BR0005189A - Compostos de ciclo-pentanona diidro-piridina úteis como abridores de canais de potássio - Google Patents
Compostos de ciclo-pentanona diidro-piridina úteis como abridores de canais de potássioInfo
- Publication number
- BR0005189A BR0005189A BR0005189-6A BR0005189A BR0005189A BR 0005189 A BR0005189 A BR 0005189A BR 0005189 A BR0005189 A BR 0005189A BR 0005189 A BR0005189 A BR 0005189A
- Authority
- BR
- Brazil
- Prior art keywords
- potassium channel
- channel openers
- dihydropyridine
- compounds useful
- cyclopentanone compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Abstract
"COMPOSTOS DE CICLO-PENTANONA DIIDRO-PIRIDINA úTEIS COMO ABRIDORES DE CANAIS DE POTáSSIO" Compostos da fórmula ( I ) são úteis no tratamento de doenças que podem ser prevenidas por abridores de canais de potássio ou melhoradas com eles. Também descritas são composições abridoras de canais de potássio e um processo para se abrir canais de potássio em um mamífero.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/262,441 US6518279B2 (en) | 1999-03-04 | 1999-03-04 | Cyclopentanone dihydropyridine compounds useful as potassium channel openers |
PCT/US2000/005828 WO2000051986A1 (en) | 1999-03-04 | 2000-03-06 | Cyclopentanone dihydropyridine compounds useful as potassium channel openers |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0005189A true BR0005189A (pt) | 2001-01-09 |
Family
ID=22997528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0005189-6A BR0005189A (pt) | 1999-03-04 | 2000-03-06 | Compostos de ciclo-pentanona diidro-piridina úteis como abridores de canais de potássio |
Country Status (20)
Country | Link |
---|---|
US (1) | US6518279B2 (pt) |
EP (1) | EP1075466A1 (pt) |
JP (1) | JP2003517454A (pt) |
KR (1) | KR20010043295A (pt) |
CN (1) | CN1318053A (pt) |
AR (1) | AR028987A1 (pt) |
AU (1) | AU3616800A (pt) |
BG (1) | BG104999A (pt) |
BR (1) | BR0005189A (pt) |
CA (1) | CA2330541A1 (pt) |
CO (1) | CO5150208A1 (pt) |
HU (1) | HUP0102895A3 (pt) |
IL (1) | IL139140A0 (pt) |
MX (1) | MXPA00010790A (pt) |
NO (1) | NO20005570L (pt) |
PL (1) | PL343883A1 (pt) |
SK (1) | SK18152000A3 (pt) |
TR (1) | TR200003202T1 (pt) |
WO (1) | WO2000051986A1 (pt) |
ZA (1) | ZA200005798B (pt) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6265417B1 (en) | 1997-12-18 | 2001-07-24 | Abbott Laboratories | Potassium channel openers |
US6593335B1 (en) | 1997-12-18 | 2003-07-15 | Abbott Laboratories | Potassium channel openers |
US7074931B2 (en) | 2000-08-02 | 2006-07-11 | Astrazeneca Ab | Process for asymmetric synthesis of substituted 1,4 -dihydropyridines |
US20030045449A1 (en) * | 2001-08-15 | 2003-03-06 | Pfizer, Inc. | Pharmaceutical combinations for the treatment of neurodegenerative diseases |
US20030199578A1 (en) * | 2002-04-19 | 2003-10-23 | Turner Sean C. | Naphthalene amides as potassium channel openers |
DE602007003697D1 (de) | 2006-02-10 | 2010-01-21 | Janssen Pharmaceutica Nv | Ffner |
CN102348702B (zh) | 2009-02-18 | 2014-01-29 | 拜耳知识产权有限责任公司 | 二环和三环吲唑-取代的1,4-二氢吡啶衍生物及其用途 |
WO2021253180A1 (en) * | 2020-06-15 | 2021-12-23 | Novartis Ag | Methyl (r) -2- (fluoromethyl) -5-oxo-4-phenyl-4, 5, 6, 7-tetrahydro-1h-cyclopenta [b] pyridine-3-carboxylate and methyl (r) -2- (fluoromethyl) -5-oxo-4-phenyl-1, 4, 5, 7-tetrahydrofuro [3, 4-b] pyridine-3-carboxylate as cav1.2 activators |
US11939316B1 (en) | 2023-11-06 | 2024-03-26 | King Faisal University | 9-(6-flouro-2-hydroxyouinolin-3-yl)-10-(2-hydroxyethyl)-3,6-diphenyl-3,4,6,7,9,10-hexhydroacridine-1,8(2h,5h)-dione as an antimicrobial compound |
US11970478B1 (en) | 2023-11-16 | 2024-04-30 | King Faisal University | 9-(2-hydroxyquinolin-3-yl)-10-(2-hydroxyethyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine1,8(2H,5H)-dione as an antimicrobial compound |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2003148A1 (de) | 1970-01-24 | 1971-07-29 | Bayer Ag | Neue 1,4-Dihydropyridinderivate |
DE3447170A1 (de) | 1984-12-22 | 1986-07-03 | Bayer Ag, 5090 Leverkusen | Mischung unterschiedlicher dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
GB8716971D0 (en) | 1987-07-17 | 1987-08-26 | Pfizer Ltd | Therapeutic agents |
GB8907401D0 (en) | 1989-04-01 | 1989-05-17 | Pfizer Ltd | Therapeutic agents |
GB9220570D0 (en) | 1991-10-21 | 1992-11-11 | Ici Plc | Therapeutic agent |
EP0539154B1 (en) | 1991-10-21 | 1997-12-29 | Zeneca Limited | Acridine-1,8-dione-derivatives as therapeutic agents |
GB9318935D0 (en) | 1992-10-20 | 1993-10-27 | Zeneca Ltd | Heterocyclic derivatives |
DE4313690A1 (de) | 1993-04-27 | 1994-11-03 | Bayer Ag | Kondensierte Chinolyl-dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
TR200001715T2 (tr) | 1997-12-18 | 2000-12-21 | Abbott Laboratories | Potasyum kanalı açıcıları. |
-
1999
- 1999-03-04 US US09/262,441 patent/US6518279B2/en not_active Expired - Fee Related
-
2000
- 2000-03-01 CO CO00014719A patent/CO5150208A1/es unknown
- 2000-03-02 AR ARP000100931A patent/AR028987A1/es not_active Application Discontinuation
- 2000-03-06 KR KR1020007012257A patent/KR20010043295A/ko not_active Application Discontinuation
- 2000-03-06 MX MXPA00010790A patent/MXPA00010790A/es unknown
- 2000-03-06 CN CN00800760A patent/CN1318053A/zh active Pending
- 2000-03-06 EP EP00914832A patent/EP1075466A1/en not_active Withdrawn
- 2000-03-06 AU AU36168/00A patent/AU3616800A/en not_active Abandoned
- 2000-03-06 IL IL13914000A patent/IL139140A0/xx unknown
- 2000-03-06 HU HU0102895A patent/HUP0102895A3/hu unknown
- 2000-03-06 TR TR2000/03202T patent/TR200003202T1/xx unknown
- 2000-03-06 CA CA002330541A patent/CA2330541A1/en not_active Abandoned
- 2000-03-06 PL PL00343883A patent/PL343883A1/xx not_active Application Discontinuation
- 2000-03-06 BR BR0005189-6A patent/BR0005189A/pt not_active IP Right Cessation
- 2000-03-06 JP JP2000602213A patent/JP2003517454A/ja not_active Withdrawn
- 2000-03-06 SK SK1815-2000A patent/SK18152000A3/sk unknown
- 2000-03-06 WO PCT/US2000/005828 patent/WO2000051986A1/en not_active Application Discontinuation
- 2000-10-18 ZA ZA200005798A patent/ZA200005798B/en unknown
- 2000-11-03 NO NO20005570A patent/NO20005570L/no not_active Application Discontinuation
- 2000-11-28 BG BG104999A patent/BG104999A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
KR20010043295A (ko) | 2001-05-25 |
EP1075466A1 (en) | 2001-02-14 |
HUP0102895A2 (hu) | 2001-12-28 |
NO20005570D0 (no) | 2000-11-03 |
US20020007065A1 (en) | 2002-01-17 |
AR028987A1 (es) | 2003-06-04 |
CA2330541A1 (en) | 2000-09-08 |
NO20005570L (no) | 2000-11-03 |
US6518279B2 (en) | 2003-02-11 |
MXPA00010790A (es) | 2002-06-04 |
SK18152000A3 (sk) | 2001-06-11 |
JP2003517454A (ja) | 2003-05-27 |
BG104999A (en) | 2001-10-31 |
WO2000051986A1 (en) | 2000-09-08 |
AU3616800A (en) | 2000-09-21 |
PL343883A1 (en) | 2001-09-10 |
CN1318053A (zh) | 2001-10-17 |
CO5150208A1 (es) | 2002-04-29 |
IL139140A0 (en) | 2001-11-25 |
ZA200005798B (en) | 2002-01-18 |
HUP0102895A3 (en) | 2002-01-28 |
TR200003202T1 (tr) | 2001-08-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1925 DE 27/11/2007. |