CO5150208A1 - Compuestos de dihidropiridina ciclopentanona utiles como abridores de canales de potasio - Google Patents

Compuestos de dihidropiridina ciclopentanona utiles como abridores de canales de potasio

Info

Publication number
CO5150208A1
CO5150208A1 CO00014719A CO00014719A CO5150208A1 CO 5150208 A1 CO5150208 A1 CO 5150208A1 CO 00014719 A CO00014719 A CO 00014719A CO 00014719 A CO00014719 A CO 00014719A CO 5150208 A1 CO5150208 A1 CO 5150208A1
Authority
CO
Colombia
Prior art keywords
group
alkyl
haloalkyl
hydrogen
dihydropiridine
Prior art date
Application number
CO00014719A
Other languages
English (en)
Inventor
William A Carroll
Chen Yiyuan
Irene Drizin
James F Kerwin
Jimmie L Moore
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of CO5150208A1 publication Critical patent/CO5150208A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Un compuesto que tiene la fórmula I<EMI FILE="00014719_1" ID="1" IMF=JPEG >o una sal, ester o amida del mismo farmacéuticamente aceptable, en donde la línea punteada representa la presencia de un enlace doble opcional; R1 es seleccionado del grupo que consiste de arilo y heteroarilo; A es seleccionado del grupo que consiste de hidrógeno, alquil, ciano, haloalquil, heteroaril, nitro y -C(O)R2, en donde R2 es seleccionado del grupo que consiste de alquil, haloalquil e hidroxi; R3 es seleccionado del grupo que consiste de hidrógeno, alquil y haloalquil; y A y R3 tomado juntos con el anillo al cual están unidos pueden formar un anillo carbocíclico de 5 o 6 miembros, dicho anillo carbocíclico de 5 o 6 miembros puede contener 1 o 2 enlaces dobles y puede ser substituido con 1 o 2 substituyentes seleccionados del grupo que consiste de hidrógeno, alquenil, alcoxi, alcoxialcoxi, alcoxialquil, alquil, alquinil, arilalcoxi, haloalquenil, haloalquil, halógeno, hidroxi, hidroxialquenil, hidroxialquil, oxo, y -NR4R5 en donde R4 y R5 son seleccionados independientemente del grupo que consiste de hidrógeno y alquilo C1-C4.
CO00014719A 1999-03-04 2000-03-01 Compuestos de dihidropiridina ciclopentanona utiles como abridores de canales de potasio CO5150208A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/262,441 US6518279B2 (en) 1999-03-04 1999-03-04 Cyclopentanone dihydropyridine compounds useful as potassium channel openers

Publications (1)

Publication Number Publication Date
CO5150208A1 true CO5150208A1 (es) 2002-04-29

Family

ID=22997528

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00014719A CO5150208A1 (es) 1999-03-04 2000-03-01 Compuestos de dihidropiridina ciclopentanona utiles como abridores de canales de potasio

Country Status (20)

Country Link
US (1) US6518279B2 (es)
EP (1) EP1075466A1 (es)
JP (1) JP2003517454A (es)
KR (1) KR20010043295A (es)
CN (1) CN1318053A (es)
AR (1) AR028987A1 (es)
AU (1) AU3616800A (es)
BG (1) BG104999A (es)
BR (1) BR0005189A (es)
CA (1) CA2330541A1 (es)
CO (1) CO5150208A1 (es)
HU (1) HUP0102895A3 (es)
IL (1) IL139140A0 (es)
MX (1) MXPA00010790A (es)
NO (1) NO20005570L (es)
PL (1) PL343883A1 (es)
SK (1) SK18152000A3 (es)
TR (1) TR200003202T1 (es)
WO (1) WO2000051986A1 (es)
ZA (1) ZA200005798B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265417B1 (en) 1997-12-18 2001-07-24 Abbott Laboratories Potassium channel openers
US6593335B1 (en) 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
US7074931B2 (en) 2000-08-02 2006-07-11 Astrazeneca Ab Process for asymmetric synthesis of substituted 1,4 -dihydropyridines
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
US20030199578A1 (en) * 2002-04-19 2003-10-23 Turner Sean C. Naphthalene amides as potassium channel openers
JP2009526079A (ja) 2006-02-10 2009-07-16 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ カリウムチャンネル開放物質としての新規な三環式ジヒドロピラジン
JP5638011B2 (ja) 2009-02-18 2014-12-10 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 二および三環式インダゾール置換１，４−ジヒドロピリジン誘導体およびそれらの使用
WO2021253180A1 (en) * 2020-06-15 2021-12-23 Novartis Ag Methyl (r) -2- (fluoromethyl) -5-oxo-4-phenyl-4, 5, 6, 7-tetrahydro-1h-cyclopenta [b] pyridine-3-carboxylate and methyl (r) -2- (fluoromethyl) -5-oxo-4-phenyl-1, 4, 5, 7-tetrahydrofuro [3, 4-b] pyridine-3-carboxylate as cav1.2 activators
US11939316B1 (en) 2023-11-06 2024-03-26 King Faisal University 9-(6-flouro-2-hydroxyouinolin-3-yl)-10-(2-hydroxyethyl)-3,6-diphenyl-3,4,6,7,9,10-hexhydroacridine-1,8(2h,5h)-dione as an antimicrobial compound
US11970478B1 (en) 2023-11-16 2024-04-30 King Faisal University 9-(2-hydroxyquinolin-3-yl)-10-(2-hydroxyethyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine1,8(2H,5H)-dione as an antimicrobial compound

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2003148A1 (de) 1970-01-24 1971-07-29 Bayer Ag Neue 1,4-Dihydropyridinderivate
DE3447170A1 (de) 1984-12-22 1986-07-03 Bayer Ag, 5090 Leverkusen Mischung unterschiedlicher dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
GB8716971D0 (en) 1987-07-17 1987-08-26 Pfizer Ltd Therapeutic agents
GB8907401D0 (en) 1989-04-01 1989-05-17 Pfizer Ltd Therapeutic agents
ATE161531T1 (de) 1991-10-21 1998-01-15 Zeneca Ltd Acridine-1,8-dionderivate als therapeutisches mittel
GB9220570D0 (en) 1991-10-21 1992-11-11 Ici Plc Therapeutic agent
GB9318935D0 (en) 1992-10-20 1993-10-27 Zeneca Ltd Heterocyclic derivatives
DE4313690A1 (de) 1993-04-27 1994-11-03 Bayer Ag Kondensierte Chinolyl-dihydropyridine, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
WO1999031059A1 (en) 1997-12-18 1999-06-24 Abbott Laboratories Potassium channel openers

Also Published As

Publication number Publication date
WO2000051986A1 (en) 2000-09-08
US20020007065A1 (en) 2002-01-17
PL343883A1 (en) 2001-09-10
MXPA00010790A (es) 2002-06-04
AU3616800A (en) 2000-09-21
HUP0102895A3 (en) 2002-01-28
CA2330541A1 (en) 2000-09-08
EP1075466A1 (en) 2001-02-14
NO20005570D0 (no) 2000-11-03
AR028987A1 (es) 2003-06-04
BR0005189A (pt) 2001-01-09
JP2003517454A (ja) 2003-05-27
BG104999A (en) 2001-10-31
HUP0102895A2 (hu) 2001-12-28
NO20005570L (no) 2000-11-03
ZA200005798B (en) 2002-01-18
IL139140A0 (en) 2001-11-25
TR200003202T1 (tr) 2001-08-21
SK18152000A3 (sk) 2001-06-11
US6518279B2 (en) 2003-02-11
CN1318053A (zh) 2001-10-17
KR20010043295A (ko) 2001-05-25

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