BR0109786A - Dispositivo e método para preparação de lâmina de citologia - Google Patents
Dispositivo e método para preparação de lâmina de citologiaInfo
- Publication number
- BR0109786A BR0109786A BR0109786-5A BR0109786A BR0109786A BR 0109786 A BR0109786 A BR 0109786A BR 0109786 A BR0109786 A BR 0109786A BR 0109786 A BR0109786 A BR 0109786A
- Authority
- BR
- Brazil
- Prior art keywords
- cytology
- preparation device
- slide preparation
- book
- sample
- Prior art date
Links
- 230000002745 absorbent Effects 0.000 abstract 1
- 239000002250 absorbent Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N1/312—Apparatus therefor for samples mounted on planar substrates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/921—Candida
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/921—Candida
- Y10S435/922—Candida albicans
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/921—Candida
- Y10S435/923—Candida lipolytica
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/921—Candida
- Y10S435/924—Candida tropicalis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/97—Test strip or test slide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/973—Simultaneous determination of more than one analyte
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/81—Tube, bottle, or dipstick
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
"DISPOSITIVO E MéTODO PARA PREPARAçãO DE LâMINA DE CITOLOGIA". Esta invenção fornece um novo dispositivo e método para preparar lâminas de citologia. O dispositivo compreende uma forma semelhante a livro incluindo um material absorvente (20) e filtro (22) fixado à superfície interna de uma tampa frontal (12) e uma lâmina de citologia (40) fixada de modo removível a uma superfície interna de uma tampa posterior (16). Uma amostra é removida do corpo de um paciente, colocada em uma solução à base de líquido, e em seguida sobre o filtro. Quando a forma semelhante a livro é fechada, a amostra é transferida de modo eficaz para a lâmina. O dispositivo pode ser modificado de modo que sejam preparadas uma série de lâminas ao mesmo tempo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/542,746 US6436662B1 (en) | 2000-04-04 | 2000-04-04 | Device and method for cytology slide preparation |
PCT/US2001/010968 WO2001075446A1 (en) | 2000-04-04 | 2001-04-04 | Device and method for cytology slide preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0109786A true BR0109786A (pt) | 2005-01-11 |
Family
ID=24165118
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0109786-5A BR0109786A (pt) | 2000-04-04 | 2001-04-04 | Dispositivo e método para preparação de lâmina de citologia |
Country Status (10)
Country | Link |
---|---|
US (3) | US6436662B1 (pt) |
EP (1) | EP1272848B1 (pt) |
JP (1) | JP2003529768A (pt) |
AT (1) | ATE369561T1 (pt) |
AU (2) | AU5314601A (pt) |
BR (1) | BR0109786A (pt) |
CA (1) | CA2402859A1 (pt) |
DE (1) | DE60129803T2 (pt) |
MX (1) | MXPA02009812A (pt) |
WO (1) | WO2001075446A1 (pt) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2313641A1 (en) * | 1997-12-12 | 1999-06-24 | Digene Corporation | Universal collection medium |
US6436662B1 (en) * | 2000-04-04 | 2002-08-20 | Digene Corporation | Device and method for cytology slide preparation |
US7601497B2 (en) * | 2000-06-15 | 2009-10-13 | Qiagen Gaithersburg, Inc. | Detection of nucleic acids by target-specific hybrid capture method |
US7439016B1 (en) * | 2000-06-15 | 2008-10-21 | Digene Corporation | Detection of nucleic acids by type-specific hybrid capture method |
US20020130074A1 (en) * | 2000-10-13 | 2002-09-19 | Domanik Richard A. | Optical analysis of cellular material |
WO2002072264A1 (en) * | 2001-03-09 | 2002-09-19 | Biomicro Systems, Inc. | Method and system for microfluidic interfacing to arrays |
US7105081B2 (en) * | 2002-12-20 | 2006-09-12 | Board Of Regents, The University Of Texas System | Methods and apparatus for electrosmear analysis |
US20040137551A1 (en) * | 2003-01-13 | 2004-07-15 | Markovic Nenad S. | Cervical acid phosphatase - papanicolaou (CAP-PAP) test kit, method and accesories, processes for producing and using the same |
US7435601B2 (en) * | 2003-02-19 | 2008-10-14 | Fitzco Incorporated | Biological specimen handling method |
US7588733B2 (en) * | 2003-12-04 | 2009-09-15 | Idexx Laboratories, Inc. | Retaining clip for reagent test slides |
US20060161076A1 (en) * | 2005-01-06 | 2006-07-20 | Diamics, Inc. | Systems and methods for collection of cell clusters |
US20060189893A1 (en) * | 2005-01-06 | 2006-08-24 | Diamics, Inc. | Systems and methods for detecting abnormal cells |
DE102005015005A1 (de) * | 2005-04-01 | 2006-10-05 | Qiagen Gmbh | Verfahren zur Behandlung einer Biomoleküle enthaltenden Probe |
US7678337B2 (en) * | 2005-04-26 | 2010-03-16 | Abbott Laboratories Inc. | Assembly for carrying and holding slides |
US20070009389A1 (en) * | 2005-07-08 | 2007-01-11 | Antti Seppo | Slide deposition chamber |
EP1915447A4 (en) * | 2005-08-19 | 2008-07-30 | Bioventures Inc | METHOD AND DEVICE FOR COLLECTING AND ISOLATING NUCLEIC ACIDS |
US7357042B2 (en) * | 2005-12-01 | 2008-04-15 | Cytyc Corporation | Filter contamination control device |
US8241593B2 (en) * | 2006-05-04 | 2012-08-14 | The Bode Technology Group, Inc. | Specimen tray |
JP2009536958A (ja) | 2006-05-11 | 2009-10-22 | ベクトン・ディキンソン・アンド・カンパニー | 細胞からのタンパク質抽出方法 |
US7758816B2 (en) * | 2007-03-01 | 2010-07-20 | Wescor Inc. | Large area cytocentrifuge sample chamber |
JP2008249565A (ja) * | 2007-03-30 | 2008-10-16 | Mie Univ | 細胞標本調製方法 |
US7951345B2 (en) * | 2007-06-01 | 2011-05-31 | Lary Research & Development, Llc | Useful specimen transport apparatus with integral capability to allow three dimensional x-ray images |
US7906317B2 (en) * | 2007-10-21 | 2011-03-15 | King Car Food Industrial Co., Ltd. | Apparatus for thin-layer cell smear preparation and in-situ hybridization |
US9207240B2 (en) | 2007-11-14 | 2015-12-08 | Arbor Vita Corporation | Method of efficient extraction of protein from cells |
JP2011518333A (ja) * | 2008-04-17 | 2011-06-23 | キアジェン ゲイサーズバーグ インコーポレイテッド | 標的核酸の存在を判別するための合成プローブを用いた組成物、方法、およびキット |
US8877436B2 (en) | 2008-10-27 | 2014-11-04 | Qiagen Gaithersburg, Inc. | Fast results hybrid capture assay on an automated platform |
US20100216147A1 (en) * | 2009-01-28 | 2010-08-26 | Qiagen Gaithersburg, Inc. | Sequence-specific large volume sample preparation method and assay |
CA2760542A1 (en) | 2009-05-01 | 2010-11-04 | Qiagen Gaithersburg, Inc. | A non-target amplification method for detection of rna splice-forms in a sample |
JP5826752B2 (ja) | 2009-09-14 | 2015-12-02 | キアジェン ゲイサーズバーグ インコーポレイテッド | 細胞学用培地に固定された組織サンプルから核酸またはタンパク質を回収するための組成物および方法 |
CN102782560B (zh) * | 2009-12-31 | 2015-07-22 | 雅培照护点公司 | 用于固定分析腔的平面方位的方法及装置 |
EP2528932B1 (en) * | 2010-01-29 | 2016-11-30 | QIAGEN Gaithersburg, Inc. | Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids |
EP2529031B1 (en) | 2010-01-29 | 2014-07-09 | QIAGEN Gaithersburg, Inc. | Method of determining and confirming the presence of hpv in a sample |
CA2799200A1 (en) | 2010-05-19 | 2011-11-24 | Qiagen Gaithersburg, Inc. | Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids |
JP5771934B2 (ja) * | 2010-10-01 | 2015-09-02 | コニカミノルタ株式会社 | 細胞染色方法及び細胞染色用キット |
CN102445368B (zh) * | 2010-10-13 | 2013-05-01 | 青岛市市立医院 | 检验载玻片 |
CN103402482B (zh) * | 2010-11-15 | 2016-08-17 | 昂法玛公司 | 用于隔绝流体转移期间所排出的流体的装置与方法 |
JP2014511182A (ja) | 2011-02-24 | 2014-05-15 | キアゲン ガイサーズバーグ アイエヌシー. | Hpv核酸を検出するための材料及び方法 |
US20130050692A1 (en) | 2011-08-30 | 2013-02-28 | Molecular Devices, Llc | Presentation system and method for low-volume solution samples |
US9453996B2 (en) | 2013-10-23 | 2016-09-27 | Tokitae Llc | Devices and methods for staining and microscopy |
WO2015146682A1 (ja) * | 2014-03-28 | 2015-10-01 | シャープ株式会社 | 濾過用具 |
CN107923821A (zh) | 2015-09-14 | 2018-04-17 | 国立大学法人滋贺医科大学 | 观察标本制作用细胞保持基材保持件及包括其的套件以及观察标本的制作方法 |
CN114018667A (zh) * | 2015-09-14 | 2022-02-08 | 国立大学法人滋贺医科大学 | 观察标本制作用细胞保持基材保持件及包括其的套件以及观察标本的制作方法 |
JP6738012B2 (ja) * | 2015-09-14 | 2020-08-12 | 国立大学法人滋賀医科大学 | 細胞観察標本作製用細胞保持基材ホルダー及びそれを含むキット |
WO2018231960A1 (en) * | 2017-06-13 | 2018-12-20 | Veterinary Diagnostics Institute, Inc. | System and procedure for stabilizing, storing and recovering blood samples |
KR101904207B1 (ko) * | 2017-08-24 | 2018-10-04 | (의)삼성의료재단 | 표시선을 가지는 조직 표본 제작용 슬라이드 글라스 |
JP7110344B2 (ja) | 2018-07-04 | 2022-08-01 | オリンパス株式会社 | 細胞検査装置及び細胞検査方法 |
US10962454B2 (en) | 2018-07-28 | 2021-03-30 | Leavitt Medical, Inc. | Methods and systems for preparing cytological samples |
CA3125235A1 (en) | 2019-01-18 | 2020-07-23 | Techcyte, Inc. | Printed coverslip and slide for identifying reference focal plane for light microscopy |
IT202000003043A1 (it) * | 2020-02-14 | 2021-08-14 | Bioevo S R L | Dispositivo e metodo per il trasporto, la conservazione, la preparazione e l’analisi di campioni biologici. |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4190314A (en) | 1973-07-13 | 1980-02-26 | Stephen Goldsmith | Microscope and microscope slide for cytological analysis |
US3933594A (en) * | 1974-08-16 | 1976-01-20 | Polaroid Corporation | Method and device for determining the concentration of a substance in a fluid |
US5301685A (en) * | 1989-01-10 | 1994-04-12 | Guirguis Raouf A | Method and apparatus for obtaining a cytology monolayer |
JP2517777Y2 (ja) * | 1989-05-09 | 1996-11-20 | ベックマン インスツルメンツ インコーポレーテッド | 試料採集装置 |
US5240606A (en) | 1990-07-09 | 1993-08-31 | Cytyc Corporation | Apparatus for preparing cells for examination |
US5494828A (en) | 1994-07-13 | 1996-02-27 | Leopando; Mark E. | Slide dispensing device and method |
US5470758A (en) * | 1994-12-14 | 1995-11-28 | Shandon, Inc. | Large cytology sample chamber for distributing material onto a microscope slide |
US6300140B1 (en) * | 1997-10-01 | 2001-10-09 | Leonard Bloom | Rapid test employing an adhesive slide |
DK1146817T3 (en) * | 1998-10-05 | 2017-02-27 | Biopath Automation Llc | Apparatus and Method for Sampling and Handling Tissue Samples for Biopsy Analysis |
US6436662B1 (en) * | 2000-04-04 | 2002-08-20 | Digene Corporation | Device and method for cytology slide preparation |
-
2000
- 2000-04-04 US US09/542,746 patent/US6436662B1/en not_active Expired - Lifetime
-
2001
- 2001-04-04 CA CA002402859A patent/CA2402859A1/en not_active Abandoned
- 2001-04-04 DE DE60129803T patent/DE60129803T2/de not_active Expired - Lifetime
- 2001-04-04 EP EP01926624A patent/EP1272848B1/en not_active Expired - Lifetime
- 2001-04-04 BR BR0109786-5A patent/BR0109786A/pt active Search and Examination
- 2001-04-04 AU AU5314601A patent/AU5314601A/xx active Pending
- 2001-04-04 WO PCT/US2001/010968 patent/WO2001075446A1/en active IP Right Grant
- 2001-04-04 JP JP2001572872A patent/JP2003529768A/ja active Pending
- 2001-04-04 AU AU2001253146A patent/AU2001253146B2/en not_active Ceased
- 2001-04-04 AT AT01926624T patent/ATE369561T1/de not_active IP Right Cessation
- 2001-04-04 US US09/826,327 patent/US7001776B2/en not_active Expired - Lifetime
- 2001-04-04 MX MXPA02009812A patent/MXPA02009812A/es active IP Right Grant
-
2002
- 2002-05-22 US US10/153,340 patent/US6890729B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1272848B1 (en) | 2007-08-08 |
EP1272848A1 (en) | 2003-01-08 |
US20020177184A1 (en) | 2002-11-28 |
DE60129803T2 (de) | 2008-04-30 |
US6890729B2 (en) | 2005-05-10 |
JP2003529768A (ja) | 2003-10-07 |
US6436662B1 (en) | 2002-08-20 |
DE60129803D1 (de) | 2007-09-20 |
CA2402859A1 (en) | 2001-10-11 |
ATE369561T1 (de) | 2007-08-15 |
AU2001253146B2 (en) | 2005-03-17 |
WO2001075446A9 (en) | 2002-12-19 |
EP1272848A4 (en) | 2006-01-18 |
AU5314601A (en) | 2001-10-15 |
WO2001075446A1 (en) | 2001-10-11 |
MXPA02009812A (es) | 2004-09-06 |
US20020039796A1 (en) | 2002-04-04 |
US7001776B2 (en) | 2006-02-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B25D | Requested change of name of applicant approved |
Owner name: QIAGEN GAITHERSBURG, INC. (US) Free format text: NOME ALTERADO DE: DIGENE CORPORATION |
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