BR0207578A - Proteìna isolada susceptìvel de ser obtida por extração da planta pilocarpus heterophyllus, anticorpo monoclonal, composição farmacêutica, utilização de uma proteìna, e processo de extração e de isolamento de heterocarpina a partir de células da planta pilocarpus heterophyllus - Google Patents
Proteìna isolada susceptìvel de ser obtida por extração da planta pilocarpus heterophyllus, anticorpo monoclonal, composição farmacêutica, utilização de uma proteìna, e processo de extração e de isolamento de heterocarpina a partir de células da planta pilocarpus heterophyllusInfo
- Publication number
- BR0207578A BR0207578A BR0207578-4A BR0207578A BR0207578A BR 0207578 A BR0207578 A BR 0207578A BR 0207578 A BR0207578 A BR 0207578A BR 0207578 A BR0207578 A BR 0207578A
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- pilocarpus heterophyllus
- heterophyllus plant
- pharmaceutical composition
- monoclonal antibody
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 6
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 241000123963 Pilocarpus heterophyllus Species 0.000 title abstract 4
- 238000000605 extraction Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 101000825742 Homo sapiens Somatoliberin Proteins 0.000 abstract 3
- 102000045304 human GHRH Human genes 0.000 abstract 3
- 206010000599 Acromegaly Diseases 0.000 abstract 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010038923 Retinopathy Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000009413 insulation Methods 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Botany (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
"PROTEìNA ISOLADA SUSCEPTìVEL DE SER OBTIDA POR EXTRAçãO DA PLANTA PILOCARPUS HETEROPHYLLUS, ANTICORPO MONOCLONAL, COMPOSIçãO FARMACêUTICA, UTILIZAçãO DE UMA PROTEìNA, E PROCESSO DE EXTRAçAO E DE ISOLAMENTO DE HETEROCARPINA A PARTIR DE CéLULAS DA PLANTA PILOCARPUS HETEROPHYLLUS". A invenção refere-se a uma proteína que fixa o GHRH humano (human growth hormone releasing hormone ou hormónio liberador de hormónio de crescimento humano). Esta proteína, obtida a partir da planta Pilocarpus Heterophyllus, pode ser utilizada para preparar medicamentos destinados a antagonizar os efeitos de GHRH, para tratar as doenças proliferativas (e notadamente o câncer), para tratar a acromegalia ou para tratar as retinopatias e as nefropatias diabéticas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0102631A FR2821359B1 (fr) | 2001-02-27 | 2001-02-27 | L'heterocarpine, une proteine fixant le ghrh humain |
| PCT/FR2002/000691 WO2002068461A2 (fr) | 2001-02-27 | 2002-02-26 | L'heterocarpine, une proteine fixant le ghrh humain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0207578A true BR0207578A (pt) | 2004-03-02 |
Family
ID=8860481
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0207578-4A BR0207578A (pt) | 2001-02-27 | 2002-02-26 | Proteìna isolada susceptìvel de ser obtida por extração da planta pilocarpus heterophyllus, anticorpo monoclonal, composição farmacêutica, utilização de uma proteìna, e processo de extração e de isolamento de heterocarpina a partir de células da planta pilocarpus heterophyllus |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7385024B2 (pt) |
| EP (1) | EP1409531B1 (pt) |
| JP (1) | JP4117194B2 (pt) |
| KR (1) | KR20030094262A (pt) |
| CN (1) | CN100340573C (pt) |
| AT (1) | ATE309269T1 (pt) |
| AU (1) | AU2002241065B2 (pt) |
| BR (1) | BR0207578A (pt) |
| CA (1) | CA2437516A1 (pt) |
| CZ (1) | CZ20032612A3 (pt) |
| DE (1) | DE60207257T2 (pt) |
| ES (1) | ES2252431T3 (pt) |
| FR (1) | FR2821359B1 (pt) |
| HU (1) | HU225431B1 (pt) |
| IL (2) | IL157150A0 (pt) |
| MX (1) | MXPA03007626A (pt) |
| NZ (1) | NZ527749A (pt) |
| PL (1) | PL207581B1 (pt) |
| RU (1) | RU2305683C2 (pt) |
| WO (1) | WO2002068461A2 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2843697B1 (fr) * | 2002-08-26 | 2005-12-09 | Sod Conseils Rech Applic | L'heterocarpine, une proteine d'origine vegetale aux proprietes anticancereuses |
| US7494969B2 (en) | 2002-02-26 | 2009-02-24 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Heterocarpine, a plant-derived protein with anti-cancer properties |
| CN1688696A (zh) * | 2002-09-18 | 2005-10-26 | 蒙特利尔大学医疗中心 | Ghrh类似物 |
| FR2848221B1 (fr) * | 2002-12-10 | 2007-09-28 | Sod Conseils Rech Applic | Procede de preparation d'heterocarpine recombinante |
| JP2005289895A (ja) * | 2004-03-31 | 2005-10-20 | Kagoshima Tlo Co Ltd | 植物タンパク質分離精製法及びそれに用いるタンニン中和剤並びにその調製法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5550212A (en) * | 1993-12-17 | 1996-08-27 | The Administrators Of The Tulane Educational Fund | Analogues of hGH-RH(1-29)NH2 having antagonistic activity |
| ES2134280T3 (es) * | 1994-03-21 | 1999-10-01 | Nestle Sa | Procedimiento de produccion de pilocarpina. |
| US20050160088A1 (en) | 2001-05-17 | 2005-07-21 | Todd Scallan | System and method for metadata-based distribution of content |
-
2001
- 2001-02-27 FR FR0102631A patent/FR2821359B1/fr not_active Expired - Fee Related
-
2002
- 2002-02-26 CA CA002437516A patent/CA2437516A1/fr not_active Abandoned
- 2002-02-26 RU RU2003128963/13A patent/RU2305683C2/ru not_active IP Right Cessation
- 2002-02-26 KR KR10-2003-7011194A patent/KR20030094262A/ko not_active Application Discontinuation
- 2002-02-26 AU AU2002241065A patent/AU2002241065B2/en not_active Ceased
- 2002-02-26 CZ CZ20032612A patent/CZ20032612A3/cs unknown
- 2002-02-26 DE DE60207257T patent/DE60207257T2/de not_active Expired - Lifetime
- 2002-02-26 MX MXPA03007626A patent/MXPA03007626A/es active IP Right Grant
- 2002-02-26 BR BR0207578-4A patent/BR0207578A/pt not_active Application Discontinuation
- 2002-02-26 HU HU0303244A patent/HU225431B1/hu not_active IP Right Cessation
- 2002-02-26 US US10/470,112 patent/US7385024B2/en not_active Expired - Fee Related
- 2002-02-26 PL PL369469A patent/PL207581B1/pl unknown
- 2002-02-26 ES ES02706900T patent/ES2252431T3/es not_active Expired - Lifetime
- 2002-02-26 NZ NZ527749A patent/NZ527749A/en unknown
- 2002-02-26 IL IL15715002A patent/IL157150A0/xx active IP Right Grant
- 2002-02-26 CN CNB028054660A patent/CN100340573C/zh not_active Expired - Fee Related
- 2002-02-26 EP EP02706900A patent/EP1409531B1/fr not_active Expired - Lifetime
- 2002-02-26 WO PCT/FR2002/000691 patent/WO2002068461A2/fr active IP Right Grant
- 2002-02-26 AT AT02706900T patent/ATE309269T1/de not_active IP Right Cessation
- 2002-02-26 JP JP2002567971A patent/JP4117194B2/ja not_active Expired - Fee Related
-
2003
- 2003-07-29 IL IL157150A patent/IL157150A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2252431T3 (es) | 2006-05-16 |
| PL369469A1 (en) | 2005-04-18 |
| FR2821359B1 (fr) | 2003-05-09 |
| FR2821359A1 (fr) | 2002-08-30 |
| CZ20032612A3 (cs) | 2004-08-18 |
| CA2437516A1 (fr) | 2002-09-06 |
| DE60207257T2 (de) | 2006-07-27 |
| IL157150A0 (en) | 2004-02-08 |
| RU2003128963A (ru) | 2005-02-20 |
| CN100340573C (zh) | 2007-10-03 |
| US7385024B2 (en) | 2008-06-10 |
| EP1409531A2 (fr) | 2004-04-21 |
| DE60207257D1 (de) | 2005-12-15 |
| JP4117194B2 (ja) | 2008-07-16 |
| NZ527749A (en) | 2006-09-29 |
| CN1531550A (zh) | 2004-09-22 |
| WO2002068461A2 (fr) | 2002-09-06 |
| HUP0303244A2 (hu) | 2003-12-29 |
| MXPA03007626A (es) | 2003-12-04 |
| JP2004538254A (ja) | 2004-12-24 |
| ATE309269T1 (de) | 2005-11-15 |
| PL207581B1 (pl) | 2011-01-31 |
| US20040063621A1 (en) | 2004-04-01 |
| RU2305683C2 (ru) | 2007-09-10 |
| IL157150A (en) | 2008-11-26 |
| EP1409531B1 (fr) | 2005-11-09 |
| KR20030094262A (ko) | 2003-12-11 |
| AU2002241065B2 (en) | 2006-09-28 |
| WO2002068461A3 (fr) | 2004-02-12 |
| HU225431B1 (en) | 2006-11-28 |
| HUP0303244A3 (en) | 2005-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B25D | Requested change of name of applicant approved |
Owner name: IPSEN PHARMA S.A.S. (FR) |
|
| B25G | Requested change of headquarter approved |
Owner name: IPSEN PHARMA S.A.S. (FR) |
|
| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
| B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |