BR0011943A - Derivados de amÈnio quaternário, seu processo de preparo e seu uso em farmácia - Google Patents

Derivados de amÈnio quaternário, seu processo de preparo e seu uso em farmácia

Info

Publication number
BR0011943A
BR0011943A BR0011943-1A BR0011943A BR0011943A BR 0011943 A BR0011943 A BR 0011943A BR 0011943 A BR0011943 A BR 0011943A BR 0011943 A BR0011943 A BR 0011943A
Authority
BR
Brazil
Prior art keywords
pharmacy
quaternary ammonium
preparation process
ammonium derivatives
diagnosis
Prior art date
Application number
BR0011943-1A
Other languages
English (en)
Inventor
Jean-Claude Madelmont
Isabelle Giraud
Colette Nicolas
Jean-Claude Maurizis
Maryse Rapp
Monique Ollier
Pierre Renard
Daniel-Henri Caignard
Original Assignee
Servier Lab
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab, Inst Nat Sante Rech Med filed Critical Servier Lab
Publication of BR0011943A publication Critical patent/BR0011943A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/02—1,2-Thiazines; Hydrogenated 1,2-thiazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
    • C07H5/06—Aminosugars
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Patente de Invenção: "DERIVADOS DE AMÈNIO QUATERNáRIO, SEU PROCESSO DE PREPARO E SEU USO EM FARMáCIA". Compostos de fórmula, correspondendo a uma das fórmulas (Ia) ou (Ib), na qual M representa uma molécula utilizável para a terapia ou o diagnóstico das patologias devido a um atingimento da cartilagem, R~ 1~, R~ 2~, R~ 3~ representam um grupamento alquila no qual R~ 1~, R~ 2~, R~ 3~, considerados juntos com o átomo de nitrogênio que os porta formam um heterociclo, X representa uma cadeia alquileno (C~ 1~-C~ 6~), na qual um ou vários grupamentos -CH~ 2~- são eventualmente substituídos por um átomo de enxofre, de oxigênio, um grupamento -NR-, -CO-, -CO-NH-, -CO~ 2~-, -SO- OU -SO~ 2~-; n representa 0 ou 1; Hal representa um átomo de halogênio; R~ 4~ representa um grupamento alquila, Hal representa um átomo de halogênio, a Fórmula geral (F1) representa uma molécula utilizável para a terapia ou o diagnóstico das patologias devido a um atingimento da cartilagem, naturalmente que o átomo de nitrogênio pode ser eventualmente incluído em um sistema heterocíclico nitrogenado, saturado ou não-saturado, ou engajado em uma dupla ligação.
BR0011943-1A 1999-06-23 2000-06-22 Derivados de amÈnio quaternário, seu processo de preparo e seu uso em farmácia BR0011943A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9908020A FR2795412B1 (fr) 1999-06-23 1999-06-23 Nouveaux derives d'ammonium quaternaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2000/001731 WO2001000621A1 (fr) 1999-06-23 2000-06-22 Derives d'ammonium quaternaire, leur procede de preparation et leur usage en pharmacie

Publications (1)

Publication Number Publication Date
BR0011943A true BR0011943A (pt) 2002-05-14

Family

ID=9547207

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011943-1A BR0011943A (pt) 1999-06-23 2000-06-22 Derivados de amÈnio quaternário, seu processo de preparo e seu uso em farmácia

Country Status (21)

Country Link
US (2) US6759406B1 (pt)
EP (1) EP1185526B1 (pt)
JP (1) JP2003503407A (pt)
KR (1) KR20020016846A (pt)
CN (1) CN1370161A (pt)
AT (1) ATE276251T1 (pt)
AU (1) AU771865B2 (pt)
BR (1) BR0011943A (pt)
CA (1) CA2377154A1 (pt)
DE (1) DE60013818T2 (pt)
EA (1) EA004292B1 (pt)
ES (1) ES2231222T3 (pt)
FR (1) FR2795412B1 (pt)
HK (1) HK1048319A1 (pt)
HU (1) HUP0201552A3 (pt)
MX (1) MXPA01013148A (pt)
NO (1) NO20016267L (pt)
NZ (1) NZ516337A (pt)
PL (1) PL353032A1 (pt)
WO (1) WO2001000621A1 (pt)
ZA (1) ZA200109850B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19627523C1 (de) 1996-07-09 1997-10-23 Alpha Calcit Fuellstoff Gmbh Verfahren zur Wiederverwertung von Füllstoffen und Streichpigmenten der Papier-, Pappe- und Kartonherstellung
FR2818641B1 (fr) * 2000-12-21 2004-03-05 Servier Lab Nouveaux derives de 1,1-dioxo-2h-1,2-benzothiazine 3-carboxamides, leur procede de preparation et les compositions pharmaceutiques que les contiennent
WO2008041059A1 (en) 2006-10-03 2008-04-10 Techfields Biochem Co. Ltd Positively charged water-soluble prodrugs of mustards and related compounds with very high skin penetration rates
CN104987296B (zh) * 2006-10-03 2018-11-23 于崇曦 具有快速皮肤穿透速度的带正电荷的水溶性的芥子类化合物及其相关化合物的前药
FR2981849B1 (fr) * 2011-10-28 2014-01-03 Univ Claude Bernard Lyon Nanoparticules fonctionnalisees pour le ciblage des proteoglycanes et leurs applications
EP2639227A1 (en) * 2012-03-14 2013-09-18 Bracco Imaging S.p.A A new class of diazepine derivative chelating agents and complexes with paramagnetic metals as MRI contrast agents
FR2989280B1 (fr) 2012-04-13 2017-02-24 Univ Claude Bernard Lyon Nanoparticules ultrafines comme agent de contraste multimodal
WO2016016272A1 (en) 2014-07-28 2016-02-04 Institut National De La Sante Et De La Recherche Medicale (Inserm) Macrocyclic complexes, their process of preparation and use as pet imaging agents
FR3072281B1 (fr) 2017-10-13 2020-12-04 Nh Theraguix Nanovecteurs et utilisations, en particulier pour le traitement de tumeurs
GB202102243D0 (en) 2021-02-17 2021-03-31 Royal Veterinary College New compounds and uses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4623486A (en) * 1985-05-29 1986-11-18 Pfizer Inc. [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
IL115113A (en) * 1995-08-31 2002-11-10 Israel State 3-carbamoyloxy pyridinium derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
MXPA01013148A (es) 2004-08-19
DE60013818D1 (de) 2004-10-21
DE60013818T2 (de) 2005-11-17
US7008613B2 (en) 2006-03-07
FR2795412B1 (fr) 2001-07-13
CN1370161A (zh) 2002-09-18
JP2003503407A (ja) 2003-01-28
KR20020016846A (ko) 2002-03-06
NZ516337A (en) 2003-11-28
AU771865B2 (en) 2004-04-01
PL353032A1 (en) 2003-10-06
EA004292B1 (ru) 2004-02-26
EP1185526A1 (fr) 2002-03-13
US20040208822A1 (en) 2004-10-21
WO2001000621A1 (fr) 2001-01-04
FR2795412A1 (fr) 2000-12-29
EP1185526B1 (fr) 2004-09-15
HUP0201552A2 (en) 2002-08-28
CA2377154A1 (fr) 2001-01-04
HUP0201552A3 (en) 2004-03-01
ATE276251T1 (de) 2004-10-15
AU5989300A (en) 2001-01-31
NO20016267L (no) 2002-01-30
EA200200041A1 (ru) 2002-06-27
ES2231222T3 (es) 2005-05-16
US6759406B1 (en) 2004-07-06
HK1048319A1 (zh) 2003-03-28
NO20016267D0 (no) 2001-12-20
ZA200109850B (en) 2003-02-26

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7O, 8O E 9O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009.