BR0005189A - Compostos de ciclo-pentanona diidro-piridina úteis como abridores de canais de potássio - Google Patents

Compostos de ciclo-pentanona diidro-piridina úteis como abridores de canais de potássio

Info

Publication number
BR0005189A
BR0005189A BR0005189-6A BR0005189A BR0005189A BR 0005189 A BR0005189 A BR 0005189A BR 0005189 A BR0005189 A BR 0005189A BR 0005189 A BR0005189 A BR 0005189A
Authority
BR
Brazil
Prior art keywords
potassium channel
channel openers
dihydropyridine
compounds useful
cyclopentanone compounds
Prior art date
Application number
BR0005189-6A
Other languages
English (en)
Inventor
William A Carroll
Yiyuan Chen
Irene Drizin
James F Kerwin
Jimmie L Moore
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of BR0005189A publication Critical patent/BR0005189A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/298Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • C07D221/06Ring systems of three rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

"COMPOSTOS DE CICLO-PENTANONA DIIDRO-PIRIDINA úTEIS COMO ABRIDORES DE CANAIS DE POTáSSIO" Compostos da fórmula ( I ) são úteis no tratamento de doenças que podem ser prevenidas por abridores de canais de potássio ou melhoradas com eles. Também descritas são composições abridoras de canais de potássio e um processo para se abrir canais de potássio em um mamífero.
BR0005189-6A 1999-03-04 2000-03-06 Compostos de ciclo-pentanona diidro-piridina úteis como abridores de canais de potássio BR0005189A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/262,441 US6518279B2 (en) 1999-03-04 1999-03-04 Cyclopentanone dihydropyridine compounds useful as potassium channel openers
PCT/US2000/005828 WO2000051986A1 (en) 1999-03-04 2000-03-06 Cyclopentanone dihydropyridine compounds useful as potassium channel openers

Publications (1)

Publication Number Publication Date
BR0005189A true BR0005189A (pt) 2001-01-09

Family

ID=22997528

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0005189-6A BR0005189A (pt) 1999-03-04 2000-03-06 Compostos de ciclo-pentanona diidro-piridina úteis como abridores de canais de potássio

Country Status (20)

Country Link
US (1) US6518279B2 (pt)
EP (1) EP1075466A1 (pt)
JP (1) JP2003517454A (pt)
KR (1) KR20010043295A (pt)
CN (1) CN1318053A (pt)
AR (1) AR028987A1 (pt)
AU (1) AU3616800A (pt)
BG (1) BG104999A (pt)
BR (1) BR0005189A (pt)
CA (1) CA2330541A1 (pt)
CO (1) CO5150208A1 (pt)
HU (1) HUP0102895A3 (pt)
IL (1) IL139140A0 (pt)
MX (1) MXPA00010790A (pt)
NO (1) NO20005570L (pt)
PL (1) PL343883A1 (pt)
SK (1) SK18152000A3 (pt)
TR (1) TR200003202T1 (pt)
WO (1) WO2000051986A1 (pt)
ZA (1) ZA200005798B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265417B1 (en) 1997-12-18 2001-07-24 Abbott Laboratories Potassium channel openers
US6593335B1 (en) 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
US7074931B2 (en) 2000-08-02 2006-07-11 Astrazeneca Ab Process for asymmetric synthesis of substituted 1,4 -dihydropyridines
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
US20030199578A1 (en) * 2002-04-19 2003-10-23 Turner Sean C. Naphthalene amides as potassium channel openers
DE602007003697D1 (de) 2006-02-10 2010-01-21 Janssen Pharmaceutica Nv Ffner
CN102348702B (zh) 2009-02-18 2014-01-29 拜耳知识产权有限责任公司 二环和三环吲唑-取代的1,4-二氢吡啶衍生物及其用途
WO2021253180A1 (en) * 2020-06-15 2021-12-23 Novartis Ag Methyl (r) -2- (fluoromethyl) -5-oxo-4-phenyl-4, 5, 6, 7-tetrahydro-1h-cyclopenta [b] pyridine-3-carboxylate and methyl (r) -2- (fluoromethyl) -5-oxo-4-phenyl-1, 4, 5, 7-tetrahydrofuro [3, 4-b] pyridine-3-carboxylate as cav1.2 activators
US11939316B1 (en) 2023-11-06 2024-03-26 King Faisal University 9-(6-flouro-2-hydroxyouinolin-3-yl)-10-(2-hydroxyethyl)-3,6-diphenyl-3,4,6,7,9,10-hexhydroacridine-1,8(2h,5h)-dione as an antimicrobial compound
US11970478B1 (en) 2023-11-16 2024-04-30 King Faisal University 9-(2-hydroxyquinolin-3-yl)-10-(2-hydroxyethyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine1,8(2H,5H)-dione as an antimicrobial compound

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2003148A1 (de) 1970-01-24 1971-07-29 Bayer Ag Neue 1,4-Dihydropyridinderivate
DE3447170A1 (de) 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen Mischung unterschiedlicher dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
GB8716971D0 (en) 1987-07-17 1987-08-26 Pfizer Ltd Therapeutic agents
GB8907401D0 (en) 1989-04-01 1989-05-17 Pfizer Ltd Therapeutic agents
GB9220570D0 (en) 1991-10-21 1992-11-11 Ici Plc Therapeutic agent
EP0539154B1 (en) 1991-10-21 1997-12-29 Zeneca Limited Acridine-1,8-dione-derivatives as therapeutic agents
GB9318935D0 (en) 1992-10-20 1993-10-27 Zeneca Ltd Heterocyclic derivatives
DE4313690A1 (de) 1993-04-27 1994-11-03 Bayer Ag Kondensierte Chinolyl-dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
TR200001715T2 (tr) 1997-12-18 2000-12-21 Abbott Laboratories Potasyum kanalı açıcıları.

Also Published As

Publication number Publication date
KR20010043295A (ko) 2001-05-25
EP1075466A1 (en) 2001-02-14
HUP0102895A2 (hu) 2001-12-28
NO20005570D0 (no) 2000-11-03
US20020007065A1 (en) 2002-01-17
AR028987A1 (es) 2003-06-04
CA2330541A1 (en) 2000-09-08
NO20005570L (no) 2000-11-03
US6518279B2 (en) 2003-02-11
MXPA00010790A (es) 2002-06-04
SK18152000A3 (sk) 2001-06-11
JP2003517454A (ja) 2003-05-27
BG104999A (en) 2001-10-31
WO2000051986A1 (en) 2000-09-08
AU3616800A (en) 2000-09-21
PL343883A1 (en) 2001-09-10
CN1318053A (zh) 2001-10-17
CO5150208A1 (es) 2002-04-29
IL139140A0 (en) 2001-11-25
ZA200005798B (en) 2002-01-18
HUP0102895A3 (en) 2002-01-28
TR200003202T1 (tr) 2001-08-21

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1925 DE 27/11/2007.