CO5190683A1 - Analogos de vitamina d3 - Google Patents

Analogos de vitamina d3

Info

Publication number
CO5190683A1
CO5190683A1 CO00051318A CO00051318A CO5190683A1 CO 5190683 A1 CO5190683 A1 CO 5190683A1 CO 00051318 A CO00051318 A CO 00051318A CO 00051318 A CO00051318 A CO 00051318A CO 5190683 A1 CO5190683 A1 CO 5190683A1
Authority
CO
Colombia
Prior art keywords
alkyl
analogs
vitamin
imf
fluoroalkyl
Prior art date
Application number
CO00051318A
Other languages
English (en)
Inventor
Andrew David Batcho
Bernard Michael Hennessy
Milan Radoje Uskokovic
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO5190683A1 publication Critical patent/CO5190683A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un compuestos de la fórmula<EMI FILE="00051318_1" ID="1" IMF=JPEG >en dondeR1 es hidrógeno o un grupo alquilo;R2 es hidrógeno o un grupo alquilo; óR1, R2 y C20 conjuntamente son ciclopropilo;<EMI FILE="00051318_2" ID="2" IMF=JPEG >R3 es alquilo, hidroxi-alquilo o fluoroalquilo; yR4 es alquilo, hidroxi-alquilo o fluoroalquilo.
CO00051318A 1999-07-12 2000-07-10 Analogos de vitamina d3 CO5190683A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14341399P 1999-07-12 1999-07-12

Publications (1)

Publication Number Publication Date
CO5190683A1 true CO5190683A1 (es) 2002-08-29

Family

ID=22503954

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00051318A CO5190683A1 (es) 1999-07-12 2000-07-10 Analogos de vitamina d3

Country Status (36)

Country Link
US (1) US6331642B1 (es)
EP (1) EP1200399B1 (es)
JP (1) JP3803579B2 (es)
KR (1) KR100477161B1 (es)
CN (1) CN1174964C (es)
AR (1) AR024695A1 (es)
AT (1) ATE262508T1 (es)
AU (1) AU779408B2 (es)
BR (1) BR0012419A (es)
CA (1) CA2378803C (es)
CO (1) CO5190683A1 (es)
DE (1) DE60009303T2 (es)
DK (1) DK1200399T3 (es)
EG (1) EG23909A (es)
ES (1) ES2215707T3 (es)
GC (1) GC0000198A (es)
HK (1) HK1047578B (es)
HR (1) HRP20020007A2 (es)
HU (1) HUP0202157A3 (es)
IL (2) IL147254A0 (es)
JO (1) JO2255B1 (es)
MA (1) MA26808A1 (es)
MX (1) MXPA02000313A (es)
MY (1) MY122633A (es)
NO (1) NO20020161L (es)
NZ (1) NZ516339A (es)
PE (1) PE20010328A1 (es)
PL (1) PL201877B1 (es)
PT (1) PT1200399E (es)
RS (1) RS50229B (es)
RU (1) RU2235721C2 (es)
TR (1) TR200200054T2 (es)
TW (1) TWI268276B (es)
UY (1) UY26239A1 (es)
WO (1) WO2001004089A1 (es)
ZA (1) ZA200110487B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030220307A1 (en) * 2000-08-17 2003-11-27 Akira Kawase Remedial agent for osteoporosis
AU2001296542B2 (en) 2000-10-02 2007-10-25 Emory University Triptolide analogs for the treatment of autoimmune and inflammatory disorders
RU2296121C2 (ru) * 2001-09-21 2007-03-27 Ф.Хоффманн-Ля Рош Аг Соединения, способ их получения, способы лечения
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
WO2004098522A2 (en) * 2003-04-30 2004-11-18 Bioxell S.P.A. Gemini vitamin d3 compounds and methods of use thereof
US20050113348A1 (en) * 2003-06-12 2005-05-26 Yanchun Li Vitamin D and vitamin D analogs or derivatives as new anti-hypertensive agents
CA2476224A1 (en) * 2003-09-24 2005-03-24 Bioxell Spa Compound and use in treatment
GB2407499B (en) * 2003-11-03 2008-02-27 Bioxell Spa Vitamin D3 analogue for use in the treatment of BPH
BRPI0414701A (pt) * 2003-09-24 2006-11-14 Bioxell Spa uso de um composto de vitamina d, método de prevenção ou tratamnento de disfunção de bexiga em um paciente, composto de vitamina d, e, kit
US8404667B2 (en) * 2006-12-29 2013-03-26 Wisconsin Alumni Research Foundation Compounds, compositions, kits and methods of use to orally and topically treat acne and other skin conditions by 19-Nor vitamin D analog
EP1797033A4 (en) * 2004-09-24 2010-04-28 Bioxell Spa 20-CYCLOALKYL-26,27-ALKYL / HALOGENALKYL-VITAMIN-D3 COMPOUNDS AND METHODS FOR THEIR APPLICATION
WO2006051106A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
US20100009949A1 (en) * 2006-03-24 2010-01-14 Bioxell S.P.A. Novel method
CA2688083C (en) * 2007-05-30 2015-07-07 Cytochroma Inc. Process for producing phosphine oxide vitamin d precursors
PL2275443T3 (pl) 2008-04-11 2016-05-31 Chugai Pharmaceutical Co Ltd Cząsteczka wiążąca antygen zdolna do wiązania dwóch lub więcej cząsteczek antygenu w sposób powtarzalny
WO2012118154A1 (ja) * 2011-03-02 2012-09-07 学校法人日本大学 パーシャルアゴニスト活性を持つ新規ビタミンd受容体モジュレーター
KR102523660B1 (ko) 2016-09-26 2023-04-19 (주)하이플 박스용 테두리 부재보강부재와 에셈블리컨테이너 원터치크립이 포함된 박스

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4749710A (en) 1985-05-01 1988-06-07 Hoffmann-La Roche Inc. Immunosuppressive agents
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
US5087619A (en) * 1988-01-20 1992-02-11 Hoffman-La Roche Inc. Vitamin D3 analogs
CA2096105A1 (en) * 1992-10-07 1994-04-08 Enrico Giuseppe Baggiolini (Deceased) Vitamin d3 fluorinated analogs
US5401733A (en) * 1993-10-01 1995-03-28 Hoffmann-La Roche Inc. Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
US6040300A (en) * 1995-04-07 2000-03-21 Arch Development Corporation Method of preventing colon cancer with vitamin D3 analogues
AU708679B2 (en) 1996-03-21 1999-08-12 F. Hoffmann-La Roche Ag 1,25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives

Also Published As

Publication number Publication date
AU779408B2 (en) 2005-01-20
ZA200110487B (en) 2003-03-20
MA26808A1 (fr) 2004-12-20
CN1174964C (zh) 2004-11-10
MXPA02000313A (es) 2002-06-21
IL147254A (en) 2006-07-05
PT1200399E (pt) 2004-06-30
PL356124A1 (en) 2004-06-14
NZ516339A (en) 2003-07-25
TWI268276B (en) 2006-12-11
RU2235721C2 (ru) 2004-09-10
ATE262508T1 (de) 2004-04-15
AU6689400A (en) 2001-01-30
HUP0202157A3 (en) 2004-04-28
YU92701A (sh) 2004-09-03
HK1047578B (zh) 2005-04-29
KR100477161B1 (ko) 2005-03-18
PE20010328A1 (es) 2001-03-22
PL201877B1 (pl) 2009-05-29
EP1200399B1 (en) 2004-03-24
NO20020161D0 (no) 2002-01-11
DK1200399T3 (da) 2004-07-19
TR200200054T2 (tr) 2002-06-21
HUP0202157A2 (en) 2002-10-28
EP1200399A1 (en) 2002-05-02
KR20020033728A (ko) 2002-05-07
RS50229B (sr) 2009-07-15
DE60009303D1 (de) 2004-04-29
JP2003504354A (ja) 2003-02-04
CA2378803A1 (en) 2001-01-18
HK1047578A1 (en) 2003-02-28
AR024695A1 (es) 2002-10-23
UY26239A1 (es) 2000-10-31
DE60009303T2 (de) 2005-02-24
MY122633A (en) 2006-04-29
CA2378803C (en) 2009-01-27
IL147254A0 (en) 2002-08-14
JO2255B1 (en) 2004-10-07
GC0000198A (en) 2006-03-29
JP3803579B2 (ja) 2006-08-02
CN1360572A (zh) 2002-07-24
WO2001004089A1 (en) 2001-01-18
ES2215707T3 (es) 2004-10-16
US6331642B1 (en) 2001-12-18
EG23909A (en) 2007-12-30
NO20020161L (no) 2002-01-11
HRP20020007A2 (en) 2003-04-30
BR0012419A (pt) 2002-03-26

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