AR023381A1 - Nuevo derivado de tiazolbenzoimidazol - Google Patents

Nuevo derivado de tiazolbenzoimidazol

Info

Publication number
AR023381A1
AR023381A1 ARP000101529A ARP000101529A AR023381A1 AR 023381 A1 AR023381 A1 AR 023381A1 AR P000101529 A ARP000101529 A AR P000101529A AR P000101529 A ARP000101529 A AR P000101529A AR 023381 A1 AR023381 A1 AR 023381A1
Authority
AR
Argentina
Prior art keywords
derivative
lower alkyl
hydrogen
tiazolbenzoimidazol
different
Prior art date
Application number
ARP000101529A
Other languages
English (en)
Original Assignee
Yamanouchi Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd
Publication of AR023381A1 publication Critical patent/AR023381A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Derivado de tiazolbenzoimidazol de formula general (1) o una sal del mismo. Los símbolos R1 y R2 pueden ser los mismos o diferentes entre si y cada unorepresenta hidrogeno, un alquilo o cicloalquilo inferior R3 : hidrogeno o un alquilo inferior, R4:un grupo representado por la formula -CH2-N(R5)-R6, y R5 yR6: estos pueden ser los mismos o diferentes entre sí y cada uno representa un hidrogeno o un alquilo inferior que pueden ser sustituidos, con la condicion deque R5 y R6 junto con el átomo denitrogeno adyacente, puedan tener un sustituyente o formar un hétero anillo o un heteroarilo saturado que puede tener otro(s)heteroátomos(s). El derivado actua específicamente sobre el receptor de glutamanto metabotropico y se usa como medicamento. Se proveen compuestos utiles comointermediarios a ser usados en la síntesis del derivado.
ARP000101529A 1999-04-06 2000-04-04 Nuevo derivado de tiazolbenzoimidazol AR023381A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9906299 1999-04-06

Publications (1)

Publication Number Publication Date
AR023381A1 true AR023381A1 (es) 2002-09-04

Family

ID=14237271

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000101529A AR023381A1 (es) 1999-04-06 2000-04-04 Nuevo derivado de tiazolbenzoimidazol

Country Status (10)

Country Link
US (1) US6642264B1 (es)
EP (1) EP1167369A4 (es)
KR (1) KR20010006951A (es)
CN (1) CN1120842C (es)
AR (1) AR023381A1 (es)
AU (2) AU2241400A (es)
CA (1) CA2365419A1 (es)
MX (1) MXPA00003390A (es)
PL (1) PL339443A1 (es)
WO (1) WO2000059913A1 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI290136B (en) 2000-04-05 2007-11-21 Daiichi Seiyaku Co Ethylenediamine derivatives
WO2002062803A1 (fr) * 2001-02-08 2002-08-15 Yamanouchi Pharmaceutical Co., Ltd. Derive de thienopyrimidine
PL220739B1 (pl) * 2001-06-20 2015-12-31 Daiichi Sankyo Company Pochodne diaminy
US7365205B2 (en) 2001-06-20 2008-04-29 Daiichi Sankyo Company, Limited Diamine derivatives
BR0211565A (pt) * 2001-08-09 2004-06-29 Daiichi Seiyaku Co Derivados de diamina
US6927036B2 (en) 2002-02-19 2005-08-09 Xero Port, Inc. Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
US7250429B2 (en) 2002-03-20 2007-07-31 Astellas Pharma Inc. Aminomethyl-substituted thiazolobenzimidazole compounds
AU2003255022A1 (en) * 2002-08-14 2004-03-03 Banyu Pharmaceutical Co., Ltd. Remedies for schizophrenia
TW200819458A (en) * 2006-06-23 2008-05-01 Merz Pharma Gmbh & Co Kgaa Metabotropic glutamate receptor modulators
GB0800411D0 (en) * 2008-01-10 2008-02-20 Glaxo Group Ltd Novel compounds
EP2298778A4 (en) * 2008-06-12 2011-10-05 Daiichi Sankyo Co Ltd IMIDAZOTHIAZOL DERIVATIVE WITH 4,7-DIAZASPIRO [2.5] OCTAN RING STRUCTURE
WO2010077295A1 (en) * 2008-12-09 2010-07-08 King Faisal Specialist Hospital & Research Centre Substituted tricyclic heterocycles and uses to treat tumors and proliferative disorders
HRP20211156T1 (hr) * 2015-08-28 2021-12-24 Chdi Foundation, Inc. Kontrastna sredstva za slikovnu dijagnostiku huntingtin proteina
CN108017659A (zh) * 2017-12-04 2018-05-11 沈阳药科大学 苯并咪唑并噻唑甲酰胺类化合物及其应用
TW202044646A (zh) * 2019-04-04 2020-12-01 美商希爾格得有限公司 用於高能量可充電鋰電池之聚醯胺—醯亞胺塗覆分隔件

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2782823B2 (ja) * 1989-08-21 1998-08-06 吉富製薬株式会社 ニコチン酸アミド化合物
US5576323A (en) 1993-12-03 1996-11-19 Eli Lilly And Company Excitatory amino acid receptor antagonists
MX9604023A (es) 1994-03-14 1997-09-30 Novo Nordisk As Compuestos heterociclicos, su preparacion y su uso.
JP3993651B2 (ja) 1994-10-21 2007-10-17 アスビオファーマ株式会社 シクロプロパクロメンカルボン酸誘導体
JPH11509847A (ja) 1995-07-31 1999-08-31 ノボ ノルディスク アクティーゼルスカブ ヘテロ環式化合物、それらの調製及び使用
WO1997005137A1 (en) 1995-07-31 1997-02-13 Novo Nordisk A/S Heterocyclic compounds, their preparation and use
WO1998006724A1 (fr) * 1996-08-09 1998-02-19 Yamanouchi Pharmaceutical Co., Ltd. Agonistes du recepteur du glutamate metabotropique
AU2642699A (en) * 1998-03-03 1999-09-20 Yamanouchi Pharmaceutical Co., Ltd. Remedies for brain infarction

Also Published As

Publication number Publication date
AU3670000A (en) 2000-10-23
US6642264B1 (en) 2003-11-04
AU2241400A (en) 2000-10-12
EP1167369A1 (en) 2002-01-02
CA2365419A1 (en) 2000-10-12
CN1120842C (zh) 2003-09-10
KR20010006951A (ko) 2001-01-26
EP1167369A4 (en) 2003-05-28
CN1271731A (zh) 2000-11-01
WO2000059913A1 (fr) 2000-10-12
PL339443A1 (en) 2000-10-09
MXPA00003390A (es) 2005-09-15

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