BR0103180A - Derivados do diazabiciclooctano e suas utilizações terapêuticas - Google Patents
Derivados do diazabiciclooctano e suas utilizações terapêuticasInfo
- Publication number
- BR0103180A BR0103180A BR0103180-5A BR0103180A BR0103180A BR 0103180 A BR0103180 A BR 0103180A BR 0103180 A BR0103180 A BR 0103180A BR 0103180 A BR0103180 A BR 0103180A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- chem
- formula
- aryl
- heteroaryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Anesthesiology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Patente de Invenção: "DERIVADOS DO DIAZABICICLOOCTANO E SUAS UTILIZAçõES TERAPêUTICAS". A presente invenção refere-se a derivados de diazabiciclooctano de fórmula (I): e sais farmaceuticamente aceitáveis dos mesmos, onde o grupo represente R^ 1^ e R^ 2^ são selecionados independentemente a partir de H, (C~ 1~-C~ 6~)alquila, (C~ 1~-C~ 6~)fluoroalquila, halogênio (por exemplo, F, CI, Br, I), ciano, nitro, O-(C~ 1~-C~ 6~)alquila, O-(C~ 1~-C~ 6~)fluoroalquila, -NHC(O)R^ 4^ e -OR^ 4^ onde R^ 4^ e R^ 5^ são selecionados independentemente a partir de H, (C~ 1~-C~ 6~)alquila, e anel arila de 5- a 7-membros, ou R^ 1^ e R^ 2^ juntamente com os átomos aos quais eles estão ligados, formam um anel carboxíclico de 5- ou 6-membros ou anel heterocíclico de 5- ou 6-membros; e R^ 3^ é selecionado a partir do grupo consistindo em H, (C~ 1~-C~ 6~) alquila, (CH~ 2~)~ m~ arila ou (CH~ 2~)~ m~ heteroarila onde m é um número inteiro de 1 a 4, cada grupo arila ou heteroarila opcionalmente substituído com CI, Br, CN, CF~ 3~, O-(C~ 1~-C~ 6~)alquila, (C~ 1~-C~ 6~)alquila, sulfonil(C~ 1~-C~ 6~)alquila, -CO(C~ 1~-C~ 6~)alquila, -CONH~ 2~, -CONH(C~ 1~-C~ 6~)alquila, -CON((C~ 1~-C~ 6~)alquila)~ 2~, ou CH(OH)(C~ 1~-C~ 6~) alquila. A invenção também refere-se a composições farmaceuticamente aceitáveis de um composto de fórmula (I), e métodos de utilização deles no tratamento de doenças, condições ou distúrbios do sistema nervoso central. Além disso, a presente invenção é também dirigida a processos para a preparação de compostos de fórmula (I) e intermediários úteis.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22270600P | 2000-08-03 | 2000-08-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0103180A true BR0103180A (pt) | 2002-03-26 |
Family
ID=22833344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0103180-5A BR0103180A (pt) | 2000-08-03 | 2001-08-01 | Derivados do diazabiciclooctano e suas utilizações terapêuticas |
Country Status (12)
Country | Link |
---|---|
US (1) | US6531468B2 (pt) |
EP (1) | EP1178047B1 (pt) |
JP (1) | JP3825657B2 (pt) |
AT (1) | ATE260281T1 (pt) |
BR (1) | BR0103180A (pt) |
CA (1) | CA2354605C (pt) |
DE (1) | DE60102106T2 (pt) |
DK (1) | DK1178047T3 (pt) |
ES (1) | ES2211738T3 (pt) |
MX (1) | MXPA01007955A (pt) |
PT (1) | PT1178047E (pt) |
TR (1) | TR200400510T4 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060270847A1 (en) * | 2003-06-27 | 2006-11-30 | Seiji Morii | Process for producing nitrogenous heterocyclic compound |
US7704991B2 (en) | 2005-04-04 | 2010-04-27 | Neurosearch A/S | Substituted diazabicyclo derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
JP2011512340A (ja) * | 2008-02-15 | 2011-04-21 | エフ.ホフマン−ラ ロシュ アーゲー | 3−アルキルピペラジン誘導体及びその使用 |
MX2011000897A (es) | 2008-07-23 | 2011-03-30 | Toray Industries | Agente terapeutico para falla renal cronica. |
CN102459198B (zh) | 2009-06-26 | 2014-09-24 | 日本新药株式会社 | 晶体 |
ES2595240T3 (es) | 2012-07-09 | 2016-12-28 | Lupin Limited | Derivados de tetrahidroquinazolinona como inhibidores de PARP |
US10231970B2 (en) * | 2014-09-30 | 2019-03-19 | NV Heterocycles | Methods of producing heteropolycycles via bis-epoxidation |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3951980A (en) * | 1974-05-09 | 1976-04-20 | Stanford Research Institute | 3-Substituted-8-methyl-3,8-diazabicyclo[3.2.1]octanes |
FR2531709A1 (fr) * | 1982-08-13 | 1984-02-17 | Sanofi Sa | Diazabicyclooctanes, procede pour leur preparation et compositions pharmaceutiques les renfermant |
-
2001
- 2001-07-23 ES ES01306313T patent/ES2211738T3/es not_active Expired - Lifetime
- 2001-07-23 EP EP01306313A patent/EP1178047B1/en not_active Expired - Lifetime
- 2001-07-23 PT PT01306313T patent/PT1178047E/pt unknown
- 2001-07-23 DK DK01306313T patent/DK1178047T3/da active
- 2001-07-23 AT AT01306313T patent/ATE260281T1/de not_active IP Right Cessation
- 2001-07-23 DE DE60102106T patent/DE60102106T2/de not_active Expired - Fee Related
- 2001-07-23 TR TR2004/00510T patent/TR200400510T4/xx unknown
- 2001-08-01 BR BR0103180-5A patent/BR0103180A/pt not_active IP Right Cessation
- 2001-08-01 US US09/920,587 patent/US6531468B2/en not_active Expired - Fee Related
- 2001-08-01 CA CA002354605A patent/CA2354605C/en not_active Expired - Fee Related
- 2001-08-02 JP JP2001235227A patent/JP3825657B2/ja not_active Expired - Fee Related
- 2001-08-03 MX MXPA01007955A patent/MXPA01007955A/es unknown
Also Published As
Publication number | Publication date |
---|---|
DE60102106D1 (de) | 2004-04-01 |
MXPA01007955A (es) | 2002-08-06 |
JP2002088084A (ja) | 2002-03-27 |
JP3825657B2 (ja) | 2006-09-27 |
CA2354605C (en) | 2006-05-30 |
TR200400510T4 (tr) | 2004-08-23 |
DE60102106T2 (de) | 2004-07-15 |
ATE260281T1 (de) | 2004-03-15 |
US6531468B2 (en) | 2003-03-11 |
EP1178047B1 (en) | 2004-02-25 |
PT1178047E (pt) | 2004-05-31 |
ES2211738T3 (es) | 2004-07-16 |
CA2354605A1 (en) | 2002-02-03 |
US20020068748A1 (en) | 2002-06-06 |
DK1178047T3 (da) | 2004-05-24 |
EP1178047A1 (en) | 2002-02-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2012 DE 28/07/2009. |