), 두발 제품 조성물(샴푸, 린스, 헤어컨디셔너, 헤어젤) 및 비누 등의 형태로 제조될 수 있다.
또한, 본 발명의 화장료 조성물은 추가로 지방 물질, 유기 용매, 용해제, 농축제 및 겔화제, 연화제, 항산화제, 현탁화제, 안정화제, 발포제(foaming agent), 방향제, 계면활성제, 물, 이온형 또는 비이온형 유화제, 충전제, 금속이온 봉쇄제 및 킬레이트화제, 보존제, 비타민, 차단제, 습윤화제, 필수 오일, 염료, 안료, 친수성 또는 친유성 활성제, 지질 소낭 또는 화장품에 통상적으로 사용되는 임의의 다른 성분과 같은 화장품학 또는 피부과학 분야에서 통상적으로 사용되는 보조제를 함유할 수 있다. 그리고 상기의 성분들은 피부과학 분야에서 일반적으로 사용되는 양으로 도입될 수 있다.
상기 부형제로는 이에 한정되지는 않으나 예를 들어, 피부연화제, 피부 침투 증강제, 착색제, 방향제, 유화제, 연화제, 농화제, 농축제, 겔화제, 현택화제, 안정화제, 발포제(foaming agent), 계면활성제, 충전제 또는 용매를 포함할 수 있다. 또한 향료, 색소, 살균제, 산화방지제, 방부제, 보조제 및 보습제 등을 추가로 포함할 수 있으며, 물성 개선을 목적으로 점증제, 무기염류, 합성 고분자 물질 등을 포함할 수 있다. 예를 들면, 본 발명의 화장료 조성물로 세안제 및 비누를 제조하는 경우에는 통상의 세안제 및 비누 베이스에 본 발명의 추출물을 첨가하여 용이하게 제조할 수 있다. 크림을 제조하는 경우에는 일반적인 수중유적형(O/W)의 크림베이스에 본 발명의 보툴리눔 독소 재조합 단백질을 첨가하여 제조할 수 있다. 여기에 향료, 킬레이트제, 색소, 산화방지제, 방부제 등과 물성 개선을 목적으로 한 단백질, 미네랄, 비타민 등 합성 또는 천연 소재를 추가로 첨가할 수 있다.
적합한 화장료 조성물의 제형으로는 예를 들면 용액, 겔, 고체 또는 반죽 무수 생성물, 수상에 유상을 분산시켜 얻은 에멀젼, 현탁액, 마이크로에멀젼, 마이크로캡슐, 미세과립구 또는 이온형(리포좀), 비이온형의 소낭 분산제의 형태, 크림, 스킨, 로션, 파우더, 연고, 스프레이 또는 콘실 스틱(conceal stick)의 형태로 제공될 수 있다. 또한, 포말(foam)의 형태 또는 압축된 추진제를 더 함유한 에어로졸 조성물의 형태로도 제조될 수 있다.
본 발명의 화장료 조성물을 첨가할 수 있는 제품으로는 이에 한정되는 것은 아니나 스킨로션, 스킨 소프너, 스킨토너, 수렴화장수, 유연화장수, 영양화장수, 아스트린젠트, 로션, 밀크로션, 모이스처 로션, 영양로션, 바디크림, 마사지크림, 영양크림, 모이스처 크림, 핸드크림, 에센스, 영양에센스, 팩, 비누, 샴푸, 클렌징폼, 클렌징로션, 클렌징크림, 바디로션, 바디클렌저, 트리트먼트, 미용액, 유액, 프레스파우더, 루스파우더, 아이섀도 등의 제형을 포함한다.
본 발명에 따른 조성물은 멘톨(Menthol), 시어 버터(Shea Butter), 스카치 파인 잎(Scotch Pine Leaf), 알로에 베라(Aloe Vera), 박하(Peppermint), 로즈마리(Rosemary) 등의 추출물 더 포함할 수 있으나, 이에 제한되지 않는다.
이하, 본 발명의 이해를 돕기 위하여 바람직한 실시예를 제시한다. 그러나 하기의 실시예는 본 발명을 보다 쉽게 이해하기 위하여 제공되는 것일 뿐, 하기 실시예에 의해 본 발명의 내용이 한정되는 것은 아니다.
[실시예]
실시예 1. 두통개선 효과 확인
1-1. 실험 재료 및 실험 방법
두통으로 일상 생활에 불편함을 느끼며 진통제를 복용하고 있는 23 ~ 53세 성인 남녀 총 9명(여성 7명, 남성 2명, 평균 연령 36세)을 대상으로 대한민국 등록특허 제10-1882461호에 따라 제조한 보툴리눔 독소 재조합 단백질(피부 투과형 보툴리눔 유래 성분 펩타이드)이 함유된 용액 2.5 cc를 통증이 있는 두피 부위와 이마에 매일 아침마다 직접 도포하였다.
평가는 시험 전 피험자들에게 설문 조사 후 두통학회의 '두통일기 앱'을 통해 두통이 있는 날마다 피험자가 두통횟수 및 진통제 복용횟수를 직접 입력하도록 하였다. 시험기간은 총 12주로 피험자가 직접 입력한 정보로 두통횟수는 사용 전, 사용 후 1 ~ 4주, 사용 후 5 ~ 8주, 사용 후 9 ~ 12주로 4가지를 비교 평가하였다. 진통제 복용횟수는 사용 후 1 ~ 4주, 사용 후 5 ~ 8주, 사용 후 9 ~ 12주로 3가지를 비교 평가하였다.
1-2. 두통횟수
두통횟수를 비교 평가한 결과, 도 1에 나타낸 바와 같이, 피험자 9명 모두 두통이 개선된 것을 확인할 수 있었다. 구체적으로, 사용 후 기간별 평균 두통발생횟수는 사용 전 4주간(14.3회), 사용 후 1 ~ 4주(8.5회), 사용 후 5 ~ 8주(6.9회), 사용 후 9 ~ 12주(2.5회)로 피부 투과형 보툴리눔 유래 성분 펩타이드가 함유된 용액을 사용하기 전 4주간에 비해 사용 후 9 ~ 12주 기간 동안 피험자들의 평균 두통발생횟수는 84% 감소한 것을 확인할 수 있었다.
또한, 도 2에 나타낸 바와 같이, 사용 후 기간별 두통횟수 감소율은 사용 초기인 1 ~ 4주와 사용 마지막인 9 ~ 12주를 비교한 결과, 20% 이상 개선된 피험자가 2명(7명 → 9명), 50% 이상 개선된 피험자가 4명(4명 → 8명), 70% 이상 개선된 피험자가 4명(1명 → 5명), 100% 개선된 피험자가 3명(0명 → 3명)으로 증가한 것을 확인할 수 있었다.
1-3. 진통제 복용횟수
사용 후 1 ~ 4주와 9 ~ 12주의 진통제 복용횟수를 비교 평가한 결과, 피험자 9명 중 8명에서 진통제 복용횟수가 감소하였으며, 1명은 1회 증가한 것으로 나타났다.
사용 후 기간별 진통제 복용횟수를 비교한 결과, 도 3에 나타낸 바와 같이, 사용 후 1 ~ 4주 동안은 2회 3명, 1회 3명, 0회 3명이였으며, 사용 후 5 ~ 8주 동안은 3회 1명, 2회 1명, 1회 4명, 0 회 3명으로 복용횟수가 1회 증가한 사람이 1명, 복용횟수가 1회 감소한 사람이 1명이었다. 사용 후 9 ~ 12주 동안은 3회 1명, 2회 0명, 1회 2명, 0회 6명으로 사용 초기 1 ~ 4주에 비해 진통제 복용이 필요 없는 피험자가 3명 증가한 것을 확인할 수 있었다.
상기 결과로부터, 보툴리눔 독소 주사와 유사한 주름 개선 효과를 보이는 피부 투과형 보툴리눔 유래 성분 펩타이드를 두경부에 도포할 경우, 전반적으로 두통횟수와 진통제 복용횟수가 감소하였는바, 두통 개선효과가 있을 것으로 판단되었다.
실시예 2. 통증개선 효과 확인
2-1. 실험 재료 및 실험 방법
30 ~ 75세의 만성 통증, 섬유근통, 근막통, 또는 근육통 환자인 성인 24명을 대상으로 피부에 도포한 피부투과형 보툴리눔 유래 성분 펩타이드가 근육 긴장을 완화하여 통증을 감소시킬 수 있는지 여부 및 근육 경련성 통증을 감소시킬 수 있는지 여부, 및 피부투과형 보툴리눔 유래 성분 펩타이드의 반복적인 움직임, 기계적 충격으로 유발되는 만성 통증의 개선 정도를 확인하였다.
실험 대상은 하기 표 1의 3가지 조건 중 하나를 충족하도록 구성하였으며, 피부투과형 보툴리눔 유래 성분 펩타이드가 함유된 보툴리눔 로션 적당량을 매일 2회 통증 부위에 직접 도포하도록 하였다.
실험 대상 24명을 다음과 같이 3개의 그룹으로 나누어 분석하였다:
Group A: 만성 통증 환자
Group B: 섬유근통, 및 근육통 환자
Group C: 마약성 진통제 사용 그룹(Group C의 경우, Group A, B와 표본 중복 있음).
2-2. Group A
만성 통증 환자 14명(표 1의 각 조건을 만족하는 환자를 적절하게 섞음)에서 보툴리눔 로션 사용 후 6일 간의 통증 변화를 확인한 결과, 도 4에 나타낸 바와 같이, 보툴리눔 로션 사용 후 78.57%의 환자에서 통증이 감소한 것을 확인할 수 있었다 (14명 중 11명이 통증이 감소함). 보툴리눔 로션을 사용하는 동안 통증은 감소된 상태를 유지하였다. 보툴리눔 로션 사용 직후 즉각적인 통증 감소 효과가 나타났으며, 전반적으로 로션을 바르는 동안 통증 감소 효과가 유지되는 것을 확인할 수 있었다.
2-3. Group B
섬유근통, 및 근육통 환자 7명(표 1의 각 조건을 만족하는 환자를 적절하게 섞음)에서 보툴리눔 로션 사용 후, 통증 감소 지속 여부 확인한 결과, 보툴리눔 로션 사용 직후 71.43%의 환자에서 통증이 감소하였으며(7명 중 5명이 통증이 감소한 것으로 나타남, 도면에 나타내지는 않음), 도 5에 나타낸 바와 같이, 57.14%의 환자에서 로션을 바르는 동안 통증 감소 상태가 유지되는 것으로 나타났다 (7명 중 4명이 통증 감소 상태가 유지됨). 전반적으로 보툴리눔 로션 사용 직후 즉각적인 통증 감소 효과를 경험했으며, 보툴리눔 로션을 바르는 동안 효과가 유지되는 것으로 나타났다.
2-4. Group C
마약성 진통제를 사용하는 환자 15명에서 보툴리눔 로션 사용 후, 통증 감소 지속 여부를 확인한 결과, 도 6에 나타낸 바와 같이, 80%의 환자가 즉각적으로 통증이 완화되었다고 응답하였으며(도면에 나타내지는 않음), 도 6에 나타낸 바와 같이, 66.67%의 환자가(15명 중 10명) 보툴리눔 로션을 사용하는 동안 지속적인 통증 개선 효과가 있었다고 응답하였다. 보툴리눔 로션 사용 직후, 전반적으로 즉각적인 통증 감소 효과를 경험했으며, 로션을 바르는 동안 효과가 유지되는 것으로 나타났다.
전술한 본 발명의 설명은 예시를 위한 것이며, 본 발명이 속하는 기술분야의 통상의 지식을 가진 자는 본 발명의 기술적 사상이나 필수적인 특징을 변경하지 않고서 다른 구체적인 형태로 쉽게 변형이 가능하다는 것을 이해할 수 있을 것이다. 그러므로 이상에서 기술한 실시예들은 모든 면에서 예시적인 것이며 한정적이 아닌 것으로 이해해야만 한다.
<110> BPMed Co., Ltd.
<120> Composition for alleviating pain comprising botulinum-derived
peptide
<130> MP21-215P1
<150> KR 10-2021-0143024
<151> 2021-10-25
<160> 86
<170> KoPatentIn 3.0
<210> 1
<211> 13
<212> PRT
<213> Artificial Sequence
<220>
<223> MTD Amino Acid Sequence
<400> 1
Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys
1 5 10
<210> 2
<211> 39
<212> DNA
<213> Artificial Sequence
<220>
<223> MTD cDNA Sequence
<400> 2
aaggcgatga taaacataaa caagttcctg aaccagtgc 39
<210> 3
<211> 448
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/A Light chain Amino Acid Sequence
<400> 3
Met Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly
1 5 10 15
Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met Gln Pro
20 25 30
Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg
35 40 45
Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu
50 55 60
Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr
65 70 75 80
Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu
85 90 95
Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val
100 105 110
Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys
115 120 125
Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr
130 135 140
Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile
145 150 155 160
Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr
165 170 175
Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe
180 185 190
Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu
195 200 205
Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Glu
210 215 220
Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn
225 230 235 240
Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu
245 250 255
Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys
260 265 270
Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn
275 280 285
Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val
290 295 300
Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys
305 310 315 320
Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu
325 330 335
Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp
340 345 350
Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn
355 360 365
Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr
370 375 380
Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn
385 390 395 400
Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu
405 410 415
Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys Val Arg
420 425 430
Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Asp Lys Gly Tyr Asn Lys
435 440 445
<210> 4
<211> 441
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/B Light chain Amino Acid Sequence
<400> 4
Met Pro Val Thr Ile Asn Asn Phe Asn Tyr Asn Asp Pro Ile Asp Asn
1 5 10 15
Asn Asn Ile Ile Met Met Glu Pro Pro Phe Ala Arg Gly Thr Gly Arg
20 25 30
Tyr Tyr Lys Ala Phe Lys Ile Thr Asp Arg Ile Trp Ile Ile Pro Glu
35 40 45
Arg Tyr Thr Phe Gly Tyr Lys Pro Glu Asp Phe Asn Lys Ser Ser Gly
50 55 60
Ile Phe Asn Arg Asp Val Cys Glu Tyr Tyr Asp Pro Asp Tyr Leu Asn
65 70 75 80
Thr Asn Asp Lys Lys Asn Ile Phe Leu Gln Thr Met Ile Lys Leu Phe
85 90 95
Asn Arg Ile Lys Ser Lys Pro Leu Gly Glu Lys Leu Leu Glu Met Ile
100 105 110
Ile Asn Gly Ile Pro Tyr Leu Gly Asp Arg Arg Val Pro Leu Glu Glu
115 120 125
Phe Asn Thr Asn Ile Ala Ser Val Thr Val Asn Lys Leu Ile Ser Asn
130 135 140
Pro Gly Glu Val Glu Arg Lys Lys Gly Ile Phe Ala Asn Leu Ile Ile
145 150 155 160
Phe Gly Pro Gly Pro Val Leu Asn Glu Asn Glu Thr Ile Asp Ile Gly
165 170 175
Ile Gln Asn His Phe Ala Ser Arg Glu Gly Phe Gly Gly Ile Met Gln
180 185 190
Met Lys Phe Cys Pro Glu Tyr Val Ser Val Phe Asn Asn Val Gln Glu
195 200 205
Asn Lys Gly Ala Ser Ile Phe Asn Arg Arg Gly Tyr Phe Ser Asp Pro
210 215 220
Ala Leu Ile Leu Met His Glu Leu Ile His Val Leu His Gly Leu Tyr
225 230 235 240
Gly Ile Lys Val Asp Asp Leu Pro Ile Val Pro Asn Glu Lys Lys Phe
245 250 255
Phe Met Gln Ser Thr Asp Ala Ile Gln Ala Glu Glu Leu Tyr Thr Phe
260 265 270
Gly Gly Gln Asp Pro Ser Ile Ile Thr Pro Ser Thr Asp Lys Ser Ile
275 280 285
Tyr Asp Lys Val Leu Gln Asn Phe Arg Gly Ile Val Asp Arg Leu Asn
290 295 300
Lys Val Leu Val Cys Ile Ser Asp Pro Asn Ile Asn Ile Asn Ile Tyr
305 310 315 320
Lys Asn Lys Phe Lys Asp Lys Tyr Lys Phe Val Glu Asp Ser Glu Gly
325 330 335
Lys Tyr Ser Ile Asp Val Glu Ser Phe Asp Lys Leu Tyr Lys Ser Leu
340 345 350
Met Phe Gly Phe Thr Glu Thr Asn Ile Ala Glu Asn Tyr Lys Ile Lys
355 360 365
Thr Arg Ala Ser Tyr Phe Ser Asp Ser Leu Pro Pro Val Lys Ile Lys
370 375 380
Asn Leu Leu Asp Asn Glu Ile Tyr Thr Ile Glu Glu Gly Phe Asn Ile
385 390 395 400
Ser Asp Lys Asp Met Glu Lys Glu Tyr Arg Gly Gln Asn Lys Ala Ile
405 410 415
Asn Lys Gln Ala Tyr Glu Glu Ile Ser Lys Glu His Leu Ala Val Tyr
420 425 430
Lys Ile Gln Met Cys Lys Ser Val Lys
435 440
<210> 5
<211> 449
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/C Light chain Amino Acid Sequence
<400> 5
Met Pro Ile Thr Ile Asn Asn Phe Asn Tyr Ser Asp Pro Val Asp Asn
1 5 10 15
Lys Asn Ile Leu Tyr Leu Asp Thr His Leu Asn Thr Leu Ala Asn Glu
20 25 30
Pro Glu Lys Ala Phe Arg Ile Thr Gly Asn Ile Trp Val Ile Pro Asp
35 40 45
Arg Phe Ser Arg Asn Ser Asn Pro Asn Leu Asn Lys Pro Pro Arg Val
50 55 60
Thr Ser Pro Lys Ser Gly Tyr Tyr Asp Pro Asn Tyr Leu Ser Thr Asp
65 70 75 80
Ser Asp Lys Asp Pro Phe Leu Lys Glu Ile Ile Lys Leu Phe Lys Arg
85 90 95
Ile Asn Ser Arg Glu Ile Gly Glu Glu Leu Ile Tyr Arg Leu Ser Thr
100 105 110
Asp Ile Pro Phe Pro Gly Asn Asn Asn Thr Pro Ile Asn Thr Phe Asp
115 120 125
Phe Asp Val Asp Phe Asn Ser Val Asp Val Lys Thr Arg Gln Gly Asn
130 135 140
Asn Trp Val Lys Thr Gly Ser Ile Asn Pro Ser Val Ile Ile Thr Gly
145 150 155 160
Pro Arg Glu Asn Ile Ile Asp Pro Glu Thr Ser Thr Phe Lys Leu Thr
165 170 175
Asn Asn Thr Phe Ala Ala Gln Glu Gly Phe Gly Ala Leu Ser Ile Ile
180 185 190
Ser Ile Ser Pro Arg Phe Met Leu Thr Tyr Ser Asn Ala Thr Asn Asp
195 200 205
Val Gly Glu Gly Arg Phe Ser Lys Ser Glu Phe Cys Met Asp Pro Ile
210 215 220
Leu Ile Leu Met His Glu Leu Asn His Ala Met His Asn Leu Tyr Gly
225 230 235 240
Ile Ala Ile Pro Asn Asp Gln Thr Ile Ser Ser Val Thr Ser Asn Ile
245 250 255
Phe Tyr Ser Gln Tyr Asn Val Lys Leu Glu Tyr Ala Glu Ile Tyr Ala
260 265 270
Phe Gly Gly Pro Thr Ile Asp Leu Ile Pro Lys Ser Ala Arg Lys Tyr
275 280 285
Phe Glu Glu Lys Ala Leu Asp Tyr Tyr Arg Ser Ile Ala Lys Arg Leu
290 295 300
Asn Ser Ile Thr Thr Ala Asn Pro Ser Ser Phe Asn Lys Tyr Ile Gly
305 310 315 320
Glu Tyr Lys Gln Lys Leu Ile Arg Lys Tyr Arg Phe Val Val Glu Ser
325 330 335
Ser Gly Glu Val Thr Val Asn Arg Asn Lys Phe Val Glu Leu Tyr Asn
340 345 350
Glu Leu Thr Gln Ile Phe Thr Glu Phe Asn Tyr Ala Lys Ile Tyr Asn
355 360 365
Val Gln Asn Arg Lys Ile Tyr Leu Ser Asn Val Tyr Thr Pro Val Thr
370 375 380
Ala Asn Ile Leu Asp Asp Asn Val Tyr Asp Ile Gln Asn Gly Phe Asn
385 390 395 400
Ile Pro Lys Ser Asn Leu Asn Val Leu Phe Met Gly Gln Asn Leu Ser
405 410 415
Arg Asn Pro Ala Leu Arg Lys Val Asn Pro Glu Asn Met Leu Tyr Leu
420 425 430
Phe Thr Lys Phe Cys His Lys Ala Ile Asp Gly Arg Ser Leu Tyr Asn
435 440 445
Lys
<210> 6
<211> 442
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/D Light chain Amino Acid Sequence
<400> 6
Met Thr Trp Pro Val Lys Asp Phe Asn Tyr Ser Asp Pro Val Asn Asp
1 5 10 15
Asn Asp Ile Leu Tyr Leu Arg Ile Pro Gln Asn Lys Leu Ile Thr Thr
20 25 30
Pro Val Lys Ala Phe Met Ile Thr Gln Asn Ile Trp Val Ile Pro Glu
35 40 45
Arg Phe Ser Ser Asp Thr Asn Pro Ser Leu Ser Lys Pro Pro Arg Pro
50 55 60
Thr Ser Lys Tyr Gln Ser Tyr Tyr Asp Pro Ser Tyr Leu Ser Thr Asp
65 70 75 80
Glu Gln Lys Asp Thr Phe Leu Lys Gly Ile Ile Lys Leu Phe Lys Arg
85 90 95
Ile Asn Glu Arg Asp Ile Gly Lys Lys Leu Ile Asn Tyr Leu Val Val
100 105 110
Gly Ser Pro Phe Met Gly Asp Ser Ser Thr Pro Glu Asp Thr Phe Asp
115 120 125
Phe Thr Arg His Thr Thr Asn Ile Ala Val Glu Lys Phe Glu Asn Gly
130 135 140
Ser Trp Lys Val Thr Asn Ile Ile Thr Pro Ser Val Leu Ile Phe Gly
145 150 155 160
Pro Leu Pro Asn Ile Leu Asp Tyr Thr Ala Ser Leu Thr Leu Gln Gly
165 170 175
Gln Gln Ser Asn Pro Ser Phe Glu Gly Phe Gly Thr Leu Ser Ile Leu
180 185 190
Lys Val Ala Pro Glu Phe Leu Leu Thr Phe Ser Asp Val Thr Ser Asn
195 200 205
Gln Ser Ser Ala Val Leu Gly Lys Ser Ile Phe Cys Met Asp Pro Val
210 215 220
Ile Ala Leu Met His Glu Leu Thr His Ser Leu His Gln Leu Tyr Gly
225 230 235 240
Ile Asn Ile Pro Ser Asp Lys Arg Ile Arg Pro Gln Val Ser Glu Gly
245 250 255
Phe Phe Ser Gln Asp Gly Pro Asn Val Gln Phe Glu Glu Leu Tyr Thr
260 265 270
Phe Gly Gly Leu Asp Val Glu Ile Ile Pro Gln Ile Glu Arg Ser Gln
275 280 285
Leu Arg Glu Lys Ala Leu Gly His Tyr Lys Asp Ile Ala Lys Arg Leu
290 295 300
Asn Asn Ile Asn Lys Thr Ile Pro Ser Ser Trp Ile Ser Asn Ile Asp
305 310 315 320
Lys Tyr Lys Lys Ile Phe Ser Glu Lys Tyr Asn Phe Asp Lys Asp Asn
325 330 335
Thr Gly Asn Phe Val Val Asn Ile Asp Lys Phe Asn Ser Leu Tyr Ser
340 345 350
Asp Leu Thr Asn Val Met Ser Glu Val Val Tyr Ser Ser Gln Tyr Asn
355 360 365
Val Lys Asn Arg Thr His Tyr Phe Ser Arg His Tyr Leu Pro Val Phe
370 375 380
Ala Asn Ile Leu Asp Asp Asn Ile Tyr Thr Ile Arg Asp Gly Phe Asn
385 390 395 400
Leu Thr Asn Lys Gly Phe Asn Ile Glu Asn Ser Gly Gln Asn Ile Glu
405 410 415
Arg Asn Pro Ala Leu Gln Lys Leu Ser Ser Glu Ser Val Val Asp Leu
420 425 430
Phe Thr Lys Val Cys Leu Arg Leu Thr Lys
435 440
<210> 7
<211> 422
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/E Light chain Amino Acid Sequence
<400> 7
Met Pro Thr Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asn Arg
1 5 10 15
Thr Ile Leu Tyr Ile Lys Pro Gly Gly Cys Gln Gln Phe Tyr Lys Ser
20 25 30
Phe Asn Ile Met Lys Asn Ile Trp Ile Ile Pro Glu Arg Asn Val Ile
35 40 45
Gly Thr Ile Pro Gln Asp Phe Leu Pro Pro Thr Ser Leu Lys Asn Gly
50 55 60
Asp Ser Ser Tyr Tyr Asp Pro Asn Tyr Leu Gln Ser Asp Gln Glu Lys
65 70 75 80
Asp Lys Phe Leu Lys Ile Val Thr Lys Ile Phe Asn Arg Ile Asn Asp
85 90 95
Asn Leu Ser Gly Arg Ile Leu Leu Glu Glu Leu Ser Lys Ala Asn Pro
100 105 110
Tyr Leu Gly Asn Asp Asn Thr Pro Asp Gly Asp Phe Ile Ile Asn Asp
115 120 125
Ala Ser Ala Val Pro Ile Gln Phe Ser Asn Gly Ser Gln Ser Ile Leu
130 135 140
Leu Pro Asn Val Ile Ile Met Gly Ala Glu Pro Asp Leu Phe Glu Thr
145 150 155 160
Asn Ser Ser Asn Ile Ser Leu Arg Asn Asn Tyr Met Pro Ser Asn His
165 170 175
Gly Phe Gly Ser Ile Ala Ile Val Thr Phe Ser Pro Glu Tyr Ser Phe
180 185 190
Arg Phe Lys Asp Asn Ser Met Asn Glu Phe Ile Gln Asp Pro Ala Leu
195 200 205
Thr Leu Met His Glu Leu Ile His Ser Leu His Gly Leu Tyr Gly Ala
210 215 220
Lys Gly Ile Thr Thr Lys Tyr Thr Ile Thr Gln Lys Gln Asn Pro Leu
225 230 235 240
Ile Thr Asn Ile Arg Gly Thr Asn Ile Glu Glu Phe Leu Thr Phe Gly
245 250 255
Gly Thr Asp Leu Asn Ile Ile Thr Ser Ala Gln Ser Asn Asp Ile Tyr
260 265 270
Thr Asn Leu Leu Ala Asp Tyr Lys Lys Ile Ala Ser Lys Leu Ser Lys
275 280 285
Val Gln Val Ser Asn Pro Leu Leu Asn Pro Tyr Lys Asp Val Phe Glu
290 295 300
Ala Lys Tyr Gly Leu Asp Lys Asp Ala Ser Gly Ile Tyr Ser Val Asn
305 310 315 320
Ile Asn Lys Phe Asn Asp Ile Phe Lys Lys Leu Tyr Ser Phe Thr Glu
325 330 335
Phe Asp Leu Ala Thr Lys Phe Gln Val Lys Cys Arg Gln Thr Tyr Ile
340 345 350
Gly Gln Tyr Lys Tyr Phe Lys Leu Ser Asn Leu Leu Asn Asp Ser Ile
355 360 365
Tyr Asn Ile Ser Glu Gly Tyr Asn Ile Asn Asn Leu Lys Val Asn Phe
370 375 380
Arg Gly Gln Asn Ala Asn Leu Asn Pro Arg Ile Ile Thr Pro Ile Thr
385 390 395 400
Gly Arg Gly Leu Val Lys Lys Ile Ile Arg Phe Cys Lys Asn Ile Val
405 410 415
Ser Val Lys Gly Ile Arg
420
<210> 8
<211> 436
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/F Light chain Amino Acid Sequence
<400> 8
Met Pro Val Ala Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp
1 5 10 15
Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys
20 25 30
Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu
35 40 45
Arg Asn Thr Ile Gly Thr Asn Pro Ser Asp Phe Asp Pro Pro Ala Ser
50 55 60
Leu Lys Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr
65 70 75 80
Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys
85 90 95
Arg Ile Asn Ser Asn Pro Ala Gly Lys Val Leu Leu Gln Glu Ile Ser
100 105 110
Tyr Ala Lys Pro Tyr Leu Gly Asn Asp His Thr Pro Ile Asp Glu Phe
115 120 125
Ser Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Leu Ser Thr Asn
130 135 140
Val Glu Ser Ser Met Leu Leu Asn Leu Leu Val Leu Gly Ala Gly Pro
145 150 155 160
Asp Ile Phe Glu Ser Cys Cys Tyr Pro Val Arg Lys Leu Ile Asp Pro
165 170 175
Asp Val Val Tyr Asp Pro Ser Asn Tyr Gly Phe Gly Ser Ile Asn Ile
180 185 190
Val Thr Phe Ser Pro Glu Tyr Glu Tyr Thr Phe Asn Asp Ile Ser Gly
195 200 205
Gly His Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser
210 215 220
Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Arg
225 230 235 240
Gly Val Thr Tyr Glu Glu Thr Ile Glu Val Lys Gln Ala Pro Leu Met
245 250 255
Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly
260 265 270
Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn
275 280 285
Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Glu Val
290 295 300
Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe
305 310 315 320
Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val
325 330 335
Asn Glu Asn Lys Phe Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr
340 345 350
Glu Ser Asp Leu Ala Asn Lys Phe Lys Val Lys Cys Arg Asn Thr Tyr
355 360 365
Phe Ile Lys Tyr Glu Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp
370 375 380
Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly Asn Leu Ala Val Asn
385 390 395 400
Asn Arg Gly Gln Ser Ile Lys Leu Asn Pro Lys Ile Ile Asp Ser Ile
405 410 415
Pro Asp Lys Gly Leu Val Glu Lys Ile Val Lys Phe Cys Lys Ser Val
420 425 430
Ile Pro Arg Lys
435
<210> 9
<211> 441
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/G Light chain Amino Acid Sequence
<400> 9
Met Pro Val Asn Ile Lys Phe Asn Tyr Asn Asp Pro Ile Asn Asn Asp
1 5 10 15
Asp Ile Ile Met Met Glu Pro Phe Asn Asp Pro Gly Pro Gly Thr Tyr
20 25 30
Tyr Lys Ala Phe Arg Ile Ile Asp Arg Ile Trp Ile Val Pro Glu Arg
35 40 45
Phe Thr Tyr Gly Phe Gln Pro Asp Gln Phe Asn Ala Ser Thr Gly Val
50 55 60
Phe Ser Lys Asp Val Tyr Glu Tyr Tyr Asp Pro Thr Tyr Leu Lys Thr
65 70 75 80
Asp Ala Glu Lys Asp Lys Phe Leu Lys Thr Met Ile Lys Leu Phe Asn
85 90 95
Arg Ile Asn Ser Lys Pro Ser Gly Gln Arg Leu Leu Asp Met Ile Val
100 105 110
Asp Ala Ile Pro Tyr Leu Gly Asn Ala Ser Thr Pro Pro Asp Lys Phe
115 120 125
Ala Ala Asn Val Ala Asn Val Ser Ile Asn Lys Lys Ile Ile Gln Pro
130 135 140
Gly Ala Glu Asp Gln Ile Lys Gly Leu Met Thr Asn Leu Ile Ile Phe
145 150 155 160
Gly Pro Gly Pro Val Leu Ser Asp Asn Phe Thr Asp Ser Met Ile Met
165 170 175
Asn Gly His Ser Pro Ile Ser Glu Gly Phe Gly Ala Arg Met Met Ile
180 185 190
Arg Phe Cys Pro Ser Cys Leu Asn Val Phe Asn Asn Val Gln Glu Asn
195 200 205
Lys Asp Thr Ser Ile Phe Ser Arg Arg Ala Tyr Phe Ala Asp Pro Ala
210 215 220
Leu Thr Leu Met His Glu Leu Ile His Val Leu His Gly Leu Tyr Gly
225 230 235 240
Ile Lys Ile Ser Asn Leu Pro Ile Thr Pro Asn Thr Lys Glu Phe Phe
245 250 255
Met Gln His Ser Asp Pro Val Gln Ala Glu Glu Leu Tyr Thr Phe Gly
260 265 270
Gly His Asp Pro Ser Val Ile Ser Pro Ser Thr Asp Met Asn Ile Tyr
275 280 285
Asn Lys Ala Leu Gln Asn Phe Gln Asp Ile Ala Asn Arg Leu Asn Ile
290 295 300
Val Ser Ser Ala Gln Gly Ser Gly Ile Asp Ile Ser Leu Tyr Lys Gln
305 310 315 320
Ile Tyr Lys Asn Lys Tyr Asp Phe Val Glu Asp Pro Asn Gly Lys Tyr
325 330 335
Ser Val Asp Lys Asp Lys Phe Asp Lys Leu Tyr Lys Ala Leu Met Phe
340 345 350
Gly Phe Thr Glu Thr Asn Leu Ala Gly Glu Tyr Gly Ile Lys Thr Arg
355 360 365
Tyr Ser Tyr Phe Ser Glu Tyr Leu Pro Pro Ile Lys Thr Glu Lys Leu
370 375 380
Leu Asp Asn Thr Ile Tyr Thr Gln Asn Glu Gly Phe Asn Ile Ala Ser
385 390 395 400
Lys Asn Leu Lys Thr Glu Phe Asn Gly Gln Asn Lys Ala Val Asn Lys
405 410 415
Glu Ala Tyr Glu Glu Ile Ser Leu Glu His Leu Val Ile Tyr Arg Ile
420 425 430
Ala Met Cys Lys Pro Val Met Tyr Lys
435 440
<210> 10
<211> 1347
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/A Light chain cDNA Sequence
<400> 10
atgccctttg tcaacaaaca gttcaactac aaggacccag ttaatggagt agacatcgca 60
tatatcaaga ttcccaacgc tggccagatg caacccgtta aggcatttaa aatccataac 120
aaaatctggg ttatcccaga gcgggatacc ttcaccaacc ccgaggaggg cgatctgaac 180
cccccgccgg aggcgaagca ggtcccagtg agctactacg atagcaccta cctcagcacc 240
gacaacgaga aggacaacta cctcaaagga gtcacgaagt tgttcgagag aatctactcc 300
acagacctcg gccgcatgct tctaaccagc attgtgcgtg gcattccctt ttggggcggc 360
tctaccatcg acacagagct gaaggtgata gacaccaact gcatcaacgt aatccagcct 420
gacggcagct accgaagcga ggagcttaac ctggtgatca tcggcccttc cgccgatatc 480
atccaattcg agtgcaagag cttcggccac gaggtcctga acctcacccg gaacggctat 540
ggaagcaccc agtacataag attcagccct gacttcacct tcgggtttga ggagagcttg 600
gaggtcgaca caaaccccct gctgggagcc gggaagttcg ccactgaccc agccgtgact 660
ctggcacacg agctgatcca cgccggtcac cgcctgtacg gcatagctat aaacccaaac 720
agggtgttca aagtgaacac caacgcttac tatgaaatga gcggcctgga ggtgagcttc 780
gaggagctga gaacgttcgg gggacatgat gctaaattta tcgacagcct gcaggagaac 840
gagttcaggc tgtactacta caataagttc aaggatatag cgagcactct gaacaaggcc 900
aagtccatcg taggcactac tgcatccctc cagtatatga agaatgtgtt caaagagaaa 960
tacctgctga gcgaggatac cagcggtaag ttcagcgtgg ataagcttaa gttcgacaag 1020
ctgtataaga tgctcaccga aatctacacc gaggataatt tcgttaagtt cttcaaggtc 1080
ctgaaccgga agacctacct gaacttcgac aaggccgtgt tcaagatcaa catcgtgcct 1140
aaagtgaact acaccatcta cgacgggttt aacctgagga acaccaacct ggccgctaac 1200
ttcaacgggc agaacacaga gatcaacaac atgaatttca cgaagttgaa gaacttcacc 1260
ggactgtttg agttctacaa attgctgtgt gtgcgcggga tcatcactag caagaccaag 1320
agccttgaca aaggctacaa caagtga 1347
<210> 11
<211> 1323
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/B Light chain cDNA Sequence
<400> 11
atgccagtta caataaataa ttttaattat aatgatccta ttgataataa taatattatt 60
atgatggagc ctccatttgc gagaggtacg gggagatatt ataaagcttt taaaatcaca 120
gatcgtattt ggataatacc ggaaagatat acttttggat ataaacctga ggattttaat 180
aaaagttccg gtatttttaa tagagatgtt tgtgaatatt atgatccaga ttacttaaat 240
actaatgata aaaagaatat atttttacaa acaatgatca agttatttaa tagaatcaaa 300
tcaaaaccat tgggtgaaaa gttattagag atgattataa atggtatacc ttatcttgga 360
gatagacgtg ttccactcga agagtttaac acaaacattg ctagtgtaac tgttaataaa 420
ttaatcagta atccaggaga agtggagcga aaaaaaggta ttttcgcaaa tttaataata 480
tttggacctg ggccagtttt aaatgaaaat gagactatag atataggtat acaaaatcat 540
tttgcatcaa gggaaggctt cgggggtata atgcaaatga agttttgccc agaatatgta 600
agcgtattta ataatgttca agaaaacaaa ggcgcaagta tatttaatag acgtggatat 660
ttttcagatc cagccttgat attaatgcat gaacttatac atgttttaca tggattatat 720
ggcattaaag tagatgattt accaattgta ccaaatgaaa aaaaattttt tatgcaatct 780
acagatgcta tacaggcaga agaactatat acatttggag gacaagatcc cagcatcata 840
actccttcta cggataaaag tatctatgat aaagttttgc aaaattttag agggatagtt 900
gatagactta acaaggtttt agtttgcata tcagatccta acattaatat taatatatat 960
aaaaataaat ttaaagataa atataaattc gttgaagatt ctgagggaaa atatagtata 1020
gatgtagaaa gttttgataa attatataaa agcttaatgt ttggttttac agaaactaat 1080
atagcagaaa attataaaat aaaaactaga gcttcttatt ttagtgattc cttaccacca 1140
gtaaaaataa aaaatttatt agataatgaa atctatacta tagaggaagg gtttaatata 1200
tctgataaag atatggaaaa agaatataga ggtcagaata aagctataaa taaacaagct 1260
tatgaagaaa ttagcaagga gcatttggct gtatataaga tacaaatgtg taaaagtgtt 1320
aaa 1323
<210> 12
<211> 1347
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/C Light chain cDNA Sequence
<400> 12
atgccaataa caattaacaa ctttaattat tcagatcctg ttgataataa aaatatttta 60
tatttagata ctcatttaaa tacactagct aatgagcctg aaaaagcctt tcgcattaca 120
ggaaatatat gggtaatacc tgatagattt tcaagaaatt ctaatccaaa tttaaataaa 180
cctcctcgag ttacaagccc taaaagtggt tattatgatc ctaattattt gagtactgat 240
tctgacaaag atacattttt aaaagaaatt ataaagttat ttaaaagaat taattctaga 300
gaaataggag aagaattaat atatagactt tcgacagata taccctttcc tgggaataac 360
aatactccaa ttaatacttt tgattttgat gtagatttta acagtgttga tgttaaaact 420
agacaaggta acaactgggt taaaactggt agcataaatc ctagtgttat aataactgga 480
cctagagaaa acattataga tccagaaact tctacgttta aattaactaa caatactttt 540
gcggcacaag aaggatttgg tgctttatca ataatttcaa tatcacctag atttatgcta 600
acatatagta atgcaactaa tgatgtagga gagggtagat tttctaagtc tgaattttgc 660
atggatccaa tactaatttt aatgcatgaa cttaatcatg caatgcataa tttatatgga 720
atagctatac caaatgatca aacaatttca tctgtaacta gtaatatttt ttattctcaa 780
tataatgtga aattagagta tgcagaaata tatgcatttg gaggtccaac tatagacctt 840
attcctaaaa gtgcaaggaa atattttgag gaaaaggcat tggattatta tagatctata 900
gctaaaagac ttaatagtat aactactgca aatccttcaa gctttaataa atatataggg 960
gaatataaac agaaacttat tagaaagtat agattcgtag tagaatcttc aggtgaagtt 1020
acagtaaatc gtaataagtt tgttgagtta tataatgaac ttacacaaat atttacagaa 1080
tttaactacg ctaaaatata taatgtacaa aataggaaaa tatatctttc aaatgtatat 1140
actccggtta cggcgaatat attagacgat aatgtttatg atatacaaaa tggatttaat 1200
atacctaaaa gtaatttaaa tgtactattt atgggtcaaa atttatctcg aaatccagca 1260
ttaagaaaag tcaatcctga aaatatgctt tatttattta caaaattttg tcataaagca 1320
atagatggta gatcattata taataaa 1347
<210> 13
<211> 1326
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/D Light chain cDNA Sequence
<400> 13
atgacatggc cagtaaaaga ttttaattat agtgatcctg ttaatgacaa tgatatatta 60
tatttaagaa taccacaaaa taagttaatt actacacctg taaaagcttt tatgattact 120
caaaatattt gggtaatacc agaaagattt tcatcagata ctaatccaag tttaagtaaa 180
ccgcccagac ctacttcaaa gtatcaaagt tattatgatc ctagttattt atctactgat 240
gaacaaaaag atacattttt aaaagggatt ataaaattat ttaaaagaat taatgaaaga 300
gatataggaa aaaaattaat aaattattta gtagttggtt caccttttat gggagattca 360
agtacgcctg aagatacatt tgattttaca cgtcatacta ctaatattgc agttgaaaag 420
tttgaaaatg gtagttggaa agtaacaaat attataacac caagtgtatt gatatttgga 480
ccacttccta atatattaga ctatacagca tcccttacat tgcaaggaca acaatcaaat 540
ccatcatttg aagggtttgg aacattatct atactaaaag tagcacctga atttttgtta 600
acatttagtg atgtaacatc taatcaaagt tcagctgtat taggcaaatc tatattttgt 660
atggatccag taatagcttt aatgcatgag ttaacacatt ctttgcatca attatatgga 720
ataaatatac catctgataa aaggattcgt ccacaagtta gcgagggatt tttctctcaa 780
gatggaccca acgtacaatt tgaggaatta tatacatttg gaggattaga tgttgaaata 840
atacctcaaa ttgaaagatc acaattaaga gaaaaagcat taggtcacta taaagatata 900
gcgaaaagac ttaataatat taataaaact attccttcta gttggattag taatatagat 960
aaatataaaa aaatattttc tgaaaagtat aattttgata aagataatac aggaaatttt 1020
gttgtaaata ttgataaatt caatagctta tattcagact tgactaatgt tatgtcagaa 1080
gttgtttatt cttcgcaata taatgttaaa aacaggactc attatttttc aaggcattat 1140
ctacctgtat ttgcaaatat attagatgat aatatttata ctataagaga tggttttaat 1200
ttaacaaata aaggttttaa tatagaaaat tcgggtcaga atatagaaag gaatcctgca 1260
ctacaaaagc ttagttcaga aagtgtagta gatttattta caaaagtatg tttaagatta 1320
acaaaa 1326
<210> 14
<211> 1266
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/E Light chain cDNA Sequence
<400> 14
atgccaacaa ttaatagttt taattataat gatcctgtta ataatagaac aattttatat 60
attaaaccag gcggttgtca acaattttat aaatcattta atattatgaa aaatatttgg 120
ataattccag agagaaatgt aattggtaca attccccaag attttcttcc gcctacttca 180
ttgaaaaatg gagatagtag ttattatgac cctaattatt tacaaagtga tcaagaaaag 240
gataaatttt taaaaatagt cacaaaaata tttaatagaa taaatgataa tctttcagga 300
aggattttat tagaagaact gtcaaaagct aatccatatt taggaaatga taatactcca 360
gatggtgact tcattattaa tgatgcatca gcagttccaa ttcaattctc aaatggtagc 420
caaagcatac tattacctaa tgttattata atgggagcag agcctgattt atttgaaact 480
aacagttcca atatttctct aagaaataat tatatgccaa gcaatcacgg ttttggatca 540
atagctatag taacattctc acctgaatat tcttttagat ttaaagataa tagtatgaat 600
gaatttattc aagatcctgc tcttacatta atgcatgaat taatacattc attacatgga 660
ctatatgggg ctaaagggat tactacaaag tatactataa cacaaaaaca aaatccccta 720
ataacaaata taagaggtac aaatattgaa gaattcttaa cttttggagg tactgattta 780
aacattatta ctagtgctca gtccaatgat atctatacta atcttctagc tgattataaa 840
aaaatagcgt ctaaacttag caaagtacaa gtatctaatc cactacttaa tccttataaa 900
gatgtttttg aagcaaagta tggattagat aaagatgcta gcggaattta ttcggtaaat 960
ataaacaaat ttaatgatat ttttaaaaaa ttatacagct ttacggaatt tgatttagca 1020
actaaatttc aagttaaatg taggcaaact tatattggac agtataaata cttcaaactt 1080
tcaaacttgt taaatgattc tatttataat atatcagaag gctataatat aaataattta 1140
aaggtaaatt ttagaggaca gaatgcaaat ttaaatccta gaattattac accaattaca 1200
ggtagaggac tagtaaaaaa aatcattaga ttttgtaaaa atattgtttc tgtaaaaggc 1260
ataagg 1266
<210> 15
<211> 1308
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/F Light chain cDNA Sequence
<400> 15
atgccagttg caataaatag ttttaattat aatgaccctg ttaatgatga tacaatttta 60
tacatgcaga taccatatga agaaaaaagt aaaaaatatt ataaagcttt tgagattatg 120
cgtaatgttt ggataattcc tgagagaaat acaataggaa cgaatcctag tgattttgat 180
ccaccggctt cattaaagaa cggaagcagt gcttattatg atcctaatta tttaaccact 240
gatgctgaaa aagatagata tttaaaaaca acgataaaat tatttaagag aattaatagt 300
aatcctgcag ggaaagtttt gttacaagaa atatcatatg ctaaaccata tttaggaaat 360
gaccacacgc caattgatga attctctcca gttactagaa ctacaagtgt taatataaaa 420
ttatcaacta atgttgaaag ttcaatgtta ttgaatcttc ttgtattggg agcaggacct 480
gatatatttg aaagttgttg ttaccccgtt agaaaactaa tagatccaga tgtagtttat 540
gatccaagta attatggttt tggatcaatt aatatcgtga cattttcacc tgagtatgaa 600
tatactttta atgatattag tggagggcat aatagtagta cagaatcatt tattgcagat 660
cctgcaattt cactagctca tgaattgata catgcactgc atggattata cggggctagg 720
ggagttactt atgaagagac tatagaagta aagcaagcac ctcttatgat agccgaaaaa 780
cccataaggc tagaagaatt tttaaccttt ggaggtcagg atttaaatat tattactagt 840
gctatgaagg aaaaaatata taacaatctt ttagctaact atgaaaaaat agctactaga 900
cttagtgaag ttaatagtgc tcctcctgaa tatgatatta atgaatataa agattatttt 960
caatggaagt atgggctaga taaaaatgct gatggaagtt atactgtaaa tgaaaataaa 1020
tttaatgaaa tttataaaaa attatatagt tttacagaga gtgacttagc aaataaattt 1080
aaagtaaaat gtagaaatac ttattttatt aaatatgaat ttttaaaagt tccaaatttg 1140
ttagatgatg atatttatac tgtatcagag gggtttaata taggtaattt agcagtaaac 1200
aatcgcggac aaagtataaa gttaaatcct aaaattattg attccattcc agataaaggt 1260
ctagtagaaa agatcgttaa attttgtaag agcgttattc ctagaaaa 1308
<210> 16
<211> 1326
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/G Light chain cDNA Sequence
<400> 16
atgccagtta atataaaaan ctttaattat aatgacccta ttaataatga tgacattatt 60
atgatggaac cattcaatga cccagggcca ggaacatatt ataaagcttt taggattata 120
gatcgtattt ggatagtacc agaaaggttt acttatggat ttcaacctga ccaatttaat 180
gccagtacag gagtttttag taaagatgtc tacgaatatt acgatccaac ttatttaaaa 240
accgatgctg aaaaagataa atttttaaaa acaatgatta aattatttaa tagaattaat 300
tcaaaaccat caggacagag attactggat atgatagtag atgctatacc ttatcttgga 360
aatgcatcta caccgcccga caaatttgca gcaaatgttg caaatgtatc tattaataaa 420
aaaattatcc aacctggagc tgaagatcaa ataaaaggtt taatgacaaa tttaataata 480
tttggaccag gaccagttct aagtgataat tttactgata gtatgattat gaatggccat 540
tccccaatat cagaaggatt tggtgcaaga atgatgataa gattttgtcc tagttgttta 600
aatgtattta ataatgttca ggaaaataaa gatacatcta tatttagtag acgcgcgtat 660
tttgcagatc cagctctaac gttaatgcat gaacttatac atgtgttaca tggattatat 720
ggaattaaga taagtaattt accaattact ccaaatacaa aagaattttt catgcaacat 780
agcgatcctg tacaagcaga agaactatat acattcggag gacatgatcc tagtgttata 840
agtccttcta cggatatgaa tatttataat aaagcgttac aaaattttca agatatagct 900
aataggctta atattgtttc aagtgcccaa gggagtggaa ttgatatttc cttatataaa 960
caaatatata aaaataaata tgattttgtt gaagatccta atggaaaata tagtgtagat 1020
aaggataagt ttgataaatt atataaggcc ttaatgtttg gctttactga aactaatcta 1080
gctggtgaat atggaataaa aactaggtat tcttatttta gtgaatattt gccaccgata 1140
aaaactgaaa aattgttaga caatacaatt tatactcaaa atgaaggctt taacatagct 1200
agtaaaaatc tcaaaacgga atttaatggt cagaataagg cggtaaataa agaggcttat 1260
gaagaaatca gcctagaaca tctcgttata tatagaatag caatgtgcaa gcctgtaatg 1320
tacaaa 1326
<210> 17
<211> 468
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/A Light chain Amino Acid Sequence with hexahistidine
<400> 17
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro
1 5 10 15
Arg Gly Ser His Met Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp
20 25 30
Pro Val Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly
35 40 45
Gln Met Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val
50 55 60
Ile Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn
65 70 75 80
Pro Pro Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr
85 90 95
Tyr Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr
100 105 110
Lys Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu
115 120 125
Thr Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp
130 135 140
Thr Glu Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro
145 150 155 160
Asp Gly Ser Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro
165 170 175
Ser Ala Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val
180 185 190
Leu Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe
195 200 205
Ser Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr
210 215 220
Asn Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr
225 230 235 240
Leu Ala His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala
245 250 255
Ile Asn Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu
260 265 270
Met Ser Gly Leu Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly
275 280 285
His Asp Ala Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu
290 295 300
Tyr Tyr Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala
305 310 315 320
Lys Ser Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val
325 330 335
Phe Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser
340 345 350
Val Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile
355 360 365
Tyr Thr Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys
370 375 380
Thr Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro
385 390 395 400
Lys Val Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn
405 410 415
Leu Ala Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn
420 425 430
Phe Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu
435 440 445
Leu Cys Val Arg Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Asp Lys
450 455 460
Gly Tyr Asn Lys
465
<210> 18
<211> 461
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/B Light chain Amino Acid Sequence with hexahistidine
<400> 18
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro
1 5 10 15
Arg Gly Ser His Met Pro Val Thr Ile Asn Asn Phe Asn Tyr Asn Asp
20 25 30
Pro Ile Asp Asn Asn Asn Ile Ile Met Met Glu Pro Pro Phe Ala Arg
35 40 45
Gly Thr Gly Arg Tyr Tyr Lys Ala Phe Lys Ile Thr Asp Arg Ile Trp
50 55 60
Ile Ile Pro Glu Arg Tyr Thr Phe Gly Tyr Lys Pro Glu Asp Phe Asn
65 70 75 80
Lys Ser Ser Gly Ile Phe Asn Arg Asp Val Cys Glu Tyr Tyr Asp Pro
85 90 95
Asp Tyr Leu Asn Thr Asn Asp Lys Lys Asn Ile Phe Leu Gln Thr Met
100 105 110
Ile Lys Leu Phe Asn Arg Ile Lys Ser Lys Pro Leu Gly Glu Lys Leu
115 120 125
Leu Glu Met Ile Ile Asn Gly Ile Pro Tyr Leu Gly Asp Arg Arg Val
130 135 140
Pro Leu Glu Glu Phe Asn Thr Asn Ile Ala Ser Val Thr Val Asn Lys
145 150 155 160
Leu Ile Ser Asn Pro Gly Glu Val Glu Arg Lys Lys Gly Ile Phe Ala
165 170 175
Asn Leu Ile Ile Phe Gly Pro Gly Pro Val Leu Asn Glu Asn Glu Thr
180 185 190
Ile Asp Ile Gly Ile Gln Asn His Phe Ala Ser Arg Glu Gly Phe Gly
195 200 205
Gly Ile Met Gln Met Lys Phe Cys Pro Glu Tyr Val Ser Val Phe Asn
210 215 220
Asn Val Gln Glu Asn Lys Gly Ala Ser Ile Phe Asn Arg Arg Gly Tyr
225 230 235 240
Phe Ser Asp Pro Ala Leu Ile Leu Met His Glu Leu Ile His Val Leu
245 250 255
His Gly Leu Tyr Gly Ile Lys Val Asp Asp Leu Pro Ile Val Pro Asn
260 265 270
Glu Lys Lys Phe Phe Met Gln Ser Thr Asp Ala Ile Gln Ala Glu Glu
275 280 285
Leu Tyr Thr Phe Gly Gly Gln Asp Pro Ser Ile Ile Thr Pro Ser Thr
290 295 300
Asp Lys Ser Ile Tyr Asp Lys Val Leu Gln Asn Phe Arg Gly Ile Val
305 310 315 320
Asp Arg Leu Asn Lys Val Leu Val Cys Ile Ser Asp Pro Asn Ile Asn
325 330 335
Ile Asn Ile Tyr Lys Asn Lys Phe Lys Asp Lys Tyr Lys Phe Val Glu
340 345 350
Asp Ser Glu Gly Lys Tyr Ser Ile Asp Val Glu Ser Phe Asp Lys Leu
355 360 365
Tyr Lys Ser Leu Met Phe Gly Phe Thr Glu Thr Asn Ile Ala Glu Asn
370 375 380
Tyr Lys Ile Lys Thr Arg Ala Ser Tyr Phe Ser Asp Ser Leu Pro Pro
385 390 395 400
Val Lys Ile Lys Asn Leu Leu Asp Asn Glu Ile Tyr Thr Ile Glu Glu
405 410 415
Gly Phe Asn Ile Ser Asp Lys Asp Met Glu Lys Glu Tyr Arg Gly Gln
420 425 430
Asn Lys Ala Ile Asn Lys Gln Ala Tyr Glu Glu Ile Ser Lys Glu His
435 440 445
Leu Ala Val Tyr Lys Ile Gln Met Cys Lys Ser Val Lys
450 455 460
<210> 19
<211> 469
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/C Light chain Amino Acid Sequence with hexahistidine
<400> 19
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro
1 5 10 15
Arg Gly Ser His Met Pro Ile Thr Ile Asn Asn Phe Asn Tyr Ser Asp
20 25 30
Pro Val Asp Asn Lys Asn Ile Leu Tyr Leu Asp Thr His Leu Asn Thr
35 40 45
Leu Ala Asn Glu Pro Glu Lys Ala Phe Arg Ile Thr Gly Asn Ile Trp
50 55 60
Val Ile Pro Asp Arg Phe Ser Arg Asn Ser Asn Pro Asn Leu Asn Lys
65 70 75 80
Pro Pro Arg Val Thr Ser Pro Lys Ser Gly Tyr Tyr Asp Pro Asn Tyr
85 90 95
Leu Ser Thr Asp Ser Asp Lys Asp Pro Phe Leu Lys Glu Ile Ile Lys
100 105 110
Leu Phe Lys Arg Ile Asn Ser Arg Glu Ile Gly Glu Glu Leu Ile Tyr
115 120 125
Arg Leu Ser Thr Asp Ile Pro Phe Pro Gly Asn Asn Asn Thr Pro Ile
130 135 140
Asn Thr Phe Asp Phe Asp Val Asp Phe Asn Ser Val Asp Val Lys Thr
145 150 155 160
Arg Gln Gly Asn Asn Trp Val Lys Thr Gly Ser Ile Asn Pro Ser Val
165 170 175
Ile Ile Thr Gly Pro Arg Glu Asn Ile Ile Asp Pro Glu Thr Ser Thr
180 185 190
Phe Lys Leu Thr Asn Asn Thr Phe Ala Ala Gln Glu Gly Phe Gly Ala
195 200 205
Leu Ser Ile Ile Ser Ile Ser Pro Arg Phe Met Leu Thr Tyr Ser Asn
210 215 220
Ala Thr Asn Asp Val Gly Glu Gly Arg Phe Ser Lys Ser Glu Phe Cys
225 230 235 240
Met Asp Pro Ile Leu Ile Leu Met His Glu Leu Asn His Ala Met His
245 250 255
Asn Leu Tyr Gly Ile Ala Ile Pro Asn Asp Gln Thr Ile Ser Ser Val
260 265 270
Thr Ser Asn Ile Phe Tyr Ser Gln Tyr Asn Val Lys Leu Glu Tyr Ala
275 280 285
Glu Ile Tyr Ala Phe Gly Gly Pro Thr Ile Asp Leu Ile Pro Lys Ser
290 295 300
Ala Arg Lys Tyr Phe Glu Glu Lys Ala Leu Asp Tyr Tyr Arg Ser Ile
305 310 315 320
Ala Lys Arg Leu Asn Ser Ile Thr Thr Ala Asn Pro Ser Ser Phe Asn
325 330 335
Lys Tyr Ile Gly Glu Tyr Lys Gln Lys Leu Ile Arg Lys Tyr Arg Phe
340 345 350
Val Val Glu Ser Ser Gly Glu Val Thr Val Asn Arg Asn Lys Phe Val
355 360 365
Glu Leu Tyr Asn Glu Leu Thr Gln Ile Phe Thr Glu Phe Asn Tyr Ala
370 375 380
Lys Ile Tyr Asn Val Gln Asn Arg Lys Ile Tyr Leu Ser Asn Val Tyr
385 390 395 400
Thr Pro Val Thr Ala Asn Ile Leu Asp Asp Asn Val Tyr Asp Ile Gln
405 410 415
Asn Gly Phe Asn Ile Pro Lys Ser Asn Leu Asn Val Leu Phe Met Gly
420 425 430
Gln Asn Leu Ser Arg Asn Pro Ala Leu Arg Lys Val Asn Pro Glu Asn
435 440 445
Met Leu Tyr Leu Phe Thr Lys Phe Cys His Lys Ala Ile Asp Gly Arg
450 455 460
Ser Leu Tyr Asn Lys
465
<210> 20
<211> 462
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/D Light chain Amino Acid Sequence with hexahistidine
<400> 20
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro
1 5 10 15
Arg Gly Ser His Met Thr Trp Pro Val Lys Asp Phe Asn Tyr Ser Asp
20 25 30
Pro Val Asn Asp Asn Asp Ile Leu Tyr Leu Arg Ile Pro Gln Asn Lys
35 40 45
Leu Ile Thr Thr Pro Val Lys Ala Phe Met Ile Thr Gln Asn Ile Trp
50 55 60
Val Ile Pro Glu Arg Phe Ser Ser Asp Thr Asn Pro Ser Leu Ser Lys
65 70 75 80
Pro Pro Arg Pro Thr Ser Lys Tyr Gln Ser Tyr Tyr Asp Pro Ser Tyr
85 90 95
Leu Ser Thr Asp Glu Gln Lys Asp Thr Phe Leu Lys Gly Ile Ile Lys
100 105 110
Leu Phe Lys Arg Ile Asn Glu Arg Asp Ile Gly Lys Lys Leu Ile Asn
115 120 125
Tyr Leu Val Val Gly Ser Pro Phe Met Gly Asp Ser Ser Thr Pro Glu
130 135 140
Asp Thr Phe Asp Phe Thr Arg His Thr Thr Asn Ile Ala Val Glu Lys
145 150 155 160
Phe Glu Asn Gly Ser Trp Lys Val Thr Asn Ile Ile Thr Pro Ser Val
165 170 175
Leu Ile Phe Gly Pro Leu Pro Asn Ile Leu Asp Tyr Thr Ala Ser Leu
180 185 190
Thr Leu Gln Gly Gln Gln Ser Asn Pro Ser Phe Glu Gly Phe Gly Thr
195 200 205
Leu Ser Ile Leu Lys Val Ala Pro Glu Phe Leu Leu Thr Phe Ser Asp
210 215 220
Val Thr Ser Asn Gln Ser Ser Ala Val Leu Gly Lys Ser Ile Phe Cys
225 230 235 240
Met Asp Pro Val Ile Ala Leu Met His Glu Leu Thr His Ser Leu His
245 250 255
Gln Leu Tyr Gly Ile Asn Ile Pro Ser Asp Lys Arg Ile Arg Pro Gln
260 265 270
Val Ser Glu Gly Phe Phe Ser Gln Asp Gly Pro Asn Val Gln Phe Glu
275 280 285
Glu Leu Tyr Thr Phe Gly Gly Leu Asp Val Glu Ile Ile Pro Gln Ile
290 295 300
Glu Arg Ser Gln Leu Arg Glu Lys Ala Leu Gly His Tyr Lys Asp Ile
305 310 315 320
Ala Lys Arg Leu Asn Asn Ile Asn Lys Thr Ile Pro Ser Ser Trp Ile
325 330 335
Ser Asn Ile Asp Lys Tyr Lys Lys Ile Phe Ser Glu Lys Tyr Asn Phe
340 345 350
Asp Lys Asp Asn Thr Gly Asn Phe Val Val Asn Ile Asp Lys Phe Asn
355 360 365
Ser Leu Tyr Ser Asp Leu Thr Asn Val Met Ser Glu Val Val Tyr Ser
370 375 380
Ser Gln Tyr Asn Val Lys Asn Arg Thr His Tyr Phe Ser Arg His Tyr
385 390 395 400
Leu Pro Val Phe Ala Asn Ile Leu Asp Asp Asn Ile Tyr Thr Ile Arg
405 410 415
Asp Gly Phe Asn Leu Thr Asn Lys Gly Phe Asn Ile Glu Asn Ser Gly
420 425 430
Gln Asn Ile Glu Arg Asn Pro Ala Leu Gln Lys Leu Ser Ser Glu Ser
435 440 445
Val Val Asp Leu Phe Thr Lys Val Cys Leu Arg Leu Thr Lys
450 455 460
<210> 21
<211> 442
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/E Light chain Amino Acid Sequence with hexahistidine
<400> 21
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro
1 5 10 15
Arg Gly Ser His Met Pro Thr Ile Asn Ser Phe Asn Tyr Asn Asp Pro
20 25 30
Val Asn Asn Arg Thr Ile Leu Tyr Ile Lys Pro Gly Gly Cys Gln Gln
35 40 45
Phe Tyr Lys Ser Phe Asn Ile Met Lys Asn Ile Trp Ile Ile Pro Glu
50 55 60
Arg Asn Val Ile Gly Thr Ile Pro Gln Asp Phe Leu Pro Pro Thr Ser
65 70 75 80
Leu Lys Asn Gly Asp Ser Ser Tyr Tyr Asp Pro Asn Tyr Leu Gln Ser
85 90 95
Asp Gln Glu Lys Asp Lys Phe Leu Lys Ile Val Thr Lys Ile Phe Asn
100 105 110
Arg Ile Asn Asp Asn Leu Ser Gly Arg Ile Leu Leu Glu Glu Leu Ser
115 120 125
Lys Ala Asn Pro Tyr Leu Gly Asn Asp Asn Thr Pro Asp Gly Asp Phe
130 135 140
Ile Ile Asn Asp Ala Ser Ala Val Pro Ile Gln Phe Ser Asn Gly Ser
145 150 155 160
Gln Ser Ile Leu Leu Pro Asn Val Ile Ile Met Gly Ala Glu Pro Asp
165 170 175
Leu Phe Glu Thr Asn Ser Ser Asn Ile Ser Leu Arg Asn Asn Tyr Met
180 185 190
Pro Ser Asn His Gly Phe Gly Ser Ile Ala Ile Val Thr Phe Ser Pro
195 200 205
Glu Tyr Ser Phe Arg Phe Lys Asp Asn Ser Met Asn Glu Phe Ile Gln
210 215 220
Asp Pro Ala Leu Thr Leu Met His Glu Leu Ile His Ser Leu His Gly
225 230 235 240
Leu Tyr Gly Ala Lys Gly Ile Thr Thr Lys Tyr Thr Ile Thr Gln Lys
245 250 255
Gln Asn Pro Leu Ile Thr Asn Ile Arg Gly Thr Asn Ile Glu Glu Phe
260 265 270
Leu Thr Phe Gly Gly Thr Asp Leu Asn Ile Ile Thr Ser Ala Gln Ser
275 280 285
Asn Asp Ile Tyr Thr Asn Leu Leu Ala Asp Tyr Lys Lys Ile Ala Ser
290 295 300
Lys Leu Ser Lys Val Gln Val Ser Asn Pro Leu Leu Asn Pro Tyr Lys
305 310 315 320
Asp Val Phe Glu Ala Lys Tyr Gly Leu Asp Lys Asp Ala Ser Gly Ile
325 330 335
Tyr Ser Val Asn Ile Asn Lys Phe Asn Asp Ile Phe Lys Lys Leu Tyr
340 345 350
Ser Phe Thr Glu Phe Asp Leu Ala Thr Lys Phe Gln Val Lys Cys Arg
355 360 365
Gln Thr Tyr Ile Gly Gln Tyr Lys Tyr Phe Lys Leu Ser Asn Leu Leu
370 375 380
Asn Asp Ser Ile Tyr Asn Ile Ser Glu Gly Tyr Asn Ile Asn Asn Leu
385 390 395 400
Lys Val Asn Phe Arg Gly Gln Asn Ala Asn Leu Asn Pro Arg Ile Ile
405 410 415
Thr Pro Ile Thr Gly Arg Gly Leu Val Lys Lys Ile Ile Arg Phe Cys
420 425 430
Lys Asn Ile Val Ser Val Lys Gly Ile Arg
435 440
<210> 22
<211> 456
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/F Light chain Amino Acid Sequence with hexahistidine
<400> 22
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro
1 5 10 15
Arg Gly Ser His Met Pro Val Ala Ile Asn Ser Phe Asn Tyr Asn Asp
20 25 30
Pro Val Asn Asp Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu
35 40 45
Lys Ser Lys Lys Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp
50 55 60
Ile Ile Pro Glu Arg Asn Thr Ile Gly Thr Asn Pro Ser Asp Phe Asp
65 70 75 80
Pro Pro Ala Ser Leu Lys Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn
85 90 95
Tyr Leu Thr Thr Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile
100 105 110
Lys Leu Phe Lys Arg Ile Asn Ser Asn Pro Ala Gly Lys Val Leu Leu
115 120 125
Gln Glu Ile Ser Tyr Ala Lys Pro Tyr Leu Gly Asn Asp His Thr Pro
130 135 140
Ile Asp Glu Phe Ser Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys
145 150 155 160
Leu Ser Thr Asn Val Glu Ser Ser Met Leu Leu Asn Leu Leu Val Leu
165 170 175
Gly Ala Gly Pro Asp Ile Phe Glu Ser Cys Cys Tyr Pro Val Arg Lys
180 185 190
Leu Ile Asp Pro Asp Val Val Tyr Asp Pro Ser Asn Tyr Gly Phe Gly
195 200 205
Ser Ile Asn Ile Val Thr Phe Ser Pro Glu Tyr Glu Tyr Thr Phe Asn
210 215 220
Asp Ile Ser Gly Gly His Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp
225 230 235 240
Pro Ala Ile Ser Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu
245 250 255
Tyr Gly Ala Arg Gly Val Thr Tyr Glu Glu Thr Ile Glu Val Lys Gln
260 265 270
Ala Pro Leu Met Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu
275 280 285
Thr Phe Gly Gly Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu
290 295 300
Lys Ile Tyr Asn Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg
305 310 315 320
Leu Ser Glu Val Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr
325 330 335
Lys Asp Tyr Phe Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly
340 345 350
Ser Tyr Thr Val Asn Glu Asn Lys Phe Asn Glu Ile Tyr Lys Lys Leu
355 360 365
Tyr Ser Phe Thr Glu Ser Asp Leu Ala Asn Lys Phe Lys Val Lys Cys
370 375 380
Arg Asn Thr Tyr Phe Ile Lys Tyr Glu Phe Leu Lys Val Pro Asn Leu
385 390 395 400
Leu Asp Asp Asp Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly Asn
405 410 415
Leu Ala Val Asn Asn Arg Gly Gln Ser Ile Lys Leu Asn Pro Lys Ile
420 425 430
Ile Asp Ser Ile Pro Asp Lys Gly Leu Val Glu Lys Ile Val Lys Phe
435 440 445
Cys Lys Ser Val Ile Pro Arg Lys
450 455
<210> 23
<211> 461
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/G Light chain Amino Acid Sequence with hexahistidine
<400> 23
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro
1 5 10 15
Arg Gly Ser His Met Pro Val Asn Ile Lys Phe Asn Tyr Asn Asp Pro
20 25 30
Ile Asn Asn Asp Asp Ile Ile Met Met Glu Pro Phe Asn Asp Pro Gly
35 40 45
Pro Gly Thr Tyr Tyr Lys Ala Phe Arg Ile Ile Asp Arg Ile Trp Ile
50 55 60
Val Pro Glu Arg Phe Thr Tyr Gly Phe Gln Pro Asp Gln Phe Asn Ala
65 70 75 80
Ser Thr Gly Val Phe Ser Lys Asp Val Tyr Glu Tyr Tyr Asp Pro Thr
85 90 95
Tyr Leu Lys Thr Asp Ala Glu Lys Asp Lys Phe Leu Lys Thr Met Ile
100 105 110
Lys Leu Phe Asn Arg Ile Asn Ser Lys Pro Ser Gly Gln Arg Leu Leu
115 120 125
Asp Met Ile Val Asp Ala Ile Pro Tyr Leu Gly Asn Ala Ser Thr Pro
130 135 140
Pro Asp Lys Phe Ala Ala Asn Val Ala Asn Val Ser Ile Asn Lys Lys
145 150 155 160
Ile Ile Gln Pro Gly Ala Glu Asp Gln Ile Lys Gly Leu Met Thr Asn
165 170 175
Leu Ile Ile Phe Gly Pro Gly Pro Val Leu Ser Asp Asn Phe Thr Asp
180 185 190
Ser Met Ile Met Asn Gly His Ser Pro Ile Ser Glu Gly Phe Gly Ala
195 200 205
Arg Met Met Ile Arg Phe Cys Pro Ser Cys Leu Asn Val Phe Asn Asn
210 215 220
Val Gln Glu Asn Lys Asp Thr Ser Ile Phe Ser Arg Arg Ala Tyr Phe
225 230 235 240
Ala Asp Pro Ala Leu Thr Leu Met His Glu Leu Ile His Val Leu His
245 250 255
Gly Leu Tyr Gly Ile Lys Ile Ser Asn Leu Pro Ile Thr Pro Asn Thr
260 265 270
Lys Glu Phe Phe Met Gln His Ser Asp Pro Val Gln Ala Glu Glu Leu
275 280 285
Tyr Thr Phe Gly Gly His Asp Pro Ser Val Ile Ser Pro Ser Thr Asp
290 295 300
Met Asn Ile Tyr Asn Lys Ala Leu Gln Asn Phe Gln Asp Ile Ala Asn
305 310 315 320
Arg Leu Asn Ile Val Ser Ser Ala Gln Gly Ser Gly Ile Asp Ile Ser
325 330 335
Leu Tyr Lys Gln Ile Tyr Lys Asn Lys Tyr Asp Phe Val Glu Asp Pro
340 345 350
Asn Gly Lys Tyr Ser Val Asp Lys Asp Lys Phe Asp Lys Leu Tyr Lys
355 360 365
Ala Leu Met Phe Gly Phe Thr Glu Thr Asn Leu Ala Gly Glu Tyr Gly
370 375 380
Ile Lys Thr Arg Tyr Ser Tyr Phe Ser Glu Tyr Leu Pro Pro Ile Lys
385 390 395 400
Thr Glu Lys Leu Leu Asp Asn Thr Ile Tyr Thr Gln Asn Glu Gly Phe
405 410 415
Asn Ile Ala Ser Lys Asn Leu Lys Thr Glu Phe Asn Gly Gln Asn Lys
420 425 430
Ala Val Asn Lys Glu Ala Tyr Glu Glu Ile Ser Leu Glu His Leu Val
435 440 445
Ile Tyr Arg Ile Ala Met Cys Lys Pro Val Met Tyr Lys
450 455 460
<210> 24
<211> 1437
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/A Light chain cDNA Sequence with hexahistidine
<400> 24
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat 60
atgatgccct ttgtcaacaa acagttcaac tacaaggacc cagttaatgg agtagacatc 120
gcatatatca agattcccaa cgctggccag atgcaacccg ttaaggcatt taaaatccat 180
aacaaaatct gggttatccc agagcgggat accttcacca accccgagga gggcgatctg 240
aaccccccgc cggaggcgaa gcaggtccca gtgagctact acgatagcac ctacctcagc 300
accgacaacg agaaggacaa ctacctcaaa ggagtcacga agttgttcga gagaatctac 360
tccacagacc tcggccgcat gcttctaacc agcattgtgc gtggcattcc cttttggggc 420
ggctctacca tcgacacaga gctgaaggtg atagacacca actgcatcaa cgtaatccag 480
cctgacggca gctaccgaag cgaggagctt aacctggtga tcatcggccc ttccgccgat 540
atcatccaat tcgagtgcaa gagcttcggc cacgaggtcc tgaacctcac ccggaacggc 600
tatggaagca cccagtacat aagattcagc cctgacttca ccttcgggtt tgaggagagc 660
ttggaggtcg acacaaaccc cctgctggga gccgggaagt tcgccactga cccagccgtg 720
actctggcac acgagctgat ccacgccggt caccgcctgt acggcatagc tataaaccca 780
aacagggtgt tcaaagtgaa caccaacgct tactatgaaa tgagcggcct ggaggtgagc 840
ttcgaggagc tgagaacgtt cgggggacat gatgctaaat ttatcgacag cctgcaggag 900
aacgagttca ggctgtacta ctacaataag ttcaaggata tagcgagcac tctgaacaag 960
gccaagtcca tcgtaggcac tactgcatcc ctccagtata tgaagaatgt gttcaaagag 1020
aaatacctgc tgagcgagga taccagcggt aagttcagcg tggataagct taagttcgac 1080
aagctgtata agatgctcac cgaaatctac accgaggata atttcgttaa gttcttcaag 1140
gtcctgaacc ggaagaccta cctgaacttc gacaaggccg tgttcaagat caacatcgtg 1200
cctaaagtga actacaccat ctacgacggg tttaacctga ggaacaccaa cctggccgct 1260
aacttcaacg ggcagaacac agagatcaac aacatgaatt tcacgaagtt gaagaacttc 1320
accggactgt ttgagttcta caaattgctg tgtgtgcgcg ggatcatcac tagcaagacc 1380
aagagccttg acaaaggcta caacaagtga ctcgagcacc accaccacca ccactga 1437
<210> 25
<211> 1413
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/B Light chain cDNA Sequence with hexahistidine
<400> 25
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat 60
atgatgccag ttacaataaa taattttaat tataatgatc ctattgataa taataatatt 120
attatgatgg agcctccatt tgcgagaggt acggggagat attataaagc ttttaaaatc 180
acagatcgta tttggataat accggaaaga tatacttttg gatataaacc tgaggatttt 240
aataaaagtt ccggtatttt taatagagat gtttgtgaat attatgatcc agattactta 300
aatactaatg ataaaaagaa tatattttta caaacaatga tcaagttatt taatagaatc 360
aaatcaaaac cattgggtga aaagttatta gagatgatta taaatggtat accttatctt 420
ggagatagac gtgttccact cgaagagttt aacacaaaca ttgctagtgt aactgttaat 480
aaattaatca gtaatccagg agaagtggag cgaaaaaaag gtattttcgc aaatttaata 540
atatttggac ctgggccagt tttaaatgaa aatgagacta tagatatagg tatacaaaat 600
cattttgcat caagggaagg cttcgggggt ataatgcaaa tgaagttttg cccagaatat 660
gtaagcgtat ttaataatgt tcaagaaaac aaaggcgcaa gtatatttaa tagacgtgga 720
tatttttcag atccagcctt gatattaatg catgaactta tacatgtttt acatggatta 780
tatggcatta aagtagatga tttaccaatt gtaccaaatg aaaaaaaatt ttttatgcaa 840
tctacagatg ctatacaggc agaagaacta tatacatttg gaggacaaga tcccagcatc 900
ataactcctt ctacggataa aagtatctat gataaagttt tgcaaaattt tagagggata 960
gttgatagac ttaacaaggt tttagtttgc atatcagatc ctaacattaa tattaatata 1020
tataaaaata aatttaaaga taaatataaa ttcgttgaag attctgaggg aaaatatagt 1080
atagatgtag aaagttttga taaattatat aaaagcttaa tgtttggttt tacagaaact 1140
aatatagcag aaaattataa aataaaaact agagcttctt attttagtga ttccttacca 1200
ccagtaaaaa taaaaaattt attagataat gaaatctata ctatagagga agggtttaat 1260
atatctgata aagatatgga aaaagaatat agaggtcaga ataaagctat aaataaacaa 1320
gcttatgaag aaattagcaa ggagcatttg gctgtatata agatacaaat gtgtaaaagt 1380
gttaaactcg agcaccacca ccaccaccac tga 1413
<210> 26
<211> 1437
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/C Light chain cDNA Sequence with hexahistidine
<400> 26
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat 60
atgatgccaa taacaattaa caactttaat tattcagatc ctgttgataa taaaaatatt 120
ttatatttag atactcattt aaatacacta gctaatgagc ctgaaaaagc ctttcgcatt 180
acaggaaata tatgggtaat acctgataga ttttcaagaa attctaatcc aaatttaaat 240
aaacctcctc gagttacaag ccctaaaagt ggttattatg atcctaatta tttgagtact 300
gattctgaca aagatacatt tttaaaagaa attataaagt tatttaaaag aattaattct 360
agagaaatag gagaagaatt aatatataga ctttcgacag atataccctt tcctgggaat 420
aacaatactc caattaatac ttttgatttt gatgtagatt ttaacagtgt tgatgttaaa 480
actagacaag gtaacaactg ggttaaaact ggtagcataa atcctagtgt tataataact 540
ggacctagag aaaacattat agatccagaa acttctacgt ttaaattaac taacaatact 600
tttgcggcac aagaaggatt tggtgcttta tcaataattt caatatcacc tagatttatg 660
ctaacatata gtaatgcaac taatgatgta ggagagggta gattttctaa gtctgaattt 720
tgcatggatc caatactaat tttaatgcat gaacttaatc atgcaatgca taatttatat 780
ggaatagcta taccaaatga tcaaacaatt tcatctgtaa ctagtaatat tttttattct 840
caatataatg tgaaattaga gtatgcagaa atatatgcat ttggaggtcc aactatagac 900
cttattccta aaagtgcaag gaaatatttt gaggaaaagg cattggatta ttatagatct 960
atagctaaaa gacttaatag tataactact gcaaatcctt caagctttaa taaatatata 1020
ggggaatata aacagaaact tattagaaag tatagattcg tagtagaatc ttcaggtgaa 1080
gttacagtaa atcgtaataa gtttgttgag ttatataatg aacttacaca aatatttaca 1140
gaatttaact acgctaaaat atataatgta caaaatagga aaatatatct ttcaaatgta 1200
tatactccgg ttacggcgaa tatattagac gataatgttt atgatataca aaatggattt 1260
aatataccta aaagtaattt aaatgtacta tttatgggtc aaaatttatc tcgaaatcca 1320
gcattaagaa aagtcaatcc tgaaaatatg ctttatttat ttacaaaatt ttgtcataaa 1380
gcaatagatg gtagatcatt atataataaa ctcgagcacc accaccacca ccactga 1437
<210> 27
<211> 1416
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/D Light chain cDNA Sequence with hexahistidine
<400> 27
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat 60
atgatgacat ggccagtaaa agattttaat tatagtgatc ctgttaatga caatgatata 120
ttatatttaa gaataccaca aaataagtta attactacac ctgtaaaagc ttttatgatt 180
actcaaaata tttgggtaat accagaaaga ttttcatcag atactaatcc aagtttaagt 240
aaaccgccca gacctacttc aaagtatcaa agttattatg atcctagtta tttatctact 300
gatgaacaaa aagatacatt tttaaaaggg attataaaat tatttaaaag aattaatgaa 360
agagatatag gaaaaaaatt aataaattat ttagtagttg gttcaccttt tatgggagat 420
tcaagtacgc ctgaagatac atttgatttt acacgtcata ctactaatat tgcagttgaa 480
aagtttgaaa atggtagttg gaaagtaaca aatattataa caccaagtgt attgatattt 540
ggaccacttc ctaatatatt agactataca gcatccctta cattgcaagg acaacaatca 600
aatccatcat ttgaagggtt tggaacatta tctatactaa aagtagcacc tgaatttttg 660
ttaacattta gtgatgtaac atctaatcaa agttcagctg tattaggcaa atctatattt 720
tgtatggatc cagtaatagc tttaatgcat gagttaacac attctttgca tcaattatat 780
ggaataaata taccatctga taaaaggatt cgtccacaag ttagcgaggg atttttctct 840
caagatggac ccaacgtaca atttgaggaa ttatatacat ttggaggatt agatgttgaa 900
ataatacctc aaattgaaag atcacaatta agagaaaaag cattaggtca ctataaagat 960
atagcgaaaa gacttaataa tattaataaa actattcctt ctagttggat tagtaatata 1020
gataaatata aaaaaatatt ttctgaaaag tataattttg ataaagataa tacaggaaat 1080
tttgttgtaa atattgataa attcaatagc ttatattcag acttgactaa tgttatgtca 1140
gaagttgttt attcttcgca atataatgtt aaaaacagga ctcattattt ttcaaggcat 1200
tatctacctg tatttgcaaa tatattagat gataatattt atactataag agatggtttt 1260
aatttaacaa ataaaggttt taatatagaa aattcgggtc agaatataga aaggaatcct 1320
gcactacaaa agcttagttc agaaagtgta gtagatttat ttacaaaagt atgtttaaga 1380
ttaacaaaac tcgagcacca ccaccaccac cactga 1416
<210> 28
<211> 1356
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/E Light chain cDNA Sequence with hexahistidine
<400> 28
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat 60
atgatgccaa caattaatag ttttaattat aatgatcctg ttaataatag aacaatttta 120
tatattaaac caggcggttg tcaacaattt tataaatcat ttaatattat gaaaaatatt 180
tggataattc cagagagaaa tgtaattggt acaattcccc aagattttct tccgcctact 240
tcattgaaaa atggagatag tagttattat gaccctaatt atttacaaag tgatcaagaa 300
aaggataaat ttttaaaaat agtcacaaaa atatttaata gaataaatga taatctttca 360
ggaaggattt tattagaaga actgtcaaaa gctaatccat atttaggaaa tgataatact 420
ccagatggtg acttcattat taatgatgca tcagcagttc caattcaatt ctcaaatggt 480
agccaaagca tactattacc taatgttatt ataatgggag cagagcctga tttatttgaa 540
actaacagtt ccaatatttc tctaagaaat aattatatgc caagcaatca cggttttgga 600
tcaatagcta tagtaacatt ctcacctgaa tattctttta gatttaaaga taatagtatg 660
aatgaattta ttcaagatcc tgctcttaca ttaatgcatg aattaataca ttcattacat 720
ggactatatg gggctaaagg gattactaca aagtatacta taacacaaaa acaaaatccc 780
ctaataacaa atataagagg tacaaatatt gaagaattct taacttttgg aggtactgat 840
ttaaacatta ttactagtgc tcagtccaat gatatctata ctaatcttct agctgattat 900
aaaaaaatag cgtctaaact tagcaaagta caagtatcta atccactact taatccttat 960
aaagatgttt ttgaagcaaa gtatggatta gataaagatg ctagcggaat ttattcggta 1020
aatataaaca aatttaatga tatttttaaa aaattataca gctttacgga atttgattta 1080
gcaactaaat ttcaagttaa atgtaggcaa acttatattg gacagtataa atacttcaaa 1140
ctttcaaact tgttaaatga ttctatttat aatatatcag aaggctataa tataaataat 1200
ttaaaggtaa attttagagg acagaatgca aatttaaatc ctagaattat tacaccaatt 1260
acaggtagag gactagtaaa aaaaatcatt agattttgta aaaatattgt ttctgtaaaa 1320
ggcataaggc tcgagcacca ccaccaccac cactga 1356
<210> 29
<211> 1398
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/F Light chain cDNA Sequence with hexahistidine
<400> 29
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat 60
atgatgccag ttgcaataaa tagttttaat tataatgacc ctgttaatga tgatacaatt 120
ttatacatgc agataccata tgaagaaaaa agtaaaaaat attataaagc ttttgagatt 180
atgcgtaatg tttggataat tcctgagaga aatacaatag gaacgaatcc tagtgatttt 240
gatccaccgg cttcattaaa gaacggaagc agtgcttatt atgatcctaa ttatttaacc 300
actgatgctg aaaaagatag atatttaaaa acaacgataa aattatttaa gagaattaat 360
agtaatcctg cagggaaagt tttgttacaa gaaatatcat atgctaaacc atatttagga 420
aatgaccaca cgccaattga tgaattctct ccagttacta gaactacaag tgttaatata 480
aaattatcaa ctaatgttga aagttcaatg ttattgaatc ttcttgtatt gggagcagga 540
cctgatatat ttgaaagttg ttgttacccc gttagaaaac taatagatcc agatgtagtt 600
tatgatccaa gtaattatgg ttttggatca attaatatcg tgacattttc acctgagtat 660
gaatatactt ttaatgatat tagtggaggg cataatagta gtacagaatc atttattgca 720
gatcctgcaa tttcactagc tcatgaattg atacatgcac tgcatggatt atacggggct 780
aggggagtta cttatgaaga gactatagaa gtaaagcaag cacctcttat gatagccgaa 840
aaacccataa ggctagaaga atttttaacc tttggaggtc aggatttaaa tattattact 900
agtgctatga aggaaaaaat atataacaat cttttagcta actatgaaaa aatagctact 960
agacttagtg aagttaatag tgctcctcct gaatatgata ttaatgaata taaagattat 1020
tttcaatgga agtatgggct agataaaaat gctgatggaa gttatactgt aaatgaaaat 1080
aaatttaatg aaatttataa aaaattatat agttttacag agagtgactt agcaaataaa 1140
tttaaagtaa aatgtagaaa tacttatttt attaaatatg aatttttaaa agttccaaat 1200
ttgttagatg atgatattta tactgtatca gaggggttta atataggtaa tttagcagta 1260
aacaatcgcg gacaaagtat aaagttaaat cctaaaatta ttgattccat tccagataaa 1320
ggtctagtag aaaagatcgt taaattttgt aagagcgtta ttcctagaaa actcgagcac 1380
caccaccacc accactga 1398
<210> 30
<211> 1416
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/G Light chain cDNA Sequence with hexahistidine
<400> 30
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat 60
atgatgccag ttaatataaa aanctttaat tataatgacc ctattaataa tgatgacatt 120
attatgatgg aaccattcaa tgacccaggg ccaggaacat attataaagc ttttaggatt 180
atagatcgta tttggatagt accagaaagg tttacttatg gatttcaacc tgaccaattt 240
aatgccagta caggagtttt tagtaaagat gtctacgaat attacgatcc aacttattta 300
aaaaccgatg ctgaaaaaga taaattttta aaaacaatga ttaaattatt taatagaatt 360
aattcaaaac catcaggaca gagattactg gatatgatag tagatgctat accttatctt 420
ggaaatgcat ctacaccgcc cgacaaattt gcagcaaatg ttgcaaatgt atctattaat 480
aaaaaaatta tccaacctgg agctgaagat caaataaaag gtttaatgac aaatttaata 540
atatttggac caggaccagt tctaagtgat aattttactg atagtatgat tatgaatggc 600
cattccccaa tatcagaagg atttggtgca agaatgatga taagattttg tcctagttgt 660
ttaaatgtat ttaataatgt tcaggaaaat aaagatacat ctatatttag tagacgcgcg 720
tattttgcag atccagctct aacgttaatg catgaactta tacatgtgtt acatggatta 780
tatggaatta agataagtaa tttaccaatt actccaaata caaaagaatt tttcatgcaa 840
catagcgatc ctgtacaagc agaagaacta tatacattcg gaggacatga tcctagtgtt 900
ataagtcctt ctacggatat gaatatttat aataaagcgt tacaaaattt tcaagatata 960
gctaataggc ttaatattgt ttcaagtgcc caagggagtg gaattgatat ttccttatat 1020
aaacaaatat ataaaaataa atatgatttt gttgaagatc ctaatggaaa atatagtgta 1080
gataaggata agtttgataa attatataag gccttaatgt ttggctttac tgaaactaat 1140
ctagctggtg aatatggaat aaaaactagg tattcttatt ttagtgaata tttgccaccg 1200
ataaaaactg aaaaattgtt agacaataca atttatactc aaaatgaagg ctttaacata 1260
gctagtaaaa atctcaaaac ggaatttaat ggtcagaata aggcggtaaa taaagaggct 1320
tatgaagaaa tcagcctaga acatctcgtt atatatagaa tagcaatgtg caagcctgta 1380
atgtacaaac tcgagcacca ccaccaccac cactga 1416
<210> 31
<211> 461
<212> PRT
<213> Artificial Sequence
<220>
<223> MTD-BoNT/A Light chain Amino Acid Sequence
<400> 31
Met Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Pro Phe
1 5 10 15
Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly Val Asp Ile
20 25 30
Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met Gln Pro Val Lys Ala
35 40 45
Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg Asp Thr Phe
50 55 60
Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu Ala Lys Gln
65 70 75 80
Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr Asp Asn Glu
85 90 95
Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu Arg Ile Tyr
100 105 110
Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val Arg Gly Ile
115 120 125
Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys Val Ile Asp
130 135 140
Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr Arg Ser Glu
145 150 155 160
Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile Ile Gln Phe
165 170 175
Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr Arg Asn Gly
180 185 190
Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe Thr Phe Gly
195 200 205
Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu Gly Ala Gly
210 215 220
Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Glu Leu Ile His
225 230 235 240
Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn Arg Val Phe
245 250 255
Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu Glu Val Ser
260 265 270
Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys Phe Ile Asp
275 280 285
Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn Lys Phe Lys
290 295 300
Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val Gly Thr Thr
305 310 315 320
Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys Tyr Leu Leu
325 330 335
Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu Lys Phe Asp
340 345 350
Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp Asn Phe Val
355 360 365
Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn Phe Asp Lys
370 375 380
Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr Thr Ile Tyr
385 390 395 400
Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn Phe Asn Gly
405 410 415
Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu Lys Asn Phe
420 425 430
Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys Val Arg Gly Ile Ile
435 440 445
Thr Ser Lys Thr Lys Ser Leu Asp Lys Gly Tyr Asn Lys
450 455 460
<210> 32
<211> 454
<212> PRT
<213> Artificial Sequence
<220>
<223> MTD-BoNT/B Light chain Amino Acid Sequence
<400> 32
Met Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Pro Val
1 5 10 15
Thr Ile Asn Asn Phe Asn Tyr Asn Asp Pro Ile Asp Asn Asn Asn Ile
20 25 30
Ile Met Met Glu Pro Pro Phe Ala Arg Gly Thr Gly Arg Tyr Tyr Lys
35 40 45
Ala Phe Lys Ile Thr Asp Arg Ile Trp Ile Ile Pro Glu Arg Tyr Thr
50 55 60
Phe Gly Tyr Lys Pro Glu Asp Phe Asn Lys Ser Ser Gly Ile Phe Asn
65 70 75 80
Arg Asp Val Cys Glu Tyr Tyr Asp Pro Asp Tyr Leu Asn Thr Asn Asp
85 90 95
Lys Lys Asn Ile Phe Leu Gln Thr Met Ile Lys Leu Phe Asn Arg Ile
100 105 110
Lys Ser Lys Pro Leu Gly Glu Lys Leu Leu Glu Met Ile Ile Asn Gly
115 120 125
Ile Pro Tyr Leu Gly Asp Arg Arg Val Pro Leu Glu Glu Phe Asn Thr
130 135 140
Asn Ile Ala Ser Val Thr Val Asn Lys Leu Ile Ser Asn Pro Gly Glu
145 150 155 160
Val Glu Arg Lys Lys Gly Ile Phe Ala Asn Leu Ile Ile Phe Gly Pro
165 170 175
Gly Pro Val Leu Asn Glu Asn Glu Thr Ile Asp Ile Gly Ile Gln Asn
180 185 190
His Phe Ala Ser Arg Glu Gly Phe Gly Gly Ile Met Gln Met Lys Phe
195 200 205
Cys Pro Glu Tyr Val Ser Val Phe Asn Asn Val Gln Glu Asn Lys Gly
210 215 220
Ala Ser Ile Phe Asn Arg Arg Gly Tyr Phe Ser Asp Pro Ala Leu Ile
225 230 235 240
Leu Met His Glu Leu Ile His Val Leu His Gly Leu Tyr Gly Ile Lys
245 250 255
Val Asp Asp Leu Pro Ile Val Pro Asn Glu Lys Lys Phe Phe Met Gln
260 265 270
Ser Thr Asp Ala Ile Gln Ala Glu Glu Leu Tyr Thr Phe Gly Gly Gln
275 280 285
Asp Pro Ser Ile Ile Thr Pro Ser Thr Asp Lys Ser Ile Tyr Asp Lys
290 295 300
Val Leu Gln Asn Phe Arg Gly Ile Val Asp Arg Leu Asn Lys Val Leu
305 310 315 320
Val Cys Ile Ser Asp Pro Asn Ile Asn Ile Asn Ile Tyr Lys Asn Lys
325 330 335
Phe Lys Asp Lys Tyr Lys Phe Val Glu Asp Ser Glu Gly Lys Tyr Ser
340 345 350
Ile Asp Val Glu Ser Phe Asp Lys Leu Tyr Lys Ser Leu Met Phe Gly
355 360 365
Phe Thr Glu Thr Asn Ile Ala Glu Asn Tyr Lys Ile Lys Thr Arg Ala
370 375 380
Ser Tyr Phe Ser Asp Ser Leu Pro Pro Val Lys Ile Lys Asn Leu Leu
385 390 395 400
Asp Asn Glu Ile Tyr Thr Ile Glu Glu Gly Phe Asn Ile Ser Asp Lys
405 410 415
Asp Met Glu Lys Glu Tyr Arg Gly Gln Asn Lys Ala Ile Asn Lys Gln
420 425 430
Ala Tyr Glu Glu Ile Ser Lys Glu His Leu Ala Val Tyr Lys Ile Gln
435 440 445
Met Cys Lys Ser Val Lys
450
<210> 33
<211> 462
<212> PRT
<213> Artificial Sequence
<220>
<223> MTD-BoNT/C Light chain Amino Acid Sequence
<400> 33
Met Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Pro Ile
1 5 10 15
Thr Ile Asn Asn Phe Asn Tyr Ser Asp Pro Val Asp Asn Lys Asn Ile
20 25 30
Leu Tyr Leu Asp Thr His Leu Asn Thr Leu Ala Asn Glu Pro Glu Lys
35 40 45
Ala Phe Arg Ile Thr Gly Asn Ile Trp Val Ile Pro Asp Arg Phe Ser
50 55 60
Arg Asn Ser Asn Pro Asn Leu Asn Lys Pro Pro Arg Val Thr Ser Pro
65 70 75 80
Lys Ser Gly Tyr Tyr Asp Pro Asn Tyr Leu Ser Thr Asp Ser Asp Lys
85 90 95
Asp Pro Phe Leu Lys Glu Ile Ile Lys Leu Phe Lys Arg Ile Asn Ser
100 105 110
Arg Glu Ile Gly Glu Glu Leu Ile Tyr Arg Leu Ser Thr Asp Ile Pro
115 120 125
Phe Pro Gly Asn Asn Asn Thr Pro Ile Asn Thr Phe Asp Phe Asp Val
130 135 140
Asp Phe Asn Ser Val Asp Val Lys Thr Arg Gln Gly Asn Asn Trp Val
145 150 155 160
Lys Thr Gly Ser Ile Asn Pro Ser Val Ile Ile Thr Gly Pro Arg Glu
165 170 175
Asn Ile Ile Asp Pro Glu Thr Ser Thr Phe Lys Leu Thr Asn Asn Thr
180 185 190
Phe Ala Ala Gln Glu Gly Phe Gly Ala Leu Ser Ile Ile Ser Ile Ser
195 200 205
Pro Arg Phe Met Leu Thr Tyr Ser Asn Ala Thr Asn Asp Val Gly Glu
210 215 220
Gly Arg Phe Ser Lys Ser Glu Phe Cys Met Asp Pro Ile Leu Ile Leu
225 230 235 240
Met His Glu Leu Asn His Ala Met His Asn Leu Tyr Gly Ile Ala Ile
245 250 255
Pro Asn Asp Gln Thr Ile Ser Ser Val Thr Ser Asn Ile Phe Tyr Ser
260 265 270
Gln Tyr Asn Val Lys Leu Glu Tyr Ala Glu Ile Tyr Ala Phe Gly Gly
275 280 285
Pro Thr Ile Asp Leu Ile Pro Lys Ser Ala Arg Lys Tyr Phe Glu Glu
290 295 300
Lys Ala Leu Asp Tyr Tyr Arg Ser Ile Ala Lys Arg Leu Asn Ser Ile
305 310 315 320
Thr Thr Ala Asn Pro Ser Ser Phe Asn Lys Tyr Ile Gly Glu Tyr Lys
325 330 335
Gln Lys Leu Ile Arg Lys Tyr Arg Phe Val Val Glu Ser Ser Gly Glu
340 345 350
Val Thr Val Asn Arg Asn Lys Phe Val Glu Leu Tyr Asn Glu Leu Thr
355 360 365
Gln Ile Phe Thr Glu Phe Asn Tyr Ala Lys Ile Tyr Asn Val Gln Asn
370 375 380
Arg Lys Ile Tyr Leu Ser Asn Val Tyr Thr Pro Val Thr Ala Asn Ile
385 390 395 400
Leu Asp Asp Asn Val Tyr Asp Ile Gln Asn Gly Phe Asn Ile Pro Lys
405 410 415
Ser Asn Leu Asn Val Leu Phe Met Gly Gln Asn Leu Ser Arg Asn Pro
420 425 430
Ala Leu Arg Lys Val Asn Pro Glu Asn Met Leu Tyr Leu Phe Thr Lys
435 440 445
Phe Cys His Lys Ala Ile Asp Gly Arg Ser Leu Tyr Asn Lys
450 455 460
<210> 34
<211> 455
<212> PRT
<213> Artificial Sequence
<220>
<223> MTD-BoNT/D Light chain Amino Acid Sequence
<400> 34
Met Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Thr Trp
1 5 10 15
Pro Val Lys Asp Phe Asn Tyr Ser Asp Pro Val Asn Asp Asn Asp Ile
20 25 30
Leu Tyr Leu Arg Ile Pro Gln Asn Lys Leu Ile Thr Thr Pro Val Lys
35 40 45
Ala Phe Met Ile Thr Gln Asn Ile Trp Val Ile Pro Glu Arg Phe Ser
50 55 60
Ser Asp Thr Asn Pro Ser Leu Ser Lys Pro Pro Arg Pro Thr Ser Lys
65 70 75 80
Tyr Gln Ser Tyr Tyr Asp Pro Ser Tyr Leu Ser Thr Asp Glu Gln Lys
85 90 95
Asp Thr Phe Leu Lys Gly Ile Ile Lys Leu Phe Lys Arg Ile Asn Glu
100 105 110
Arg Asp Ile Gly Lys Lys Leu Ile Asn Tyr Leu Val Val Gly Ser Pro
115 120 125
Phe Met Gly Asp Ser Ser Thr Pro Glu Asp Thr Phe Asp Phe Thr Arg
130 135 140
His Thr Thr Asn Ile Ala Val Glu Lys Phe Glu Asn Gly Ser Trp Lys
145 150 155 160
Val Thr Asn Ile Ile Thr Pro Ser Val Leu Ile Phe Gly Pro Leu Pro
165 170 175
Asn Ile Leu Asp Tyr Thr Ala Ser Leu Thr Leu Gln Gly Gln Gln Ser
180 185 190
Asn Pro Ser Phe Glu Gly Phe Gly Thr Leu Ser Ile Leu Lys Val Ala
195 200 205
Pro Glu Phe Leu Leu Thr Phe Ser Asp Val Thr Ser Asn Gln Ser Ser
210 215 220
Ala Val Leu Gly Lys Ser Ile Phe Cys Met Asp Pro Val Ile Ala Leu
225 230 235 240
Met His Glu Leu Thr His Ser Leu His Gln Leu Tyr Gly Ile Asn Ile
245 250 255
Pro Ser Asp Lys Arg Ile Arg Pro Gln Val Ser Glu Gly Phe Phe Ser
260 265 270
Gln Asp Gly Pro Asn Val Gln Phe Glu Glu Leu Tyr Thr Phe Gly Gly
275 280 285
Leu Asp Val Glu Ile Ile Pro Gln Ile Glu Arg Ser Gln Leu Arg Glu
290 295 300
Lys Ala Leu Gly His Tyr Lys Asp Ile Ala Lys Arg Leu Asn Asn Ile
305 310 315 320
Asn Lys Thr Ile Pro Ser Ser Trp Ile Ser Asn Ile Asp Lys Tyr Lys
325 330 335
Lys Ile Phe Ser Glu Lys Tyr Asn Phe Asp Lys Asp Asn Thr Gly Asn
340 345 350
Phe Val Val Asn Ile Asp Lys Phe Asn Ser Leu Tyr Ser Asp Leu Thr
355 360 365
Asn Val Met Ser Glu Val Val Tyr Ser Ser Gln Tyr Asn Val Lys Asn
370 375 380
Arg Thr His Tyr Phe Ser Arg His Tyr Leu Pro Val Phe Ala Asn Ile
385 390 395 400
Leu Asp Asp Asn Ile Tyr Thr Ile Arg Asp Gly Phe Asn Leu Thr Asn
405 410 415
Lys Gly Phe Asn Ile Glu Asn Ser Gly Gln Asn Ile Glu Arg Asn Pro
420 425 430
Ala Leu Gln Lys Leu Ser Ser Glu Ser Val Val Asp Leu Phe Thr Lys
435 440 445
Val Cys Leu Arg Leu Thr Lys
450 455
<210> 35
<211> 435
<212> PRT
<213> Artificial Sequence
<220>
<223> MTD-BoNT/E Light chain Amino Acid Sequence
<400> 35
Met Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Pro Thr
1 5 10 15
Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asn Arg Thr Ile Leu
20 25 30
Tyr Ile Lys Pro Gly Gly Cys Gln Gln Phe Tyr Lys Ser Phe Asn Ile
35 40 45
Met Lys Asn Ile Trp Ile Ile Pro Glu Arg Asn Val Ile Gly Thr Ile
50 55 60
Pro Gln Asp Phe Leu Pro Pro Thr Ser Leu Lys Asn Gly Asp Ser Ser
65 70 75 80
Tyr Tyr Asp Pro Asn Tyr Leu Gln Ser Asp Gln Glu Lys Asp Lys Phe
85 90 95
Leu Lys Ile Val Thr Lys Ile Phe Asn Arg Ile Asn Asp Asn Leu Ser
100 105 110
Gly Arg Ile Leu Leu Glu Glu Leu Ser Lys Ala Asn Pro Tyr Leu Gly
115 120 125
Asn Asp Asn Thr Pro Asp Gly Asp Phe Ile Ile Asn Asp Ala Ser Ala
130 135 140
Val Pro Ile Gln Phe Ser Asn Gly Ser Gln Ser Ile Leu Leu Pro Asn
145 150 155 160
Val Ile Ile Met Gly Ala Glu Pro Asp Leu Phe Glu Thr Asn Ser Ser
165 170 175
Asn Ile Ser Leu Arg Asn Asn Tyr Met Pro Ser Asn His Gly Phe Gly
180 185 190
Ser Ile Ala Ile Val Thr Phe Ser Pro Glu Tyr Ser Phe Arg Phe Lys
195 200 205
Asp Asn Ser Met Asn Glu Phe Ile Gln Asp Pro Ala Leu Thr Leu Met
210 215 220
His Glu Leu Ile His Ser Leu His Gly Leu Tyr Gly Ala Lys Gly Ile
225 230 235 240
Thr Thr Lys Tyr Thr Ile Thr Gln Lys Gln Asn Pro Leu Ile Thr Asn
245 250 255
Ile Arg Gly Thr Asn Ile Glu Glu Phe Leu Thr Phe Gly Gly Thr Asp
260 265 270
Leu Asn Ile Ile Thr Ser Ala Gln Ser Asn Asp Ile Tyr Thr Asn Leu
275 280 285
Leu Ala Asp Tyr Lys Lys Ile Ala Ser Lys Leu Ser Lys Val Gln Val
290 295 300
Ser Asn Pro Leu Leu Asn Pro Tyr Lys Asp Val Phe Glu Ala Lys Tyr
305 310 315 320
Gly Leu Asp Lys Asp Ala Ser Gly Ile Tyr Ser Val Asn Ile Asn Lys
325 330 335
Phe Asn Asp Ile Phe Lys Lys Leu Tyr Ser Phe Thr Glu Phe Asp Leu
340 345 350
Ala Thr Lys Phe Gln Val Lys Cys Arg Gln Thr Tyr Ile Gly Gln Tyr
355 360 365
Lys Tyr Phe Lys Leu Ser Asn Leu Leu Asn Asp Ser Ile Tyr Asn Ile
370 375 380
Ser Glu Gly Tyr Asn Ile Asn Asn Leu Lys Val Asn Phe Arg Gly Gln
385 390 395 400
Asn Ala Asn Leu Asn Pro Arg Ile Ile Thr Pro Ile Thr Gly Arg Gly
405 410 415
Leu Val Lys Lys Ile Ile Arg Phe Cys Lys Asn Ile Val Ser Val Lys
420 425 430
Gly Ile Arg
435
<210> 36
<211> 449
<212> PRT
<213> Artificial Sequence
<220>
<223> MTD-BoNT/F Light chain Amino Acid Sequence
<400> 36
Met Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Pro Val
1 5 10 15
Ala Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp Asp Thr Ile
20 25 30
Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys Tyr Tyr Lys
35 40 45
Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu Arg Asn Thr
50 55 60
Ile Gly Thr Asn Pro Ser Asp Phe Asp Pro Pro Ala Ser Leu Lys Asn
65 70 75 80
Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr Asp Ala Glu
85 90 95
Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys Arg Ile Asn
100 105 110
Ser Asn Pro Ala Gly Lys Val Leu Leu Gln Glu Ile Ser Tyr Ala Lys
115 120 125
Pro Tyr Leu Gly Asn Asp His Thr Pro Ile Asp Glu Phe Ser Pro Val
130 135 140
Thr Arg Thr Thr Ser Val Asn Ile Lys Leu Ser Thr Asn Val Glu Ser
145 150 155 160
Ser Met Leu Leu Asn Leu Leu Val Leu Gly Ala Gly Pro Asp Ile Phe
165 170 175
Glu Ser Cys Cys Tyr Pro Val Arg Lys Leu Ile Asp Pro Asp Val Val
180 185 190
Tyr Asp Pro Ser Asn Tyr Gly Phe Gly Ser Ile Asn Ile Val Thr Phe
195 200 205
Ser Pro Glu Tyr Glu Tyr Thr Phe Asn Asp Ile Ser Gly Gly His Asn
210 215 220
Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser Leu Ala His
225 230 235 240
Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Arg Gly Val Thr
245 250 255
Tyr Glu Glu Thr Ile Glu Val Lys Gln Ala Pro Leu Met Ile Ala Glu
260 265 270
Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly Gln Asp Leu
275 280 285
Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn Asn Leu Leu
290 295 300
Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Glu Val Asn Ser Ala
305 310 315 320
Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe Gln Trp Lys
325 330 335
Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val Asn Glu Asn
340 345 350
Lys Phe Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr Glu Ser Asp
355 360 365
Leu Ala Asn Lys Phe Lys Val Lys Cys Arg Asn Thr Tyr Phe Ile Lys
370 375 380
Tyr Glu Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp Ile Tyr Thr
385 390 395 400
Val Ser Glu Gly Phe Asn Ile Gly Asn Leu Ala Val Asn Asn Arg Gly
405 410 415
Gln Ser Ile Lys Leu Asn Pro Lys Ile Ile Asp Ser Ile Pro Asp Lys
420 425 430
Gly Leu Val Glu Lys Ile Val Lys Phe Cys Lys Ser Val Ile Pro Arg
435 440 445
Lys
<210> 37
<211> 454
<212> PRT
<213> Artificial Sequence
<220>
<223> MTD-BoNT/G Light chain Amino Acid Sequence
<400> 37
Met Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Pro Val
1 5 10 15
Asn Ile Lys Phe Asn Tyr Asn Asp Pro Ile Asn Asn Asp Asp Ile Ile
20 25 30
Met Met Glu Pro Phe Asn Asp Pro Gly Pro Gly Thr Tyr Tyr Lys Ala
35 40 45
Phe Arg Ile Ile Asp Arg Ile Trp Ile Val Pro Glu Arg Phe Thr Tyr
50 55 60
Gly Phe Gln Pro Asp Gln Phe Asn Ala Ser Thr Gly Val Phe Ser Lys
65 70 75 80
Asp Val Tyr Glu Tyr Tyr Asp Pro Thr Tyr Leu Lys Thr Asp Ala Glu
85 90 95
Lys Asp Lys Phe Leu Lys Thr Met Ile Lys Leu Phe Asn Arg Ile Asn
100 105 110
Ser Lys Pro Ser Gly Gln Arg Leu Leu Asp Met Ile Val Asp Ala Ile
115 120 125
Pro Tyr Leu Gly Asn Ala Ser Thr Pro Pro Asp Lys Phe Ala Ala Asn
130 135 140
Val Ala Asn Val Ser Ile Asn Lys Lys Ile Ile Gln Pro Gly Ala Glu
145 150 155 160
Asp Gln Ile Lys Gly Leu Met Thr Asn Leu Ile Ile Phe Gly Pro Gly
165 170 175
Pro Val Leu Ser Asp Asn Phe Thr Asp Ser Met Ile Met Asn Gly His
180 185 190
Ser Pro Ile Ser Glu Gly Phe Gly Ala Arg Met Met Ile Arg Phe Cys
195 200 205
Pro Ser Cys Leu Asn Val Phe Asn Asn Val Gln Glu Asn Lys Asp Thr
210 215 220
Ser Ile Phe Ser Arg Arg Ala Tyr Phe Ala Asp Pro Ala Leu Thr Leu
225 230 235 240
Met His Glu Leu Ile His Val Leu His Gly Leu Tyr Gly Ile Lys Ile
245 250 255
Ser Asn Leu Pro Ile Thr Pro Asn Thr Lys Glu Phe Phe Met Gln His
260 265 270
Ser Asp Pro Val Gln Ala Glu Glu Leu Tyr Thr Phe Gly Gly His Asp
275 280 285
Pro Ser Val Ile Ser Pro Ser Thr Asp Met Asn Ile Tyr Asn Lys Ala
290 295 300
Leu Gln Asn Phe Gln Asp Ile Ala Asn Arg Leu Asn Ile Val Ser Ser
305 310 315 320
Ala Gln Gly Ser Gly Ile Asp Ile Ser Leu Tyr Lys Gln Ile Tyr Lys
325 330 335
Asn Lys Tyr Asp Phe Val Glu Asp Pro Asn Gly Lys Tyr Ser Val Asp
340 345 350
Lys Asp Lys Phe Asp Lys Leu Tyr Lys Ala Leu Met Phe Gly Phe Thr
355 360 365
Glu Thr Asn Leu Ala Gly Glu Tyr Gly Ile Lys Thr Arg Tyr Ser Tyr
370 375 380
Phe Ser Glu Tyr Leu Pro Pro Ile Lys Thr Glu Lys Leu Leu Asp Asn
385 390 395 400
Thr Ile Tyr Thr Gln Asn Glu Gly Phe Asn Ile Ala Ser Lys Asn Leu
405 410 415
Lys Thr Glu Phe Asn Gly Gln Asn Lys Ala Val Asn Lys Glu Ala Tyr
420 425 430
Glu Glu Ile Ser Leu Glu His Leu Val Ile Tyr Arg Ile Ala Met Cys
435 440 445
Lys Pro Val Met Tyr Lys
450
<210> 38
<211> 461
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/A Light chain-MTDr Amino Acid Sequence
<400> 38
Met Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly
1 5 10 15
Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met Gln Pro
20 25 30
Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg
35 40 45
Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu
50 55 60
Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr
65 70 75 80
Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu
85 90 95
Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val
100 105 110
Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys
115 120 125
Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr
130 135 140
Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile
145 150 155 160
Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr
165 170 175
Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe
180 185 190
Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu
195 200 205
Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Glu
210 215 220
Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn
225 230 235 240
Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu
245 250 255
Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys
260 265 270
Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn
275 280 285
Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val
290 295 300
Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys
305 310 315 320
Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu
325 330 335
Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp
340 345 350
Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn
355 360 365
Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr
370 375 380
Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn
385 390 395 400
Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu
405 410 415
Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys Val Arg
420 425 430
Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Asp Lys Gly Tyr Asn Lys
435 440 445
Cys Gln Asn Leu Phe Lys Asn Ile Asn Ile Met Ala Lys
450 455 460
<210> 39
<211> 454
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/B Light chain-MTDr Amino Acid Sequence
<400> 39
Met Pro Val Thr Ile Asn Asn Phe Asn Tyr Asn Asp Pro Ile Asp Asn
1 5 10 15
Asn Asn Ile Ile Met Met Glu Pro Pro Phe Ala Arg Gly Thr Gly Arg
20 25 30
Tyr Tyr Lys Ala Phe Lys Ile Thr Asp Arg Ile Trp Ile Ile Pro Glu
35 40 45
Arg Tyr Thr Phe Gly Tyr Lys Pro Glu Asp Phe Asn Lys Ser Ser Gly
50 55 60
Ile Phe Asn Arg Asp Val Cys Glu Tyr Tyr Asp Pro Asp Tyr Leu Asn
65 70 75 80
Thr Asn Asp Lys Lys Asn Ile Phe Leu Gln Thr Met Ile Lys Leu Phe
85 90 95
Asn Arg Ile Lys Ser Lys Pro Leu Gly Glu Lys Leu Leu Glu Met Ile
100 105 110
Ile Asn Gly Ile Pro Tyr Leu Gly Asp Arg Arg Val Pro Leu Glu Glu
115 120 125
Phe Asn Thr Asn Ile Ala Ser Val Thr Val Asn Lys Leu Ile Ser Asn
130 135 140
Pro Gly Glu Val Glu Arg Lys Lys Gly Ile Phe Ala Asn Leu Ile Ile
145 150 155 160
Phe Gly Pro Gly Pro Val Leu Asn Glu Asn Glu Thr Ile Asp Ile Gly
165 170 175
Ile Gln Asn His Phe Ala Ser Arg Glu Gly Phe Gly Gly Ile Met Gln
180 185 190
Met Lys Phe Cys Pro Glu Tyr Val Ser Val Phe Asn Asn Val Gln Glu
195 200 205
Asn Lys Gly Ala Ser Ile Phe Asn Arg Arg Gly Tyr Phe Ser Asp Pro
210 215 220
Ala Leu Ile Leu Met His Glu Leu Ile His Val Leu His Gly Leu Tyr
225 230 235 240
Gly Ile Lys Val Asp Asp Leu Pro Ile Val Pro Asn Glu Lys Lys Phe
245 250 255
Phe Met Gln Ser Thr Asp Ala Ile Gln Ala Glu Glu Leu Tyr Thr Phe
260 265 270
Gly Gly Gln Asp Pro Ser Ile Ile Thr Pro Ser Thr Asp Lys Ser Ile
275 280 285
Tyr Asp Lys Val Leu Gln Asn Phe Arg Gly Ile Val Asp Arg Leu Asn
290 295 300
Lys Val Leu Val Cys Ile Ser Asp Pro Asn Ile Asn Ile Asn Ile Tyr
305 310 315 320
Lys Asn Lys Phe Lys Asp Lys Tyr Lys Phe Val Glu Asp Ser Glu Gly
325 330 335
Lys Tyr Ser Ile Asp Val Glu Ser Phe Asp Lys Leu Tyr Lys Ser Leu
340 345 350
Met Phe Gly Phe Thr Glu Thr Asn Ile Ala Glu Asn Tyr Lys Ile Lys
355 360 365
Thr Arg Ala Ser Tyr Phe Ser Asp Ser Leu Pro Pro Val Lys Ile Lys
370 375 380
Asn Leu Leu Asp Asn Glu Ile Tyr Thr Ile Glu Glu Gly Phe Asn Ile
385 390 395 400
Ser Asp Lys Asp Met Glu Lys Glu Tyr Arg Gly Gln Asn Lys Ala Ile
405 410 415
Asn Lys Gln Ala Tyr Glu Glu Ile Ser Lys Glu His Leu Ala Val Tyr
420 425 430
Lys Ile Gln Met Cys Lys Ser Val Lys Cys Gln Asn Leu Phe Lys Asn
435 440 445
Ile Asn Ile Met Ala Lys
450
<210> 40
<211> 462
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/C Light chain-MTDr Amino Acid Sequence
<400> 40
Met Pro Ile Thr Ile Asn Asn Phe Asn Tyr Ser Asp Pro Val Asp Asn
1 5 10 15
Lys Asn Ile Leu Tyr Leu Asp Thr His Leu Asn Thr Leu Ala Asn Glu
20 25 30
Pro Glu Lys Ala Phe Arg Ile Thr Gly Asn Ile Trp Val Ile Pro Asp
35 40 45
Arg Phe Ser Arg Asn Ser Asn Pro Asn Leu Asn Lys Pro Pro Arg Val
50 55 60
Thr Ser Pro Lys Ser Gly Tyr Tyr Asp Pro Asn Tyr Leu Ser Thr Asp
65 70 75 80
Ser Asp Lys Asp Pro Phe Leu Lys Glu Ile Ile Lys Leu Phe Lys Arg
85 90 95
Ile Asn Ser Arg Glu Ile Gly Glu Glu Leu Ile Tyr Arg Leu Ser Thr
100 105 110
Asp Ile Pro Phe Pro Gly Asn Asn Asn Thr Pro Ile Asn Thr Phe Asp
115 120 125
Phe Asp Val Asp Phe Asn Ser Val Asp Val Lys Thr Arg Gln Gly Asn
130 135 140
Asn Trp Val Lys Thr Gly Ser Ile Asn Pro Ser Val Ile Ile Thr Gly
145 150 155 160
Pro Arg Glu Asn Ile Ile Asp Pro Glu Thr Ser Thr Phe Lys Leu Thr
165 170 175
Asn Asn Thr Phe Ala Ala Gln Glu Gly Phe Gly Ala Leu Ser Ile Ile
180 185 190
Ser Ile Ser Pro Arg Phe Met Leu Thr Tyr Ser Asn Ala Thr Asn Asp
195 200 205
Val Gly Glu Gly Arg Phe Ser Lys Ser Glu Phe Cys Met Asp Pro Ile
210 215 220
Leu Ile Leu Met His Glu Leu Asn His Ala Met His Asn Leu Tyr Gly
225 230 235 240
Ile Ala Ile Pro Asn Asp Gln Thr Ile Ser Ser Val Thr Ser Asn Ile
245 250 255
Phe Tyr Ser Gln Tyr Asn Val Lys Leu Glu Tyr Ala Glu Ile Tyr Ala
260 265 270
Phe Gly Gly Pro Thr Ile Asp Leu Ile Pro Lys Ser Ala Arg Lys Tyr
275 280 285
Phe Glu Glu Lys Ala Leu Asp Tyr Tyr Arg Ser Ile Ala Lys Arg Leu
290 295 300
Asn Ser Ile Thr Thr Ala Asn Pro Ser Ser Phe Asn Lys Tyr Ile Gly
305 310 315 320
Glu Tyr Lys Gln Lys Leu Ile Arg Lys Tyr Arg Phe Val Val Glu Ser
325 330 335
Ser Gly Glu Val Thr Val Asn Arg Asn Lys Phe Val Glu Leu Tyr Asn
340 345 350
Glu Leu Thr Gln Ile Phe Thr Glu Phe Asn Tyr Ala Lys Ile Tyr Asn
355 360 365
Val Gln Asn Arg Lys Ile Tyr Leu Ser Asn Val Tyr Thr Pro Val Thr
370 375 380
Ala Asn Ile Leu Asp Asp Asn Val Tyr Asp Ile Gln Asn Gly Phe Asn
385 390 395 400
Ile Pro Lys Ser Asn Leu Asn Val Leu Phe Met Gly Gln Asn Leu Ser
405 410 415
Arg Asn Pro Ala Leu Arg Lys Val Asn Pro Glu Asn Met Leu Tyr Leu
420 425 430
Phe Thr Lys Phe Cys His Lys Ala Ile Asp Gly Arg Ser Leu Tyr Asn
435 440 445
Lys Cys Gln Asn Leu Phe Lys Asn Ile Asn Ile Met Ala Lys
450 455 460
<210> 41
<211> 455
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/D Light chain-MTDr Amino Acid Sequence
<400> 41
Met Thr Trp Pro Val Lys Asp Phe Asn Tyr Ser Asp Pro Val Asn Asp
1 5 10 15
Asn Asp Ile Leu Tyr Leu Arg Ile Pro Gln Asn Lys Leu Ile Thr Thr
20 25 30
Pro Val Lys Ala Phe Met Ile Thr Gln Asn Ile Trp Val Ile Pro Glu
35 40 45
Arg Phe Ser Ser Asp Thr Asn Pro Ser Leu Ser Lys Pro Pro Arg Pro
50 55 60
Thr Ser Lys Tyr Gln Ser Tyr Tyr Asp Pro Ser Tyr Leu Ser Thr Asp
65 70 75 80
Glu Gln Lys Asp Thr Phe Leu Lys Gly Ile Ile Lys Leu Phe Lys Arg
85 90 95
Ile Asn Glu Arg Asp Ile Gly Lys Lys Leu Ile Asn Tyr Leu Val Val
100 105 110
Gly Ser Pro Phe Met Gly Asp Ser Ser Thr Pro Glu Asp Thr Phe Asp
115 120 125
Phe Thr Arg His Thr Thr Asn Ile Ala Val Glu Lys Phe Glu Asn Gly
130 135 140
Ser Trp Lys Val Thr Asn Ile Ile Thr Pro Ser Val Leu Ile Phe Gly
145 150 155 160
Pro Leu Pro Asn Ile Leu Asp Tyr Thr Ala Ser Leu Thr Leu Gln Gly
165 170 175
Gln Gln Ser Asn Pro Ser Phe Glu Gly Phe Gly Thr Leu Ser Ile Leu
180 185 190
Lys Val Ala Pro Glu Phe Leu Leu Thr Phe Ser Asp Val Thr Ser Asn
195 200 205
Gln Ser Ser Ala Val Leu Gly Lys Ser Ile Phe Cys Met Asp Pro Val
210 215 220
Ile Ala Leu Met His Glu Leu Thr His Ser Leu His Gln Leu Tyr Gly
225 230 235 240
Ile Asn Ile Pro Ser Asp Lys Arg Ile Arg Pro Gln Val Ser Glu Gly
245 250 255
Phe Phe Ser Gln Asp Gly Pro Asn Val Gln Phe Glu Glu Leu Tyr Thr
260 265 270
Phe Gly Gly Leu Asp Val Glu Ile Ile Pro Gln Ile Glu Arg Ser Gln
275 280 285
Leu Arg Glu Lys Ala Leu Gly His Tyr Lys Asp Ile Ala Lys Arg Leu
290 295 300
Asn Asn Ile Asn Lys Thr Ile Pro Ser Ser Trp Ile Ser Asn Ile Asp
305 310 315 320
Lys Tyr Lys Lys Ile Phe Ser Glu Lys Tyr Asn Phe Asp Lys Asp Asn
325 330 335
Thr Gly Asn Phe Val Val Asn Ile Asp Lys Phe Asn Ser Leu Tyr Ser
340 345 350
Asp Leu Thr Asn Val Met Ser Glu Val Val Tyr Ser Ser Gln Tyr Asn
355 360 365
Val Lys Asn Arg Thr His Tyr Phe Ser Arg His Tyr Leu Pro Val Phe
370 375 380
Ala Asn Ile Leu Asp Asp Asn Ile Tyr Thr Ile Arg Asp Gly Phe Asn
385 390 395 400
Leu Thr Asn Lys Gly Phe Asn Ile Glu Asn Ser Gly Gln Asn Ile Glu
405 410 415
Arg Asn Pro Ala Leu Gln Lys Leu Ser Ser Glu Ser Val Val Asp Leu
420 425 430
Phe Thr Lys Val Cys Leu Arg Leu Thr Lys Cys Gln Asn Leu Phe Lys
435 440 445
Asn Ile Asn Ile Met Ala Lys
450 455
<210> 42
<211> 435
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/E Light chain-MTDr Amino Acid Sequence
<400> 42
Met Pro Thr Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asn Arg
1 5 10 15
Thr Ile Leu Tyr Ile Lys Pro Gly Gly Cys Gln Gln Phe Tyr Lys Ser
20 25 30
Phe Asn Ile Met Lys Asn Ile Trp Ile Ile Pro Glu Arg Asn Val Ile
35 40 45
Gly Thr Ile Pro Gln Asp Phe Leu Pro Pro Thr Ser Leu Lys Asn Gly
50 55 60
Asp Ser Ser Tyr Tyr Asp Pro Asn Tyr Leu Gln Ser Asp Gln Glu Lys
65 70 75 80
Asp Lys Phe Leu Lys Ile Val Thr Lys Ile Phe Asn Arg Ile Asn Asp
85 90 95
Asn Leu Ser Gly Arg Ile Leu Leu Glu Glu Leu Ser Lys Ala Asn Pro
100 105 110
Tyr Leu Gly Asn Asp Asn Thr Pro Asp Gly Asp Phe Ile Ile Asn Asp
115 120 125
Ala Ser Ala Val Pro Ile Gln Phe Ser Asn Gly Ser Gln Ser Ile Leu
130 135 140
Leu Pro Asn Val Ile Ile Met Gly Ala Glu Pro Asp Leu Phe Glu Thr
145 150 155 160
Asn Ser Ser Asn Ile Ser Leu Arg Asn Asn Tyr Met Pro Ser Asn His
165 170 175
Gly Phe Gly Ser Ile Ala Ile Val Thr Phe Ser Pro Glu Tyr Ser Phe
180 185 190
Arg Phe Lys Asp Asn Ser Met Asn Glu Phe Ile Gln Asp Pro Ala Leu
195 200 205
Thr Leu Met His Glu Leu Ile His Ser Leu His Gly Leu Tyr Gly Ala
210 215 220
Lys Gly Ile Thr Thr Lys Tyr Thr Ile Thr Gln Lys Gln Asn Pro Leu
225 230 235 240
Ile Thr Asn Ile Arg Gly Thr Asn Ile Glu Glu Phe Leu Thr Phe Gly
245 250 255
Gly Thr Asp Leu Asn Ile Ile Thr Ser Ala Gln Ser Asn Asp Ile Tyr
260 265 270
Thr Asn Leu Leu Ala Asp Tyr Lys Lys Ile Ala Ser Lys Leu Ser Lys
275 280 285
Val Gln Val Ser Asn Pro Leu Leu Asn Pro Tyr Lys Asp Val Phe Glu
290 295 300
Ala Lys Tyr Gly Leu Asp Lys Asp Ala Ser Gly Ile Tyr Ser Val Asn
305 310 315 320
Ile Asn Lys Phe Asn Asp Ile Phe Lys Lys Leu Tyr Ser Phe Thr Glu
325 330 335
Phe Asp Leu Ala Thr Lys Phe Gln Val Lys Cys Arg Gln Thr Tyr Ile
340 345 350
Gly Gln Tyr Lys Tyr Phe Lys Leu Ser Asn Leu Leu Asn Asp Ser Ile
355 360 365
Tyr Asn Ile Ser Glu Gly Tyr Asn Ile Asn Asn Leu Lys Val Asn Phe
370 375 380
Arg Gly Gln Asn Ala Asn Leu Asn Pro Arg Ile Ile Thr Pro Ile Thr
385 390 395 400
Gly Arg Gly Leu Val Lys Lys Ile Ile Arg Phe Cys Lys Asn Ile Val
405 410 415
Ser Val Lys Gly Ile Arg Cys Gln Asn Leu Phe Lys Asn Ile Asn Ile
420 425 430
Met Ala Lys
435
<210> 43
<211> 449
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/F Light chain-MTDr Amino Acid Sequence
<400> 43
Met Pro Val Ala Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp
1 5 10 15
Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys
20 25 30
Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu
35 40 45
Arg Asn Thr Ile Gly Thr Asn Pro Ser Asp Phe Asp Pro Pro Ala Ser
50 55 60
Leu Lys Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr
65 70 75 80
Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys
85 90 95
Arg Ile Asn Ser Asn Pro Ala Gly Lys Val Leu Leu Gln Glu Ile Ser
100 105 110
Tyr Ala Lys Pro Tyr Leu Gly Asn Asp His Thr Pro Ile Asp Glu Phe
115 120 125
Ser Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys Leu Ser Thr Asn
130 135 140
Val Glu Ser Ser Met Leu Leu Asn Leu Leu Val Leu Gly Ala Gly Pro
145 150 155 160
Asp Ile Phe Glu Ser Cys Cys Tyr Pro Val Arg Lys Leu Ile Asp Pro
165 170 175
Asp Val Val Tyr Asp Pro Ser Asn Tyr Gly Phe Gly Ser Ile Asn Ile
180 185 190
Val Thr Phe Ser Pro Glu Tyr Glu Tyr Thr Phe Asn Asp Ile Ser Gly
195 200 205
Gly His Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser
210 215 220
Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Arg
225 230 235 240
Gly Val Thr Tyr Glu Glu Thr Ile Glu Val Lys Gln Ala Pro Leu Met
245 250 255
Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly
260 265 270
Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn
275 280 285
Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Glu Val
290 295 300
Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe
305 310 315 320
Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val
325 330 335
Asn Glu Asn Lys Phe Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr
340 345 350
Glu Ser Asp Leu Ala Asn Lys Phe Lys Val Lys Cys Arg Asn Thr Tyr
355 360 365
Phe Ile Lys Tyr Glu Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp
370 375 380
Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly Asn Leu Ala Val Asn
385 390 395 400
Asn Arg Gly Gln Ser Ile Lys Leu Asn Pro Lys Ile Ile Asp Ser Ile
405 410 415
Pro Asp Lys Gly Leu Val Glu Lys Ile Val Lys Phe Cys Lys Ser Val
420 425 430
Ile Pro Arg Lys Cys Gln Asn Leu Phe Lys Asn Ile Asn Ile Met Ala
435 440 445
Lys
<210> 44
<211> 454
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/G Light chain-MTDr Amino Acid Sequence
<400> 44
Met Pro Val Asn Ile Lys Phe Asn Tyr Asn Asp Pro Ile Asn Asn Asp
1 5 10 15
Asp Ile Ile Met Met Glu Pro Phe Asn Asp Pro Gly Pro Gly Thr Tyr
20 25 30
Tyr Lys Ala Phe Arg Ile Ile Asp Arg Ile Trp Ile Val Pro Glu Arg
35 40 45
Phe Thr Tyr Gly Phe Gln Pro Asp Gln Phe Asn Ala Ser Thr Gly Val
50 55 60
Phe Ser Lys Asp Val Tyr Glu Tyr Tyr Asp Pro Thr Tyr Leu Lys Thr
65 70 75 80
Asp Ala Glu Lys Asp Lys Phe Leu Lys Thr Met Ile Lys Leu Phe Asn
85 90 95
Arg Ile Asn Ser Lys Pro Ser Gly Gln Arg Leu Leu Asp Met Ile Val
100 105 110
Asp Ala Ile Pro Tyr Leu Gly Asn Ala Ser Thr Pro Pro Asp Lys Phe
115 120 125
Ala Ala Asn Val Ala Asn Val Ser Ile Asn Lys Lys Ile Ile Gln Pro
130 135 140
Gly Ala Glu Asp Gln Ile Lys Gly Leu Met Thr Asn Leu Ile Ile Phe
145 150 155 160
Gly Pro Gly Pro Val Leu Ser Asp Asn Phe Thr Asp Ser Met Ile Met
165 170 175
Asn Gly His Ser Pro Ile Ser Glu Gly Phe Gly Ala Arg Met Met Ile
180 185 190
Arg Phe Cys Pro Ser Cys Leu Asn Val Phe Asn Asn Val Gln Glu Asn
195 200 205
Lys Asp Thr Ser Ile Phe Ser Arg Arg Ala Tyr Phe Ala Asp Pro Ala
210 215 220
Leu Thr Leu Met His Glu Leu Ile His Val Leu His Gly Leu Tyr Gly
225 230 235 240
Ile Lys Ile Ser Asn Leu Pro Ile Thr Pro Asn Thr Lys Glu Phe Phe
245 250 255
Met Gln His Ser Asp Pro Val Gln Ala Glu Glu Leu Tyr Thr Phe Gly
260 265 270
Gly His Asp Pro Ser Val Ile Ser Pro Ser Thr Asp Met Asn Ile Tyr
275 280 285
Asn Lys Ala Leu Gln Asn Phe Gln Asp Ile Ala Asn Arg Leu Asn Ile
290 295 300
Val Ser Ser Ala Gln Gly Ser Gly Ile Asp Ile Ser Leu Tyr Lys Gln
305 310 315 320
Ile Tyr Lys Asn Lys Tyr Asp Phe Val Glu Asp Pro Asn Gly Lys Tyr
325 330 335
Ser Val Asp Lys Asp Lys Phe Asp Lys Leu Tyr Lys Ala Leu Met Phe
340 345 350
Gly Phe Thr Glu Thr Asn Leu Ala Gly Glu Tyr Gly Ile Lys Thr Arg
355 360 365
Tyr Ser Tyr Phe Ser Glu Tyr Leu Pro Pro Ile Lys Thr Glu Lys Leu
370 375 380
Leu Asp Asn Thr Ile Tyr Thr Gln Asn Glu Gly Phe Asn Ile Ala Ser
385 390 395 400
Lys Asn Leu Lys Thr Glu Phe Asn Gly Gln Asn Lys Ala Val Asn Lys
405 410 415
Glu Ala Tyr Glu Glu Ile Ser Leu Glu His Leu Val Ile Tyr Arg Ile
420 425 430
Ala Met Cys Lys Pro Val Met Tyr Lys Cys Gln Asn Leu Phe Lys Asn
435 440 445
Ile Asn Ile Met Ala Lys
450
<210> 45
<211> 469
<212> PRT
<213> Artificial Sequence
<220>
<223> MTD-BoNT/A Light chain Amino Acid Sequence with hexahistidine
<400> 45
Met Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Pro Phe
1 5 10 15
Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly Val Asp Ile
20 25 30
Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met Gln Pro Val Lys Ala
35 40 45
Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg Asp Thr Phe
50 55 60
Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu Ala Lys Gln
65 70 75 80
Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr Asp Asn Glu
85 90 95
Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu Arg Ile Tyr
100 105 110
Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val Arg Gly Ile
115 120 125
Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys Val Ile Asp
130 135 140
Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr Arg Ser Glu
145 150 155 160
Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile Ile Gln Phe
165 170 175
Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr Arg Asn Gly
180 185 190
Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe Thr Phe Gly
195 200 205
Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu Gly Ala Gly
210 215 220
Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Glu Leu Ile His
225 230 235 240
Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn Arg Val Phe
245 250 255
Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu Glu Val Ser
260 265 270
Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys Phe Ile Asp
275 280 285
Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn Lys Phe Lys
290 295 300
Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val Gly Thr Thr
305 310 315 320
Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys Tyr Leu Leu
325 330 335
Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu Lys Phe Asp
340 345 350
Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp Asn Phe Val
355 360 365
Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn Phe Asp Lys
370 375 380
Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr Thr Ile Tyr
385 390 395 400
Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn Phe Asn Gly
405 410 415
Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu Lys Asn Phe
420 425 430
Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys Val Arg Gly Ile Ile
435 440 445
Thr Ser Lys Thr Lys Ser Leu Asp Lys Gly Tyr Asn Lys Leu Glu His
450 455 460
His His His His His
465
<210> 46
<211> 462
<212> PRT
<213> Artificial Sequence
<220>
<223> MTD-BoNT/B Light chain Amino Acid Sequence with hexahistidine
<400> 46
Met Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Pro Val
1 5 10 15
Thr Ile Asn Asn Phe Asn Tyr Asn Asp Pro Ile Asp Asn Asn Asn Ile
20 25 30
Ile Met Met Glu Pro Pro Phe Ala Arg Gly Thr Gly Arg Tyr Tyr Lys
35 40 45
Ala Phe Lys Ile Thr Asp Arg Ile Trp Ile Ile Pro Glu Arg Tyr Thr
50 55 60
Phe Gly Tyr Lys Pro Glu Asp Phe Asn Lys Ser Ser Gly Ile Phe Asn
65 70 75 80
Arg Asp Val Cys Glu Tyr Tyr Asp Pro Asp Tyr Leu Asn Thr Asn Asp
85 90 95
Lys Lys Asn Ile Phe Leu Gln Thr Met Ile Lys Leu Phe Asn Arg Ile
100 105 110
Lys Ser Lys Pro Leu Gly Glu Lys Leu Leu Glu Met Ile Ile Asn Gly
115 120 125
Ile Pro Tyr Leu Gly Asp Arg Arg Val Pro Leu Glu Glu Phe Asn Thr
130 135 140
Asn Ile Ala Ser Val Thr Val Asn Lys Leu Ile Ser Asn Pro Gly Glu
145 150 155 160
Val Glu Arg Lys Lys Gly Ile Phe Ala Asn Leu Ile Ile Phe Gly Pro
165 170 175
Gly Pro Val Leu Asn Glu Asn Glu Thr Ile Asp Ile Gly Ile Gln Asn
180 185 190
His Phe Ala Ser Arg Glu Gly Phe Gly Gly Ile Met Gln Met Lys Phe
195 200 205
Cys Pro Glu Tyr Val Ser Val Phe Asn Asn Val Gln Glu Asn Lys Gly
210 215 220
Ala Ser Ile Phe Asn Arg Arg Gly Tyr Phe Ser Asp Pro Ala Leu Ile
225 230 235 240
Leu Met His Glu Leu Ile His Val Leu His Gly Leu Tyr Gly Ile Lys
245 250 255
Val Asp Asp Leu Pro Ile Val Pro Asn Glu Lys Lys Phe Phe Met Gln
260 265 270
Ser Thr Asp Ala Ile Gln Ala Glu Glu Leu Tyr Thr Phe Gly Gly Gln
275 280 285
Asp Pro Ser Ile Ile Thr Pro Ser Thr Asp Lys Ser Ile Tyr Asp Lys
290 295 300
Val Leu Gln Asn Phe Arg Gly Ile Val Asp Arg Leu Asn Lys Val Leu
305 310 315 320
Val Cys Ile Ser Asp Pro Asn Ile Asn Ile Asn Ile Tyr Lys Asn Lys
325 330 335
Phe Lys Asp Lys Tyr Lys Phe Val Glu Asp Ser Glu Gly Lys Tyr Ser
340 345 350
Ile Asp Val Glu Ser Phe Asp Lys Leu Tyr Lys Ser Leu Met Phe Gly
355 360 365
Phe Thr Glu Thr Asn Ile Ala Glu Asn Tyr Lys Ile Lys Thr Arg Ala
370 375 380
Ser Tyr Phe Ser Asp Ser Leu Pro Pro Val Lys Ile Lys Asn Leu Leu
385 390 395 400
Asp Asn Glu Ile Tyr Thr Ile Glu Glu Gly Phe Asn Ile Ser Asp Lys
405 410 415
Asp Met Glu Lys Glu Tyr Arg Gly Gln Asn Lys Ala Ile Asn Lys Gln
420 425 430
Ala Tyr Glu Glu Ile Ser Lys Glu His Leu Ala Val Tyr Lys Ile Gln
435 440 445
Met Cys Lys Ser Val Lys Leu Glu His His His His His His
450 455 460
<210> 47
<211> 470
<212> PRT
<213> Artificial Sequence
<220>
<223> MTD-BoNT/C Light chain Amino Acid Sequence with hexahistidine
<400> 47
Met Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Pro Ile
1 5 10 15
Thr Ile Asn Asn Phe Asn Tyr Ser Asp Pro Val Asp Asn Lys Asn Ile
20 25 30
Leu Tyr Leu Asp Thr His Leu Asn Thr Leu Ala Asn Glu Pro Glu Lys
35 40 45
Ala Phe Arg Ile Thr Gly Asn Ile Trp Val Ile Pro Asp Arg Phe Ser
50 55 60
Arg Asn Ser Asn Pro Asn Leu Asn Lys Pro Pro Arg Val Thr Ser Pro
65 70 75 80
Lys Ser Gly Tyr Tyr Asp Pro Asn Tyr Leu Ser Thr Asp Ser Asp Lys
85 90 95
Asp Pro Phe Leu Lys Glu Ile Ile Lys Leu Phe Lys Arg Ile Asn Ser
100 105 110
Arg Glu Ile Gly Glu Glu Leu Ile Tyr Arg Leu Ser Thr Asp Ile Pro
115 120 125
Phe Pro Gly Asn Asn Asn Thr Pro Ile Asn Thr Phe Asp Phe Asp Val
130 135 140
Asp Phe Asn Ser Val Asp Val Lys Thr Arg Gln Gly Asn Asn Trp Val
145 150 155 160
Lys Thr Gly Ser Ile Asn Pro Ser Val Ile Ile Thr Gly Pro Arg Glu
165 170 175
Asn Ile Ile Asp Pro Glu Thr Ser Thr Phe Lys Leu Thr Asn Asn Thr
180 185 190
Phe Ala Ala Gln Glu Gly Phe Gly Ala Leu Ser Ile Ile Ser Ile Ser
195 200 205
Pro Arg Phe Met Leu Thr Tyr Ser Asn Ala Thr Asn Asp Val Gly Glu
210 215 220
Gly Arg Phe Ser Lys Ser Glu Phe Cys Met Asp Pro Ile Leu Ile Leu
225 230 235 240
Met His Glu Leu Asn His Ala Met His Asn Leu Tyr Gly Ile Ala Ile
245 250 255
Pro Asn Asp Gln Thr Ile Ser Ser Val Thr Ser Asn Ile Phe Tyr Ser
260 265 270
Gln Tyr Asn Val Lys Leu Glu Tyr Ala Glu Ile Tyr Ala Phe Gly Gly
275 280 285
Pro Thr Ile Asp Leu Ile Pro Lys Ser Ala Arg Lys Tyr Phe Glu Glu
290 295 300
Lys Ala Leu Asp Tyr Tyr Arg Ser Ile Ala Lys Arg Leu Asn Ser Ile
305 310 315 320
Thr Thr Ala Asn Pro Ser Ser Phe Asn Lys Tyr Ile Gly Glu Tyr Lys
325 330 335
Gln Lys Leu Ile Arg Lys Tyr Arg Phe Val Val Glu Ser Ser Gly Glu
340 345 350
Val Thr Val Asn Arg Asn Lys Phe Val Glu Leu Tyr Asn Glu Leu Thr
355 360 365
Gln Ile Phe Thr Glu Phe Asn Tyr Ala Lys Ile Tyr Asn Val Gln Asn
370 375 380
Arg Lys Ile Tyr Leu Ser Asn Val Tyr Thr Pro Val Thr Ala Asn Ile
385 390 395 400
Leu Asp Asp Asn Val Tyr Asp Ile Gln Asn Gly Phe Asn Ile Pro Lys
405 410 415
Ser Asn Leu Asn Val Leu Phe Met Gly Gln Asn Leu Ser Arg Asn Pro
420 425 430
Ala Leu Arg Lys Val Asn Pro Glu Asn Met Leu Tyr Leu Phe Thr Lys
435 440 445
Phe Cys His Lys Ala Ile Asp Gly Arg Ser Leu Tyr Asn Lys Leu Glu
450 455 460
His His His His His His
465 470
<210> 48
<211> 463
<212> PRT
<213> Artificial Sequence
<220>
<223> MTD-BoNT/D Light chain Amino Acid Sequence with hexahistidine
<400> 48
Met Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Thr Trp
1 5 10 15
Pro Val Lys Asp Phe Asn Tyr Ser Asp Pro Val Asn Asp Asn Asp Ile
20 25 30
Leu Tyr Leu Arg Ile Pro Gln Asn Lys Leu Ile Thr Thr Pro Val Lys
35 40 45
Ala Phe Met Ile Thr Gln Asn Ile Trp Val Ile Pro Glu Arg Phe Ser
50 55 60
Ser Asp Thr Asn Pro Ser Leu Ser Lys Pro Pro Arg Pro Thr Ser Lys
65 70 75 80
Tyr Gln Ser Tyr Tyr Asp Pro Ser Tyr Leu Ser Thr Asp Glu Gln Lys
85 90 95
Asp Thr Phe Leu Lys Gly Ile Ile Lys Leu Phe Lys Arg Ile Asn Glu
100 105 110
Arg Asp Ile Gly Lys Lys Leu Ile Asn Tyr Leu Val Val Gly Ser Pro
115 120 125
Phe Met Gly Asp Ser Ser Thr Pro Glu Asp Thr Phe Asp Phe Thr Arg
130 135 140
His Thr Thr Asn Ile Ala Val Glu Lys Phe Glu Asn Gly Ser Trp Lys
145 150 155 160
Val Thr Asn Ile Ile Thr Pro Ser Val Leu Ile Phe Gly Pro Leu Pro
165 170 175
Asn Ile Leu Asp Tyr Thr Ala Ser Leu Thr Leu Gln Gly Gln Gln Ser
180 185 190
Asn Pro Ser Phe Glu Gly Phe Gly Thr Leu Ser Ile Leu Lys Val Ala
195 200 205
Pro Glu Phe Leu Leu Thr Phe Ser Asp Val Thr Ser Asn Gln Ser Ser
210 215 220
Ala Val Leu Gly Lys Ser Ile Phe Cys Met Asp Pro Val Ile Ala Leu
225 230 235 240
Met His Glu Leu Thr His Ser Leu His Gln Leu Tyr Gly Ile Asn Ile
245 250 255
Pro Ser Asp Lys Arg Ile Arg Pro Gln Val Ser Glu Gly Phe Phe Ser
260 265 270
Gln Asp Gly Pro Asn Val Gln Phe Glu Glu Leu Tyr Thr Phe Gly Gly
275 280 285
Leu Asp Val Glu Ile Ile Pro Gln Ile Glu Arg Ser Gln Leu Arg Glu
290 295 300
Lys Ala Leu Gly His Tyr Lys Asp Ile Ala Lys Arg Leu Asn Asn Ile
305 310 315 320
Asn Lys Thr Ile Pro Ser Ser Trp Ile Ser Asn Ile Asp Lys Tyr Lys
325 330 335
Lys Ile Phe Ser Glu Lys Tyr Asn Phe Asp Lys Asp Asn Thr Gly Asn
340 345 350
Phe Val Val Asn Ile Asp Lys Phe Asn Ser Leu Tyr Ser Asp Leu Thr
355 360 365
Asn Val Met Ser Glu Val Val Tyr Ser Ser Gln Tyr Asn Val Lys Asn
370 375 380
Arg Thr His Tyr Phe Ser Arg His Tyr Leu Pro Val Phe Ala Asn Ile
385 390 395 400
Leu Asp Asp Asn Ile Tyr Thr Ile Arg Asp Gly Phe Asn Leu Thr Asn
405 410 415
Lys Gly Phe Asn Ile Glu Asn Ser Gly Gln Asn Ile Glu Arg Asn Pro
420 425 430
Ala Leu Gln Lys Leu Ser Ser Glu Ser Val Val Asp Leu Phe Thr Lys
435 440 445
Val Cys Leu Arg Leu Thr Lys Leu Glu His His His His His His
450 455 460
<210> 49
<211> 443
<212> PRT
<213> Artificial Sequence
<220>
<223> MTD-BoNT/E Light chain Amino Acid Sequence with hexahistidine
<400> 49
Met Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Pro Thr
1 5 10 15
Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asn Arg Thr Ile Leu
20 25 30
Tyr Ile Lys Pro Gly Gly Cys Gln Gln Phe Tyr Lys Ser Phe Asn Ile
35 40 45
Met Lys Asn Ile Trp Ile Ile Pro Glu Arg Asn Val Ile Gly Thr Ile
50 55 60
Pro Gln Asp Phe Leu Pro Pro Thr Ser Leu Lys Asn Gly Asp Ser Ser
65 70 75 80
Tyr Tyr Asp Pro Asn Tyr Leu Gln Ser Asp Gln Glu Lys Asp Lys Phe
85 90 95
Leu Lys Ile Val Thr Lys Ile Phe Asn Arg Ile Asn Asp Asn Leu Ser
100 105 110
Gly Arg Ile Leu Leu Glu Glu Leu Ser Lys Ala Asn Pro Tyr Leu Gly
115 120 125
Asn Asp Asn Thr Pro Asp Gly Asp Phe Ile Ile Asn Asp Ala Ser Ala
130 135 140
Val Pro Ile Gln Phe Ser Asn Gly Ser Gln Ser Ile Leu Leu Pro Asn
145 150 155 160
Val Ile Ile Met Gly Ala Glu Pro Asp Leu Phe Glu Thr Asn Ser Ser
165 170 175
Asn Ile Ser Leu Arg Asn Asn Tyr Met Pro Ser Asn His Gly Phe Gly
180 185 190
Ser Ile Ala Ile Val Thr Phe Ser Pro Glu Tyr Ser Phe Arg Phe Lys
195 200 205
Asp Asn Ser Met Asn Glu Phe Ile Gln Asp Pro Ala Leu Thr Leu Met
210 215 220
His Glu Leu Ile His Ser Leu His Gly Leu Tyr Gly Ala Lys Gly Ile
225 230 235 240
Thr Thr Lys Tyr Thr Ile Thr Gln Lys Gln Asn Pro Leu Ile Thr Asn
245 250 255
Ile Arg Gly Thr Asn Ile Glu Glu Phe Leu Thr Phe Gly Gly Thr Asp
260 265 270
Leu Asn Ile Ile Thr Ser Ala Gln Ser Asn Asp Ile Tyr Thr Asn Leu
275 280 285
Leu Ala Asp Tyr Lys Lys Ile Ala Ser Lys Leu Ser Lys Val Gln Val
290 295 300
Ser Asn Pro Leu Leu Asn Pro Tyr Lys Asp Val Phe Glu Ala Lys Tyr
305 310 315 320
Gly Leu Asp Lys Asp Ala Ser Gly Ile Tyr Ser Val Asn Ile Asn Lys
325 330 335
Phe Asn Asp Ile Phe Lys Lys Leu Tyr Ser Phe Thr Glu Phe Asp Leu
340 345 350
Ala Thr Lys Phe Gln Val Lys Cys Arg Gln Thr Tyr Ile Gly Gln Tyr
355 360 365
Lys Tyr Phe Lys Leu Ser Asn Leu Leu Asn Asp Ser Ile Tyr Asn Ile
370 375 380
Ser Glu Gly Tyr Asn Ile Asn Asn Leu Lys Val Asn Phe Arg Gly Gln
385 390 395 400
Asn Ala Asn Leu Asn Pro Arg Ile Ile Thr Pro Ile Thr Gly Arg Gly
405 410 415
Leu Val Lys Lys Ile Ile Arg Phe Cys Lys Asn Ile Val Ser Val Lys
420 425 430
Gly Ile Arg Leu Glu His His His His His His
435 440
<210> 50
<211> 457
<212> PRT
<213> Artificial Sequence
<220>
<223> MTD-BoNT/F Light chain Amino Acid Sequence with hexahistidine
<400> 50
Met Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Pro Val
1 5 10 15
Ala Ile Asn Ser Phe Asn Tyr Asn Asp Pro Val Asn Asp Asp Thr Ile
20 25 30
Leu Tyr Met Gln Ile Pro Tyr Glu Glu Lys Ser Lys Lys Tyr Tyr Lys
35 40 45
Ala Phe Glu Ile Met Arg Asn Val Trp Ile Ile Pro Glu Arg Asn Thr
50 55 60
Ile Gly Thr Asn Pro Ser Asp Phe Asp Pro Pro Ala Ser Leu Lys Asn
65 70 75 80
Gly Ser Ser Ala Tyr Tyr Asp Pro Asn Tyr Leu Thr Thr Asp Ala Glu
85 90 95
Lys Asp Arg Tyr Leu Lys Thr Thr Ile Lys Leu Phe Lys Arg Ile Asn
100 105 110
Ser Asn Pro Ala Gly Lys Val Leu Leu Gln Glu Ile Ser Tyr Ala Lys
115 120 125
Pro Tyr Leu Gly Asn Asp His Thr Pro Ile Asp Glu Phe Ser Pro Val
130 135 140
Thr Arg Thr Thr Ser Val Asn Ile Lys Leu Ser Thr Asn Val Glu Ser
145 150 155 160
Ser Met Leu Leu Asn Leu Leu Val Leu Gly Ala Gly Pro Asp Ile Phe
165 170 175
Glu Ser Cys Cys Tyr Pro Val Arg Lys Leu Ile Asp Pro Asp Val Val
180 185 190
Tyr Asp Pro Ser Asn Tyr Gly Phe Gly Ser Ile Asn Ile Val Thr Phe
195 200 205
Ser Pro Glu Tyr Glu Tyr Thr Phe Asn Asp Ile Ser Gly Gly His Asn
210 215 220
Ser Ser Thr Glu Ser Phe Ile Ala Asp Pro Ala Ile Ser Leu Ala His
225 230 235 240
Glu Leu Ile His Ala Leu His Gly Leu Tyr Gly Ala Arg Gly Val Thr
245 250 255
Tyr Glu Glu Thr Ile Glu Val Lys Gln Ala Pro Leu Met Ile Ala Glu
260 265 270
Lys Pro Ile Arg Leu Glu Glu Phe Leu Thr Phe Gly Gly Gln Asp Leu
275 280 285
Asn Ile Ile Thr Ser Ala Met Lys Glu Lys Ile Tyr Asn Asn Leu Leu
290 295 300
Ala Asn Tyr Glu Lys Ile Ala Thr Arg Leu Ser Glu Val Asn Ser Ala
305 310 315 320
Pro Pro Glu Tyr Asp Ile Asn Glu Tyr Lys Asp Tyr Phe Gln Trp Lys
325 330 335
Tyr Gly Leu Asp Lys Asn Ala Asp Gly Ser Tyr Thr Val Asn Glu Asn
340 345 350
Lys Phe Asn Glu Ile Tyr Lys Lys Leu Tyr Ser Phe Thr Glu Ser Asp
355 360 365
Leu Ala Asn Lys Phe Lys Val Lys Cys Arg Asn Thr Tyr Phe Ile Lys
370 375 380
Tyr Glu Phe Leu Lys Val Pro Asn Leu Leu Asp Asp Asp Ile Tyr Thr
385 390 395 400
Val Ser Glu Gly Phe Asn Ile Gly Asn Leu Ala Val Asn Asn Arg Gly
405 410 415
Gln Ser Ile Lys Leu Asn Pro Lys Ile Ile Asp Ser Ile Pro Asp Lys
420 425 430
Gly Leu Val Glu Lys Ile Val Lys Phe Cys Lys Ser Val Ile Pro Arg
435 440 445
Lys Leu Glu His His His His His His
450 455
<210> 51
<211> 462
<212> PRT
<213> Artificial Sequence
<220>
<223> MTD-BoNT/G Light chain Amino Acid Sequence with hexahistidine
<400> 51
Met Lys Ala Met Ile Asn Ile Asn Lys Phe Leu Asn Gln Cys Pro Val
1 5 10 15
Asn Ile Lys Phe Asn Tyr Asn Asp Pro Ile Asn Asn Asp Asp Ile Ile
20 25 30
Met Met Glu Pro Phe Asn Asp Pro Gly Pro Gly Thr Tyr Tyr Lys Ala
35 40 45
Phe Arg Ile Ile Asp Arg Ile Trp Ile Val Pro Glu Arg Phe Thr Tyr
50 55 60
Gly Phe Gln Pro Asp Gln Phe Asn Ala Ser Thr Gly Val Phe Ser Lys
65 70 75 80
Asp Val Tyr Glu Tyr Tyr Asp Pro Thr Tyr Leu Lys Thr Asp Ala Glu
85 90 95
Lys Asp Lys Phe Leu Lys Thr Met Ile Lys Leu Phe Asn Arg Ile Asn
100 105 110
Ser Lys Pro Ser Gly Gln Arg Leu Leu Asp Met Ile Val Asp Ala Ile
115 120 125
Pro Tyr Leu Gly Asn Ala Ser Thr Pro Pro Asp Lys Phe Ala Ala Asn
130 135 140
Val Ala Asn Val Ser Ile Asn Lys Lys Ile Ile Gln Pro Gly Ala Glu
145 150 155 160
Asp Gln Ile Lys Gly Leu Met Thr Asn Leu Ile Ile Phe Gly Pro Gly
165 170 175
Pro Val Leu Ser Asp Asn Phe Thr Asp Ser Met Ile Met Asn Gly His
180 185 190
Ser Pro Ile Ser Glu Gly Phe Gly Ala Arg Met Met Ile Arg Phe Cys
195 200 205
Pro Ser Cys Leu Asn Val Phe Asn Asn Val Gln Glu Asn Lys Asp Thr
210 215 220
Ser Ile Phe Ser Arg Arg Ala Tyr Phe Ala Asp Pro Ala Leu Thr Leu
225 230 235 240
Met His Glu Leu Ile His Val Leu His Gly Leu Tyr Gly Ile Lys Ile
245 250 255
Ser Asn Leu Pro Ile Thr Pro Asn Thr Lys Glu Phe Phe Met Gln His
260 265 270
Ser Asp Pro Val Gln Ala Glu Glu Leu Tyr Thr Phe Gly Gly His Asp
275 280 285
Pro Ser Val Ile Ser Pro Ser Thr Asp Met Asn Ile Tyr Asn Lys Ala
290 295 300
Leu Gln Asn Phe Gln Asp Ile Ala Asn Arg Leu Asn Ile Val Ser Ser
305 310 315 320
Ala Gln Gly Ser Gly Ile Asp Ile Ser Leu Tyr Lys Gln Ile Tyr Lys
325 330 335
Asn Lys Tyr Asp Phe Val Glu Asp Pro Asn Gly Lys Tyr Ser Val Asp
340 345 350
Lys Asp Lys Phe Asp Lys Leu Tyr Lys Ala Leu Met Phe Gly Phe Thr
355 360 365
Glu Thr Asn Leu Ala Gly Glu Tyr Gly Ile Lys Thr Arg Tyr Ser Tyr
370 375 380
Phe Ser Glu Tyr Leu Pro Pro Ile Lys Thr Glu Lys Leu Leu Asp Asn
385 390 395 400
Thr Ile Tyr Thr Gln Asn Glu Gly Phe Asn Ile Ala Ser Lys Asn Leu
405 410 415
Lys Thr Glu Phe Asn Gly Gln Asn Lys Ala Val Asn Lys Glu Ala Tyr
420 425 430
Glu Glu Ile Ser Leu Glu His Leu Val Ile Tyr Arg Ile Ala Met Cys
435 440 445
Lys Pro Val Met Tyr Lys Leu Glu His His His His His His
450 455 460
<210> 52
<211> 481
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/A Light chain-MTDr Amino Acid Sequence with hexahistidine
<400> 52
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro
1 5 10 15
Arg Gly Ser His Met Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp
20 25 30
Pro Val Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly
35 40 45
Gln Met Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val
50 55 60
Ile Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn
65 70 75 80
Pro Pro Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr
85 90 95
Tyr Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr
100 105 110
Lys Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu
115 120 125
Thr Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp
130 135 140
Thr Glu Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro
145 150 155 160
Asp Gly Ser Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro
165 170 175
Ser Ala Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val
180 185 190
Leu Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe
195 200 205
Ser Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr
210 215 220
Asn Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr
225 230 235 240
Leu Ala His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala
245 250 255
Ile Asn Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu
260 265 270
Met Ser Gly Leu Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly
275 280 285
His Asp Ala Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu
290 295 300
Tyr Tyr Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala
305 310 315 320
Lys Ser Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val
325 330 335
Phe Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser
340 345 350
Val Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile
355 360 365
Tyr Thr Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys
370 375 380
Thr Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro
385 390 395 400
Lys Val Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn
405 410 415
Leu Ala Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn
420 425 430
Phe Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu
435 440 445
Leu Cys Val Arg Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Asp Lys
450 455 460
Gly Tyr Asn Lys Cys Gln Asn Leu Phe Lys Asn Ile Asn Ile Met Ala
465 470 475 480
Lys
<210> 53
<211> 474
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/B Light chain-MTDr Amino Acid Sequence with hexahistidine
<400> 53
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro
1 5 10 15
Arg Gly Ser His Met Pro Val Thr Ile Asn Asn Phe Asn Tyr Asn Asp
20 25 30
Pro Ile Asp Asn Asn Asn Ile Ile Met Met Glu Pro Pro Phe Ala Arg
35 40 45
Gly Thr Gly Arg Tyr Tyr Lys Ala Phe Lys Ile Thr Asp Arg Ile Trp
50 55 60
Ile Ile Pro Glu Arg Tyr Thr Phe Gly Tyr Lys Pro Glu Asp Phe Asn
65 70 75 80
Lys Ser Ser Gly Ile Phe Asn Arg Asp Val Cys Glu Tyr Tyr Asp Pro
85 90 95
Asp Tyr Leu Asn Thr Asn Asp Lys Lys Asn Ile Phe Leu Gln Thr Met
100 105 110
Ile Lys Leu Phe Asn Arg Ile Lys Ser Lys Pro Leu Gly Glu Lys Leu
115 120 125
Leu Glu Met Ile Ile Asn Gly Ile Pro Tyr Leu Gly Asp Arg Arg Val
130 135 140
Pro Leu Glu Glu Phe Asn Thr Asn Ile Ala Ser Val Thr Val Asn Lys
145 150 155 160
Leu Ile Ser Asn Pro Gly Glu Val Glu Arg Lys Lys Gly Ile Phe Ala
165 170 175
Asn Leu Ile Ile Phe Gly Pro Gly Pro Val Leu Asn Glu Asn Glu Thr
180 185 190
Ile Asp Ile Gly Ile Gln Asn His Phe Ala Ser Arg Glu Gly Phe Gly
195 200 205
Gly Ile Met Gln Met Lys Phe Cys Pro Glu Tyr Val Ser Val Phe Asn
210 215 220
Asn Val Gln Glu Asn Lys Gly Ala Ser Ile Phe Asn Arg Arg Gly Tyr
225 230 235 240
Phe Ser Asp Pro Ala Leu Ile Leu Met His Glu Leu Ile His Val Leu
245 250 255
His Gly Leu Tyr Gly Ile Lys Val Asp Asp Leu Pro Ile Val Pro Asn
260 265 270
Glu Lys Lys Phe Phe Met Gln Ser Thr Asp Ala Ile Gln Ala Glu Glu
275 280 285
Leu Tyr Thr Phe Gly Gly Gln Asp Pro Ser Ile Ile Thr Pro Ser Thr
290 295 300
Asp Lys Ser Ile Tyr Asp Lys Val Leu Gln Asn Phe Arg Gly Ile Val
305 310 315 320
Asp Arg Leu Asn Lys Val Leu Val Cys Ile Ser Asp Pro Asn Ile Asn
325 330 335
Ile Asn Ile Tyr Lys Asn Lys Phe Lys Asp Lys Tyr Lys Phe Val Glu
340 345 350
Asp Ser Glu Gly Lys Tyr Ser Ile Asp Val Glu Ser Phe Asp Lys Leu
355 360 365
Tyr Lys Ser Leu Met Phe Gly Phe Thr Glu Thr Asn Ile Ala Glu Asn
370 375 380
Tyr Lys Ile Lys Thr Arg Ala Ser Tyr Phe Ser Asp Ser Leu Pro Pro
385 390 395 400
Val Lys Ile Lys Asn Leu Leu Asp Asn Glu Ile Tyr Thr Ile Glu Glu
405 410 415
Gly Phe Asn Ile Ser Asp Lys Asp Met Glu Lys Glu Tyr Arg Gly Gln
420 425 430
Asn Lys Ala Ile Asn Lys Gln Ala Tyr Glu Glu Ile Ser Lys Glu His
435 440 445
Leu Ala Val Tyr Lys Ile Gln Met Cys Lys Ser Val Lys Cys Gln Asn
450 455 460
Leu Phe Lys Asn Ile Asn Ile Met Ala Lys
465 470
<210> 54
<211> 482
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/C Light chain-MTDr Amino Acid Sequence with hexahistidine
<400> 54
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro
1 5 10 15
Arg Gly Ser His Met Pro Ile Thr Ile Asn Asn Phe Asn Tyr Ser Asp
20 25 30
Pro Val Asp Asn Lys Asn Ile Leu Tyr Leu Asp Thr His Leu Asn Thr
35 40 45
Leu Ala Asn Glu Pro Glu Lys Ala Phe Arg Ile Thr Gly Asn Ile Trp
50 55 60
Val Ile Pro Asp Arg Phe Ser Arg Asn Ser Asn Pro Asn Leu Asn Lys
65 70 75 80
Pro Pro Arg Val Thr Ser Pro Lys Ser Gly Tyr Tyr Asp Pro Asn Tyr
85 90 95
Leu Ser Thr Asp Ser Asp Lys Asp Pro Phe Leu Lys Glu Ile Ile Lys
100 105 110
Leu Phe Lys Arg Ile Asn Ser Arg Glu Ile Gly Glu Glu Leu Ile Tyr
115 120 125
Arg Leu Ser Thr Asp Ile Pro Phe Pro Gly Asn Asn Asn Thr Pro Ile
130 135 140
Asn Thr Phe Asp Phe Asp Val Asp Phe Asn Ser Val Asp Val Lys Thr
145 150 155 160
Arg Gln Gly Asn Asn Trp Val Lys Thr Gly Ser Ile Asn Pro Ser Val
165 170 175
Ile Ile Thr Gly Pro Arg Glu Asn Ile Ile Asp Pro Glu Thr Ser Thr
180 185 190
Phe Lys Leu Thr Asn Asn Thr Phe Ala Ala Gln Glu Gly Phe Gly Ala
195 200 205
Leu Ser Ile Ile Ser Ile Ser Pro Arg Phe Met Leu Thr Tyr Ser Asn
210 215 220
Ala Thr Asn Asp Val Gly Glu Gly Arg Phe Ser Lys Ser Glu Phe Cys
225 230 235 240
Met Asp Pro Ile Leu Ile Leu Met His Glu Leu Asn His Ala Met His
245 250 255
Asn Leu Tyr Gly Ile Ala Ile Pro Asn Asp Gln Thr Ile Ser Ser Val
260 265 270
Thr Ser Asn Ile Phe Tyr Ser Gln Tyr Asn Val Lys Leu Glu Tyr Ala
275 280 285
Glu Ile Tyr Ala Phe Gly Gly Pro Thr Ile Asp Leu Ile Pro Lys Ser
290 295 300
Ala Arg Lys Tyr Phe Glu Glu Lys Ala Leu Asp Tyr Tyr Arg Ser Ile
305 310 315 320
Ala Lys Arg Leu Asn Ser Ile Thr Thr Ala Asn Pro Ser Ser Phe Asn
325 330 335
Lys Tyr Ile Gly Glu Tyr Lys Gln Lys Leu Ile Arg Lys Tyr Arg Phe
340 345 350
Val Val Glu Ser Ser Gly Glu Val Thr Val Asn Arg Asn Lys Phe Val
355 360 365
Glu Leu Tyr Asn Glu Leu Thr Gln Ile Phe Thr Glu Phe Asn Tyr Ala
370 375 380
Lys Ile Tyr Asn Val Gln Asn Arg Lys Ile Tyr Leu Ser Asn Val Tyr
385 390 395 400
Thr Pro Val Thr Ala Asn Ile Leu Asp Asp Asn Val Tyr Asp Ile Gln
405 410 415
Asn Gly Phe Asn Ile Pro Lys Ser Asn Leu Asn Val Leu Phe Met Gly
420 425 430
Gln Asn Leu Ser Arg Asn Pro Ala Leu Arg Lys Val Asn Pro Glu Asn
435 440 445
Met Leu Tyr Leu Phe Thr Lys Phe Cys His Lys Ala Ile Asp Gly Arg
450 455 460
Ser Leu Tyr Asn Lys Cys Gln Asn Leu Phe Lys Asn Ile Asn Ile Met
465 470 475 480
Ala Lys
<210> 55
<211> 475
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/D Light chain-MTDr Amino Acid Sequence with hexahistidine
<400> 55
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro
1 5 10 15
Arg Gly Ser His Met Thr Trp Pro Val Lys Asp Phe Asn Tyr Ser Asp
20 25 30
Pro Val Asn Asp Asn Asp Ile Leu Tyr Leu Arg Ile Pro Gln Asn Lys
35 40 45
Leu Ile Thr Thr Pro Val Lys Ala Phe Met Ile Thr Gln Asn Ile Trp
50 55 60
Val Ile Pro Glu Arg Phe Ser Ser Asp Thr Asn Pro Ser Leu Ser Lys
65 70 75 80
Pro Pro Arg Pro Thr Ser Lys Tyr Gln Ser Tyr Tyr Asp Pro Ser Tyr
85 90 95
Leu Ser Thr Asp Glu Gln Lys Asp Thr Phe Leu Lys Gly Ile Ile Lys
100 105 110
Leu Phe Lys Arg Ile Asn Glu Arg Asp Ile Gly Lys Lys Leu Ile Asn
115 120 125
Tyr Leu Val Val Gly Ser Pro Phe Met Gly Asp Ser Ser Thr Pro Glu
130 135 140
Asp Thr Phe Asp Phe Thr Arg His Thr Thr Asn Ile Ala Val Glu Lys
145 150 155 160
Phe Glu Asn Gly Ser Trp Lys Val Thr Asn Ile Ile Thr Pro Ser Val
165 170 175
Leu Ile Phe Gly Pro Leu Pro Asn Ile Leu Asp Tyr Thr Ala Ser Leu
180 185 190
Thr Leu Gln Gly Gln Gln Ser Asn Pro Ser Phe Glu Gly Phe Gly Thr
195 200 205
Leu Ser Ile Leu Lys Val Ala Pro Glu Phe Leu Leu Thr Phe Ser Asp
210 215 220
Val Thr Ser Asn Gln Ser Ser Ala Val Leu Gly Lys Ser Ile Phe Cys
225 230 235 240
Met Asp Pro Val Ile Ala Leu Met His Glu Leu Thr His Ser Leu His
245 250 255
Gln Leu Tyr Gly Ile Asn Ile Pro Ser Asp Lys Arg Ile Arg Pro Gln
260 265 270
Val Ser Glu Gly Phe Phe Ser Gln Asp Gly Pro Asn Val Gln Phe Glu
275 280 285
Glu Leu Tyr Thr Phe Gly Gly Leu Asp Val Glu Ile Ile Pro Gln Ile
290 295 300
Glu Arg Ser Gln Leu Arg Glu Lys Ala Leu Gly His Tyr Lys Asp Ile
305 310 315 320
Ala Lys Arg Leu Asn Asn Ile Asn Lys Thr Ile Pro Ser Ser Trp Ile
325 330 335
Ser Asn Ile Asp Lys Tyr Lys Lys Ile Phe Ser Glu Lys Tyr Asn Phe
340 345 350
Asp Lys Asp Asn Thr Gly Asn Phe Val Val Asn Ile Asp Lys Phe Asn
355 360 365
Ser Leu Tyr Ser Asp Leu Thr Asn Val Met Ser Glu Val Val Tyr Ser
370 375 380
Ser Gln Tyr Asn Val Lys Asn Arg Thr His Tyr Phe Ser Arg His Tyr
385 390 395 400
Leu Pro Val Phe Ala Asn Ile Leu Asp Asp Asn Ile Tyr Thr Ile Arg
405 410 415
Asp Gly Phe Asn Leu Thr Asn Lys Gly Phe Asn Ile Glu Asn Ser Gly
420 425 430
Gln Asn Ile Glu Arg Asn Pro Ala Leu Gln Lys Leu Ser Ser Glu Ser
435 440 445
Val Val Asp Leu Phe Thr Lys Val Cys Leu Arg Leu Thr Lys Cys Gln
450 455 460
Asn Leu Phe Lys Asn Ile Asn Ile Met Ala Lys
465 470 475
<210> 56
<211> 455
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/E Light chain-MTDr Amino Acid Sequence with hexahistidine
<400> 56
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro
1 5 10 15
Arg Gly Ser His Met Pro Thr Ile Asn Ser Phe Asn Tyr Asn Asp Pro
20 25 30
Val Asn Asn Arg Thr Ile Leu Tyr Ile Lys Pro Gly Gly Cys Gln Gln
35 40 45
Phe Tyr Lys Ser Phe Asn Ile Met Lys Asn Ile Trp Ile Ile Pro Glu
50 55 60
Arg Asn Val Ile Gly Thr Ile Pro Gln Asp Phe Leu Pro Pro Thr Ser
65 70 75 80
Leu Lys Asn Gly Asp Ser Ser Tyr Tyr Asp Pro Asn Tyr Leu Gln Ser
85 90 95
Asp Gln Glu Lys Asp Lys Phe Leu Lys Ile Val Thr Lys Ile Phe Asn
100 105 110
Arg Ile Asn Asp Asn Leu Ser Gly Arg Ile Leu Leu Glu Glu Leu Ser
115 120 125
Lys Ala Asn Pro Tyr Leu Gly Asn Asp Asn Thr Pro Asp Gly Asp Phe
130 135 140
Ile Ile Asn Asp Ala Ser Ala Val Pro Ile Gln Phe Ser Asn Gly Ser
145 150 155 160
Gln Ser Ile Leu Leu Pro Asn Val Ile Ile Met Gly Ala Glu Pro Asp
165 170 175
Leu Phe Glu Thr Asn Ser Ser Asn Ile Ser Leu Arg Asn Asn Tyr Met
180 185 190
Pro Ser Asn His Gly Phe Gly Ser Ile Ala Ile Val Thr Phe Ser Pro
195 200 205
Glu Tyr Ser Phe Arg Phe Lys Asp Asn Ser Met Asn Glu Phe Ile Gln
210 215 220
Asp Pro Ala Leu Thr Leu Met His Glu Leu Ile His Ser Leu His Gly
225 230 235 240
Leu Tyr Gly Ala Lys Gly Ile Thr Thr Lys Tyr Thr Ile Thr Gln Lys
245 250 255
Gln Asn Pro Leu Ile Thr Asn Ile Arg Gly Thr Asn Ile Glu Glu Phe
260 265 270
Leu Thr Phe Gly Gly Thr Asp Leu Asn Ile Ile Thr Ser Ala Gln Ser
275 280 285
Asn Asp Ile Tyr Thr Asn Leu Leu Ala Asp Tyr Lys Lys Ile Ala Ser
290 295 300
Lys Leu Ser Lys Val Gln Val Ser Asn Pro Leu Leu Asn Pro Tyr Lys
305 310 315 320
Asp Val Phe Glu Ala Lys Tyr Gly Leu Asp Lys Asp Ala Ser Gly Ile
325 330 335
Tyr Ser Val Asn Ile Asn Lys Phe Asn Asp Ile Phe Lys Lys Leu Tyr
340 345 350
Ser Phe Thr Glu Phe Asp Leu Ala Thr Lys Phe Gln Val Lys Cys Arg
355 360 365
Gln Thr Tyr Ile Gly Gln Tyr Lys Tyr Phe Lys Leu Ser Asn Leu Leu
370 375 380
Asn Asp Ser Ile Tyr Asn Ile Ser Glu Gly Tyr Asn Ile Asn Asn Leu
385 390 395 400
Lys Val Asn Phe Arg Gly Gln Asn Ala Asn Leu Asn Pro Arg Ile Ile
405 410 415
Thr Pro Ile Thr Gly Arg Gly Leu Val Lys Lys Ile Ile Arg Phe Cys
420 425 430
Lys Asn Ile Val Ser Val Lys Gly Ile Arg Cys Gln Asn Leu Phe Lys
435 440 445
Asn Ile Asn Ile Met Ala Lys
450 455
<210> 57
<211> 469
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/F Light chain-MTDr Amino Acid Sequence with hexahistidine
<400> 57
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro
1 5 10 15
Arg Gly Ser His Met Pro Val Ala Ile Asn Ser Phe Asn Tyr Asn Asp
20 25 30
Pro Val Asn Asp Asp Thr Ile Leu Tyr Met Gln Ile Pro Tyr Glu Glu
35 40 45
Lys Ser Lys Lys Tyr Tyr Lys Ala Phe Glu Ile Met Arg Asn Val Trp
50 55 60
Ile Ile Pro Glu Arg Asn Thr Ile Gly Thr Asn Pro Ser Asp Phe Asp
65 70 75 80
Pro Pro Ala Ser Leu Lys Asn Gly Ser Ser Ala Tyr Tyr Asp Pro Asn
85 90 95
Tyr Leu Thr Thr Asp Ala Glu Lys Asp Arg Tyr Leu Lys Thr Thr Ile
100 105 110
Lys Leu Phe Lys Arg Ile Asn Ser Asn Pro Ala Gly Lys Val Leu Leu
115 120 125
Gln Glu Ile Ser Tyr Ala Lys Pro Tyr Leu Gly Asn Asp His Thr Pro
130 135 140
Ile Asp Glu Phe Ser Pro Val Thr Arg Thr Thr Ser Val Asn Ile Lys
145 150 155 160
Leu Ser Thr Asn Val Glu Ser Ser Met Leu Leu Asn Leu Leu Val Leu
165 170 175
Gly Ala Gly Pro Asp Ile Phe Glu Ser Cys Cys Tyr Pro Val Arg Lys
180 185 190
Leu Ile Asp Pro Asp Val Val Tyr Asp Pro Ser Asn Tyr Gly Phe Gly
195 200 205
Ser Ile Asn Ile Val Thr Phe Ser Pro Glu Tyr Glu Tyr Thr Phe Asn
210 215 220
Asp Ile Ser Gly Gly His Asn Ser Ser Thr Glu Ser Phe Ile Ala Asp
225 230 235 240
Pro Ala Ile Ser Leu Ala His Glu Leu Ile His Ala Leu His Gly Leu
245 250 255
Tyr Gly Ala Arg Gly Val Thr Tyr Glu Glu Thr Ile Glu Val Lys Gln
260 265 270
Ala Pro Leu Met Ile Ala Glu Lys Pro Ile Arg Leu Glu Glu Phe Leu
275 280 285
Thr Phe Gly Gly Gln Asp Leu Asn Ile Ile Thr Ser Ala Met Lys Glu
290 295 300
Lys Ile Tyr Asn Asn Leu Leu Ala Asn Tyr Glu Lys Ile Ala Thr Arg
305 310 315 320
Leu Ser Glu Val Asn Ser Ala Pro Pro Glu Tyr Asp Ile Asn Glu Tyr
325 330 335
Lys Asp Tyr Phe Gln Trp Lys Tyr Gly Leu Asp Lys Asn Ala Asp Gly
340 345 350
Ser Tyr Thr Val Asn Glu Asn Lys Phe Asn Glu Ile Tyr Lys Lys Leu
355 360 365
Tyr Ser Phe Thr Glu Ser Asp Leu Ala Asn Lys Phe Lys Val Lys Cys
370 375 380
Arg Asn Thr Tyr Phe Ile Lys Tyr Glu Phe Leu Lys Val Pro Asn Leu
385 390 395 400
Leu Asp Asp Asp Ile Tyr Thr Val Ser Glu Gly Phe Asn Ile Gly Asn
405 410 415
Leu Ala Val Asn Asn Arg Gly Gln Ser Ile Lys Leu Asn Pro Lys Ile
420 425 430
Ile Asp Ser Ile Pro Asp Lys Gly Leu Val Glu Lys Ile Val Lys Phe
435 440 445
Cys Lys Ser Val Ile Pro Arg Lys Cys Gln Asn Leu Phe Lys Asn Ile
450 455 460
Asn Ile Met Ala Lys
465
<210> 58
<211> 474
<212> PRT
<213> Artificial Sequence
<220>
<223> BoNT/G Light chain-MTDr Amino Acid Sequence with hexahistidine
<400> 58
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro
1 5 10 15
Arg Gly Ser His Met Pro Val Asn Ile Lys Phe Asn Tyr Asn Asp Pro
20 25 30
Ile Asn Asn Asp Asp Ile Ile Met Met Glu Pro Phe Asn Asp Pro Gly
35 40 45
Pro Gly Thr Tyr Tyr Lys Ala Phe Arg Ile Ile Asp Arg Ile Trp Ile
50 55 60
Val Pro Glu Arg Phe Thr Tyr Gly Phe Gln Pro Asp Gln Phe Asn Ala
65 70 75 80
Ser Thr Gly Val Phe Ser Lys Asp Val Tyr Glu Tyr Tyr Asp Pro Thr
85 90 95
Tyr Leu Lys Thr Asp Ala Glu Lys Asp Lys Phe Leu Lys Thr Met Ile
100 105 110
Lys Leu Phe Asn Arg Ile Asn Ser Lys Pro Ser Gly Gln Arg Leu Leu
115 120 125
Asp Met Ile Val Asp Ala Ile Pro Tyr Leu Gly Asn Ala Ser Thr Pro
130 135 140
Pro Asp Lys Phe Ala Ala Asn Val Ala Asn Val Ser Ile Asn Lys Lys
145 150 155 160
Ile Ile Gln Pro Gly Ala Glu Asp Gln Ile Lys Gly Leu Met Thr Asn
165 170 175
Leu Ile Ile Phe Gly Pro Gly Pro Val Leu Ser Asp Asn Phe Thr Asp
180 185 190
Ser Met Ile Met Asn Gly His Ser Pro Ile Ser Glu Gly Phe Gly Ala
195 200 205
Arg Met Met Ile Arg Phe Cys Pro Ser Cys Leu Asn Val Phe Asn Asn
210 215 220
Val Gln Glu Asn Lys Asp Thr Ser Ile Phe Ser Arg Arg Ala Tyr Phe
225 230 235 240
Ala Asp Pro Ala Leu Thr Leu Met His Glu Leu Ile His Val Leu His
245 250 255
Gly Leu Tyr Gly Ile Lys Ile Ser Asn Leu Pro Ile Thr Pro Asn Thr
260 265 270
Lys Glu Phe Phe Met Gln His Ser Asp Pro Val Gln Ala Glu Glu Leu
275 280 285
Tyr Thr Phe Gly Gly His Asp Pro Ser Val Ile Ser Pro Ser Thr Asp
290 295 300
Met Asn Ile Tyr Asn Lys Ala Leu Gln Asn Phe Gln Asp Ile Ala Asn
305 310 315 320
Arg Leu Asn Ile Val Ser Ser Ala Gln Gly Ser Gly Ile Asp Ile Ser
325 330 335
Leu Tyr Lys Gln Ile Tyr Lys Asn Lys Tyr Asp Phe Val Glu Asp Pro
340 345 350
Asn Gly Lys Tyr Ser Val Asp Lys Asp Lys Phe Asp Lys Leu Tyr Lys
355 360 365
Ala Leu Met Phe Gly Phe Thr Glu Thr Asn Leu Ala Gly Glu Tyr Gly
370 375 380
Ile Lys Thr Arg Tyr Ser Tyr Phe Ser Glu Tyr Leu Pro Pro Ile Lys
385 390 395 400
Thr Glu Lys Leu Leu Asp Asn Thr Ile Tyr Thr Gln Asn Glu Gly Phe
405 410 415
Asn Ile Ala Ser Lys Asn Leu Lys Thr Glu Phe Asn Gly Gln Asn Lys
420 425 430
Ala Val Asn Lys Glu Ala Tyr Glu Glu Ile Ser Leu Glu His Leu Val
435 440 445
Ile Tyr Arg Ile Ala Met Cys Lys Pro Val Met Tyr Lys Cys Gln Asn
450 455 460
Leu Phe Lys Asn Ile Asn Ile Met Ala Lys
465 470
<210> 59
<211> 1386
<212> DNA
<213> Artificial Sequence
<220>
<223> MTD-BoNT/A Light chain cDNA Sequence
<400> 59
atgaaggcca tgatcaatat taacaagttc ttaaatcaat gtccctttgt caacaaacag 60
ttcaactaca aggacccagt taatggagta gacatcgcat atatcaagat tcccaacgct 120
ggccagatgc aacccgttaa ggcatttaaa atccataaca aaatctgggt tatcccagag 180
cgggatacct tcaccaaccc cgaggagggc gatctgaacc ccccgccgga ggcgaagcag 240
gtcccagtga gctactacga tagcacctac ctcagcaccg acaacgagaa ggacaactac 300
ctcaaaggag tcacgaagtt gttcgagaga atctactcca cagacctcgg ccgcatgctt 360
ctaaccagca ttgtgcgtgg cattcccttt tggggcggct ctaccatcga cacagagctg 420
aaggtgatag acaccaactg catcaacgta atccagcctg acggcagcta ccgaagcgag 480
gagcttaacc tggtgatcat cggcccttcc gccgatatca tccaattcga gtgcaagagc 540
ttcggccacg aggtcctgaa cctcacccgg aacggctatg gaagcaccca gtacataaga 600
ttcagccctg acttcacctt cgggtttgag gagagcttgg aggtcgacac aaaccccctg 660
ctgggagccg ggaagttcgc cactgaccca gccgtgactc tggcacacga gctgatccac 720
gccggtcacc gcctgtacgg catagctata aacccaaaca gggtgttcaa agtgaacacc 780
aacgcttact atgaaatgag cggcctggag gtgagcttcg aggagctgag aacgttcggg 840
ggacatgatg ctaaatttat cgacagcctg caggagaacg agttcaggct gtactactac 900
aataagttca aggatatagc gagcactctg aacaaggcca agtccatcgt aggcactact 960
gcatccctcc agtatatgaa gaatgtgttc aaagagaaat acctgctgag cgaggatacc 1020
agcggtaagt tcagcgtgga taagcttaag ttcgacaagc tgtataagat gctcaccgaa 1080
atctacaccg aggataattt cgttaagttc ttcaaggtcc tgaaccggaa gacctacctg 1140
aacttcgaca aggccgtgtt caagatcaac atcgtgccta aagtgaacta caccatctac 1200
gacgggttta acctgaggaa caccaacctg gccgctaact tcaacgggca gaacacagag 1260
atcaacaaca tgaatttcac gaagttgaag aacttcaccg gactgtttga gttctacaaa 1320
ttgctgtgtg tgcgcgggat catcactagc aagaccaaga gccttgacaa aggctacaac 1380
aagtga 1386
<210> 60
<211> 1362
<212> DNA
<213> Artificial Sequence
<220>
<223> MTD-BoNT/B Light chain cDNA Sequence
<400> 60
atgaaggcca tgatcaatat taacaagttc ttaaatcaat gtccagttac aataaataat 60
tttaattata atgatcctat tgataataat aatattatta tgatggagcc tccatttgcg 120
agaggtacgg ggagatatta taaagctttt aaaatcacag atcgtatttg gataataccg 180
gaaagatata cttttggata taaacctgag gattttaata aaagttccgg tatttttaat 240
agagatgttt gtgaatatta tgatccagat tacttaaata ctaatgataa aaagaatata 300
tttttacaaa caatgatcaa gttatttaat agaatcaaat caaaaccatt gggtgaaaag 360
ttattagaga tgattataaa tggtatacct tatcttggag atagacgtgt tccactcgaa 420
gagtttaaca caaacattgc tagtgtaact gttaataaat taatcagtaa tccaggagaa 480
gtggagcgaa aaaaaggtat tttcgcaaat ttaataatat ttggacctgg gccagtttta 540
aatgaaaatg agactataga tataggtata caaaatcatt ttgcatcaag ggaaggcttc 600
gggggtataa tgcaaatgaa gttttgccca gaatatgtaa gcgtatttaa taatgttcaa 660
gaaaacaaag gcgcaagtat atttaataga cgtggatatt tttcagatcc agccttgata 720
ttaatgcatg aacttataca tgttttacat ggattatatg gcattaaagt agatgattta 780
ccaattgtac caaatgaaaa aaaatttttt atgcaatcta cagatgctat acaggcagaa 840
gaactatata catttggagg acaagatccc agcatcataa ctccttctac ggataaaagt 900
atctatgata aagttttgca aaattttaga gggatagttg atagacttaa caaggtttta 960
gtttgcatat cagatcctaa cattaatatt aatatatata aaaataaatt taaagataaa 1020
tataaattcg ttgaagattc tgagggaaaa tatagtatag atgtagaaag ttttgataaa 1080
ttatataaaa gcttaatgtt tggttttaca gaaactaata tagcagaaaa ttataaaata 1140
aaaactagag cttcttattt tagtgattcc ttaccaccag taaaaataaa aaatttatta 1200
gataatgaaa tctatactat agaggaaggg tttaatatat ctgataaaga tatggaaaaa 1260
gaatatagag gtcagaataa agctataaat aaacaagctt atgaagaaat tagcaaggag 1320
catttggctg tatataagat acaaatgtgt aaaagtgtta aa 1362
<210> 61
<211> 1386
<212> DNA
<213> Artificial Sequence
<220>
<223> MTD-BoNT/C Light chain cDNA Sequence
<400> 61
atgaaggcca tgatcaatat taacaagttc ttaaatcaat gtccaataac aattaacaac 60
tttaattatt cagatcctgt tgataataaa aatattttat atttagatac tcatttaaat 120
acactagcta atgagcctga aaaagccttt cgcattacag gaaatatatg ggtaatacct 180
gatagatttt caagaaattc taatccaaat ttaaataaac ctcctcgagt tacaagccct 240
aaaagtggtt attatgatcc taattatttg agtactgatt ctgacaaaga tacattttta 300
aaagaaatta taaagttatt taaaagaatt aattctagag aaataggaga agaattaata 360
tatagacttt cgacagatat accctttcct gggaataaca atactccaat taatactttt 420
gattttgatg tagattttaa cagtgttgat gttaaaacta gacaaggtaa caactgggtt 480
aaaactggta gcataaatcc tagtgttata ataactggac ctagagaaaa cattatagat 540
ccagaaactt ctacgtttaa attaactaac aatacttttg cggcacaaga aggatttggt 600
gctttatcaa taatttcaat atcacctaga tttatgctaa catatagtaa tgcaactaat 660
gatgtaggag agggtagatt ttctaagtct gaattttgca tggatccaat actaatttta 720
atgcatgaac ttaatcatgc aatgcataat ttatatggaa tagctatacc aaatgatcaa 780
acaatttcat ctgtaactag taatattttt tattctcaat ataatgtgaa attagagtat 840
gcagaaatat atgcatttgg aggtccaact atagacctta ttcctaaaag tgcaaggaaa 900
tattttgagg aaaaggcatt ggattattat agatctatag ctaaaagact taatagtata 960
actactgcaa atccttcaag ctttaataaa tatatagggg aatataaaca gaaacttatt 1020
agaaagtata gattcgtagt agaatcttca ggtgaagtta cagtaaatcg taataagttt 1080
gttgagttat ataatgaact tacacaaata tttacagaat ttaactacgc taaaatatat 1140
aatgtacaaa ataggaaaat atatctttca aatgtatata ctccggttac ggcgaatata 1200
ttagacgata atgtttatga tatacaaaat ggatttaata tacctaaaag taatttaaat 1260
gtactattta tgggtcaaaa tttatctcga aatccagcat taagaaaagt caatcctgaa 1320
aatatgcttt atttatttac aaaattttgt cataaagcaa tagatggtag atcattatat 1380
aataaa 1386
<210> 62
<211> 1365
<212> DNA
<213> Artificial Sequence
<220>
<223> MTD-BoNT/D Light chain cDNA Sequence
<400> 62
atgaaggcca tgatcaatat taacaagttc ttaaatcaat gtacatggcc agtaaaagat 60
tttaattata gtgatcctgt taatgacaat gatatattat atttaagaat accacaaaat 120
aagttaatta ctacacctgt aaaagctttt atgattactc aaaatatttg ggtaatacca 180
gaaagatttt catcagatac taatccaagt ttaagtaaac cgcccagacc tacttcaaag 240
tatcaaagtt attatgatcc tagttattta tctactgatg aacaaaaaga tacattttta 300
aaagggatta taaaattatt taaaagaatt aatgaaagag atataggaaa aaaattaata 360
aattatttag tagttggttc accttttatg ggagattcaa gtacgcctga agatacattt 420
gattttacac gtcatactac taatattgca gttgaaaagt ttgaaaatgg tagttggaaa 480
gtaacaaata ttataacacc aagtgtattg atatttggac cacttcctaa tatattagac 540
tatacagcat cccttacatt gcaaggacaa caatcaaatc catcatttga agggtttgga 600
acattatcta tactaaaagt agcacctgaa tttttgttaa catttagtga tgtaacatct 660
aatcaaagtt cagctgtatt aggcaaatct atattttgta tggatccagt aatagcttta 720
atgcatgagt taacacattc tttgcatcaa ttatatggaa taaatatacc atctgataaa 780
aggattcgtc cacaagttag cgagggattt ttctctcaag atggacccaa cgtacaattt 840
gaggaattat atacatttgg aggattagat gttgaaataa tacctcaaat tgaaagatca 900
caattaagag aaaaagcatt aggtcactat aaagatatag cgaaaagact taataatatt 960
aataaaacta ttccttctag ttggattagt aatatagata aatataaaaa aatattttct 1020
gaaaagtata attttgataa agataataca ggaaattttg ttgtaaatat tgataaattc 1080
aatagcttat attcagactt gactaatgtt atgtcagaag ttgtttattc ttcgcaatat 1140
aatgttaaaa acaggactca ttatttttca aggcattatc tacctgtatt tgcaaatata 1200
ttagatgata atatttatac tataagagat ggttttaatt taacaaataa aggttttaat 1260
atagaaaatt cgggtcagaa tatagaaagg aatcctgcac tacaaaagct tagttcagaa 1320
agtgtagtag atttatttac aaaagtatgt ttaagattaa caaaa 1365
<210> 63
<211> 1305
<212> DNA
<213> Artificial Sequence
<220>
<223> MTD-BoNT/E Light chain cDNA Sequence
<400> 63
atgaaggcca tgatcaatat taacaagttc ttaaatcaat gtccaacaat taatagtttt 60
aattataatg atcctgttaa taatagaaca attttatata ttaaaccagg cggttgtcaa 120
caattttata aatcatttaa tattatgaaa aatatttgga taattccaga gagaaatgta 180
attggtacaa ttccccaaga ttttcttccg cctacttcat tgaaaaatgg agatagtagt 240
tattatgacc ctaattattt acaaagtgat caagaaaagg ataaattttt aaaaatagtc 300
acaaaaatat ttaatagaat aaatgataat ctttcaggaa ggattttatt agaagaactg 360
tcaaaagcta atccatattt aggaaatgat aatactccag atggtgactt cattattaat 420
gatgcatcag cagttccaat tcaattctca aatggtagcc aaagcatact attacctaat 480
gttattataa tgggagcaga gcctgattta tttgaaacta acagttccaa tatttctcta 540
agaaataatt atatgccaag caatcacggt tttggatcaa tagctatagt aacattctca 600
cctgaatatt cttttagatt taaagataat agtatgaatg aatttattca agatcctgct 660
cttacattaa tgcatgaatt aatacattca ttacatggac tatatggggc taaagggatt 720
actacaaagt atactataac acaaaaacaa aatcccctaa taacaaatat aagaggtaca 780
aatattgaag aattcttaac ttttggaggt actgatttaa acattattac tagtgctcag 840
tccaatgata tctatactaa tcttctagct gattataaaa aaatagcgtc taaacttagc 900
aaagtacaag tatctaatcc actacttaat ccttataaag atgtttttga agcaaagtat 960
ggattagata aagatgctag cggaatttat tcggtaaata taaacaaatt taatgatatt 1020
tttaaaaaat tatacagctt tacggaattt gatttagcaa ctaaatttca agttaaatgt 1080
aggcaaactt atattggaca gtataaatac ttcaaacttt caaacttgtt aaatgattct 1140
atttataata tatcagaagg ctataatata aataatttaa aggtaaattt tagaggacag 1200
aatgcaaatt taaatcctag aattattaca ccaattacag gtagaggact agtaaaaaaa 1260
atcattagat tttgtaaaaa tattgtttct gtaaaaggca taagg 1305
<210> 64
<211> 1347
<212> DNA
<213> Artificial Sequence
<220>
<223> MTD-BoNT/F Light chain cDNA Sequence
<400> 64
atgaaggcca tgatcaatat taacaagttc ttaaatcaat gtccagttgc aataaatagt 60
tttaattata atgaccctgt taatgatgat acaattttat acatgcagat accatatgaa 120
gaaaaaagta aaaaatatta taaagctttt gagattatgc gtaatgtttg gataattcct 180
gagagaaata caataggaac gaatcctagt gattttgatc caccggcttc attaaagaac 240
ggaagcagtg cttattatga tcctaattat ttaaccactg atgctgaaaa agatagatat 300
ttaaaaacaa cgataaaatt atttaagaga attaatagta atcctgcagg gaaagttttg 360
ttacaagaaa tatcatatgc taaaccatat ttaggaaatg accacacgcc aattgatgaa 420
ttctctccag ttactagaac tacaagtgtt aatataaaat tatcaactaa tgttgaaagt 480
tcaatgttat tgaatcttct tgtattggga gcaggacctg atatatttga aagttgttgt 540
taccccgtta gaaaactaat agatccagat gtagtttatg atccaagtaa ttatggtttt 600
ggatcaatta atatcgtgac attttcacct gagtatgaat atacttttaa tgatattagt 660
ggagggcata atagtagtac agaatcattt attgcagatc ctgcaatttc actagctcat 720
gaattgatac atgcactgca tggattatac ggggctaggg gagttactta tgaagagact 780
atagaagtaa agcaagcacc tcttatgata gccgaaaaac ccataaggct agaagaattt 840
ttaacctttg gaggtcagga tttaaatatt attactagtg ctatgaagga aaaaatatat 900
aacaatcttt tagctaacta tgaaaaaata gctactagac ttagtgaagt taatagtgct 960
cctcctgaat atgatattaa tgaatataaa gattattttc aatggaagta tgggctagat 1020
aaaaatgctg atggaagtta tactgtaaat gaaaataaat ttaatgaaat ttataaaaaa 1080
ttatatagtt ttacagagag tgacttagca aataaattta aagtaaaatg tagaaatact 1140
tattttatta aatatgaatt tttaaaagtt ccaaatttgt tagatgatga tatttatact 1200
gtatcagagg ggtttaatat aggtaattta gcagtaaaca atcgcggaca aagtataaag 1260
ttaaatccta aaattattga ttccattcca gataaaggtc tagtagaaaa gatcgttaaa 1320
ttttgtaaga gcgttattcc tagaaaa 1347
<210> 65
<211> 1365
<212> DNA
<213> Artificial Sequence
<220>
<223> MTD-BoNT/G Light chain cDNA Sequence
<400> 65
atgaaggcca tgatcaatat taacaagttc ttaaatcaat gtccagttaa tataaaaanc 60
tttaattata atgaccctat taataatgat gacattatta tgatggaacc attcaatgac 120
ccagggccag gaacatatta taaagctttt aggattatag atcgtatttg gatagtacca 180
gaaaggttta cttatggatt tcaacctgac caatttaatg ccagtacagg agtttttagt 240
aaagatgtct acgaatatta cgatccaact tatttaaaaa ccgatgctga aaaagataaa 300
tttttaaaaa caatgattaa attatttaat agaattaatt caaaaccatc aggacagaga 360
ttactggata tgatagtaga tgctatacct tatcttggaa atgcatctac accgcccgac 420
aaatttgcag caaatgttgc aaatgtatct attaataaaa aaattatcca acctggagct 480
gaagatcaaa taaaaggttt aatgacaaat ttaataatat ttggaccagg accagttcta 540
agtgataatt ttactgatag tatgattatg aatggccatt ccccaatatc agaaggattt 600
ggtgcaagaa tgatgataag attttgtcct agttgtttaa atgtatttaa taatgttcag 660
gaaaataaag atacatctat atttagtaga cgcgcgtatt ttgcagatcc agctctaacg 720
ttaatgcatg aacttataca tgtgttacat ggattatatg gaattaagat aagtaattta 780
ccaattactc caaatacaaa agaatttttc atgcaacata gcgatcctgt acaagcagaa 840
gaactatata cattcggagg acatgatcct agtgttataa gtccttctac ggatatgaat 900
atttataata aagcgttaca aaattttcaa gatatagcta ataggcttaa tattgtttca 960
agtgcccaag ggagtggaat tgatatttcc ttatataaac aaatatataa aaataaatat 1020
gattttgttg aagatcctaa tggaaaatat agtgtagata aggataagtt tgataaatta 1080
tataaggcct taatgtttgg ctttactgaa actaatctag ctggtgaata tggaataaaa 1140
actaggtatt cttattttag tgaatatttg ccaccgataa aaactgaaaa attgttagac 1200
aatacaattt atactcaaaa tgaaggcttt aacatagcta gtaaaaatct caaaacggaa 1260
tttaatggtc agaataaggc ggtaaataaa gaggcttatg aagaaatcag cctagaacat 1320
ctcgttatat atagaatagc aatgtgcaag cctgtaatgt acaaa 1365
<210> 66
<211> 1386
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/A Light chain-MTDr cDNA Sequence
<400> 66
atgccctttg tcaacaaaca gttcaactac aaggacccag ttaatggagt agacatcgca 60
tatatcaaga ttcccaacgc tggccagatg caacccgtta aggcatttaa aatccataac 120
aaaatctggg ttatcccaga gcgggatacc ttcaccaacc ccgaggaggg cgatctgaac 180
cccccgccgg aggcgaagca ggtcccagtg agctactacg atagcaccta cctcagcacc 240
gacaacgaga aggacaacta cctcaaagga gtcacgaagt tgttcgagag aatctactcc 300
acagacctcg gccgcatgct tctaaccagc attgtgcgtg gcattccctt ttggggcggc 360
tctaccatcg acacagagct gaaggtgata gacaccaact gcatcaacgt aatccagcct 420
gacggcagct accgaagcga ggagcttaac ctggtgatca tcggcccttc cgccgatatc 480
atccaattcg agtgcaagag cttcggccac gaggtcctga acctcacccg gaacggctat 540
ggaagcaccc agtacataag attcagccct gacttcacct tcgggtttga ggagagcttg 600
gaggtcgaca caaaccccct gctgggagcc gggaagttcg ccactgaccc agccgtgact 660
ctggcacacg agctgatcca cgccggtcac cgcctgtacg gcatagctat aaacccaaac 720
agggtgttca aagtgaacac caacgcttac tatgaaatga gcggcctgga ggtgagcttc 780
gaggagctga gaacgttcgg gggacatgat gctaaattta tcgacagcct gcaggagaac 840
gagttcaggc tgtactacta caataagttc aaggatatag cgagcactct gaacaaggcc 900
aagtccatcg taggcactac tgcatccctc cagtatatga agaatgtgtt caaagagaaa 960
tacctgctga gcgaggatac cagcggtaag ttcagcgtgg ataagcttaa gttcgacaag 1020
ctgtataaga tgctcaccga aatctacacc gaggataatt tcgttaagtt cttcaaggtc 1080
ctgaaccgga agacctacct gaacttcgac aaggccgtgt tcaagatcaa catcgtgcct 1140
aaagtgaact acaccatcta cgacgggttt aacctgagga acaccaacct ggccgctaac 1200
ttcaacgggc agaacacaga gatcaacaac atgaatttca cgaagttgaa gaacttcacc 1260
ggactgtttg agttctacaa attgctgtgt gtgcgcggga tcatcactag caagaccaag 1320
agccttgaca aaggctacaa caagtgatgt caaaatttat tcaagaacat taatatcatg 1380
gccaag 1386
<210> 67
<211> 1362
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/B Light chain-MTDr cDNA Sequence
<400> 67
atgccagtta caataaataa ttttaattat aatgatccta ttgataataa taatattatt 60
atgatggagc ctccatttgc gagaggtacg gggagatatt ataaagcttt taaaatcaca 120
gatcgtattt ggataatacc ggaaagatat acttttggat ataaacctga ggattttaat 180
aaaagttccg gtatttttaa tagagatgtt tgtgaatatt atgatccaga ttacttaaat 240
actaatgata aaaagaatat atttttacaa acaatgatca agttatttaa tagaatcaaa 300
tcaaaaccat tgggtgaaaa gttattagag atgattataa atggtatacc ttatcttgga 360
gatagacgtg ttccactcga agagtttaac acaaacattg ctagtgtaac tgttaataaa 420
ttaatcagta atccaggaga agtggagcga aaaaaaggta ttttcgcaaa tttaataata 480
tttggacctg ggccagtttt aaatgaaaat gagactatag atataggtat acaaaatcat 540
tttgcatcaa gggaaggctt cgggggtata atgcaaatga agttttgccc agaatatgta 600
agcgtattta ataatgttca agaaaacaaa ggcgcaagta tatttaatag acgtggatat 660
ttttcagatc cagccttgat attaatgcat gaacttatac atgttttaca tggattatat 720
ggcattaaag tagatgattt accaattgta ccaaatgaaa aaaaattttt tatgcaatct 780
acagatgcta tacaggcaga agaactatat acatttggag gacaagatcc cagcatcata 840
actccttcta cggataaaag tatctatgat aaagttttgc aaaattttag agggatagtt 900
gatagactta acaaggtttt agtttgcata tcagatccta acattaatat taatatatat 960
aaaaataaat ttaaagataa atataaattc gttgaagatt ctgagggaaa atatagtata 1020
gatgtagaaa gttttgataa attatataaa agcttaatgt ttggttttac agaaactaat 1080
atagcagaaa attataaaat aaaaactaga gcttcttatt ttagtgattc cttaccacca 1140
gtaaaaataa aaaatttatt agataatgaa atctatacta tagaggaagg gtttaatata 1200
tctgataaag atatggaaaa agaatataga ggtcagaata aagctataaa taaacaagct 1260
tatgaagaaa ttagcaagga gcatttggct gtatataaga tacaaatgtg taaaagtgtt 1320
aaatgtcaaa atttattcaa gaacattaat atcatggcca ag 1362
<210> 68
<211> 1386
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/C Light chain-MTDr cDNA Sequence
<400> 68
atgccaataa caattaacaa ctttaattat tcagatcctg ttgataataa aaatatttta 60
tatttagata ctcatttaaa tacactagct aatgagcctg aaaaagcctt tcgcattaca 120
ggaaatatat gggtaatacc tgatagattt tcaagaaatt ctaatccaaa tttaaataaa 180
cctcctcgag ttacaagccc taaaagtggt tattatgatc ctaattattt gagtactgat 240
tctgacaaag atacattttt aaaagaaatt ataaagttat ttaaaagaat taattctaga 300
gaaataggag aagaattaat atatagactt tcgacagata taccctttcc tgggaataac 360
aatactccaa ttaatacttt tgattttgat gtagatttta acagtgttga tgttaaaact 420
agacaaggta acaactgggt taaaactggt agcataaatc ctagtgttat aataactgga 480
cctagagaaa acattataga tccagaaact tctacgttta aattaactaa caatactttt 540
gcggcacaag aaggatttgg tgctttatca ataatttcaa tatcacctag atttatgcta 600
acatatagta atgcaactaa tgatgtagga gagggtagat tttctaagtc tgaattttgc 660
atggatccaa tactaatttt aatgcatgaa cttaatcatg caatgcataa tttatatgga 720
atagctatac caaatgatca aacaatttca tctgtaacta gtaatatttt ttattctcaa 780
tataatgtga aattagagta tgcagaaata tatgcatttg gaggtccaac tatagacctt 840
attcctaaaa gtgcaaggaa atattttgag gaaaaggcat tggattatta tagatctata 900
gctaaaagac ttaatagtat aactactgca aatccttcaa gctttaataa atatataggg 960
gaatataaac agaaacttat tagaaagtat agattcgtag tagaatcttc aggtgaagtt 1020
acagtaaatc gtaataagtt tgttgagtta tataatgaac ttacacaaat atttacagaa 1080
tttaactacg ctaaaatata taatgtacaa aataggaaaa tatatctttc aaatgtatat 1140
actccggtta cggcgaatat attagacgat aatgtttatg atatacaaaa tggatttaat 1200
atacctaaaa gtaatttaaa tgtactattt atgggtcaaa atttatctcg aaatccagca 1260
ttaagaaaag tcaatcctga aaatatgctt tatttattta caaaattttg tcataaagca 1320
atagatggta gatcattata taataaatgt caaaatttat tcaagaacat taatatcatg 1380
gccaag 1386
<210> 69
<211> 1365
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/D Light chain-MTDr cDNA Sequence
<400> 69
atgacatggc cagtaaaaga ttttaattat agtgatcctg ttaatgacaa tgatatatta 60
tatttaagaa taccacaaaa taagttaatt actacacctg taaaagcttt tatgattact 120
caaaatattt gggtaatacc agaaagattt tcatcagata ctaatccaag tttaagtaaa 180
ccgcccagac ctacttcaaa gtatcaaagt tattatgatc ctagttattt atctactgat 240
gaacaaaaag atacattttt aaaagggatt ataaaattat ttaaaagaat taatgaaaga 300
gatataggaa aaaaattaat aaattattta gtagttggtt caccttttat gggagattca 360
agtacgcctg aagatacatt tgattttaca cgtcatacta ctaatattgc agttgaaaag 420
tttgaaaatg gtagttggaa agtaacaaat attataacac caagtgtatt gatatttgga 480
ccacttccta atatattaga ctatacagca tcccttacat tgcaaggaca acaatcaaat 540
ccatcatttg aagggtttgg aacattatct atactaaaag tagcacctga atttttgtta 600
acatttagtg atgtaacatc taatcaaagt tcagctgtat taggcaaatc tatattttgt 660
atggatccag taatagcttt aatgcatgag ttaacacatt ctttgcatca attatatgga 720
ataaatatac catctgataa aaggattcgt ccacaagtta gcgagggatt tttctctcaa 780
gatggaccca acgtacaatt tgaggaatta tatacatttg gaggattaga tgttgaaata 840
atacctcaaa ttgaaagatc acaattaaga gaaaaagcat taggtcacta taaagatata 900
gcgaaaagac ttaataatat taataaaact attccttcta gttggattag taatatagat 960
aaatataaaa aaatattttc tgaaaagtat aattttgata aagataatac aggaaatttt 1020
gttgtaaata ttgataaatt caatagctta tattcagact tgactaatgt tatgtcagaa 1080
gttgtttatt cttcgcaata taatgttaaa aacaggactc attatttttc aaggcattat 1140
ctacctgtat ttgcaaatat attagatgat aatatttata ctataagaga tggttttaat 1200
ttaacaaata aaggttttaa tatagaaaat tcgggtcaga atatagaaag gaatcctgca 1260
ctacaaaagc ttagttcaga aagtgtagta gatttattta caaaagtatg tttaagatta 1320
acaaaatgtc aaaatttatt caagaacatt aatatcatgg ccaag 1365
<210> 70
<211> 1305
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/E Light chain-MTDr cDNA Sequence
<400> 70
atgccaacaa ttaatagttt taattataat gatcctgtta ataatagaac aattttatat 60
attaaaccag gcggttgtca acaattttat aaatcattta atattatgaa aaatatttgg 120
ataattccag agagaaatgt aattggtaca attccccaag attttcttcc gcctacttca 180
ttgaaaaatg gagatagtag ttattatgac cctaattatt tacaaagtga tcaagaaaag 240
gataaatttt taaaaatagt cacaaaaata tttaatagaa taaatgataa tctttcagga 300
aggattttat tagaagaact gtcaaaagct aatccatatt taggaaatga taatactcca 360
gatggtgact tcattattaa tgatgcatca gcagttccaa ttcaattctc aaatggtagc 420
caaagcatac tattacctaa tgttattata atgggagcag agcctgattt atttgaaact 480
aacagttcca atatttctct aagaaataat tatatgccaa gcaatcacgg ttttggatca 540
atagctatag taacattctc acctgaatat tcttttagat ttaaagataa tagtatgaat 600
gaatttattc aagatcctgc tcttacatta atgcatgaat taatacattc attacatgga 660
ctatatgggg ctaaagggat tactacaaag tatactataa cacaaaaaca aaatccccta 720
ataacaaata taagaggtac aaatattgaa gaattcttaa cttttggagg tactgattta 780
aacattatta ctagtgctca gtccaatgat atctatacta atcttctagc tgattataaa 840
aaaatagcgt ctaaacttag caaagtacaa gtatctaatc cactacttaa tccttataaa 900
gatgtttttg aagcaaagta tggattagat aaagatgcta gcggaattta ttcggtaaat 960
ataaacaaat ttaatgatat ttttaaaaaa ttatacagct ttacggaatt tgatttagca 1020
actaaatttc aagttaaatg taggcaaact tatattggac agtataaata cttcaaactt 1080
tcaaacttgt taaatgattc tatttataat atatcagaag gctataatat aaataattta 1140
aaggtaaatt ttagaggaca gaatgcaaat ttaaatccta gaattattac accaattaca 1200
ggtagaggac tagtaaaaaa aatcattaga ttttgtaaaa atattgtttc tgtaaaaggc 1260
ataaggtgtc aaaatttatt caagaacatt aatatcatgg ccaag 1305
<210> 71
<211> 1347
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/F Light chain-MTDr cDNA Sequence
<400> 71
atgccagttg caataaatag ttttaattat aatgaccctg ttaatgatga tacaatttta 60
tacatgcaga taccatatga agaaaaaagt aaaaaatatt ataaagcttt tgagattatg 120
cgtaatgttt ggataattcc tgagagaaat acaataggaa cgaatcctag tgattttgat 180
ccaccggctt cattaaagaa cggaagcagt gcttattatg atcctaatta tttaaccact 240
gatgctgaaa aagatagata tttaaaaaca acgataaaat tatttaagag aattaatagt 300
aatcctgcag ggaaagtttt gttacaagaa atatcatatg ctaaaccata tttaggaaat 360
gaccacacgc caattgatga attctctcca gttactagaa ctacaagtgt taatataaaa 420
ttatcaacta atgttgaaag ttcaatgtta ttgaatcttc ttgtattggg agcaggacct 480
gatatatttg aaagttgttg ttaccccgtt agaaaactaa tagatccaga tgtagtttat 540
gatccaagta attatggttt tggatcaatt aatatcgtga cattttcacc tgagtatgaa 600
tatactttta atgatattag tggagggcat aatagtagta cagaatcatt tattgcagat 660
cctgcaattt cactagctca tgaattgata catgcactgc atggattata cggggctagg 720
ggagttactt atgaagagac tatagaagta aagcaagcac ctcttatgat agccgaaaaa 780
cccataaggc tagaagaatt tttaaccttt ggaggtcagg atttaaatat tattactagt 840
gctatgaagg aaaaaatata taacaatctt ttagctaact atgaaaaaat agctactaga 900
cttagtgaag ttaatagtgc tcctcctgaa tatgatatta atgaatataa agattatttt 960
caatggaagt atgggctaga taaaaatgct gatggaagtt atactgtaaa tgaaaataaa 1020
tttaatgaaa tttataaaaa attatatagt tttacagaga gtgacttagc aaataaattt 1080
aaagtaaaat gtagaaatac ttattttatt aaatatgaat ttttaaaagt tccaaatttg 1140
ttagatgatg atatttatac tgtatcagag gggtttaata taggtaattt agcagtaaac 1200
aatcgcggac aaagtataaa gttaaatcct aaaattattg attccattcc agataaaggt 1260
ctagtagaaa agatcgttaa attttgtaag agcgttattc ctagaaaatg tcaaaattta 1320
ttcaagaaca ttaatatcat ggccaag 1347
<210> 72
<211> 1365
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/G Light chain-MTDr cDNA Sequence
<400> 72
atgccagtta atataaaaan ctttaattat aatgacccta ttaataatga tgacattatt 60
atgatggaac cattcaatga cccagggcca ggaacatatt ataaagcttt taggattata 120
gatcgtattt ggatagtacc agaaaggttt acttatggat ttcaacctga ccaatttaat 180
gccagtacag gagtttttag taaagatgtc tacgaatatt acgatccaac ttatttaaaa 240
accgatgctg aaaaagataa atttttaaaa acaatgatta aattatttaa tagaattaat 300
tcaaaaccat caggacagag attactggat atgatagtag atgctatacc ttatcttgga 360
aatgcatcta caccgcccga caaatttgca gcaaatgttg caaatgtatc tattaataaa 420
aaaattatcc aacctggagc tgaagatcaa ataaaaggtt taatgacaaa tttaataata 480
tttggaccag gaccagttct aagtgataat tttactgata gtatgattat gaatggccat 540
tccccaatat cagaaggatt tggtgcaaga atgatgataa gattttgtcc tagttgttta 600
aatgtattta ataatgttca ggaaaataaa gatacatcta tatttagtag acgcgcgtat 660
tttgcagatc cagctctaac gttaatgcat gaacttatac atgtgttaca tggattatat 720
ggaattaaga taagtaattt accaattact ccaaatacaa aagaattttt catgcaacat 780
agcgatcctg tacaagcaga agaactatat acattcggag gacatgatcc tagtgttata 840
agtccttcta cggatatgaa tatttataat aaagcgttac aaaattttca agatatagct 900
aataggctta atattgtttc aagtgcccaa gggagtggaa ttgatatttc cttatataaa 960
caaatatata aaaataaata tgattttgtt gaagatccta atggaaaata tagtgtagat 1020
aaggataagt ttgataaatt atataaggcc ttaatgtttg gctttactga aactaatcta 1080
gctggtgaat atggaataaa aactaggtat tcttatttta gtgaatattt gccaccgata 1140
aaaactgaaa aattgttaga caatacaatt tatactcaaa atgaaggctt taacatagct 1200
agtaaaaatc tcaaaacgga atttaatggt cagaataagg cggtaaataa agaggcttat 1260
gaagaaatca gcctagaaca tctcgttata tatagaatag caatgtgcaa gcctgtaatg 1320
tacaaatgtc aaaatttatt caagaacatt aatatcatgg ccaag 1365
<210> 73
<211> 1413
<212> DNA
<213> Artificial Sequence
<220>
<223> MTD-BoNT/A Light chain cDNA Sequence with hexahistidine
<400> 73
atgaaggcca tgatcaatat taacaagttc ttaaatcaat gtccctttgt caacaaacag 60
ttcaactaca aggacccagt taatggagta gacatcgcat atatcaagat tcccaacgct 120
ggccagatgc aacccgttaa ggcatttaaa atccataaca aaatctgggt tatcccagag 180
cgggatacct tcaccaaccc cgaggagggc gatctgaacc ccccgccgga ggcgaagcag 240
gtcccagtga gctactacga tagcacctac ctcagcaccg acaacgagaa ggacaactac 300
ctcaaaggag tcacgaagtt gttcgagaga atctactcca cagacctcgg ccgcatgctt 360
ctaaccagca ttgtgcgtgg cattcccttt tggggcggct ctaccatcga cacagagctg 420
aaggtgatag acaccaactg catcaacgta atccagcctg acggcagcta ccgaagcgag 480
gagcttaacc tggtgatcat cggcccttcc gccgatatca tccaattcga gtgcaagagc 540
ttcggccacg aggtcctgaa cctcacccgg aacggctatg gaagcaccca gtacataaga 600
ttcagccctg acttcacctt cgggtttgag gagagcttgg aggtcgacac aaaccccctg 660
ctgggagccg ggaagttcgc cactgaccca gccgtgactc tggcacacga gctgatccac 720
gccggtcacc gcctgtacgg catagctata aacccaaaca gggtgttcaa agtgaacacc 780
aacgcttact atgaaatgag cggcctggag gtgagcttcg aggagctgag aacgttcggg 840
ggacatgatg ctaaatttat cgacagcctg caggagaacg agttcaggct gtactactac 900
aataagttca aggatatagc gagcactctg aacaaggcca agtccatcgt aggcactact 960
gcatccctcc agtatatgaa gaatgtgttc aaagagaaat acctgctgag cgaggatacc 1020
agcggtaagt tcagcgtgga taagcttaag ttcgacaagc tgtataagat gctcaccgaa 1080
atctacaccg aggataattt cgttaagttc ttcaaggtcc tgaaccggaa gacctacctg 1140
aacttcgaca aggccgtgtt caagatcaac atcgtgccta aagtgaacta caccatctac 1200
gacgggttta acctgaggaa caccaacctg gccgctaact tcaacgggca gaacacagag 1260
atcaacaaca tgaatttcac gaagttgaag aacttcaccg gactgtttga gttctacaaa 1320
ttgctgtgtg tgcgcgggat catcactagc aagaccaaga gccttgacaa aggctacaac 1380
aagtgactcg agcaccacca ccaccaccac tga 1413
<210> 74
<211> 1389
<212> DNA
<213> Artificial Sequence
<220>
<223> MTD-BoNT/B Light chain cDNA Sequence with hexahistidine
<400> 74
atgaaggcca tgatcaatat taacaagttc ttaaatcaat gtccagttac aataaataat 60
tttaattata atgatcctat tgataataat aatattatta tgatggagcc tccatttgcg 120
agaggtacgg ggagatatta taaagctttt aaaatcacag atcgtatttg gataataccg 180
gaaagatata cttttggata taaacctgag gattttaata aaagttccgg tatttttaat 240
agagatgttt gtgaatatta tgatccagat tacttaaata ctaatgataa aaagaatata 300
tttttacaaa caatgatcaa gttatttaat agaatcaaat caaaaccatt gggtgaaaag 360
ttattagaga tgattataaa tggtatacct tatcttggag atagacgtgt tccactcgaa 420
gagtttaaca caaacattgc tagtgtaact gttaataaat taatcagtaa tccaggagaa 480
gtggagcgaa aaaaaggtat tttcgcaaat ttaataatat ttggacctgg gccagtttta 540
aatgaaaatg agactataga tataggtata caaaatcatt ttgcatcaag ggaaggcttc 600
gggggtataa tgcaaatgaa gttttgccca gaatatgtaa gcgtatttaa taatgttcaa 660
gaaaacaaag gcgcaagtat atttaataga cgtggatatt tttcagatcc agccttgata 720
ttaatgcatg aacttataca tgttttacat ggattatatg gcattaaagt agatgattta 780
ccaattgtac caaatgaaaa aaaatttttt atgcaatcta cagatgctat acaggcagaa 840
gaactatata catttggagg acaagatccc agcatcataa ctccttctac ggataaaagt 900
atctatgata aagttttgca aaattttaga gggatagttg atagacttaa caaggtttta 960
gtttgcatat cagatcctaa cattaatatt aatatatata aaaataaatt taaagataaa 1020
tataaattcg ttgaagattc tgagggaaaa tatagtatag atgtagaaag ttttgataaa 1080
ttatataaaa gcttaatgtt tggttttaca gaaactaata tagcagaaaa ttataaaata 1140
aaaactagag cttcttattt tagtgattcc ttaccaccag taaaaataaa aaatttatta 1200
gataatgaaa tctatactat agaggaaggg tttaatatat ctgataaaga tatggaaaaa 1260
gaatatagag gtcagaataa agctataaat aaacaagctt atgaagaaat tagcaaggag 1320
catttggctg tatataagat acaaatgtgt aaaagtgtta aactcgagca ccaccaccac 1380
caccactga 1389
<210> 75
<211> 1413
<212> DNA
<213> Artificial Sequence
<220>
<223> MTD-BoNT/C Light chain cDNA Sequence with hexahistidine
<400> 75
atgaaggcca tgatcaatat taacaagttc ttaaatcaat gtccaataac aattaacaac 60
tttaattatt cagatcctgt tgataataaa aatattttat atttagatac tcatttaaat 120
acactagcta atgagcctga aaaagccttt cgcattacag gaaatatatg ggtaatacct 180
gatagatttt caagaaattc taatccaaat ttaaataaac ctcctcgagt tacaagccct 240
aaaagtggtt attatgatcc taattatttg agtactgatt ctgacaaaga tacattttta 300
aaagaaatta taaagttatt taaaagaatt aattctagag aaataggaga agaattaata 360
tatagacttt cgacagatat accctttcct gggaataaca atactccaat taatactttt 420
gattttgatg tagattttaa cagtgttgat gttaaaacta gacaaggtaa caactgggtt 480
aaaactggta gcataaatcc tagtgttata ataactggac ctagagaaaa cattatagat 540
ccagaaactt ctacgtttaa attaactaac aatacttttg cggcacaaga aggatttggt 600
gctttatcaa taatttcaat atcacctaga tttatgctaa catatagtaa tgcaactaat 660
gatgtaggag agggtagatt ttctaagtct gaattttgca tggatccaat actaatttta 720
atgcatgaac ttaatcatgc aatgcataat ttatatggaa tagctatacc aaatgatcaa 780
acaatttcat ctgtaactag taatattttt tattctcaat ataatgtgaa attagagtat 840
gcagaaatat atgcatttgg aggtccaact atagacctta ttcctaaaag tgcaaggaaa 900
tattttgagg aaaaggcatt ggattattat agatctatag ctaaaagact taatagtata 960
actactgcaa atccttcaag ctttaataaa tatatagggg aatataaaca gaaacttatt 1020
agaaagtata gattcgtagt agaatcttca ggtgaagtta cagtaaatcg taataagttt 1080
gttgagttat ataatgaact tacacaaata tttacagaat ttaactacgc taaaatatat 1140
aatgtacaaa ataggaaaat atatctttca aatgtatata ctccggttac ggcgaatata 1200
ttagacgata atgtttatga tatacaaaat ggatttaata tacctaaaag taatttaaat 1260
gtactattta tgggtcaaaa tttatctcga aatccagcat taagaaaagt caatcctgaa 1320
aatatgcttt atttatttac aaaattttgt cataaagcaa tagatggtag atcattatat 1380
aataaactcg agcaccacca ccaccaccac tga 1413
<210> 76
<211> 1392
<212> DNA
<213> Artificial Sequence
<220>
<223> MTD-BoNT/D Light chain cDNA Sequence with hexahistidine
<400> 76
atgaaggcca tgatcaatat taacaagttc ttaaatcaat gtacatggcc agtaaaagat 60
tttaattata gtgatcctgt taatgacaat gatatattat atttaagaat accacaaaat 120
aagttaatta ctacacctgt aaaagctttt atgattactc aaaatatttg ggtaatacca 180
gaaagatttt catcagatac taatccaagt ttaagtaaac cgcccagacc tacttcaaag 240
tatcaaagtt attatgatcc tagttattta tctactgatg aacaaaaaga tacattttta 300
aaagggatta taaaattatt taaaagaatt aatgaaagag atataggaaa aaaattaata 360
aattatttag tagttggttc accttttatg ggagattcaa gtacgcctga agatacattt 420
gattttacac gtcatactac taatattgca gttgaaaagt ttgaaaatgg tagttggaaa 480
gtaacaaata ttataacacc aagtgtattg atatttggac cacttcctaa tatattagac 540
tatacagcat cccttacatt gcaaggacaa caatcaaatc catcatttga agggtttgga 600
acattatcta tactaaaagt agcacctgaa tttttgttaa catttagtga tgtaacatct 660
aatcaaagtt cagctgtatt aggcaaatct atattttgta tggatccagt aatagcttta 720
atgcatgagt taacacattc tttgcatcaa ttatatggaa taaatatacc atctgataaa 780
aggattcgtc cacaagttag cgagggattt ttctctcaag atggacccaa cgtacaattt 840
gaggaattat atacatttgg aggattagat gttgaaataa tacctcaaat tgaaagatca 900
caattaagag aaaaagcatt aggtcactat aaagatatag cgaaaagact taataatatt 960
aataaaacta ttccttctag ttggattagt aatatagata aatataaaaa aatattttct 1020
gaaaagtata attttgataa agataataca ggaaattttg ttgtaaatat tgataaattc 1080
aatagcttat attcagactt gactaatgtt atgtcagaag ttgtttattc ttcgcaatat 1140
aatgttaaaa acaggactca ttatttttca aggcattatc tacctgtatt tgcaaatata 1200
ttagatgata atatttatac tataagagat ggttttaatt taacaaataa aggttttaat 1260
atagaaaatt cgggtcagaa tatagaaagg aatcctgcac tacaaaagct tagttcagaa 1320
agtgtagtag atttatttac aaaagtatgt ttaagattaa caaaactcga gcaccaccac 1380
caccaccact ga 1392
<210> 77
<211> 1332
<212> DNA
<213> Artificial Sequence
<220>
<223> MTD-BoNT/E Light chain cDNA Sequence with hexahistidine
<400> 77
atgaaggcca tgatcaatat taacaagttc ttaaatcaat gtccaacaat taatagtttt 60
aattataatg atcctgttaa taatagaaca attttatata ttaaaccagg cggttgtcaa 120
caattttata aatcatttaa tattatgaaa aatatttgga taattccaga gagaaatgta 180
attggtacaa ttccccaaga ttttcttccg cctacttcat tgaaaaatgg agatagtagt 240
tattatgacc ctaattattt acaaagtgat caagaaaagg ataaattttt aaaaatagtc 300
acaaaaatat ttaatagaat aaatgataat ctttcaggaa ggattttatt agaagaactg 360
tcaaaagcta atccatattt aggaaatgat aatactccag atggtgactt cattattaat 420
gatgcatcag cagttccaat tcaattctca aatggtagcc aaagcatact attacctaat 480
gttattataa tgggagcaga gcctgattta tttgaaacta acagttccaa tatttctcta 540
agaaataatt atatgccaag caatcacggt tttggatcaa tagctatagt aacattctca 600
cctgaatatt cttttagatt taaagataat agtatgaatg aatttattca agatcctgct 660
cttacattaa tgcatgaatt aatacattca ttacatggac tatatggggc taaagggatt 720
actacaaagt atactataac acaaaaacaa aatcccctaa taacaaatat aagaggtaca 780
aatattgaag aattcttaac ttttggaggt actgatttaa acattattac tagtgctcag 840
tccaatgata tctatactaa tcttctagct gattataaaa aaatagcgtc taaacttagc 900
aaagtacaag tatctaatcc actacttaat ccttataaag atgtttttga agcaaagtat 960
ggattagata aagatgctag cggaatttat tcggtaaata taaacaaatt taatgatatt 1020
tttaaaaaat tatacagctt tacggaattt gatttagcaa ctaaatttca agttaaatgt 1080
aggcaaactt atattggaca gtataaatac ttcaaacttt caaacttgtt aaatgattct 1140
atttataata tatcagaagg ctataatata aataatttaa aggtaaattt tagaggacag 1200
aatgcaaatt taaatcctag aattattaca ccaattacag gtagaggact agtaaaaaaa 1260
atcattagat tttgtaaaaa tattgtttct gtaaaaggca taaggctcga gcaccaccac 1320
caccaccact ga 1332
<210> 78
<211> 1374
<212> DNA
<213> Artificial Sequence
<220>
<223> MTD-BoNT/F Light chain cDNA Sequence with hexahistidine
<400> 78
atgaaggcca tgatcaatat taacaagttc ttaaatcaat gtccagttgc aataaatagt 60
tttaattata atgaccctgt taatgatgat acaattttat acatgcagat accatatgaa 120
gaaaaaagta aaaaatatta taaagctttt gagattatgc gtaatgtttg gataattcct 180
gagagaaata caataggaac gaatcctagt gattttgatc caccggcttc attaaagaac 240
ggaagcagtg cttattatga tcctaattat ttaaccactg atgctgaaaa agatagatat 300
ttaaaaacaa cgataaaatt atttaagaga attaatagta atcctgcagg gaaagttttg 360
ttacaagaaa tatcatatgc taaaccatat ttaggaaatg accacacgcc aattgatgaa 420
ttctctccag ttactagaac tacaagtgtt aatataaaat tatcaactaa tgttgaaagt 480
tcaatgttat tgaatcttct tgtattggga gcaggacctg atatatttga aagttgttgt 540
taccccgtta gaaaactaat agatccagat gtagtttatg atccaagtaa ttatggtttt 600
ggatcaatta atatcgtgac attttcacct gagtatgaat atacttttaa tgatattagt 660
ggagggcata atagtagtac agaatcattt attgcagatc ctgcaatttc actagctcat 720
gaattgatac atgcactgca tggattatac ggggctaggg gagttactta tgaagagact 780
atagaagtaa agcaagcacc tcttatgata gccgaaaaac ccataaggct agaagaattt 840
ttaacctttg gaggtcagga tttaaatatt attactagtg ctatgaagga aaaaatatat 900
aacaatcttt tagctaacta tgaaaaaata gctactagac ttagtgaagt taatagtgct 960
cctcctgaat atgatattaa tgaatataaa gattattttc aatggaagta tgggctagat 1020
aaaaatgctg atggaagtta tactgtaaat gaaaataaat ttaatgaaat ttataaaaaa 1080
ttatatagtt ttacagagag tgacttagca aataaattta aagtaaaatg tagaaatact 1140
tattttatta aatatgaatt tttaaaagtt ccaaatttgt tagatgatga tatttatact 1200
gtatcagagg ggtttaatat aggtaattta gcagtaaaca atcgcggaca aagtataaag 1260
ttaaatccta aaattattga ttccattcca gataaaggtc tagtagaaaa gatcgttaaa 1320
ttttgtaaga gcgttattcc tagaaaactc gagcaccacc accaccacca ctga 1374
<210> 79
<211> 1392
<212> DNA
<213> Artificial Sequence
<220>
<223> MTD-BoNT/G Light chain cDNA Sequence with hexahistidine
<400> 79
atgaaggcca tgatcaatat taacaagttc ttaaatcaat gtccagttaa tataaaaanc 60
tttaattata atgaccctat taataatgat gacattatta tgatggaacc attcaatgac 120
ccagggccag gaacatatta taaagctttt aggattatag atcgtatttg gatagtacca 180
gaaaggttta cttatggatt tcaacctgac caatttaatg ccagtacagg agtttttagt 240
aaagatgtct acgaatatta cgatccaact tatttaaaaa ccgatgctga aaaagataaa 300
tttttaaaaa caatgattaa attatttaat agaattaatt caaaaccatc aggacagaga 360
ttactggata tgatagtaga tgctatacct tatcttggaa atgcatctac accgcccgac 420
aaatttgcag caaatgttgc aaatgtatct attaataaaa aaattatcca acctggagct 480
gaagatcaaa taaaaggttt aatgacaaat ttaataatat ttggaccagg accagttcta 540
agtgataatt ttactgatag tatgattatg aatggccatt ccccaatatc agaaggattt 600
ggtgcaagaa tgatgataag attttgtcct agttgtttaa atgtatttaa taatgttcag 660
gaaaataaag atacatctat atttagtaga cgcgcgtatt ttgcagatcc agctctaacg 720
ttaatgcatg aacttataca tgtgttacat ggattatatg gaattaagat aagtaattta 780
ccaattactc caaatacaaa agaatttttc atgcaacata gcgatcctgt acaagcagaa 840
gaactatata cattcggagg acatgatcct agtgttataa gtccttctac ggatatgaat 900
atttataata aagcgttaca aaattttcaa gatatagcta ataggcttaa tattgtttca 960
agtgcccaag ggagtggaat tgatatttcc ttatataaac aaatatataa aaataaatat 1020
gattttgttg aagatcctaa tggaaaatat agtgtagata aggataagtt tgataaatta 1080
tataaggcct taatgtttgg ctttactgaa actaatctag ctggtgaata tggaataaaa 1140
actaggtatt cttattttag tgaatatttg ccaccgataa aaactgaaaa attgttagac 1200
aatacaattt atactcaaaa tgaaggcttt aacatagcta gtaaaaatct caaaacggaa 1260
tttaatggtc agaataaggc ggtaaataaa gaggcttatg aagaaatcag cctagaacat 1320
ctcgttatat atagaatagc aatgtgcaag cctgtaatgt acaaactcga gcaccaccac 1380
caccaccact ga 1392
<210> 80
<211> 1446
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/A Light chain-MTDr cDNA Sequence with hexahistidine
<400> 80
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat 60
atgccctttg tcaacaaaca gttcaactac aaggacccag ttaatggagt agacatcgca 120
tatatcaaga ttcccaacgc tggccagatg caacccgtta aggcatttaa aatccataac 180
aaaatctggg ttatcccaga gcgggatacc ttcaccaacc ccgaggaggg cgatctgaac 240
cccccgccgg aggcgaagca ggtcccagtg agctactacg atagcaccta cctcagcacc 300
gacaacgaga aggacaacta cctcaaagga gtcacgaagt tgttcgagag aatctactcc 360
acagacctcg gccgcatgct tctaaccagc attgtgcgtg gcattccctt ttggggcggc 420
tctaccatcg acacagagct gaaggtgata gacaccaact gcatcaacgt aatccagcct 480
gacggcagct accgaagcga ggagcttaac ctggtgatca tcggcccttc cgccgatatc 540
atccaattcg agtgcaagag cttcggccac gaggtcctga acctcacccg gaacggctat 600
ggaagcaccc agtacataag attcagccct gacttcacct tcgggtttga ggagagcttg 660
gaggtcgaca caaaccccct gctgggagcc gggaagttcg ccactgaccc agccgtgact 720
ctggcacacg agctgatcca cgccggtcac cgcctgtacg gcatagctat aaacccaaac 780
agggtgttca aagtgaacac caacgcttac tatgaaatga gcggcctgga ggtgagcttc 840
gaggagctga gaacgttcgg gggacatgat gctaaattta tcgacagcct gcaggagaac 900
gagttcaggc tgtactacta caataagttc aaggatatag cgagcactct gaacaaggcc 960
aagtccatcg taggcactac tgcatccctc cagtatatga agaatgtgtt caaagagaaa 1020
tacctgctga gcgaggatac cagcggtaag ttcagcgtgg ataagcttaa gttcgacaag 1080
ctgtataaga tgctcaccga aatctacacc gaggataatt tcgttaagtt cttcaaggtc 1140
ctgaaccgga agacctacct gaacttcgac aaggccgtgt tcaagatcaa catcgtgcct 1200
aaagtgaact acaccatcta cgacgggttt aacctgagga acaccaacct ggccgctaac 1260
ttcaacgggc agaacacaga gatcaacaac atgaatttca cgaagttgaa gaacttcacc 1320
ggactgtttg agttctacaa attgctgtgt gtgcgcggga tcatcactag caagaccaag 1380
agccttgaca aaggctacaa caagtgatgt caaaatttat tcaagaacat taatatcatg 1440
gccaag 1446
<210> 81
<211> 1422
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/B Light chain-MTDr cDNA Sequence with hexahistidine
<400> 81
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat 60
atgccagtta caataaataa ttttaattat aatgatccta ttgataataa taatattatt 120
atgatggagc ctccatttgc gagaggtacg gggagatatt ataaagcttt taaaatcaca 180
gatcgtattt ggataatacc ggaaagatat acttttggat ataaacctga ggattttaat 240
aaaagttccg gtatttttaa tagagatgtt tgtgaatatt atgatccaga ttacttaaat 300
actaatgata aaaagaatat atttttacaa acaatgatca agttatttaa tagaatcaaa 360
tcaaaaccat tgggtgaaaa gttattagag atgattataa atggtatacc ttatcttgga 420
gatagacgtg ttccactcga agagtttaac acaaacattg ctagtgtaac tgttaataaa 480
ttaatcagta atccaggaga agtggagcga aaaaaaggta ttttcgcaaa tttaataata 540
tttggacctg ggccagtttt aaatgaaaat gagactatag atataggtat acaaaatcat 600
tttgcatcaa gggaaggctt cgggggtata atgcaaatga agttttgccc agaatatgta 660
agcgtattta ataatgttca agaaaacaaa ggcgcaagta tatttaatag acgtggatat 720
ttttcagatc cagccttgat attaatgcat gaacttatac atgttttaca tggattatat 780
ggcattaaag tagatgattt accaattgta ccaaatgaaa aaaaattttt tatgcaatct 840
acagatgcta tacaggcaga agaactatat acatttggag gacaagatcc cagcatcata 900
actccttcta cggataaaag tatctatgat aaagttttgc aaaattttag agggatagtt 960
gatagactta acaaggtttt agtttgcata tcagatccta acattaatat taatatatat 1020
aaaaataaat ttaaagataa atataaattc gttgaagatt ctgagggaaa atatagtata 1080
gatgtagaaa gttttgataa attatataaa agcttaatgt ttggttttac agaaactaat 1140
atagcagaaa attataaaat aaaaactaga gcttcttatt ttagtgattc cttaccacca 1200
gtaaaaataa aaaatttatt agataatgaa atctatacta tagaggaagg gtttaatata 1260
tctgataaag atatggaaaa agaatataga ggtcagaata aagctataaa taaacaagct 1320
tatgaagaaa ttagcaagga gcatttggct gtatataaga tacaaatgtg taaaagtgtt 1380
aaatgtcaaa atttattcaa gaacattaat atcatggcca ag 1422
<210> 82
<211> 1446
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/C Light chain-MTDr cDNA Sequence with hexahistidine
<400> 82
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat 60
atgccaataa caattaacaa ctttaattat tcagatcctg ttgataataa aaatatttta 120
tatttagata ctcatttaaa tacactagct aatgagcctg aaaaagcctt tcgcattaca 180
ggaaatatat gggtaatacc tgatagattt tcaagaaatt ctaatccaaa tttaaataaa 240
cctcctcgag ttacaagccc taaaagtggt tattatgatc ctaattattt gagtactgat 300
tctgacaaag atacattttt aaaagaaatt ataaagttat ttaaaagaat taattctaga 360
gaaataggag aagaattaat atatagactt tcgacagata taccctttcc tgggaataac 420
aatactccaa ttaatacttt tgattttgat gtagatttta acagtgttga tgttaaaact 480
agacaaggta acaactgggt taaaactggt agcataaatc ctagtgttat aataactgga 540
cctagagaaa acattataga tccagaaact tctacgttta aattaactaa caatactttt 600
gcggcacaag aaggatttgg tgctttatca ataatttcaa tatcacctag atttatgcta 660
acatatagta atgcaactaa tgatgtagga gagggtagat tttctaagtc tgaattttgc 720
atggatccaa tactaatttt aatgcatgaa cttaatcatg caatgcataa tttatatgga 780
atagctatac caaatgatca aacaatttca tctgtaacta gtaatatttt ttattctcaa 840
tataatgtga aattagagta tgcagaaata tatgcatttg gaggtccaac tatagacctt 900
attcctaaaa gtgcaaggaa atattttgag gaaaaggcat tggattatta tagatctata 960
gctaaaagac ttaatagtat aactactgca aatccttcaa gctttaataa atatataggg 1020
gaatataaac agaaacttat tagaaagtat agattcgtag tagaatcttc aggtgaagtt 1080
acagtaaatc gtaataagtt tgttgagtta tataatgaac ttacacaaat atttacagaa 1140
tttaactacg ctaaaatata taatgtacaa aataggaaaa tatatctttc aaatgtatat 1200
actccggtta cggcgaatat attagacgat aatgtttatg atatacaaaa tggatttaat 1260
atacctaaaa gtaatttaaa tgtactattt atgggtcaaa atttatctcg aaatccagca 1320
ttaagaaaag tcaatcctga aaatatgctt tatttattta caaaattttg tcataaagca 1380
atagatggta gatcattata taataaatgt caaaatttat tcaagaacat taatatcatg 1440
gccaag 1446
<210> 83
<211> 1425
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/D Light chain-MTDr cDNA Sequence with hexahistidine
<400> 83
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat 60
atgacatggc cagtaaaaga ttttaattat agtgatcctg ttaatgacaa tgatatatta 120
tatttaagaa taccacaaaa taagttaatt actacacctg taaaagcttt tatgattact 180
caaaatattt gggtaatacc agaaagattt tcatcagata ctaatccaag tttaagtaaa 240
ccgcccagac ctacttcaaa gtatcaaagt tattatgatc ctagttattt atctactgat 300
gaacaaaaag atacattttt aaaagggatt ataaaattat ttaaaagaat taatgaaaga 360
gatataggaa aaaaattaat aaattattta gtagttggtt caccttttat gggagattca 420
agtacgcctg aagatacatt tgattttaca cgtcatacta ctaatattgc agttgaaaag 480
tttgaaaatg gtagttggaa agtaacaaat attataacac caagtgtatt gatatttgga 540
ccacttccta atatattaga ctatacagca tcccttacat tgcaaggaca acaatcaaat 600
ccatcatttg aagggtttgg aacattatct atactaaaag tagcacctga atttttgtta 660
acatttagtg atgtaacatc taatcaaagt tcagctgtat taggcaaatc tatattttgt 720
atggatccag taatagcttt aatgcatgag ttaacacatt ctttgcatca attatatgga 780
ataaatatac catctgataa aaggattcgt ccacaagtta gcgagggatt tttctctcaa 840
gatggaccca acgtacaatt tgaggaatta tatacatttg gaggattaga tgttgaaata 900
atacctcaaa ttgaaagatc acaattaaga gaaaaagcat taggtcacta taaagatata 960
gcgaaaagac ttaataatat taataaaact attccttcta gttggattag taatatagat 1020
aaatataaaa aaatattttc tgaaaagtat aattttgata aagataatac aggaaatttt 1080
gttgtaaata ttgataaatt caatagctta tattcagact tgactaatgt tatgtcagaa 1140
gttgtttatt cttcgcaata taatgttaaa aacaggactc attatttttc aaggcattat 1200
ctacctgtat ttgcaaatat attagatgat aatatttata ctataagaga tggttttaat 1260
ttaacaaata aaggttttaa tatagaaaat tcgggtcaga atatagaaag gaatcctgca 1320
ctacaaaagc ttagttcaga aagtgtagta gatttattta caaaagtatg tttaagatta 1380
acaaaatgtc aaaatttatt caagaacatt aatatcatgg ccaag 1425
<210> 84
<211> 1365
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/E Light chain-MTDr cDNA Sequence with hexahistidine
<400> 84
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat 60
atgccaacaa ttaatagttt taattataat gatcctgtta ataatagaac aattttatat 120
attaaaccag gcggttgtca acaattttat aaatcattta atattatgaa aaatatttgg 180
ataattccag agagaaatgt aattggtaca attccccaag attttcttcc gcctacttca 240
ttgaaaaatg gagatagtag ttattatgac cctaattatt tacaaagtga tcaagaaaag 300
gataaatttt taaaaatagt cacaaaaata tttaatagaa taaatgataa tctttcagga 360
aggattttat tagaagaact gtcaaaagct aatccatatt taggaaatga taatactcca 420
gatggtgact tcattattaa tgatgcatca gcagttccaa ttcaattctc aaatggtagc 480
caaagcatac tattacctaa tgttattata atgggagcag agcctgattt atttgaaact 540
aacagttcca atatttctct aagaaataat tatatgccaa gcaatcacgg ttttggatca 600
atagctatag taacattctc acctgaatat tcttttagat ttaaagataa tagtatgaat 660
gaatttattc aagatcctgc tcttacatta atgcatgaat taatacattc attacatgga 720
ctatatgggg ctaaagggat tactacaaag tatactataa cacaaaaaca aaatccccta 780
ataacaaata taagaggtac aaatattgaa gaattcttaa cttttggagg tactgattta 840
aacattatta ctagtgctca gtccaatgat atctatacta atcttctagc tgattataaa 900
aaaatagcgt ctaaacttag caaagtacaa gtatctaatc cactacttaa tccttataaa 960
gatgtttttg aagcaaagta tggattagat aaagatgcta gcggaattta ttcggtaaat 1020
ataaacaaat ttaatgatat ttttaaaaaa ttatacagct ttacggaatt tgatttagca 1080
actaaatttc aagttaaatg taggcaaact tatattggac agtataaata cttcaaactt 1140
tcaaacttgt taaatgattc tatttataat atatcagaag gctataatat aaataattta 1200
aaggtaaatt ttagaggaca gaatgcaaat ttaaatccta gaattattac accaattaca 1260
ggtagaggac tagtaaaaaa aatcattaga ttttgtaaaa atattgtttc tgtaaaaggc 1320
ataaggtgtc aaaatttatt caagaacatt aatatcatgg ccaag 1365
<210> 85
<211> 1407
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/F Light chain-MTDr cDNA Sequence with hexahistidine
<400> 85
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat 60
atgccagttg caataaatag ttttaattat aatgaccctg ttaatgatga tacaatttta 120
tacatgcaga taccatatga agaaaaaagt aaaaaatatt ataaagcttt tgagattatg 180
cgtaatgttt ggataattcc tgagagaaat acaataggaa cgaatcctag tgattttgat 240
ccaccggctt cattaaagaa cggaagcagt gcttattatg atcctaatta tttaaccact 300
gatgctgaaa aagatagata tttaaaaaca acgataaaat tatttaagag aattaatagt 360
aatcctgcag ggaaagtttt gttacaagaa atatcatatg ctaaaccata tttaggaaat 420
gaccacacgc caattgatga attctctcca gttactagaa ctacaagtgt taatataaaa 480
ttatcaacta atgttgaaag ttcaatgtta ttgaatcttc ttgtattggg agcaggacct 540
gatatatttg aaagttgttg ttaccccgtt agaaaactaa tagatccaga tgtagtttat 600
gatccaagta attatggttt tggatcaatt aatatcgtga cattttcacc tgagtatgaa 660
tatactttta atgatattag tggagggcat aatagtagta cagaatcatt tattgcagat 720
cctgcaattt cactagctca tgaattgata catgcactgc atggattata cggggctagg 780
ggagttactt atgaagagac tatagaagta aagcaagcac ctcttatgat agccgaaaaa 840
cccataaggc tagaagaatt tttaaccttt ggaggtcagg atttaaatat tattactagt 900
gctatgaagg aaaaaatata taacaatctt ttagctaact atgaaaaaat agctactaga 960
cttagtgaag ttaatagtgc tcctcctgaa tatgatatta atgaatataa agattatttt 1020
caatggaagt atgggctaga taaaaatgct gatggaagtt atactgtaaa tgaaaataaa 1080
tttaatgaaa tttataaaaa attatatagt tttacagaga gtgacttagc aaataaattt 1140
aaagtaaaat gtagaaatac ttattttatt aaatatgaat ttttaaaagt tccaaatttg 1200
ttagatgatg atatttatac tgtatcagag gggtttaata taggtaattt agcagtaaac 1260
aatcgcggac aaagtataaa gttaaatcct aaaattattg attccattcc agataaaggt 1320
ctagtagaaa agatcgttaa attttgtaag agcgttattc ctagaaaatg tcaaaattta 1380
ttcaagaaca ttaatatcat ggccaag 1407
<210> 86
<211> 1425
<212> DNA
<213> Artificial Sequence
<220>
<223> BoNT/G Light chain-MTDr cDNA Sequence with hexahistidine
<400> 86
atgggcagca gccatcatca tcatcatcac agcagcggcc tggtgccgcg cggcagccat 60
atgccagtta atataaaaan ctttaattat aatgacccta ttaataatga tgacattatt 120
atgatggaac cattcaatga cccagggcca ggaacatatt ataaagcttt taggattata 180
gatcgtattt ggatagtacc agaaaggttt acttatggat ttcaacctga ccaatttaat 240
gccagtacag gagtttttag taaagatgtc tacgaatatt acgatccaac ttatttaaaa 300
accgatgctg aaaaagataa atttttaaaa acaatgatta aattatttaa tagaattaat 360
tcaaaaccat caggacagag attactggat atgatagtag atgctatacc ttatcttgga 420
aatgcatcta caccgcccga caaatttgca gcaaatgttg caaatgtatc tattaataaa 480
aaaattatcc aacctggagc tgaagatcaa ataaaaggtt taatgacaaa tttaataata 540
tttggaccag gaccagttct aagtgataat tttactgata gtatgattat gaatggccat 600
tccccaatat cagaaggatt tggtgcaaga atgatgataa gattttgtcc tagttgttta 660
aatgtattta ataatgttca ggaaaataaa gatacatcta tatttagtag acgcgcgtat 720
tttgcagatc cagctctaac gttaatgcat gaacttatac atgtgttaca tggattatat 780
ggaattaaga taagtaattt accaattact ccaaatacaa aagaattttt catgcaacat 840
agcgatcctg tacaagcaga agaactatat acattcggag gacatgatcc tagtgttata 900
agtccttcta cggatatgaa tatttataat aaagcgttac aaaattttca agatatagct 960
aataggctta atattgtttc aagtgcccaa gggagtggaa ttgatatttc cttatataaa 1020
caaatatata aaaataaata tgattttgtt gaagatccta atggaaaata tagtgtagat 1080
aaggataagt ttgataaatt atataaggcc ttaatgtttg gctttactga aactaatcta 1140
gctggtgaat atggaataaa aactaggtat tcttatttta gtgaatattt gccaccgata 1200
aaaactgaaa aattgttaga caatacaatt tatactcaaa atgaaggctt taacatagct 1260
agtaaaaatc tcaaaacgga atttaatggt cagaataagg cggtaaataa agaggcttat 1320
gaagaaatca gcctagaaca tctcgttata tatagaatag caatgtgcaa gcctgtaatg 1380
tacaaatgtc aaaatttatt caagaacatt aatatcatgg ccaag 1425
Claims (13)
- 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 통증개선용 약학적 조성물로서,
상기 보툴리눔 독소 재조합 단백질은 보툴리눔 독소 경쇄의 일측 말단 또는 양측 말단에 서열번호 1의 아미노산 서열로 이루어진 세포투과성 펩타이드가 융합된 것을 특징으로 하는, 통증개선용 약학적 조성물.
- 제1항에 있어서,
상기 보툴리눔 독소 재조합 단백질은 서열번호 31 내지 서열번호 58로 이루어진 군으로부터 선택되는 하나 이상의 아미노산 서열로 이루어진 것을 특징으로 하는, 통증개선용 약학적 조성물.
- 제1항에 있어서,
상기 보툴리눔 독소 경쇄는 서열번호 3 내지 서열번호 9으로 이루어진 군으로부터 선택되는 하나 이상의 아미노산 서열로 이루어진 것을 특징으로 하는, 통증개선용 약학적 조성물.
- 제1항에 있어서,
상기 보툴리눔 독소 경쇄는 일측 말단에 헥사히스티딘(hexahistidine) 태그(tag)를 더 포함하는 것을 특징으로 하는, 통증개선용 약학적 조성물.
- 제1항에 있어서,
상기 보툴리눔 독소 경쇄는 보툴리눔 독소 혈청형(serotype) A, B, C, D, E, F 및 G로 이루어진 군으로부터 선택되는 것을 특징으로 하는, 통증개선용 약학적 조성물.
- 제1항에 있어서,
상기 융합은 상기 보툴리눔 독소 경쇄의 카복시 말단, 아미노 말단 또는 이들 모두에 상기 세포투과성 펩타이드가 융합되는 것을 특징으로 하는, 통증개선용 약학적 조성물.
- 제1항에 있어서,
상기 융합은 펩타이드 결합 또는 공유결합에 의해 이루어지는 것을 특징으로 하는, 통증개선용 약학적 조성물.
- 제1항에 있어서,
상기 보툴리눔 독소 재조합 단백질은 근육 긴장을 완화시키는 것을 특징으로 하는, 통증개선용 약학적 조성물.
- 제1항에 있어서,
상기 통증은 기계적 통증, 열 통증, 만성 통증, 급성 통증, 통각과민 통증, 체인성 통증, 신경병성 통증, 심인성 통증, 열 유도된 통증, 물리적 통증, 통각수용, 통각과민, 류마티스성 통증, 두통, 요통, 골반통, 근막통, 혈관성 통증, 편두통, 상처 연계된 통증, 염증성 통증, 관절염 통증, 당뇨병성 통증, 암 유래의 통증, 신체 내장 통증, 섬유근통, 수술 후 통증, 환상통, 삼차신경통, 포진 후 신경통, 통증이 있는 당뇨병성 신경병증, 통증이 있는 당뇨병성 말초 신경병증, 당뇨병성 다발성 신경증, 좌골 통증, 신경근병증, 척수 신경근통, 근육통, 및 요추 통증으로 이루어진 군으로부터 선택되는 것을 특징으로 하는, 통증개선용 약학적 조성물.
- 제1항에 있어서,
상기 통증개선용 약학적 조성물은 경피 투여용인 것을 특징으로 하는, 통증개선용 약학적 조성물.
- 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 통증개선용 의약외품 조성물로서,
상기 보툴리눔 독소 재조합 단백질은 보툴리눔 독소 경쇄의 일측 말단 또는 양측 말단에 서열번호 1의 아미노산 서열로 이루어진 세포투과성 펩타이드가 융합된 것을 특징으로 하는, 통증개선용 의약외품 조성물.
- 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 통증개선용 피부외용제 조성물로서,
상기 보툴리눔 독소 재조합 단백질은 보툴리눔 독소 경쇄의 일측 말단 또는 양측 말단에 서열번호 1의 아미노산 서열로 이루어진 세포투과성 펩타이드가 융합된 것을 특징으로 하는, 통증개선용 피부외용제 조성물.
- 보툴리눔 독소 재조합 단백질을 유효성분으로 포함하는 통증개선용 화장료 조성물로서,
상기 보툴리눔 독소 재조합 단백질은 보툴리눔 독소 경쇄의 일측 말단 또는 양측 말단에 서열번호 1의 아미노산 서열로 이루어진 세포투과성 펩타이드가 융합된 것을 특징으로 하는, 통증개선용 화장료 조성물.
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PCT/KR2022/007851 WO2023075060A1 (ko) | 2021-10-25 | 2022-06-02 | 보툴리눔 유래 펩타이드를 포함하는 통증개선용 조성물 |
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Citations (1)
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KR101882461B1 (ko) | 2014-05-29 | 2018-07-27 | 주식회사 프로셀테라퓨틱스 | 신규한 세포투과성 펩타이드 및 이와 보툴리눔 독소 결합체 및 이들의 용도 |
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KR101882461B1 (ko) | 2014-05-29 | 2018-07-27 | 주식회사 프로셀테라퓨틱스 | 신규한 세포투과성 펩타이드 및 이와 보툴리눔 독소 결합체 및 이들의 용도 |
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