BR0100878A - Compostos de hidroxamidas do ácido2-oxo-imidazolidino-4-carboxìlico que inibemmetaloproteinases de matriz - Google Patents

Compostos de hidroxamidas do ácido2-oxo-imidazolidino-4-carboxìlico que inibemmetaloproteinases de matriz

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Publication number
BR0100878A
BR0100878A BR0100878-1A BR0100878A BR0100878A BR 0100878 A BR0100878 A BR 0100878A BR 0100878 A BR0100878 A BR 0100878A BR 0100878 A BR0100878 A BR 0100878A
Authority
BR
Brazil
Prior art keywords
compounds
imidazolidine
oxo
carboxylic acid
matrix metalloproteinases
Prior art date
Application number
BR0100878-1A
Other languages
English (en)
Inventor
Ellen Ruth Laird
Ralph Pelton Robinson Jr
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0100878A publication Critical patent/BR0100878A/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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Abstract

Patente de Invenção: "COMPOSTOS DE HIDROXAMIDAS DOáCIDO 2-OXO-IMIDAZOLIDINO-4-CARBOXìLICO QUE INIBEMMETALOPROTEINASES DE MATRIZ". A presente invençãorefere-se a um composto de fórmula em que R^ 1^, R^ 2^, R^ 3^ eR^ 4^ são como definidos acima, e os seus sais e solvatosfarmaceuticamente aceitáveis, que são úteis, por exemplo, comoinibidores de metaloproteinases de matriz. A presente invençãotambém é dirigida a composições farmacêuticas compreendendoesses compostos e a métodos de tratamento de doenças tais comoosteoartrite, artrite reumatóide, câncer, osteoporose, ulceração detecidos, restenose, doença peridontal, inflamação, epidermólisebulhosa, esclerite, síncope, doença de Alzheimer, e outrassemelhantes, caracterizadas por atividade inapropriada demetaloproteinases de matriz. Também são descritos processos paraa síntese de compostos de formula (I).
BR0100878-1A 2000-03-13 2001-03-12 Compostos de hidroxamidas do ácido2-oxo-imidazolidino-4-carboxìlico que inibemmetaloproteinases de matriz BR0100878A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18889200P 2000-03-13 2000-03-13

Publications (1)

Publication Number Publication Date
BR0100878A true BR0100878A (pt) 2001-10-30

Family

ID=22694989

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0100878-1A BR0100878A (pt) 2000-03-13 2001-03-12 Compostos de hidroxamidas do ácido2-oxo-imidazolidino-4-carboxìlico que inibemmetaloproteinases de matriz

Country Status (10)

Country Link
US (2) US6458822B2 (pt)
EP (1) EP1134215B1 (pt)
JP (1) JP3841646B2 (pt)
AT (1) ATE278675T1 (pt)
BR (1) BR0100878A (pt)
CA (1) CA2340138C (pt)
DE (1) DE60106117T2 (pt)
DK (1) DK1134215T3 (pt)
ES (1) ES2225422T3 (pt)
PT (1) PT1134215E (pt)

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US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
EP1373199A4 (en) * 2001-03-15 2004-04-07 Bristol Myers Squibb Pharma Co SPIROCYCLIC BETA-AMINOACID DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND THE CONVERSION ENZYME OF TNF-ALPHA (TAGE)
JPWO2003080041A1 (ja) * 2002-03-27 2005-07-21 塩野義製薬株式会社 変形性関節症治療薬
CA2492035A1 (en) * 2002-07-11 2004-01-15 Vicuron Pharmaceuticals, Inc. N-hydroxyamide derivatives possessing antibacterial activity
TW200410923A (en) * 2002-10-17 2004-07-01 Ono Pharmaceutical Co Therapeutic agent for chronic obstructive pulmonary disease
ATE457716T1 (de) 2002-12-30 2010-03-15 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
GB0319069D0 (en) * 2003-08-14 2003-09-17 Glaxo Group Ltd Therapeutically useful compounds
KR20110140139A (ko) * 2003-08-29 2011-12-30 오노 야꾸힝 고교 가부시키가이샤 Ｓ１ｐ 수용체 결합능을 갖는 화합물 및 그 의약 용도
DE102004060229A1 (de) * 2004-12-15 2006-06-29 Sanofi-Aventis Deutschland Gmbh Neue zyklische Harnstoffe als Inhibitoren von Metallproteasen
US20070258941A1 (en) * 2006-05-02 2007-11-08 Pfister Brian E Methods and compositions for remediation of disc herniation by modifying structure
ATE509956T1 (de) * 2006-06-08 2011-06-15 Helmholtz Zentrum Muenchen Spezifische proteaseinhibitoren und ihre verwendung in der krebstherapie

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US5455258A (en) 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5863949A (en) 1995-03-08 1999-01-26 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives
CA2218503C (en) 1995-04-20 2001-07-24 Pfizer Inc. Arylsulfonyl hydroxamic acid derivatives
ZA966885B (en) 1995-08-22 1998-02-16 Du Pont Merck Pharma Substituted cyclic ureas and derivatives thereof useful as retroviral protease inhibitors.
US5612074A (en) 1995-12-21 1997-03-18 Leach; Robin L. Nutrient fortified food bar
NZ333303A (en) 1996-07-18 2000-06-23 Lawrence Alan Reiter Phosphinate based inhibitors of matrix metalloproteases
BR9711223A (pt) 1996-08-23 1999-08-17 Pfizer Derivados de cido arilsulfonilamino-hidrox mico
AU731319B2 (en) 1996-08-28 2001-03-29 Procter & Gamble Company, The Heterocyclic metalloprotease inhibitors
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Also Published As

Publication number Publication date
CA2340138C (en) 2005-10-18
DK1134215T3 (da) 2005-01-10
ES2225422T3 (es) 2005-03-16
PT1134215E (pt) 2004-12-31
US6458822B2 (en) 2002-10-01
US20010041710A1 (en) 2001-11-15
EP1134215B1 (en) 2004-10-06
JP3841646B2 (ja) 2006-11-01
US20020147224A1 (en) 2002-10-10
JP2001261656A (ja) 2001-09-26
DE60106117D1 (de) 2004-11-11
EP1134215A1 (en) 2001-09-19
DE60106117T2 (de) 2005-10-13
ATE278675T1 (de) 2004-10-15
CA2340138A1 (en) 2001-09-13

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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