BR0008789A - Promotor que pode ser induzido pelo calor - Google Patents

Promotor que pode ser induzido pelo calor

Info

Publication number
BR0008789A
BR0008789A BR0008789-0A BR0008789A BR0008789A BR 0008789 A BR0008789 A BR 0008789A BR 0008789 A BR0008789 A BR 0008789A BR 0008789 A BR0008789 A BR 0008789A
Authority
BR
Brazil
Prior art keywords
heat
nucleic acid
promoter
inducible promoter
inducible
Prior art date
Application number
BR0008789-0A
Other languages
English (en)
Other versions
BRPI0008789B1 (pt
Inventor
Ivano Romano
Gerd Gellissen
Claudio Virgilio
Original Assignee
Rhein Biotech Proz & Prod Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhein Biotech Proz & Prod Gmbh filed Critical Rhein Biotech Proz & Prod Gmbh
Publication of BR0008789A publication Critical patent/BR0008789A/pt
Publication of BRPI0008789B1 publication Critical patent/BRPI0008789B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Air Conditioning Control Device (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Tires In General (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Sorption Type Refrigeration Machines (AREA)

Abstract

Patente de invenção: "PROMOTOR QUE PODE SER INDUZIDO PELO CALOR". A invenção refere-se a moléculas de ácido nucléico que compreendem um promotor que pode ser induzido pelo calor e a vetores de expressão e a células hospedeiras que contêm pelo menos uma molécula de ácido nucléico de acordo com a invenção. A presente invenção refere-se ainda a kits e a processos para a produção de uma ou mais proteínas utilizando as moléculas de ácido nucléico de acordo com a invenção e a vários usos das mesmas. O objetivo da invenção é fornecer um promotor cuja característica induzível por calor seja a mais seletiva possível, em particular um promotor que seja ativo em leveduras e que seja adequado para a expressão de proteínas a altas temperaturas. Este objetivo é alcançado por uma molécula de ácido nucléico que compreende um promotor que pode ser induzido pelo calor e que é selecionado dos ácidos nucléicos a seguir: (a) um ácido nucléico cuja seq³ência compreende a seq³ência promotora de um gene de Hansenula polymorpha que codifica uma proteína com atividade trealose-6-fosfato sintase; (b) um ácido nucléico com a seq³ência indicada na SEQ ID N<0>:1;(c) um ácido nucléico com uma seq³ência que exibe pelo menos 40% de identidade em relação a um comprimento de 300 pb com uma das seq³ências indicadas em (a) ou (b); (d) um ácido nucléico que se hibridiza à fita complementar de um dos ácidos nucléicos indicados em (a), (b) ou (c); (e) um derivado de um dos ácidos nucléicos indicados em (a), (b) ou (c) obtido pela substituição, adição e/ou deleção de um ou mais nucleotídeos; (f) um fragmento de um dos ácidos nucléicos indicados em (a) até (e) que mantém a função do promotor que pode ser induzido por calor; (g) uma combinação de vários dos ácidos nucléicos indicados em (a) até (f), em que as seq³ências dos ácidos nucléicos podem ser diferentes ou iguais; ou através de uma molécula de ácido nucléico cuja seq³ência é complementar à seq³ência de um dos ácidos nucléicos indicados em (a) até (g).
BRPI0008789A 1999-02-11 2000-02-11 molécula de ácido nucleico que compreende um promotor que pode ser induzido pelo calor, microorganismo transgênico, vetor de expressão, kit e processo para a produção de uma proteína BRPI0008789B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH00279/99A CH690127A5 (de) 1999-02-11 1999-02-11 Hitzeschock induzierter Promotor.
PCT/EP2000/001144 WO2000047749A1 (de) 1999-02-11 2000-02-11 Hitzeinduzierbarer promotor

Publications (2)

Publication Number Publication Date
BR0008789A true BR0008789A (pt) 2001-11-06
BRPI0008789B1 BRPI0008789B1 (pt) 2015-09-08

Family

ID=4183386

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0008789A BRPI0008789B1 (pt) 1999-02-11 2000-02-11 molécula de ácido nucleico que compreende um promotor que pode ser induzido pelo calor, microorganismo transgênico, vetor de expressão, kit e processo para a produção de uma proteína

Country Status (14)

Country Link
US (1) US6852511B2 (pt)
EP (1) EP1151112B1 (pt)
JP (1) JP3914389B2 (pt)
KR (1) KR100473882B1 (pt)
AT (1) ATE455856T1 (pt)
AU (1) AU3422200A (pt)
BR (1) BRPI0008789B1 (pt)
CA (1) CA2362518C (pt)
CH (1) CH690127A5 (pt)
DE (1) DE50015851D1 (pt)
IL (2) IL144648A0 (pt)
RU (1) RU2230786C2 (pt)
TR (1) TR200102302T2 (pt)
WO (1) WO2000047749A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7901191B1 (en) 2005-04-07 2011-03-08 Parker Hannifan Corporation Enclosure with fluid inducement chamber
US8682619B2 (en) * 2005-12-14 2014-03-25 The Invention Science Fund I, Llc Device including altered microorganisms, and methods and systems of use
US8278094B2 (en) 2005-12-14 2012-10-02 The Invention Science Fund I, Llc Bone semi-permeable device
US20110172826A1 (en) * 2005-12-14 2011-07-14 Amodei Dario G Device including altered microorganisms, and methods and systems of use
US8734823B2 (en) * 2005-12-14 2014-05-27 The Invention Science Fund I, Llc Device including altered microorganisms, and methods and systems of use
US8852916B2 (en) 2010-01-22 2014-10-07 The Invention Science Fund I, Llc Compositions and methods for therapeutic delivery with microorganisms
WO2011159153A2 (en) * 2010-06-15 2011-12-22 Universiteit Utrecht Holding B.V. Inducible promoter and its use
US11504427B2 (en) 2016-11-22 2022-11-22 The Regents Of The University Of California Acoustic and ultrasound-based mechanogenetics and thermogenetics for immunotherapy
US20220298515A1 (en) * 2019-09-10 2022-09-22 The Regents Of The University Of California Ultrasound-based thermogenetics for immunotherapy

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5792921A (en) * 1992-02-14 1998-08-11 Londesborough; John Increasing the trehalose content of organisms by transforming them with combinations of the structural genes for trehalose synthase
US5422254A (en) * 1992-02-14 1995-06-06 Oy Alko Ab Method to increase the trehalose content of organisms by transforming them with the structural genes for the short and long chains of yeast trehalose synthase

Also Published As

Publication number Publication date
ATE455856T1 (de) 2010-02-15
US6852511B2 (en) 2005-02-08
JP2002536020A (ja) 2002-10-29
AU3422200A (en) 2000-08-29
JP3914389B2 (ja) 2007-05-16
TR200102302T2 (tr) 2002-02-21
RU2230786C2 (ru) 2004-06-20
KR100473882B1 (ko) 2005-03-08
IL144648A (en) 2007-08-19
CA2362518C (en) 2009-04-21
IL144648A0 (en) 2002-05-23
WO2000047749A1 (de) 2000-08-17
EP1151112A1 (de) 2001-11-07
DE50015851D1 (de) 2010-03-11
CA2362518A1 (en) 2000-08-17
KR20010108200A (ko) 2001-12-07
EP1151112B1 (de) 2010-01-20
CH690127A5 (de) 2000-05-15
BRPI0008789B1 (pt) 2015-09-08
US20040086998A1 (en) 2004-05-06

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B09Y Publication of grant cancelled [chapter 9.1.2 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B11D Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time
B11N Dismissal: publication cancelled [chapter 11.14 patent gazette]

Free format text: PUBLICACAO ANULADA REFERENTE RPI/2330 DE 01/09/2015, POR TER SIDO INDEVIDA.

B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 08/09/2015, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 19A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2500 DE 04-12-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.