BR0010323A - Composições imunogênicas, kit e método de confecção da mesma para uso na imunização de um mamìfero - Google Patents
Composições imunogênicas, kit e método de confecção da mesma para uso na imunização de um mamìferoInfo
- Publication number
- BR0010323A BR0010323A BR0010323-3A BR0010323A BR0010323A BR 0010323 A BR0010323 A BR 0010323A BR 0010323 A BR0010323 A BR 0010323A BR 0010323 A BR0010323 A BR 0010323A
- Authority
- BR
- Brazil
- Prior art keywords
- mammal
- immunogenic compositions
- iss
- hiv antigen
- adjuvant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
"COMPOSIçõES IMUNOGêNICAS, KIT E MéTODO DE CONFECçãO DA MESMA PARA USO NA IMUNIZAçãO DE UM MAMìFERO". A invenção provê composições imunogênicas, as quais melhoram os níveis de <225>-quimiocina em um mamífero. As composições imunogênicas contêm um antígeno de HIV, uma molécula de ácido nucléico isolada contendo uma seq³ência imunoestimulante (ISS) e um adjuvante. O antígeno de HIV pode ser um vírus HIV completamente morto destituído da proteína de envoltória externa gp120. Alternativamente, o antígeno de HIV pode ser um vírus HIV completamente morto, ou um antígeno de p24. Também são providos kits, cujos componentes, quando combinados, produzem as composições imunogênicas da invenção. A invenção também provê métodos de confecção de composições imunogênicas, pela combinação de um antígeno de HIV, uma molécula de ácido nucléico isolada contendo uma seq³ência imunoestimulante (ISS) e um adjuvante. A invenção ainda prove um método de imunização de um mamífero, pela melhoria da produção de <225>-quimiocina no mamífero, pela administração ao mamífero de uma composição imunogênica contendo um antígeno de HIV, uma molécula de ácido nucléico isolada contendo uma seq³ência imunoestimulante (ISS) e um adjuvante. Também é provido um método de inibição de AIDS, melhorando a produção de <225>-quimiocina no mamífero, pela administração ao mamífero de uma composição imunogênica contendo um antígeno de HIV, uma molécula de ácido nucléico isolada contendo uma seq³ência imunoestimulante (ISS) e um adjuvante.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13276299P | 1999-05-06 | 1999-05-06 | |
| US15066799P | 1999-08-25 | 1999-08-25 | |
| PCT/US2000/012495 WO2000067787A2 (en) | 1999-05-06 | 2000-05-05 | Hiv immunogenic compositions and methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0010323A true BR0010323A (pt) | 2002-01-08 |
Family
ID=26830710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0010323-3A BR0010323A (pt) | 1999-05-06 | 2000-05-05 | Composições imunogênicas, kit e método de confecção da mesma para uso na imunização de um mamìfero |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1176978A2 (pt) |
| AP (1) | AP1891A (pt) |
| AU (1) | AU4992900A (pt) |
| BR (1) | BR0010323A (pt) |
| CA (1) | CA2372960C (pt) |
| CR (1) | CR6491A (pt) |
| OA (1) | OA11937A (pt) |
| WO (1) | WO2000067787A2 (pt) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| NZ508927A (en) | 1998-05-22 | 2003-12-19 | Ottawa Health Research Inst | Methods and products for inducing mucosal immunity |
| EP1141314A2 (en) | 1998-12-31 | 2001-10-10 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| JP5084984B2 (ja) | 1999-02-17 | 2012-11-28 | シーエスエル、リミテッド | 免疫原複合体およびそれに関する方法 |
| DE60023300T2 (de) * | 1999-06-29 | 2006-07-06 | Glaxosmithkline Biologicals S.A. | Verwendung von cpg als adjuvans für hivimpstoff |
| WO2002052002A2 (en) | 2000-12-27 | 2002-07-04 | Dynavax Technologies Corporation | Immunomodulatory polynucleotides and methods of using the same |
| WO2002058726A1 (en) * | 2001-01-26 | 2002-08-01 | The Immune Response Corporation | Method for treating an hiv-infected individual by combining immunization with structured interruption of anti-retroviral treatment |
| DK2423335T3 (da) | 2001-06-21 | 2014-08-18 | Dynavax Tech Corp | Kimæriske immunmodulatoriske forbindelser og fremgangsmåder til anvendelse deraf |
| CA2452015C (en) | 2001-07-05 | 2012-07-03 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| IL160157A0 (en) | 2001-08-17 | 2004-07-25 | Coley Pharm Group Inc | Combination motif immune stimulation oligonucleotides with improved activity |
| AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| CA2388049A1 (en) | 2002-05-30 | 2003-11-30 | Immunotech S.A. | Immunostimulatory oligonucleotides and uses thereof |
| US7807803B2 (en) | 2002-07-03 | 2010-10-05 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| CA2494508A1 (en) * | 2002-07-03 | 2004-01-15 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| US20040053880A1 (en) | 2002-07-03 | 2004-03-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
| BR0315810A (pt) | 2002-10-29 | 2005-09-13 | Coley Pharmaceutical Group Ltd | Uso de oligonucleotìdeos cpg no tratamento de infecção por vìrus da hepatite c |
| EP1578954A4 (en) | 2002-12-11 | 2010-08-11 | Coley Pharm Group Inc | 5'-CPG NUCLEIC ACIDS AND USE METHOD |
| SG2011035342A (en) | 2002-12-23 | 2016-12-29 | Dynavax Tech Corp | Immunostimulatory sequence oligonucleotides and methods of using the same |
| US8158768B2 (en) | 2002-12-23 | 2012-04-17 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
| AP2006003530A0 (en) * | 2003-08-28 | 2006-02-28 | Immune Response Corp Inc | Immunogenic HIV compositions and related methods. |
| MY159370A (en) | 2004-10-20 | 2016-12-30 | Coley Pharm Group Inc | Semi-soft-class immunostimulatory oligonucleotides |
| NZ575437A (en) | 2006-09-27 | 2012-02-24 | Coley Pharm Gmbh | Cpg oligonucleotide analogs containing hydrophobic t analogs with enhanced immunostimulatory activity |
| WO2010051820A1 (en) * | 2008-11-10 | 2010-05-14 | Aarhus Universitet | Multiplexed cytokine vaccination |
| WO2013006837A1 (en) | 2011-07-06 | 2013-01-10 | Novartis Ag | Cationic oil-in-water emulsions |
| MX350198B (es) | 2011-07-06 | 2017-08-30 | Novartis Ag | Emulsiones aceite en agua que contienen acidos nucleicos. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998040100A1 (en) * | 1997-03-10 | 1998-09-17 | Ottawa Civic Loeb Research Institute | USE OF NUCLEIC ACIDS CONTAINING UNMETHYLATED CpG DINUCLEOTIDE AS AN ADJUVANT |
| WO1998055495A2 (en) * | 1997-06-06 | 1998-12-10 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
-
2000
- 2000-05-05 CA CA002372960A patent/CA2372960C/en not_active Expired - Fee Related
- 2000-05-05 OA OA1200100291A patent/OA11937A/en unknown
- 2000-05-05 AU AU49929/00A patent/AU4992900A/en not_active Abandoned
- 2000-05-05 BR BR0010323-3A patent/BR0010323A/pt not_active IP Right Cessation
- 2000-05-05 AP APAP/P/2001/002300A patent/AP1891A/en active
- 2000-05-05 EP EP00932163A patent/EP1176978A2/en not_active Withdrawn
- 2000-05-05 WO PCT/US2000/012495 patent/WO2000067787A2/en active Application Filing
-
2001
- 2001-10-25 CR CR6491A patent/CR6491A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000067787A2 (en) | 2000-11-16 |
| WO2000067787A3 (en) | 2001-04-26 |
| CR6491A (es) | 2005-05-31 |
| AP1891A (en) | 2008-09-23 |
| CA2372960C (en) | 2006-03-28 |
| AP2001002300A0 (en) | 2001-12-31 |
| CA2372960A1 (en) | 2000-11-16 |
| OA11937A (en) | 2006-04-12 |
| AU4992900A (en) | 2000-11-21 |
| EP1176978A2 (en) | 2002-02-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: dismissal - article 86 of industrial property law |
Free format text: REFERENTE A 9A ANUIDADE(S) |
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| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2047 DE 30/03/2010. |