BR0007499A - Composto - Google Patents

Composto

Info

Publication number
BR0007499A
BR0007499A BR0007499-3A BR0007499A BR0007499A BR 0007499 A BR0007499 A BR 0007499A BR 0007499 A BR0007499 A BR 0007499A BR 0007499 A BR0007499 A BR 0007499A
Authority
BR
Brazil
Prior art keywords
compound
contrast media
group
contrast
arginine
Prior art date
Application number
BR0007499-3A
Other languages
English (en)
Inventor
Don A Gabriel
Laura J Melton
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina filed Critical Univ North Carolina
Publication of BR0007499A publication Critical patent/BR0007499A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPOSTO". A presente invenção provê agentes de contraste iónico básicos que tem atividade anticoagulante. Os meios de contraste incorporam um grupo lisina ou arginina ou derivado, e tem um grupo amino ou guanidino livre. Os métodos para usar os meios de contraste também são descritos.
BR0007499-3A 1999-01-12 2000-01-12 Composto BR0007499A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11558699P 1999-01-12 1999-01-12
PCT/US2000/000755 WO2000042010A1 (en) 1999-01-12 2000-01-12 Contrast media for angiography

Publications (1)

Publication Number Publication Date
BR0007499A true BR0007499A (pt) 2001-10-23

Family

ID=22362282

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0007499-3A BR0007499A (pt) 1999-01-12 2000-01-12 Composto

Country Status (8)

Country Link
US (4) US6265610B1 (pt)
EP (1) EP1140829A4 (pt)
JP (1) JP2002534502A (pt)
AU (1) AU764788C (pt)
BR (1) BR0007499A (pt)
CA (1) CA2360560A1 (pt)
MX (1) MXPA01007130A (pt)
WO (1) WO2000042010A1 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265610B1 (en) * 1999-01-12 2001-07-24 The University Of North Carolina At Chapel Hill Contrast media for angiography
US6685733B1 (en) * 2002-04-10 2004-02-03 Radiant Medical, Inc. Methods and systems for reducing substance-induced renal damage
KR20080058436A (ko) * 2005-10-13 2008-06-25 와이어쓰 글루탐산 유도체의 제조 방법
NO20055702D0 (no) * 2005-12-02 2005-12-02 Amersham Health As Contrast agents
US8808944B2 (en) * 2006-03-15 2014-08-19 General Electric Company Method for storing holographic data
PT2063916E (pt) * 2006-09-18 2015-02-25 Forim X Ag Agente de contraste radiográfico para a angiografia experimental e post mortem
CN101888992A (zh) * 2007-11-07 2010-11-17 通用电气医疗集团股份有限公司 对比剂

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT224264B (de) * 1961-02-11 1962-11-12 Chemie Linz Ag Röntgenkontrastmittel
FR2085636B1 (pt) 1970-04-15 1973-06-08 Guerbet Lab Andre
BE795555A (fr) 1972-02-16 1973-08-16 Schering Ag Amides de triiodo-isophtaloyl-monoamino-acide, leur procede de preparation et leur utilisation
GB1488903A (en) 1974-05-31 1977-10-19 Guerbet Sa X-ray contrast media
AR207465A1 (es) 1974-05-31 1976-10-08 Guerbet Lab Andre Procedimiento de preparacion de derivados de acido triiodoi2,4,6-(triiodo-2,4,6-benzoil)-amino-alcanoilaminobenzoico de acido triiodo-2,4,6-(triiodo-2,4,6-(triiodo-2,4,6-benzoil)-aminoalcanoilaminobenzoil)-amino-alcanoil-aminobenzoico y de acido triiodo-2,4,6-bis((triiodo-2,4,6-fenil)-carbamoil-metil)-aminoalcanoil-aminobenzoico
US4065553A (en) 1974-05-31 1977-12-27 Laboratoires Andre Guerbet X-Ray contrast media
FR2427326A2 (fr) 1978-05-31 1979-12-28 Guerbet Sa Nouveaux derives ioniques polyiodes du benzene, utilisables comme produits opacifiants pour la radiographie
DE2852094A1 (de) 1978-11-30 1980-06-12 Schering Ag Neue roentgenkontrastmittel
FR2511871A1 (fr) 1981-08-28 1983-03-04 Guerbet Sa Procede pour augmenter la tolerance des produits opacifiants et produits opacifiants ainsi obtenus
US5075501A (en) 1989-10-02 1991-12-24 Ethyl Corporation Mixed tert-amine oxide dihydrates
US5614638A (en) 1989-11-29 1997-03-25 Bracco International B.V. Nonionic radiographic contrast agents
US5527926A (en) * 1990-11-26 1996-06-18 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
FR2673180B1 (fr) 1991-02-25 1994-03-04 Guerbet Sa Nouveaux composes non ioniques poly-iodes, procede de preparation, produit de contraste les contenant.
US5324503A (en) 1992-02-06 1994-06-28 Mallinckrodt Medical, Inc. Iodo-phenylated chelates for x-ray contrast
FR2695125B1 (fr) 1992-08-25 1994-12-23 Guerbet Sa Nouveaux composés poly-iodés, procédé de préparation, produit de contraste les contenant.
IL110391A (en) 1993-07-30 1998-12-06 Zambon Spa Process for the formation of infamidol
IT1274027B (it) 1994-03-03 1997-07-14 Zambon Spa Processo per la preparazione e purificazione di mezzi di contrasto iodurati
US5567410A (en) 1994-06-24 1996-10-22 The General Hospital Corporation Composotions and methods for radiographic imaging
US6265610B1 (en) * 1999-01-12 2001-07-24 The University Of North Carolina At Chapel Hill Contrast media for angiography

Also Published As

Publication number Publication date
US6498273B2 (en) 2002-12-24
US20030120034A1 (en) 2003-06-26
AU2504100A (en) 2000-08-01
US20040081620A1 (en) 2004-04-29
US6943269B2 (en) 2005-09-13
CA2360560A1 (en) 2000-07-20
US6265610B1 (en) 2001-07-24
EP1140829A4 (en) 2003-06-18
US6610850B2 (en) 2003-08-26
AU764788C (en) 2004-05-06
AU764788B2 (en) 2003-08-28
JP2002534502A (ja) 2002-10-15
US20020040162A1 (en) 2002-04-04
EP1140829A1 (en) 2001-10-10
WO2000042010A1 (en) 2000-07-20
MXPA01007130A (es) 2002-04-24

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Legal Events

Date Code Title Description
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A, 8A, 9A E 10A ANUIDAD(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2073 DE 28/09/2010.