BR0201237A - Processo de obtenção de lignanas dibenzilbutirolactÈnicas, processo de obtenção de derivados sintéticos de lignanas ostentando atividades quimioprofilática e terapêutica antichagásica - Google Patents
Processo de obtenção de lignanas dibenzilbutirolactÈnicas, processo de obtenção de derivados sintéticos de lignanas ostentando atividades quimioprofilática e terapêutica antichagásicaInfo
- Publication number
- BR0201237A BR0201237A BR0201237-5A BR0201237A BR0201237A BR 0201237 A BR0201237 A BR 0201237A BR 0201237 A BR0201237 A BR 0201237A BR 0201237 A BR0201237 A BR 0201237A
- Authority
- BR
- Brazil
- Prior art keywords
- obtaining
- lignans
- cubebin
- derivatives
- dibenzylbutyrolactinic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"PROCESSO DE OBTENçãO DE LIGNANAS DIBENZILBUTIROLACTÈNICAS; PROCESSO DE OBTENçãO DE DERIVADOS SINTéTICOS DE LIGNANAS OSTENTANDO ATIVIDADES QUIMIOPROFILáTICA E TERAPêUTICA ANTICHAGáSICA". A presente invenção se refere a um processo para obtenção de lignanas dibenzilbutirolactónicas, em especial, obtenção de cubebina e metilpluviatolido, a partir de folhas de Zanthoxylum naranjillo ou sementes Piper cubeba. Refere-se também a um processo de obtenção dos derivados semi-sintéticos de cubebina, lignana dibenzilbutirolactónica, tais como: hinoquinina, cubebina O-acetil, cubebina O-metil, 6,6'-dinitroinoquinina e cubebina O-dimetiletilamina e outros derivados que venham a ser obtidos através de processos ora descritos, os quais são utilizados na fabricação de medicamentos que proporcionarão atividade de no mínimo cinco vezes maior do que aquela observada para violeta de genciana e demais compostos utilizados, até então no tratamento de sangue, para a profilaxia da doença de Chagas.,
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR0201237-5A BR0201237A (pt) | 2002-03-25 | 2002-03-25 | Processo de obtenção de lignanas dibenzilbutirolactÈnicas, processo de obtenção de derivados sintéticos de lignanas ostentando atividades quimioprofilática e terapêutica antichagásica |
JP2003578354A JP2005532277A (ja) | 2002-03-25 | 2003-03-25 | ジベンジルブチロラクトニックリグナンを得るための方法;抗−シャーガスの化学的予防活性及び治療的活性を有する、リグナンからの合成誘導体を得る方法。 |
PCT/BR2003/000045 WO2003080600A1 (en) | 2002-03-25 | 2003-03-25 | Process to obtain dibenzylbutyrolactonic lignans; process to obtain synthetic derivatives from lignanes bearing anti-chagas chemoprophylactic and therapeutical activities |
DE60335980T DE60335980D1 (de) | 2002-03-25 | 2003-03-25 | Verfahren zur herstellung von synthetischen derivaten von dibenzylbutyrolacton-lignanen mit antichagas eigenschaften |
AT03709465T ATE497958T1 (de) | 2002-03-25 | 2003-03-25 | Verfahren zur herstellung von synthetischen derivaten von dibenzylbutyrolacton-lignanen mit antichagas eigenschaften |
EP03709465A EP1487825B1 (en) | 2002-03-25 | 2003-03-25 | Processes for the preparation of synthetic derivatives of dibenzylbutyrolactonic lignans having anti-chagas properties |
US10/508,875 US7317114B2 (en) | 2002-03-25 | 2003-03-25 | Process to obtain dibenzylbutyrolactonic lignans, process to obtain synthetic derivatives from lignans bearing anti-Chagas chemoprophylactic and therapeutical activities |
ES03709465T ES2362260T3 (es) | 2002-03-25 | 2003-03-25 | Procedimientos para la preparación de derivados sintéticos de los lignanos dibencilbutirolactónicos que presentan propiedades antichagas. |
AU2003213896A AU2003213896A1 (en) | 2002-03-25 | 2003-03-25 | Process to obtain dibenzylbutyrolactonic lignans; process to obtain synthetic derivatives from lignanes bearing anti-chagas chemoprophylactic and therapeutical activities |
US11/951,460 US7521569B2 (en) | 2002-03-25 | 2007-12-06 | Process to obtain dibenzylbutyrolactonic lignans, process to obtain synthetic derivatives from lignans bearing anti-Chagas chemoprophylactic and therapeutical activities |
JP2010275582A JP2011098968A (ja) | 2002-03-25 | 2010-12-10 | ジベンジルブチロラクトニックリグナンを得るための方法;抗−シャーガスの化学的予防活性及び治療的活性を有する、リグナンからの合成誘導体を得る方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR0201237-5A BR0201237A (pt) | 2002-03-25 | 2002-03-25 | Processo de obtenção de lignanas dibenzilbutirolactÈnicas, processo de obtenção de derivados sintéticos de lignanas ostentando atividades quimioprofilática e terapêutica antichagásica |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0201237A true BR0201237A (pt) | 2003-12-02 |
Family
ID=39303809
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0201237-5A BR0201237A (pt) | 2002-03-25 | 2002-03-25 | Processo de obtenção de lignanas dibenzilbutirolactÈnicas, processo de obtenção de derivados sintéticos de lignanas ostentando atividades quimioprofilática e terapêutica antichagásica |
Country Status (9)
Country | Link |
---|---|
US (2) | US7317114B2 (pt) |
EP (1) | EP1487825B1 (pt) |
JP (2) | JP2005532277A (pt) |
AT (1) | ATE497958T1 (pt) |
AU (1) | AU2003213896A1 (pt) |
BR (1) | BR0201237A (pt) |
DE (1) | DE60335980D1 (pt) |
ES (1) | ES2362260T3 (pt) |
WO (1) | WO2003080600A1 (pt) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011075801A1 (pt) | 2009-12-21 | 2011-06-30 | Acef S.A. | Cubebina, lignana dibenzilbutirolactólica, seus derivados semi-sintéticos e sintéticos, bem como outras lignanas e neolignanas como agente vasodilatador na terapia da disfunção erétil |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0501542A (pt) * | 2005-04-28 | 2006-12-12 | Fundacao De Amparo A Pesquisa | processo de obtenção de lignanas dibenzilbutirolactÈnicas, tetrahidrofuránicas e de seus derivados sintéticos e semi-sintéticos, suas atividades analgésica e antiinflamatória, formulações tópicas e/ou sistêmicas contendo tais lignanas e respectivo método terapêutico |
BRPI0503951A (pt) * | 2005-07-15 | 2007-03-06 | Fundacao De Amparo A Pesquisa | processo de obtenção de derivados sintéticos e semi-sintéticos de lignanas, suas atividades antiparasitárias e respectivas formulações farmacêuticas, englobando o método terapêutico utilizando tais lignanas no tratamento de parasitoses |
CH698627B1 (de) * | 2007-08-16 | 2009-09-15 | Alpinia Laudanum Inst Of Phytopharmaceutical | Herstellung und Verwendung von Extrakten oder Extraktivstoffen aus Piper cubeba L. als wirksame Bestandteile in einem Medikament zur Behandlung von Krebserkrankungen. |
CN102603754B (zh) * | 2012-04-06 | 2015-06-17 | 苏州大学 | 一种两面针喹诺酮类生物碱的制备及应用 |
WO2014086379A1 (en) | 2012-12-03 | 2014-06-12 | Alpinia Laudanum Institute Of Phytopharmaceutical Sciences Ag | Lignan compositions |
JP7197908B2 (ja) * | 2019-03-04 | 2022-12-28 | 株式会社ナチュファルマ琉球 | 骨減少性疾患の予防及び/又は治療用組成物 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK346987D0 (da) * | 1987-07-06 | 1987-07-06 | Hans Goeran Magnusson | Fremgangsmaade til fremstilling af tetrahydrofuranforbindelser |
-
2002
- 2002-03-25 BR BR0201237-5A patent/BR0201237A/pt active Search and Examination
-
2003
- 2003-03-25 JP JP2003578354A patent/JP2005532277A/ja active Pending
- 2003-03-25 EP EP03709465A patent/EP1487825B1/en not_active Expired - Lifetime
- 2003-03-25 WO PCT/BR2003/000045 patent/WO2003080600A1/en active Application Filing
- 2003-03-25 US US10/508,875 patent/US7317114B2/en not_active Expired - Fee Related
- 2003-03-25 AT AT03709465T patent/ATE497958T1/de not_active IP Right Cessation
- 2003-03-25 DE DE60335980T patent/DE60335980D1/de not_active Expired - Lifetime
- 2003-03-25 ES ES03709465T patent/ES2362260T3/es not_active Expired - Lifetime
- 2003-03-25 AU AU2003213896A patent/AU2003213896A1/en not_active Abandoned
-
2007
- 2007-12-06 US US11/951,460 patent/US7521569B2/en not_active Expired - Fee Related
-
2010
- 2010-12-10 JP JP2010275582A patent/JP2011098968A/ja active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011075801A1 (pt) | 2009-12-21 | 2011-06-30 | Acef S.A. | Cubebina, lignana dibenzilbutirolactólica, seus derivados semi-sintéticos e sintéticos, bem como outras lignanas e neolignanas como agente vasodilatador na terapia da disfunção erétil |
Also Published As
Publication number | Publication date |
---|---|
US7521569B2 (en) | 2009-04-21 |
JP2005532277A (ja) | 2005-10-27 |
ES2362260T3 (es) | 2011-06-30 |
ATE497958T1 (de) | 2011-02-15 |
WO2003080600A1 (en) | 2003-10-02 |
JP2011098968A (ja) | 2011-05-19 |
AU2003213896A1 (en) | 2003-10-08 |
US20050154215A1 (en) | 2005-07-14 |
US7317114B2 (en) | 2008-01-08 |
US20080090901A1 (en) | 2008-04-17 |
DE60335980D1 (de) | 2011-03-24 |
EP1487825B1 (en) | 2011-02-09 |
EP1487825A1 (en) | 2004-12-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B03H | Publication of an application: rectification [chapter 3.8 patent gazette] |
Free format text: REFERENTE A RPI 1717 DE 02/12/2003, QUANTO AO ITEM (72). |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 10A. ANUIDADE(S). |
|
B08G | Application fees: restoration [chapter 8.7 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 12A E 13A ANUIDADES. |
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B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
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B07F | Notification of approval that there is no relation to art. 229 of lpi (pipeline patents) [chapter 7.6 patent gazette] |