BR0115434A - Uso de agonistas de 5-ht1a e inibidores de recaptação de sertonina seletivos combinados - Google Patents
Uso de agonistas de 5-ht1a e inibidores de recaptação de sertonina seletivos combinadosInfo
- Publication number
- BR0115434A BR0115434A BR0115434-6A BR0115434A BR0115434A BR 0115434 A BR0115434 A BR 0115434A BR 0115434 A BR0115434 A BR 0115434A BR 0115434 A BR0115434 A BR 0115434A
- Authority
- BR
- Brazil
- Prior art keywords
- treatment
- reuptake inhibitors
- combined
- sertonin
- agonists
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 239000000556 agonist Substances 0.000 title abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 6
- 208000004454 Hyperalgesia Diseases 0.000 abstract 2
- 208000002193 Pain Diseases 0.000 abstract 2
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- BPSWBRVXRVOQSP-UHFFFAOYSA-N 3-[4-[4-(4-cyanophenyl)piperazin-1-yl]butyl]-1h-indole-5-carbonitrile Chemical compound C1=CC(C#N)=CC=C1N1CCN(CCCCC=2C3=CC(=CC=C3NC=2)C#N)CC1 BPSWBRVXRVOQSP-UHFFFAOYSA-N 0.000 abstract 1
- 102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 abstract 1
- 101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 abstract 1
- 208000000094 Chronic Pain Diseases 0.000 abstract 1
- 208000035154 Hyperesthesia Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 206010053552 allodynia Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000009610 hypersensitivity Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- 230000037324 pain perception Effects 0.000 abstract 1
- 239000000018 receptor agonist Substances 0.000 abstract 1
- 229940044601 receptor agonist Drugs 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
- SGEGOXDYSFKCPT-UHFFFAOYSA-N vilazodone Chemical compound C1=C(C#N)C=C2C(CCCCN3CCN(CC3)C=3C=C4C=C(OC4=CC=3)C(=O)N)=CNC2=C1 SGEGOXDYSFKCPT-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"USO DE AGONISTAS DE 5-HT~ 1A~ E INIBIDORES DE RECAPTAçãO DE SERTONINA SELETIVOS COMBINADOS". A presente invenção refere-se ao uso de compostos, inibidores de recaptação de serotonina (5-HT) seletivos (SSRIs) e agonistas de receptor de 5-HT~ 1A~ sendo combinados, em particular de 1-[4-(5-cianoindol-3-il)butil]-4-(2-carbamoil-benzofuran-5-il)-piperazina ou um seu sal fisiologicamente aceitável ou 3-{4-[4-(4-ciano-fenil)-piperazin-l-il]-butil}-1H-indol-5-carbonitrila ou um seu sal fisiologicamente aceitável, para a fabricação de um medicamento para o tratamento de distúrbios de dor crónica ou no tratamento de outras condições onde há hipersensibilização a sinais dolorosos, hiperalgesia, alodinia, percepção de dor aumentada, e memória aumentada de dor, bem como para o tratamento de síndrome de intestino irritável (IBS).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00125409 | 2000-11-20 | ||
| PCT/EP2001/012686 WO2002039989A1 (en) | 2000-11-20 | 2001-11-02 | Novel use of combined 5-ht1a agonists and selective serotonin reuptake inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0115434A true BR0115434A (pt) | 2003-10-07 |
Family
ID=8170432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0115434-6A BR0115434A (pt) | 2000-11-20 | 2001-11-02 | Uso de agonistas de 5-ht1a e inibidores de recaptação de sertonina seletivos combinados |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7479492B2 (pt) |
| EP (1) | EP1335716A1 (pt) |
| JP (1) | JP2004513916A (pt) |
| KR (1) | KR20030048477A (pt) |
| CN (1) | CN1541093A (pt) |
| AR (1) | AR031463A1 (pt) |
| AU (2) | AU2180302A (pt) |
| BR (1) | BR0115434A (pt) |
| CA (1) | CA2429216C (pt) |
| CZ (1) | CZ20031448A3 (pt) |
| HU (1) | HUP0400504A3 (pt) |
| MX (1) | MXPA03004341A (pt) |
| NO (1) | NO20032248D0 (pt) |
| PL (1) | PL361617A1 (pt) |
| RU (1) | RU2302243C2 (pt) |
| SK (1) | SK6442003A3 (pt) |
| UA (1) | UA76130C2 (pt) |
| WO (1) | WO2002039989A1 (pt) |
| ZA (1) | ZA200304757B (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10326939A1 (de) * | 2003-06-16 | 2005-01-05 | Merck Patent Gmbh | Indol-Derivate |
| WO2005094896A2 (en) * | 2004-03-26 | 2005-10-13 | Baylor University | Targeted serotonin reuptake inhibitors |
| WO2006006152A2 (en) * | 2004-07-08 | 2006-01-19 | Ramot At Tel-Aviv University Ltd | Treatment of disorders and diseases of the colon |
| US7994331B2 (en) | 2005-07-13 | 2011-08-09 | Msd K.K. | Heterocycle-substituted benzimidazole derivative |
| PL2044043T5 (pl) | 2006-06-16 | 2022-05-02 | H. Lundbeck A/S | Bromowodorek 1-[2-(2,4-dimetylofenylosulfanylo)fenylo]piperazyny jako związek o połączonym działaniu wychwytu zwrotnego serotoniny i działaniu na 5-ht3 i 5-ht1a do leczenia upośledzenia funckji poznawczych |
| TW200848411A (en) * | 2007-03-20 | 2008-12-16 | Lundbeck & Co As H | Novel therapeutic uses of 1-[2-(2, 4-dimethylphenylsulfanyl)phenyl]-piperazine |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2222768B (en) | 1988-06-17 | 1992-01-22 | Nat Res Dev | Analgesic compounds and compositions |
| US5589511A (en) * | 1990-08-13 | 1996-12-31 | Sepracor Inc. | Method for treating migraine headaches using optically pure S(+) fluoxetine |
| US5578612A (en) | 1990-10-15 | 1996-11-26 | Pfizer Inc. | Indole derivatives |
| US5434174A (en) | 1992-07-17 | 1995-07-18 | Eli Lilly And Company | Isoxazole derivatives for the treatment of irritable bowel syndrome |
| DE4333254A1 (de) * | 1993-09-30 | 1995-04-06 | Merck Patent Gmbh | Piperidine und Piperazine |
| US5576321A (en) | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| DE19512639A1 (de) * | 1995-04-05 | 1996-10-10 | Merck Patent Gmbh | Benzonitrile und -fluoride |
| US5912256A (en) * | 1996-06-20 | 1999-06-15 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| UA56185C2 (uk) | 1996-09-30 | 2003-05-15 | Пфайзер Інк. | Аралкіл- та аралкіліденгетероциклічні лактами та іміди, фармацевтична композиція та спосіб лікування |
| GB9911863D0 (en) | 1999-05-21 | 1999-07-21 | Knoll Ag | Therapeutic agents |
| TW518218B (en) * | 1999-05-27 | 2003-01-21 | Merck Patent Gmbh | Pharmaceutical compositions comprising 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine or its physiologically acceptable salts for use in the treatment of sub-type anxiety disorders |
-
2001
- 2001-02-11 UA UA2003065609A patent/UA76130C2/uk unknown
- 2001-11-02 HU HU0400504A patent/HUP0400504A3/hu unknown
- 2001-11-02 SK SK644-2003A patent/SK6442003A3/sk not_active Application Discontinuation
- 2001-11-02 PL PL36161701A patent/PL361617A1/xx not_active Application Discontinuation
- 2001-11-02 AU AU2180302A patent/AU2180302A/xx active Pending
- 2001-11-02 JP JP2002542364A patent/JP2004513916A/ja active Pending
- 2001-11-02 CA CA2429216A patent/CA2429216C/en not_active Expired - Fee Related
- 2001-11-02 EP EP01996368A patent/EP1335716A1/en not_active Ceased
- 2001-11-02 BR BR0115434-6A patent/BR0115434A/pt not_active Application Discontinuation
- 2001-11-02 MX MXPA03004341A patent/MXPA03004341A/es active IP Right Grant
- 2001-11-02 US US10/432,047 patent/US7479492B2/en not_active Expired - Lifetime
- 2001-11-02 AU AU2002221803A patent/AU2002221803B2/en not_active Ceased
- 2001-11-02 KR KR10-2003-7006755A patent/KR20030048477A/ko not_active Application Discontinuation
- 2001-11-02 RU RU2003116893/15A patent/RU2302243C2/ru not_active IP Right Cessation
- 2001-11-02 WO PCT/EP2001/012686 patent/WO2002039989A1/en not_active Application Discontinuation
- 2001-11-02 CZ CZ20031448A patent/CZ20031448A3/cs unknown
- 2001-11-02 CN CNA018191118A patent/CN1541093A/zh active Pending
- 2001-11-16 AR ARP010105360A patent/AR031463A1/es unknown
-
2003
- 2003-05-19 NO NO20032248A patent/NO20032248D0/no unknown
- 2003-06-19 ZA ZA200304757A patent/ZA200304757B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20032248L (no) | 2003-05-19 |
| ZA200304757B (en) | 2004-09-20 |
| RU2302243C2 (ru) | 2007-07-10 |
| CA2429216A1 (en) | 2002-05-23 |
| US7479492B2 (en) | 2009-01-20 |
| AU2002221803B2 (en) | 2007-02-15 |
| CA2429216C (en) | 2012-08-07 |
| CN1541093A (zh) | 2004-10-27 |
| NO20032248D0 (no) | 2003-05-19 |
| JP2004513916A (ja) | 2004-05-13 |
| UA76130C2 (en) | 2006-07-17 |
| MXPA03004341A (es) | 2003-08-19 |
| HUP0400504A3 (en) | 2006-02-28 |
| CZ20031448A3 (cs) | 2003-09-17 |
| HUP0400504A2 (hu) | 2004-06-28 |
| EP1335716A1 (en) | 2003-08-20 |
| US20040014771A1 (en) | 2004-01-22 |
| AR031463A1 (es) | 2003-09-24 |
| KR20030048477A (ko) | 2003-06-19 |
| SK6442003A3 (en) | 2003-09-11 |
| WO2002039989A1 (en) | 2002-05-23 |
| PL361617A1 (en) | 2004-10-04 |
| AU2180302A (en) | 2002-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: PARA:INT.CI. A61K 31/496, A61K 31/00, A61P 25/04, A61P 25/06, A61P 29/00, A61P 01/00 Ipc: A61K 31/00 (2006.01), A61K 31/496 (2006.01), A61P |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |