BR0012419A - Análogos da vitamina d3 - Google Patents

Análogos da vitamina d3

Info

Publication number
BR0012419A
BR0012419A BR0012419-2A BR0012419A BR0012419A BR 0012419 A BR0012419 A BR 0012419A BR 0012419 A BR0012419 A BR 0012419A BR 0012419 A BR0012419 A BR 0012419A
Authority
BR
Brazil
Prior art keywords
alkyl
analogs
vitamin
fluoroalkyl
hydroxy
Prior art date
Application number
BR0012419-2A
Other languages
English (en)
Inventor
Andrew David Batcho
Bernard Michael Hennessy
Milan Radoje Uskokovic
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0012419A publication Critical patent/BR0012419A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Patente de Invenção: "ANáLOGOS DA VITAMINA D~ 3~". Compostos de fórmula (1) em que R, é hidrogênio ou um grupo alquila, R~ 2~ é hidrogênio ou um grupo alquila; ou R~ 1~, R~ 2~ e C~ 20~ juntos são ciclopropila; A é a, b, c ou d; R3 é alquila, hidróxi-alquila ou fluoroalquila e R4 é alquila, hidróxi-alquila ou fluoroalquila que são úteis no tratamento do câncer do seio, câncer da próstata, leucemia mielóide, crescimento benigno da próstata, calvície e osteoporose.
BR0012419-2A 1999-07-12 2000-07-06 Análogos da vitamina d3 BR0012419A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14341399P 1999-07-12 1999-07-12
PCT/EP2000/006393 WO2001004089A1 (en) 1999-07-12 2000-07-06 Vitamin d3 analogs

Publications (1)

Publication Number Publication Date
BR0012419A true BR0012419A (pt) 2002-03-26

Family

ID=22503954

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0012419-2A BR0012419A (pt) 1999-07-12 2000-07-06 Análogos da vitamina d3

Country Status (36)

Country Link
US (1) US6331642B1 (pt)
EP (1) EP1200399B1 (pt)
JP (1) JP3803579B2 (pt)
KR (1) KR100477161B1 (pt)
CN (1) CN1174964C (pt)
AR (1) AR024695A1 (pt)
AT (1) ATE262508T1 (pt)
AU (1) AU779408B2 (pt)
BR (1) BR0012419A (pt)
CA (1) CA2378803C (pt)
CO (1) CO5190683A1 (pt)
DE (1) DE60009303T2 (pt)
DK (1) DK1200399T3 (pt)
EG (1) EG23909A (pt)
ES (1) ES2215707T3 (pt)
GC (1) GC0000198A (pt)
HK (1) HK1047578B (pt)
HR (1) HRP20020007A2 (pt)
HU (1) HUP0202157A3 (pt)
IL (2) IL147254A0 (pt)
JO (1) JO2255B1 (pt)
MA (1) MA26808A1 (pt)
MX (1) MXPA02000313A (pt)
MY (1) MY122633A (pt)
NO (1) NO20020161L (pt)
NZ (1) NZ516339A (pt)
PE (1) PE20010328A1 (pt)
PL (1) PL201877B1 (pt)
PT (1) PT1200399E (pt)
RS (1) RS50229B (pt)
RU (1) RU2235721C2 (pt)
TR (1) TR200200054T2 (pt)
TW (1) TWI268276B (pt)
UY (1) UY26239A1 (pt)
WO (1) WO2001004089A1 (pt)
ZA (1) ZA200110487B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001278744A1 (en) * 2000-08-17 2002-02-25 Chugai Seiyaku Kabushiki Kaisha Remedial agent for osteoporosis
CA2424555A1 (en) 2000-10-02 2002-04-11 Emory University Triptolide analogs for the treatment of autoimmune and inflammatory disorders
CN1285573C (zh) * 2001-09-21 2006-11-22 霍夫曼-拉罗奇有限公司 3－脱氧－维生素d3类似物酯
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
CA2524026A1 (en) * 2003-04-30 2004-11-18 Bioxell S.P.A. Gemini vitamin d3 compounds and methods of use thereof
US20050113348A1 (en) * 2003-06-12 2005-05-26 Yanchun Li Vitamin D and vitamin D analogs or derivatives as new anti-hypertensive agents
GB2407499B (en) * 2003-11-03 2008-02-27 Bioxell Spa Vitamin D3 analogue for use in the treatment of BPH
AU2004275845A1 (en) * 2003-09-24 2005-04-07 Bioxell, S.P.A. Methods for treating bladder dysfunction
US7332482B2 (en) * 2003-09-24 2008-02-19 Bioxell S.P.A. Method for treating benign prostatic hyperplasia
US8404667B2 (en) * 2006-12-29 2013-03-26 Wisconsin Alumni Research Foundation Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
AU2005289664A1 (en) * 2004-09-24 2006-04-06 Bioxell S.P.A. 20-cycloalkyl,26,27-alkyl/haloalkyl vitamin D3 compounds and methods of use thereof
JP2008519808A (ja) 2004-11-12 2008-06-12 ビオエクセル エスピーエー 膀胱癌治療のためのビタミンｄ誘導体及び抗増殖薬の併用
US20100009949A1 (en) * 2006-03-24 2010-01-14 Bioxell S.P.A. Novel method
CN101754971A (zh) * 2007-05-30 2010-06-23 赛特克罗公司 氧化膦维生素d前体的制备方法
LT2708559T (lt) 2008-04-11 2018-06-11 Chugai Seiyaku Kabushiki Kaisha Antigeną surišanti molekulė, galinti pakartotinai prisijungti prie dviejų ar daugiau antigeno molekulių
EP2682386B1 (en) * 2011-03-02 2016-08-17 Nihon University Novel vitamin d receptor modulator with partial agonist activity
KR102523660B1 (ko) 2016-09-26 2023-04-19 (주)하이플 박스용 테두리 부재보강부재와 에셈블리컨테이너 원터치크립이 포함된 박스

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4749710A (en) 1985-05-01 1988-06-07 Hoffmann-La Roche Inc. Immunosuppressive agents
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US5401733A (en) * 1993-10-01 1995-03-28 Hoffmann-La Roche Inc. Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
US6040300A (en) * 1995-04-07 2000-03-21 Arch Development Corporation Method of preventing colon cancer with vitamin D3 analogues
AU708679B2 (en) 1996-03-21 1999-08-12 F. Hoffmann-La Roche Ag 1,25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives

Also Published As

Publication number Publication date
CO5190683A1 (es) 2002-08-29
JP2003504354A (ja) 2003-02-04
AU6689400A (en) 2001-01-30
JO2255B1 (en) 2004-10-07
MXPA02000313A (es) 2002-06-21
NO20020161D0 (no) 2002-01-11
PE20010328A1 (es) 2001-03-22
DE60009303D1 (de) 2004-04-29
US6331642B1 (en) 2001-12-18
EP1200399B1 (en) 2004-03-24
GC0000198A (en) 2006-03-29
IL147254A (en) 2006-07-05
KR20020033728A (ko) 2002-05-07
AU779408B2 (en) 2005-01-20
HK1047578A1 (en) 2003-02-28
AR024695A1 (es) 2002-10-23
KR100477161B1 (ko) 2005-03-18
WO2001004089A1 (en) 2001-01-18
TR200200054T2 (tr) 2002-06-21
PT1200399E (pt) 2004-06-30
JP3803579B2 (ja) 2006-08-02
RU2235721C2 (ru) 2004-09-10
MY122633A (en) 2006-04-29
ZA200110487B (en) 2003-03-20
HRP20020007A2 (en) 2003-04-30
IL147254A0 (en) 2002-08-14
ATE262508T1 (de) 2004-04-15
HUP0202157A3 (en) 2004-04-28
HUP0202157A2 (en) 2002-10-28
DE60009303T2 (de) 2005-02-24
DK1200399T3 (da) 2004-07-19
ES2215707T3 (es) 2004-10-16
CN1360572A (zh) 2002-07-24
UY26239A1 (es) 2000-10-31
EP1200399A1 (en) 2002-05-02
CA2378803C (en) 2009-01-27
PL356124A1 (en) 2004-06-14
CA2378803A1 (en) 2001-01-18
NZ516339A (en) 2003-07-25
CN1174964C (zh) 2004-11-10
EG23909A (en) 2007-12-30
MA26808A1 (fr) 2004-12-20
HK1047578B (zh) 2005-04-29
PL201877B1 (pl) 2009-05-29
NO20020161L (no) 2002-01-11
RS50229B (sr) 2009-07-15
YU92701A (sh) 2004-09-03
TWI268276B (en) 2006-12-11

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 13, 24 E 25 DA LPI.

B12B Appeal against refusal [chapter 12.2 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 13A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014.