BR0208474A - método para fornecer um antìgeno alvo ao citossol de uma célula, polipeptìdeo isolado, dna isolado, vetor, composição farmacêutica, métodos para gerar uma resposta imune mediana por célula em um mamìfero, para produzir uma proteìna, e para medir uma resposta imune mediada por célula, e, kit para medir respostas imunes mediadas por célula in vitro - Google Patents
método para fornecer um antìgeno alvo ao citossol de uma célula, polipeptìdeo isolado, dna isolado, vetor, composição farmacêutica, métodos para gerar uma resposta imune mediana por célula em um mamìfero, para produzir uma proteìna, e para medir uma resposta imune mediada por célula, e, kit para medir respostas imunes mediadas por célula in vitroInfo
- Publication number
- BR0208474A BR0208474A BRPI0208474-0A BR0208474A BR0208474A BR 0208474 A BR0208474 A BR 0208474A BR 0208474 A BR0208474 A BR 0208474A BR 0208474 A BR0208474 A BR 0208474A
- Authority
- BR
- Brazil
- Prior art keywords
- cell
- measuring
- immune response
- mediated immune
- target antigen
- Prior art date
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
"MéTODO PARA FORNECER UM ANTìGENO ALVO AO CITOSSOL DE UMA CéLULA, POLIPEPTìDEO ISOLADO, DNA ISOLADO, VETOR, COMPOSIçãO FARMACêUTICA, MéTODOS PAPA GERAR UMA RESPOSTA IMUNE MEDIADA POR CéLULA EM UM MAMìFERO, PARA PRODUZIR UMA PROTEìNA, E PARA MEDIR UMA RESPOSTA IMUNE MEDIADA POR CéLULA, E, KIT PARA MEDIR RESPOSTAS IMUNES MEDIADAS POR CéLULA IN VITRO". A presente invenção é dirigida a um método para o fornecimento de proteínas exógenas ao citossol, pela ligação de um antígeno alvo (tal que uma proteína) a um fator de transporte que contém um fragmento de um exotoxina de proteína bipartida, mas não correspondendo ao antígeno protetor. De modo preferido, o antígeno alvo é fundido ao fator de transporte. Fatores de transporte preferidos incluem o domínio de ligação do antígeno protetor do fator letal (LFn) de B. anthracis, consistindo dos aminoácidos 1-255, preferivelmente de um fragmento de 80 aminoácidos, que mostra pelo menos 80% de homologia para LFn, e um fragmento de cerca de 105 aminoácidos a partir da porção carbóxi, que não liga PA. O antígeno alvo pode incluir qualquer molécula, para a qual seria desejável produzir uma resposta de CMI, incluindo antígenos virais e antígenos tumorais.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27936601P | 2001-03-28 | 2001-03-28 | |
PCT/US2002/009680 WO2002079417A2 (en) | 2001-03-28 | 2002-03-28 | Methods of delivery of exogenous proteins to the cytosol and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0208474A true BR0208474A (pt) | 2006-02-21 |
Family
ID=23068640
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0208474-0A BR0208474A (pt) | 2001-03-28 | 2002-03-28 | método para fornecer um antìgeno alvo ao citossol de uma célula, polipeptìdeo isolado, dna isolado, vetor, composição farmacêutica, métodos para gerar uma resposta imune mediana por célula em um mamìfero, para produzir uma proteìna, e para medir uma resposta imune mediada por célula, e, kit para medir respostas imunes mediadas por célula in vitro |
Country Status (8)
Country | Link |
---|---|
US (2) | US7754219B2 (pt) |
EP (1) | EP1536828B1 (pt) |
JP (2) | JP2005512505A (pt) |
CN (2) | CN101694497B (pt) |
BR (1) | BR0208474A (pt) |
CA (1) | CA2442020C (pt) |
WO (1) | WO2002079417A2 (pt) |
ZA (1) | ZA200307467B (pt) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006023598A2 (en) * | 2004-08-19 | 2006-03-02 | University Of Maryland, Baltimore | Prostate-specific antigen-derived mhc class ii-restricted peptides and their use in vaccines to treat or prevent prostate cancer |
EP1805680B1 (en) * | 2004-10-06 | 2015-03-25 | Board of Supervisors of Louisiana | Channel current cheminformatics and bioengineering methods for immunological screening, single-molecule analysis, and single-molecular-interaction analysis |
AU2007259329A1 (en) * | 2006-05-12 | 2007-12-21 | Farris, Darise | Anthrax compositions and methods of use and production |
CN101139613B (zh) * | 2007-08-01 | 2011-06-08 | 姜荣锡 | 抗肿瘤二元多肽及其应用与制备方法 |
WO2010144794A1 (en) | 2009-06-12 | 2010-12-16 | Vaccine Technologies, Incorporated | Baculovirus-expressed fusion polypeptide vaccines with enhanced immunogenicity and uses thereof |
CN102549425A (zh) * | 2009-06-12 | 2012-07-04 | 疫苗技术公司 | 用于测量细胞介导的免疫应答的诊断试验所用的方法和组合物 |
WO2010144797A2 (en) | 2009-06-12 | 2010-12-16 | Vaccine Technologies, Incorporated | Influenza vaccines with enhanced immunogenicity and uses thereof |
CN102573883A (zh) * | 2009-06-12 | 2012-07-11 | 疫苗技术公司 | 用于促进细胞-介导的免疫应答的方法和组合物 |
WO2011046983A2 (en) | 2009-10-12 | 2011-04-21 | Smith Holdings, Llc | Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro |
US20130115237A1 (en) | 2010-06-09 | 2013-05-09 | Vaccine Technologies, Incorporated | Therapeutic immunization in hiv infected subjects to augment antiretroviral treatment |
US8921328B2 (en) | 2010-09-14 | 2014-12-30 | Glycomimetics, Inc. | E-selectin antagonists |
CA2824154A1 (en) | 2011-01-10 | 2012-07-19 | President And Fellows Of Harvard College | Method for delivering agents into cells using bacterial toxins |
WO2012139112A1 (en) * | 2011-04-08 | 2012-10-11 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Ubiquitin fusions for improving the efficacy of cytosolic acting targeted toxins |
CN102417894B (zh) | 2011-10-21 | 2013-06-05 | 中国科学院广州生物医药与健康研究院 | 一种提高诱导生成多能性干细胞效率的方法 |
ES2655443T7 (es) | 2011-12-22 | 2021-03-22 | Glycomimetics Inc | Compuestos antagonistas de E-selectina |
WO2013126690A1 (en) | 2012-02-23 | 2013-08-29 | President And Fellows Of Harvard College | Modified microbial toxin receptor for delivering agents into cells |
CA2891514C (en) | 2012-12-07 | 2020-08-25 | Glycomimetics, Inc. | Compounds, compositions and methods using e-selectin antagonists for mobilization of hematopoietic cells |
CN107108679B (zh) | 2014-12-03 | 2020-10-23 | 糖模拟物有限公司 | E-选择蛋白和cxcr4趋化因子受体的异双官能抑制剂 |
LT3411388T (lt) * | 2016-02-01 | 2022-01-10 | Simplexia Ab | Sutrumpintas herpes simplex viruso 2 glikoproteinas g |
WO2017151708A1 (en) | 2016-03-02 | 2017-09-08 | Glycomimetics, Inc. | Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin |
US11433086B2 (en) | 2016-08-08 | 2022-09-06 | Glycomimetics, Inc. | Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4 |
JP7069136B2 (ja) | 2016-10-07 | 2022-05-17 | グリコミメティクス, インコーポレイテッド | 極めて強力な多量体e-セレクチンアンタゴニスト |
JP7272956B2 (ja) | 2017-03-15 | 2023-05-12 | グリコミメティクス, インコーポレイテッド | E-セレクチンアンタゴニストとしてのガラクトピラノシル-シクロヘキシル誘導体 |
US11712446B2 (en) | 2017-11-30 | 2023-08-01 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
CN111566117A (zh) | 2017-12-29 | 2020-08-21 | 糖模拟物有限公司 | E-选择蛋白和半乳凝素-3的异双功能抑制剂 |
AU2019230013A1 (en) | 2018-03-05 | 2020-09-10 | Glycomimetics, Inc. | Methods for treating acute myeloid leukemia and related conditions |
US11189029B2 (en) * | 2018-07-02 | 2021-11-30 | Tempus Labs, Inc. | 3D radiomic platform for imaging biomarker development |
AR117327A1 (es) | 2018-12-20 | 2021-07-28 | 23Andme Inc | Anticuerpos anti-cd96 y métodos de uso de estos |
US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5677274A (en) | 1993-02-12 | 1997-10-14 | The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services | Anthrax toxin fusion proteins and related methods |
US20030202989A1 (en) * | 1995-12-13 | 2003-10-30 | R. John Collier | Use of toxin peptides and/or affinity handles for delivering compounds into cells |
US6592872B1 (en) | 1996-09-17 | 2003-07-15 | The United States Of America As Represented By The Department Of Health And Human Services | Targeting antigens to the MHC class I processing pathway with an anthrax toxin fusion protein |
US6368602B1 (en) * | 2000-06-16 | 2002-04-09 | Hadasit Medical Research Services And Development Ltd | Mucosal immunization against hepatitis A virus (HAV) through rectal administration of HAV vaccine |
-
2002
- 2002-03-28 CN CN200910204431.9A patent/CN101694497B/zh not_active Expired - Lifetime
- 2002-03-28 BR BRPI0208474-0A patent/BR0208474A/pt not_active Application Discontinuation
- 2002-03-28 CN CNB028108868A patent/CN100560720C/zh not_active Expired - Lifetime
- 2002-03-28 EP EP02723658.7A patent/EP1536828B1/en not_active Expired - Lifetime
- 2002-03-28 US US10/473,190 patent/US7754219B2/en not_active Expired - Lifetime
- 2002-03-28 JP JP2002578420A patent/JP2005512505A/ja not_active Withdrawn
- 2002-03-28 CA CA2442020A patent/CA2442020C/en not_active Expired - Lifetime
- 2002-03-28 WO PCT/US2002/009680 patent/WO2002079417A2/en active Application Filing
-
2003
- 2003-09-25 ZA ZA2003/07467A patent/ZA200307467B/en unknown
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2009
- 2009-09-14 JP JP2009212567A patent/JP5270500B2/ja not_active Expired - Lifetime
-
2010
- 2010-05-18 US US12/782,659 patent/US8333953B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CA2442020C (en) | 2017-03-14 |
EP1536828A2 (en) | 2005-06-08 |
CN1636060A (zh) | 2005-07-06 |
US20100311105A1 (en) | 2010-12-09 |
US7754219B2 (en) | 2010-07-13 |
EP1536828B1 (en) | 2013-06-05 |
CN101694497B (zh) | 2014-11-26 |
CN100560720C (zh) | 2009-11-18 |
WO2002079417A3 (en) | 2005-04-14 |
EP1536828A4 (en) | 2006-01-18 |
JP5270500B2 (ja) | 2013-08-21 |
US20050220807A1 (en) | 2005-10-06 |
ZA200307467B (en) | 2005-05-25 |
JP2005512505A (ja) | 2005-05-12 |
CA2442020A1 (en) | 2002-10-10 |
US8333953B2 (en) | 2012-12-18 |
JP2010042008A (ja) | 2010-02-25 |
CN101694497A (zh) | 2010-04-14 |
WO2002079417A2 (en) | 2002-10-10 |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |