BR0117137A - Hidrogel polifuncional biocompatìvel e método para a sua produção - Google Patents
Hidrogel polifuncional biocompatìvel e método para a sua produçãoInfo
- Publication number
- BR0117137A BR0117137A BR0117137-2A BR0117137A BR0117137A BR 0117137 A BR0117137 A BR 0117137A BR 0117137 A BR0117137 A BR 0117137A BR 0117137 A BR0117137 A BR 0117137A
- Authority
- BR
- Brazil
- Prior art keywords
- hydrogel
- acrylamide
- polyfunctional
- biocompatibly
- production
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
- C08K5/0025—Crosslinking or vulcanising agents; including accelerators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/02—Elements
- C08K3/08—Metals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S524/00—Synthetic resins or natural rubbers -- part of the class 520 series
- Y10S524/916—Hydrogel compositions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Polymers & Plastics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Surgery (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Colloid Chemistry (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Macromonomer-Based Addition Polymer (AREA)
Abstract
"HIDROGEL POLIFUNCIONAL BIOCOMPATìVEL E MéTODO PARA A SUA PRODUçãO". O hidrogel polifuncional biocompatível inventivo compreende 1,3 - 15% em massa de acrilamida, 0,004 - 0,975% em massa de agentes de reticulação N,N<39>-metileno-bis-acrilamida, 0,004 5,1% em massa de N,N<39>-etileno-bis-acrilamida, 0,002 0,45% em massa de poviargolum, e água até 100% em massa. O referido hidrogel é produzido por meio da copolimerização da acrilamida com agentes de reticulação em um meio aquoso em presença de iniciador peróxido de polimerização, a incubação da mistura reacional sendo realizada em dois estágios. O primeiro estágio é conduzido na temperatura variando na faixa de 20 <198>C a 90 <198>C por 2 a 24 horas, e o segundo estágio sendo realizado na temperatura de 107 <198>C a 130 <198>C durante um tempo igual ou menor que 2 horas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/RU2001/000392 WO2003026711A1 (fr) | 2001-09-28 | 2001-09-28 | Hydrogel biocompatible polyfonctionnel et procede de production associe |
Publications (2)
Publication Number | Publication Date |
---|---|
BR0117137A true BR0117137A (pt) | 2004-10-13 |
BR0117137B1 BR0117137B1 (pt) | 2014-01-28 |
Family
ID=20129652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0117137-2A BR0117137B1 (pt) | 2001-09-28 | 2001-09-28 | Hidrogel polifuncional biocompatível e método para a sua produção |
Country Status (12)
Country | Link |
---|---|
US (1) | US7294348B2 (pt) |
EP (1) | EP1438976B1 (pt) |
CN (1) | CN1257752C (pt) |
AT (1) | ATE381356T1 (pt) |
BR (1) | BR0117137B1 (pt) |
CA (1) | CA2461821C (pt) |
DE (1) | DE60132025T2 (pt) |
DK (1) | DK1438976T3 (pt) |
ES (1) | ES2298195T3 (pt) |
MX (1) | MXPA04002967A (pt) |
RU (1) | RU2205034C1 (pt) |
WO (1) | WO2003026711A1 (pt) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0303798D0 (en) * | 2003-02-19 | 2003-03-26 | Bioartem Ltd | Gel |
GB0327310D0 (en) * | 2003-11-24 | 2003-12-24 | Oztech Pty Ltd | Pressure impulse mitigation |
DE102007040370B4 (de) * | 2007-08-20 | 2011-06-16 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Kollagenhaltiger Zellträger |
DE102009005534B3 (de) * | 2008-12-18 | 2010-04-01 | Heraeus Medical Gmbh | Sporozide Zusammensetzungen und deren Verwendung |
US11090387B2 (en) | 2008-12-22 | 2021-08-17 | The Trustees Of The University Of Pennsylvania | Hydrolytically degradable polysaccharide hydrogels |
US9486404B2 (en) * | 2011-03-28 | 2016-11-08 | The Trustees Of The University Of Pennsylvania | Infarction treatment compositions and methods |
RU2493173C1 (ru) * | 2012-03-22 | 2013-09-20 | Федеральное государственное бюджетное учреждение науки Ордена Трудового Красного Знамени Институт нефтехимического синтеза им. А.В. Топчиева Российской академии наук (ИНХС РАН) | Способ получения полиакриламидного гидрогеля |
RU2499003C1 (ru) * | 2012-03-22 | 2013-11-20 | Федеральное государственное бюджетное учреждение науки Ордена Трудового Красного Знамени Институт нефтехимического синтеза им. А.В. Топчиева Российской академии наук (ИНХС РАН) | Способ получения полиакриламидного гидрогеля |
EP4163617A1 (en) * | 2012-08-09 | 2023-04-12 | The Board of Trustees of the Leland Stanford Junior University | Methods and compositions for preparing biological specimens for microscopic analysis |
RU2545806C1 (ru) * | 2013-12-26 | 2015-04-10 | Международная коммерческая компания "НЬЮКРОСС ВЕНТУРЕС ЛТД" | Материал медицинского назначения "матрексин" на основе полиакриламидного гидрогеля и способ его получения (варианты) |
CN106133808A (zh) * | 2014-03-24 | 2016-11-16 | 富士胶片株式会社 | 生物体器官模型用水性凝胶组合物及生物体器官模型 |
CA2947898A1 (en) | 2014-05-30 | 2015-12-03 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and devices for imaging large intact tissue samples |
AU2016364917A1 (en) * | 2015-12-02 | 2018-06-21 | Clearlight Diagnostics Llc | Methods for preparing and analyzing tumor tissue samples for detection and monitoring of cancers |
US11254974B2 (en) | 2016-02-10 | 2022-02-22 | The Board Of Trustees Of The Leland Stanford Junior University | RNA fixation and detection in clarity-based hydrogel tissue |
RU2633490C1 (ru) * | 2016-11-23 | 2017-10-12 | Общество с ограниченной ответственностью "Медицина 3Д" | Материал для замещения дефектов мягких тканей |
PL241064B1 (pl) | 2018-10-01 | 2022-08-01 | Dolniak Blazej | Sposób wytwarzania lepko-sprężystego żelu uzupełniającego maź stawową i lepko-sprężysty żel uzupełniający maź stawową |
WO2023239695A1 (en) * | 2022-06-06 | 2023-12-14 | Phrixionls, Llc | Prophylaxis and treatment of degraded cartilage |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1981001290A1 (en) | 1979-11-06 | 1981-05-14 | Ki Med I | Polyacrylamide gel for medical and biological application and method of its preparation |
UA10911C2 (uk) * | 1994-08-10 | 1996-12-25 | Мале Впроваджувальне Підприємство "Іhтерфалл" | Біосумісhий гідрогель |
RU2088234C1 (ru) | 1994-11-25 | 1997-08-27 | Институт высокомолекулярных соединений РАН | Водорастворимая бактерицидная композиция и способ ее получения |
US5658329A (en) * | 1995-02-14 | 1997-08-19 | Mentor Corporation | Filling material for soft tissue implant prostheses and implants made therewith |
US5941909A (en) * | 1995-02-14 | 1999-08-24 | Mentor Corporation | Filling material for soft tissue implant prostheses and implants made therewith |
RU2127095C1 (ru) * | 1996-05-28 | 1999-03-10 | Владислав Викторович Лопатин | Эндопротез молочной железы |
RU2127129C1 (ru) * | 1996-05-28 | 1999-03-10 | Владислав Викторович Лопатин | Способ получения гелеобразного материала для пластики мягких тканей |
RU2146127C1 (ru) * | 1996-08-07 | 2000-03-10 | Закрытое акционерное общество "Агрофарм-Питер-Сиб" | Мазь для лечения инфицированных ран |
BG102375A (en) * | 1997-08-26 | 1999-11-30 | Пегас Оод | Inoculation biocompatible hydrophilic gel, method for its preparation and application |
WO2001049336A1 (en) * | 1999-12-29 | 2001-07-12 | Progen S.R.L. | Biocompatible hydrogel and method of its production |
-
2001
- 2001-09-28 AT AT01274505T patent/ATE381356T1/de active
- 2001-09-28 BR BRPI0117137-2A patent/BR0117137B1/pt not_active IP Right Cessation
- 2001-09-28 CN CNB018236650A patent/CN1257752C/zh not_active Expired - Fee Related
- 2001-09-28 RU RU2002102867/14A patent/RU2205034C1/ru not_active IP Right Cessation
- 2001-09-28 ES ES01274505T patent/ES2298195T3/es not_active Expired - Lifetime
- 2001-09-28 DK DK01274505T patent/DK1438976T3/da active
- 2001-09-28 US US10/490,969 patent/US7294348B2/en not_active Expired - Lifetime
- 2001-09-28 WO PCT/RU2001/000392 patent/WO2003026711A1/ru active IP Right Grant
- 2001-09-28 EP EP01274505A patent/EP1438976B1/en not_active Expired - Lifetime
- 2001-09-28 DE DE60132025T patent/DE60132025T2/de not_active Expired - Lifetime
- 2001-09-28 MX MXPA04002967A patent/MXPA04002967A/es active IP Right Grant
- 2001-09-28 CA CA2461821A patent/CA2461821C/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
DE60132025D1 (de) | 2008-01-31 |
RU2205034C1 (ru) | 2003-05-27 |
BR0117137B1 (pt) | 2014-01-28 |
CA2461821C (en) | 2011-03-15 |
ATE381356T1 (de) | 2008-01-15 |
CA2461821A1 (en) | 2004-04-03 |
ES2298195T3 (es) | 2008-05-16 |
CN1257752C (zh) | 2006-05-31 |
EP1438976B1 (en) | 2007-12-19 |
DE60132025T2 (de) | 2008-12-04 |
MXPA04002967A (es) | 2004-07-15 |
WO2003026711A1 (fr) | 2003-04-03 |
US20040241241A1 (en) | 2004-12-02 |
US7294348B2 (en) | 2007-11-13 |
CN1549732A (zh) | 2004-11-24 |
EP1438976A1 (en) | 2004-07-21 |
DK1438976T3 (da) | 2008-04-28 |
EP1438976A4 (en) | 2007-04-18 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0117137A (pt) | Hidrogel polifuncional biocompatìvel e método para a sua produção | |
NO20033846L (no) | Fremgangsmåte for kontrollert friradikalpolymerisering av akryl og salter derav samt de oppnådde lavpolydispersitetspolymerer og deresanvendelse | |
ATE469125T1 (de) | Unter verwendung von schwefelverbindungen in form von transfermitteln für die gesteuerte radikalische polymerisation von acrylsäure hergestellte polymere und deren verwendung | |
ATE298322T1 (de) | Ss'-bis-(alpha, alpha'-disubstituierte-alpha''- essigsäure)-trithio-carbonate und derivate davon als initiatoren, kettentransfer-verbindung, kettenabbruch-verbindung für kontrollierte radikalische polymerisationen sowie verfahren zu deren herstellung | |
MY136789A (en) | Metalloproteinase inhibitors | |
MXPA04000622A (es) | Pirazolilcarboxanilidas como funguicidas. | |
DE69313882T2 (de) | Wässriges Hochtemperaturpolymerisationsverfahren | |
TW200407339A (en) | Manufacture method of living radical polymers and the polymers | |
PL340695A1 (en) | Method of obtaining synthetic polymers of very low content of residual monomers, products obtained thereby and their application | |
CA2309279A1 (en) | Polymerization process with living characteristics and polymers made therefrom | |
WO2007003782A3 (fr) | Nouveaux agents de transfert fonctionnalises pour polymerisation radicalaire controlee raft, procedes raft mettant en œuvre de tels agents de transfert et polymeres susceptibles d'etre obtenus par de tels procedes | |
FR2861394B1 (fr) | Procede de preparation de polyalcoaxymines utilisables comme amorceurs pour la polymerisation radicalaire de (co)polymeres vivants polyfonctionnels | |
ATE255568T1 (de) | Isothiazolcarbonsäureamide | |
ATE397632T1 (de) | Gekoppelte styrolblockcopolymere und herstellungsverfahren dafür | |
GB0301014D0 (en) | Conjugation reactions | |
PL340693A1 (en) | Method of obtaining water-soluble or water-swellable polymers of very low content of residual monomers, products obtained thereby and their application | |
DK1795551T3 (da) | Polyorganosilylerede carboxylatmonomerer og polymerer samt fremgangsmåde til fremstilling deraf | |
DK0409410T3 (da) | Indenoindolforbindelser | |
BR0312348A (pt) | Processo para a preparação de copolìmeros em bloco e copolìmeros em bloco | |
DE59911415D1 (de) | Kationische polymerisate und ihre verwendung | |
DE69802331D1 (de) | Acrylsäure- oder Methacrylsäurederivate und von diesen erhaltenen Polymere | |
FI871242A (fi) | Komposition, som hindrar korrosion foerorsakad av industriella kylvatten. | |
MXPA04004453A (es) | Polimeros de injerto con cadenas laterales que comprenden n-vinilamidas ciclicas. | |
ATE327673T1 (de) | Substituierte propargylamine | |
WO2000044358A3 (de) | Verwendung von phosphororganischen verbindungen zur prophylaktischen und therapeutischen behandlung von infektionen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 28/01/2014, OBSERVADAS AS CONDICOES LEGAIS. |
|
B21F | Lapse acc. art. 78, item iv - on non-payment of the annual fees in time |
Free format text: REFERENTE A 15A ANUIDADE. |
|
B24J | Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12) |
Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2385 DE 20-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |