BR0116309A - Um método para descelularizar material estranho para produzir biopróteses - Google Patents

Um método para descelularizar material estranho para produzir biopróteses

Info

Publication number
BR0116309A
BR0116309A BR0116309-4A BR0116309A BR0116309A BR 0116309 A BR0116309 A BR 0116309A BR 0116309 A BR0116309 A BR 0116309A BR 0116309 A BR0116309 A BR 0116309A
Authority
BR
Brazil
Prior art keywords
foreign material
bioprostheses
cells
decellularize
produce
Prior art date
Application number
BR0116309-4A
Other languages
English (en)
Inventor
Wolfgang Konertz
Pascal Dohmen
Original Assignee
Auto Tissue Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Auto Tissue Gmbh filed Critical Auto Tissue Gmbh
Publication of BR0116309A publication Critical patent/BR0116309A/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/24Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2415Manufacturing methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088Liquid substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/40Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)

Abstract

"UM MéTODO PARA DESCELULARIZAR MATERIAL ESTRANHO PARA PRODUZIR BLOPRóTESES". A presente invenção relata um método para descelularizar material alogênico ou xenogênico usando biodetergentes para a produção de biopróteses revestidas com células endógenas do receptor da prótese.
BR0116309-4A 2000-12-20 2001-12-05 Um método para descelularizar material estranho para produzir biopróteses BR0116309A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10064948A DE10064948C1 (de) 2000-12-20 2000-12-20 Verfahren zur Dezellularisierung von Fremdmaterial zur Herstellung von Bioprothesen und Vorrichtung zur Durchführung des Verfahrens
PCT/DE2001/004616 WO2002049681A1 (de) 2000-12-20 2001-12-05 Verfahren zur dezellularisierung von fremdmaterial zur herstellung von bioprothesen

Publications (1)

Publication Number Publication Date
BR0116309A true BR0116309A (pt) 2003-09-30

Family

ID=7668930

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0116309-4A BR0116309A (pt) 2000-12-20 2001-12-05 Um método para descelularizar material estranho para produzir biopróteses

Country Status (18)

Country Link
US (2) US20040052830A1 (pt)
EP (1) EP1343536B1 (pt)
JP (1) JP2004531291A (pt)
KR (1) KR100650223B1 (pt)
CN (1) CN1256987C (pt)
AT (1) ATE306284T1 (pt)
AU (2) AU1900802A (pt)
BR (1) BR0116309A (pt)
CA (1) CA2428880C (pt)
DE (3) DE10064948C1 (pt)
DK (1) DK1343536T3 (pt)
ES (1) ES2249385T3 (pt)
IL (2) IL155689A0 (pt)
MX (1) MXPA03005597A (pt)
NZ (1) NZ525626A (pt)
RU (1) RU2281120C2 (pt)
WO (1) WO2002049681A1 (pt)
ZA (1) ZA200303665B (pt)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10138564B4 (de) * 2001-08-06 2007-07-12 Lamm, Peter Wilhelm, Dr. Verfahren zur Devitalisierung natürlicher Organe und/oder zur Bereitstellung extrazellulärer Matrices zum "Tissue-Engineering"
US6761735B2 (en) * 2002-04-25 2004-07-13 Medtronic, Inc. Heart valve fixation process and apparatus
JP4092397B2 (ja) 2002-09-10 2008-05-28 国立循環器病センター総長 超高静水圧印加による移植用生体組織の処理方法
DE10258121B3 (de) * 2002-12-06 2004-03-18 Auto Tissue Gmbh Verfahren zur Herstellung von Bioprothesen
EP1625832B1 (en) * 2003-05-15 2011-09-21 Waseda University Method of removing cell
DE102004047247B3 (de) * 2004-09-22 2006-03-16 Auto Tissue Gmbh Sterilisationsverfahren zur Herstellung von implantierbarem oder transplantierbarem biologischem Material
US20070010897A1 (en) * 2005-01-06 2007-01-11 Stone Kevin R Immunochemically modified and sterilized xenografts and allografts
DE102005023599A1 (de) * 2005-05-18 2006-11-23 Corlife Gbr (Vertretungsberechtigte Gesellschafter: Prof. Dr. Alex Haverich Bioartifizielles Herzgewebetransplantat und Verfahren zu seiner Herstellung
US8470520B2 (en) 2005-08-26 2013-06-25 Regents Of The University Of Minnesota Decellularization and recellularization of organs and tissues
US20100093066A1 (en) * 2005-08-26 2010-04-15 Regents Of The University Of Minnesota Decellularization and recellularization apparatuses and systems containing the same
CN100372511C (zh) * 2005-11-30 2008-03-05 烟台正海生物技术有限公司 一种脱细胞真皮基质
US20080195230A1 (en) * 2007-02-09 2008-08-14 Quijano Rodolfo C Pericardial tissue sheet
US20080195229A1 (en) * 2007-02-09 2008-08-14 Quijano Rodolfo C Decellularized pericardial tissue
US20100179639A1 (en) * 2007-04-16 2010-07-15 Stephen Bloor Vascular implant
EP2178576A2 (en) * 2007-04-16 2010-04-28 Tissue Science Laboratories PLC Bone implant
US20090163990A1 (en) * 2007-12-19 2009-06-25 Chunlin Yang Decellularized omentum matrix and uses thereof
KR101005610B1 (ko) * 2008-07-08 2011-01-10 이한출 태양열을 이용한 축열탱크
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
US8435305B2 (en) 2010-08-31 2013-05-07 Zimmer, Inc. Osteochondral graft delivery device and uses thereof
US10233420B2 (en) 2010-09-01 2019-03-19 Regents Of The University Of Minnesota Methods of recellularizing a tissue or organ for improved transplantability
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9290738B2 (en) 2012-06-13 2016-03-22 Miromatrix Medical Inc. Methods of decellularizing bone
SG11201507620VA (en) 2013-03-15 2015-10-29 Miromatrix Medical Inc Use of perfusion decellularized liver for islet cell recellularization
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
MX2016001247A (es) 2013-07-30 2016-08-17 Musculoskeletal Transplant Foundation Matrices derivadas de tejido suave acelular y metodos para preparar las mismas.
EP2832379B1 (de) * 2013-07-31 2015-07-22 Biotronik AG Verfahren zur Aufbereitung von biologischem Gewebe
US10537662B2 (en) 2013-07-31 2020-01-21 Biotronik Ag Method for preparing biological tissue
EP2918294A1 (de) * 2014-03-11 2015-09-16 Bayer Technology Services GmbH Vorrichtung und Verfahren zur kontinuierlichen Virusinaktivierung
US10293082B2 (en) 2014-07-23 2019-05-21 Clemson University Research Foundation Decellularization method and system and decellularized tissue formed thereby
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
CN105169481B (zh) * 2015-09-29 2018-05-18 陕西瑞盛生物科技有限公司 一种生物材料的脱细胞方法
CN108601645B (zh) 2015-12-15 2021-02-26 内奥瓦斯克迪亚拉公司 经中隔递送系统
EP4183372A1 (en) 2016-01-29 2023-05-24 Neovasc Tiara Inc. Prosthetic valve for avoiding obstruction of outflow
CN105770991B (zh) * 2016-03-03 2018-09-25 曾祥军 生物源性静脉瓣膜的制备方法
AU2017286715B2 (en) 2016-06-15 2022-03-03 The General Hospital Corporation Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions
WO2018048899A1 (en) 2016-09-06 2018-03-15 Micromatrix Medical Inc. Use of resected liver serum for whole liver engineering
EP3541462A4 (en) 2016-11-21 2020-06-17 Neovasc Tiara Inc. METHODS AND SYSTEMS FOR RAPID RETRACTION OF A TRANSCATHETER HEART VALVE DELIVERY SYSTEM
RU2671476C2 (ru) * 2016-12-28 2018-10-31 Федеральное государственное бюджетное учреждение "Государственный научный центр Российской Федерации - Федеральный Медицинский биофизический центр имени А.И. Бурназяна Федерального Медико-биологического агентства" (ФГБУ ГНЦ ФМБЦ им. А.И. Бурназяна ФМБА России) Устройство для двухсторонней децеллюляризации сосудистых графтов различного диаметра и способ оптимизации его работы (варианты)
US10856984B2 (en) 2017-08-25 2020-12-08 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
AU2019374743B2 (en) 2018-11-08 2022-03-03 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
CA3132873A1 (en) 2019-03-08 2020-09-17 Neovasc Tiara Inc. Retrievable prosthesis delivery system
CN113811265A (zh) 2019-04-01 2021-12-17 内奥瓦斯克迪亚拉公司 能够以可控的方式部署的假体瓣膜
AU2020271896B2 (en) 2019-04-10 2022-10-13 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
WO2020236931A1 (en) 2019-05-20 2020-11-26 Neovasc Tiara Inc. Introducer with hemostasis mechanism
WO2020257643A1 (en) 2019-06-20 2020-12-24 Neovasc Tiara Inc. Low profile prosthetic mitral valve
KR102311441B1 (ko) * 2020-05-29 2021-10-13 주식회사 로킷헬스케어 그물막을 이용한 신장 치료용 조성물, 이를 포함하는 신장 치료용 의료 키트, 및 이의 경화물을 포함하는 신장 치료용 필름
US11998662B1 (en) 2021-06-09 2024-06-04 Reprise Biomedical, Inc. Biologic matrix for a wound site and related methods
WO2023137037A1 (en) * 2022-01-12 2023-07-20 Lifenet Health System and process for decellularizing blood vessels

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4315919A (en) * 1980-10-06 1982-02-16 Edward Shanbrom Depyrogenation process
FR2523810B1 (fr) * 1982-03-23 1988-11-25 Carpentier Alain Tissu biologique greffable et procede pour sa preparation
JPS60500014A (ja) * 1982-11-12 1985-01-10 バツクスター トラベノル ラボラトリーズ インコーポレーテツド 移殖できる生物学的組織の化学滅菌
US4801299A (en) * 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US4782015A (en) * 1984-03-30 1988-11-01 Syntex (U.S.A.) Inc. Method for determining the presence of malignant cells
US4546642A (en) * 1984-08-17 1985-10-15 Dynatek, Inc. Accelerated heart valve testing apparatus and methods
US5298222A (en) * 1989-08-09 1994-03-29 Osteotech, Inc. Process for disinfecting musculoskeletal tissue and tissues prepared thereby
JPH0653160B2 (ja) * 1989-08-18 1994-07-20 呉羽化学工業株式会社 拍動発生方法及び装置
US5336616A (en) * 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
US5308763A (en) * 1991-10-01 1994-05-03 The Johns Hopkins University Method of making primary culture of olfactory neurons
FR2699408B1 (fr) * 1992-12-21 1995-03-24 Bioland Procédé de traitement de tissus osseux et biomatériaux implantables correspondants.
JPH09510108A (ja) * 1994-03-14 1997-10-14 クリオライフ,インコーポレイティド 移植用処理組織及び調製方法
US5558875A (en) * 1994-06-06 1996-09-24 Wang; Su Method of preparing collagenous tissue
EP0821573A4 (en) * 1995-04-19 2000-08-09 St Jude Medical SUBSTRATE MATRICE FOR A PROSTHESIS CONSISTING OF BIOLOGICAL LIVING TISSUE AND METHOD FOR PRODUCING THIS MATRICE
US5846828A (en) * 1995-06-07 1998-12-08 Advanced Tissue Sciences Apparatus and method for sterilizing, seeding, culturing, storing, shipping, and testing tissue, synthetic, or mechanical heart valves orvalve segments
IT1282207B1 (it) * 1995-11-20 1998-03-16 Fidia Advanced Biopolymers Srl Sistemi di coltura di cellule staminali di midollo osseo umano in matrici tridimensionali costituiti da esteri dell'acido ialuronico
US6258527B1 (en) * 1996-05-20 2001-07-10 The Aaron Diamond Aids Research Center Methods of identifying g-coupled receptors associated with macrophage-trophic HIV, and diagnostic and therapeutic uses thereof
US5993844A (en) * 1997-05-08 1999-11-30 Organogenesis, Inc. Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix
DE19828726A1 (de) * 1997-06-27 1999-01-07 Augustinus Dr Bader Bioartifizielles Transplantat und Verfahren zu seiner Herstellung
US6482584B1 (en) * 1998-11-13 2002-11-19 Regeneration Technologies, Inc. Cyclic implant perfusion cleaning and passivation process
CA2307743A1 (en) * 1997-10-30 1999-05-14 The General Hospital Corporation Bonding of cartilaginous matrices using isolated chondrocytes
US6371992B1 (en) * 1997-12-19 2002-04-16 The Regents Of The University Of California Acellular matrix grafts: preparation and use
JP2000198998A (ja) 1998-12-28 2000-07-18 Lion Corp 殺菌洗浄料
US6534095B1 (en) * 1999-09-03 2003-03-18 Lifenet Pulsatile acidification wave demineralization process for producing osteoinductive bone; and osteoinductive bone produced thereby
US6376244B1 (en) * 1999-12-29 2002-04-23 Children's Medical Center Corporation Methods and compositions for organ decellularization
EP1625832B1 (en) * 2003-05-15 2011-09-21 Waseda University Method of removing cell

Also Published As

Publication number Publication date
EP1343536B1 (de) 2005-10-12
MXPA03005597A (es) 2004-10-15
KR100650223B1 (ko) 2006-11-27
ES2249385T3 (es) 2006-04-01
DK1343536T3 (da) 2006-02-27
CN1535164A (zh) 2004-10-06
RU2003122519A (ru) 2005-01-10
ZA200303665B (en) 2004-01-22
US20040052830A1 (en) 2004-03-18
AU2002219008B2 (en) 2005-07-07
CN1256987C (zh) 2006-05-24
CA2428880C (en) 2006-12-19
WO2002049681A1 (de) 2002-06-27
AU1900802A (en) 2002-07-01
IL155689A (en) 2008-11-03
US20080095662A1 (en) 2008-04-24
US7824609B2 (en) 2010-11-02
DE50107710D1 (de) 2006-02-23
IL155689A0 (en) 2003-11-23
EP1343536A1 (de) 2003-09-17
DE10064948C1 (de) 2002-07-11
NZ525626A (en) 2005-04-29
CA2428880A1 (en) 2002-06-27
RU2281120C2 (ru) 2006-08-10
ATE306284T1 (de) 2005-10-15
JP2004531291A (ja) 2004-10-14
DE10195474D2 (de) 2004-04-15
KR20030070042A (ko) 2003-08-27

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