BR0116309A - Um método para descelularizar material estranho para produzir biopróteses - Google Patents
Um método para descelularizar material estranho para produzir bioprótesesInfo
- Publication number
- BR0116309A BR0116309A BR0116309-4A BR0116309A BR0116309A BR 0116309 A BR0116309 A BR 0116309A BR 0116309 A BR0116309 A BR 0116309A BR 0116309 A BR0116309 A BR 0116309A
- Authority
- BR
- Brazil
- Prior art keywords
- foreign material
- bioprostheses
- cells
- decellularize
- produce
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2415—Manufacturing methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3691—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Manufacturing & Machinery (AREA)
- General Chemical & Material Sciences (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
"UM MéTODO PARA DESCELULARIZAR MATERIAL ESTRANHO PARA PRODUZIR BLOPRóTESES". A presente invenção relata um método para descelularizar material alogênico ou xenogênico usando biodetergentes para a produção de biopróteses revestidas com células endógenas do receptor da prótese.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10064948A DE10064948C1 (de) | 2000-12-20 | 2000-12-20 | Verfahren zur Dezellularisierung von Fremdmaterial zur Herstellung von Bioprothesen und Vorrichtung zur Durchführung des Verfahrens |
PCT/DE2001/004616 WO2002049681A1 (de) | 2000-12-20 | 2001-12-05 | Verfahren zur dezellularisierung von fremdmaterial zur herstellung von bioprothesen |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0116309A true BR0116309A (pt) | 2003-09-30 |
Family
ID=7668930
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0116309-4A BR0116309A (pt) | 2000-12-20 | 2001-12-05 | Um método para descelularizar material estranho para produzir biopróteses |
Country Status (18)
Country | Link |
---|---|
US (2) | US20040052830A1 (pt) |
EP (1) | EP1343536B1 (pt) |
JP (1) | JP2004531291A (pt) |
KR (1) | KR100650223B1 (pt) |
CN (1) | CN1256987C (pt) |
AT (1) | ATE306284T1 (pt) |
AU (2) | AU1900802A (pt) |
BR (1) | BR0116309A (pt) |
CA (1) | CA2428880C (pt) |
DE (3) | DE10064948C1 (pt) |
DK (1) | DK1343536T3 (pt) |
ES (1) | ES2249385T3 (pt) |
IL (2) | IL155689A0 (pt) |
MX (1) | MXPA03005597A (pt) |
NZ (1) | NZ525626A (pt) |
RU (1) | RU2281120C2 (pt) |
WO (1) | WO2002049681A1 (pt) |
ZA (1) | ZA200303665B (pt) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
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DE10138564B4 (de) * | 2001-08-06 | 2007-07-12 | Lamm, Peter Wilhelm, Dr. | Verfahren zur Devitalisierung natürlicher Organe und/oder zur Bereitstellung extrazellulärer Matrices zum "Tissue-Engineering" |
US6761735B2 (en) * | 2002-04-25 | 2004-07-13 | Medtronic, Inc. | Heart valve fixation process and apparatus |
JP4092397B2 (ja) * | 2002-09-10 | 2008-05-28 | 国立循環器病センター総長 | 超高静水圧印加による移植用生体組織の処理方法 |
DE10258121B3 (de) * | 2002-12-06 | 2004-03-18 | Auto Tissue Gmbh | Verfahren zur Herstellung von Bioprothesen |
JP4444918B2 (ja) * | 2003-05-15 | 2010-03-31 | 学校法人早稲田大学 | 脱細胞化方法及び生体組織処理装置 |
DE102004047247B3 (de) * | 2004-09-22 | 2006-03-16 | Auto Tissue Gmbh | Sterilisationsverfahren zur Herstellung von implantierbarem oder transplantierbarem biologischem Material |
US20070010897A1 (en) * | 2005-01-06 | 2007-01-11 | Stone Kevin R | Immunochemically modified and sterilized xenografts and allografts |
DE102005023599A1 (de) * | 2005-05-18 | 2006-11-23 | Corlife Gbr (Vertretungsberechtigte Gesellschafter: Prof. Dr. Alex Haverich | Bioartifizielles Herzgewebetransplantat und Verfahren zu seiner Herstellung |
US20100093066A1 (en) * | 2005-08-26 | 2010-04-15 | Regents Of The University Of Minnesota | Decellularization and recellularization apparatuses and systems containing the same |
CA2618731C (en) | 2005-08-26 | 2021-12-28 | Regents Of The University Of Minnesota | Decellularization and recellularization of organs and tissues |
CN100372511C (zh) * | 2005-11-30 | 2008-03-05 | 烟台正海生物技术有限公司 | 一种脱细胞真皮基质 |
US20080195230A1 (en) * | 2007-02-09 | 2008-08-14 | Quijano Rodolfo C | Pericardial tissue sheet |
US20080195229A1 (en) * | 2007-02-09 | 2008-08-14 | Quijano Rodolfo C | Decellularized pericardial tissue |
CA2684012A1 (en) * | 2007-04-16 | 2008-10-23 | Tissue Science Laboratories Plc | Vascular implant |
US20100191346A1 (en) * | 2007-04-16 | 2010-07-29 | Stephen Bloor | Bone implant |
US20090163990A1 (en) * | 2007-12-19 | 2009-06-25 | Chunlin Yang | Decellularized omentum matrix and uses thereof |
KR101005610B1 (ko) * | 2008-07-08 | 2011-01-10 | 이한출 | 태양열을 이용한 축열탱크 |
US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
US8435305B2 (en) | 2010-08-31 | 2013-05-07 | Zimmer, Inc. | Osteochondral graft delivery device and uses thereof |
RU2611361C2 (ru) | 2010-09-01 | 2017-02-21 | Риджентс Оф Дзе Юниверсити Оф Миннесота | Способы рецеллюляризации ткани или органа для улучшения приживления трансплантата |
US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
US9290738B2 (en) | 2012-06-13 | 2016-03-22 | Miromatrix Medical Inc. | Methods of decellularizing bone |
ES2831756T3 (es) | 2013-03-15 | 2021-06-09 | Miromatrix Medical Inc | Uso de hígado descelularizado por perfusión para la recelularización de células de islotes |
US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
EP3027235A1 (en) | 2013-07-30 | 2016-06-08 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
EP2832379B1 (de) * | 2013-07-31 | 2015-07-22 | Biotronik AG | Verfahren zur Aufbereitung von biologischem Gewebe |
US10537662B2 (en) | 2013-07-31 | 2020-01-21 | Biotronik Ag | Method for preparing biological tissue |
EP2918294A1 (de) * | 2014-03-11 | 2015-09-16 | Bayer Technology Services GmbH | Vorrichtung und Verfahren zur kontinuierlichen Virusinaktivierung |
US10293082B2 (en) | 2014-07-23 | 2019-05-21 | Clemson University Research Foundation | Decellularization method and system and decellularized tissue formed thereby |
US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
CN105169481B (zh) * | 2015-09-29 | 2018-05-18 | 陕西瑞盛生物科技有限公司 | 一种生物材料的脱细胞方法 |
JP7002451B2 (ja) | 2015-12-15 | 2022-01-20 | ニオバスク ティアラ インコーポレイテッド | 経中隔送達システム |
WO2017127939A1 (en) | 2016-01-29 | 2017-08-03 | Neovasc Tiara Inc. | Prosthetic valve for avoiding obstruction of outflow |
CN105770991B (zh) * | 2016-03-03 | 2018-09-25 | 曾祥军 | 生物源性静脉瓣膜的制备方法 |
US11634448B2 (en) | 2016-06-15 | 2023-04-25 | The General Hospital Corporation | Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions |
US11278643B2 (en) | 2016-09-06 | 2022-03-22 | Mayo Foundation For Medical Education And Research | Use of resected liver serum for whole liver-engineering |
CN113893064A (zh) | 2016-11-21 | 2022-01-07 | 内奥瓦斯克迪亚拉公司 | 用于快速收回经导管心脏瓣膜递送系统的方法和系统 |
RU2671476C2 (ru) * | 2016-12-28 | 2018-10-31 | Федеральное государственное бюджетное учреждение "Государственный научный центр Российской Федерации - Федеральный Медицинский биофизический центр имени А.И. Бурназяна Федерального Медико-биологического агентства" (ФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА России) | Устройство для двухсторонней децеллюляризации сосудистых графтов различного диаметра и способ оптимизации его работы (варианты) |
US10856984B2 (en) | 2017-08-25 | 2020-12-08 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
CN113271890B (zh) | 2018-11-08 | 2024-08-30 | 内奥瓦斯克迪亚拉公司 | 经导管二尖瓣假体的心室展开 |
AU2020233892A1 (en) | 2019-03-08 | 2021-11-04 | Neovasc Tiara Inc. | Retrievable prosthesis delivery system |
WO2020206012A1 (en) | 2019-04-01 | 2020-10-08 | Neovasc Tiara Inc. | Controllably deployable prosthetic valve |
WO2020210652A1 (en) | 2019-04-10 | 2020-10-15 | Neovasc Tiara Inc. | Prosthetic valve with natural blood flow |
CN114025813B (zh) | 2019-05-20 | 2024-05-14 | 内奥瓦斯克迪亚拉公司 | 具有止血机构的引入器 |
WO2020257643A1 (en) | 2019-06-20 | 2020-12-24 | Neovasc Tiara Inc. | Low profile prosthetic mitral valve |
JP2023527435A (ja) * | 2020-05-29 | 2023-06-28 | ロキット ヘルスケア インク. | 網膜を利用した腎臓治療用組成物、それを含む腎臓治療用医療キット、及び、その硬化物を含む腎臓治療用フィルム |
US11998662B1 (en) | 2021-06-09 | 2024-06-04 | Reprise Biomedical, Inc. | Biologic matrix for a wound site and related methods |
WO2023137037A1 (en) * | 2022-01-12 | 2023-07-20 | Lifenet Health | System and process for decellularizing blood vessels |
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US6376244B1 (en) * | 1999-12-29 | 2002-04-23 | Children's Medical Center Corporation | Methods and compositions for organ decellularization |
JP4444918B2 (ja) * | 2003-05-15 | 2010-03-31 | 学校法人早稲田大学 | 脱細胞化方法及び生体組織処理装置 |
-
2000
- 2000-12-20 DE DE10064948A patent/DE10064948C1/de not_active Expired - Fee Related
-
2001
- 2001-12-05 CN CNB018199518A patent/CN1256987C/zh not_active Expired - Fee Related
- 2001-12-05 CA CA002428880A patent/CA2428880C/en not_active Expired - Fee Related
- 2001-12-05 JP JP2002551018A patent/JP2004531291A/ja active Pending
- 2001-12-05 DE DE50107710T patent/DE50107710D1/de not_active Expired - Lifetime
- 2001-12-05 DE DE10195474T patent/DE10195474D2/de not_active Expired - Fee Related
- 2001-12-05 WO PCT/DE2001/004616 patent/WO2002049681A1/de active IP Right Grant
- 2001-12-05 EP EP01271089A patent/EP1343536B1/de not_active Expired - Lifetime
- 2001-12-05 AU AU1900802A patent/AU1900802A/xx active Pending
- 2001-12-05 BR BR0116309-4A patent/BR0116309A/pt not_active Application Discontinuation
- 2001-12-05 DK DK01271089T patent/DK1343536T3/da active
- 2001-12-05 US US10/416,697 patent/US20040052830A1/en not_active Abandoned
- 2001-12-05 MX MXPA03005597A patent/MXPA03005597A/es active IP Right Grant
- 2001-12-05 RU RU2003122519/15A patent/RU2281120C2/ru not_active IP Right Cessation
- 2001-12-05 AT AT01271089T patent/ATE306284T1/de not_active IP Right Cessation
- 2001-12-05 KR KR1020037007296A patent/KR100650223B1/ko not_active IP Right Cessation
- 2001-12-05 IL IL15568901A patent/IL155689A0/xx unknown
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- 2001-12-05 AU AU2002219008A patent/AU2002219008B2/en not_active Ceased
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2003
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Also Published As
Publication number | Publication date |
---|---|
DE50107710D1 (de) | 2006-02-23 |
IL155689A (en) | 2008-11-03 |
KR100650223B1 (ko) | 2006-11-27 |
DE10064948C1 (de) | 2002-07-11 |
US7824609B2 (en) | 2010-11-02 |
CA2428880A1 (en) | 2002-06-27 |
CN1535164A (zh) | 2004-10-06 |
KR20030070042A (ko) | 2003-08-27 |
NZ525626A (en) | 2005-04-29 |
EP1343536B1 (de) | 2005-10-12 |
WO2002049681A1 (de) | 2002-06-27 |
JP2004531291A (ja) | 2004-10-14 |
MXPA03005597A (es) | 2004-10-15 |
US20040052830A1 (en) | 2004-03-18 |
EP1343536A1 (de) | 2003-09-17 |
CA2428880C (en) | 2006-12-19 |
CN1256987C (zh) | 2006-05-24 |
RU2003122519A (ru) | 2005-01-10 |
AU1900802A (en) | 2002-07-01 |
DK1343536T3 (da) | 2006-02-27 |
RU2281120C2 (ru) | 2006-08-10 |
ZA200303665B (en) | 2004-01-22 |
ES2249385T3 (es) | 2006-04-01 |
US20080095662A1 (en) | 2008-04-24 |
IL155689A0 (en) | 2003-11-23 |
DE10195474D2 (de) | 2004-04-15 |
ATE306284T1 (de) | 2005-10-15 |
AU2002219008B2 (en) | 2005-07-07 |
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