BR0003945A - Processo para a preparação de inibidores da 5-lipoxigenase possuindo diversos sistemas de anéis heterocìclicos - Google Patents

Processo para a preparação de inibidores da 5-lipoxigenase possuindo diversos sistemas de anéis heterocìclicos

Info

Publication number
BR0003945A
BR0003945A BR0003945-4A BR0003945A BR0003945A BR 0003945 A BR0003945 A BR 0003945A BR 0003945 A BR0003945 A BR 0003945A BR 0003945 A BR0003945 A BR 0003945A
Authority
BR
Brazil
Prior art keywords
preparation
formula
heterocyclic ring
ring systems
lipoxygenase inhibitors
Prior art date
Application number
BR0003945-4A
Other languages
English (en)
Inventor
Timothy Morris
John Francis Lambert
Megan Elizabeth Hnatow
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0003945A publication Critical patent/BR0003945A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Patente de Invenção: <B>"PROCESSO PARA A PREPARAçãO DE INIBIDORES DA 5-LIPOXIGENASE POSSUINDO DIVERSOS SISTEMAS DE ANéIS HETEROCìCLICOS"<D>. é descrito um novo intermediário de processo, tetrahidro-4-[3-(4-fluorofenil)tio]fenil-2H-piran-4-carboxamida, de fórmula: bem como a sua utilização um processo para a preparação de inibidores da 5-lipoxigenase de fórmula: o qual compreende a preparação de uma mistura reacional consistindo em: - e - um heterociclo de nitrogênio, monocíclico ou bicíclico fusionado em benzeno, deficiente em elétrons contendo dois átomos de nitrogênio de fórmula: um solvente aprótico; na presença de um carbonato de fórmula: (M)~ 2~-CO~ 3~, onde M é um metal alcalino, elemento do Grupo 1/Ia, selecionado a partir do grupo consistindo em lítio, Li; sódio, Na; potássio, K; rubídio, Rb; e césio, Cs; seguido do aquecimento da mistura reacional mencionada sob atmosfera de nitrogênio; através do qual é produzido o composto desejado de fórmula acima especificada. O
BR0003945-4A 1999-08-31 2000-08-31 Processo para a preparação de inibidores da 5-lipoxigenase possuindo diversos sistemas de anéis heterocìclicos BR0003945A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15161599P 1999-08-31 1999-08-31

Publications (1)

Publication Number Publication Date
BR0003945A true BR0003945A (pt) 2001-04-03

Family

ID=22539529

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0003945-4A BR0003945A (pt) 1999-08-31 2000-08-31 Processo para a preparação de inibidores da 5-lipoxigenase possuindo diversos sistemas de anéis heterocìclicos

Country Status (33)

Country Link
US (1) US6346624B1 (pt)
EP (1) EP1081143A1 (pt)
JP (1) JP2001106682A (pt)
KR (1) KR20010050256A (pt)
CN (1) CN1286250A (pt)
AP (1) AP2000001910A0 (pt)
AU (1) AU5360300A (pt)
BG (1) BG104731A (pt)
BR (1) BR0003945A (pt)
CA (1) CA2317097A1 (pt)
CZ (1) CZ20003158A3 (pt)
EA (1) EA200000801A1 (pt)
EE (1) EE200000512A (pt)
GT (1) GT200000142A (pt)
HR (1) HRP20000564A2 (pt)
HU (1) HUP0003439A3 (pt)
ID (1) ID27129A (pt)
IL (1) IL138087A0 (pt)
IS (1) IS5603A (pt)
MA (1) MA26751A1 (pt)
NO (1) NO20004313L (pt)
NZ (1) NZ506632A (pt)
OA (1) OA11452A (pt)
PA (1) PA8499701A1 (pt)
PE (1) PE20010520A1 (pt)
PL (1) PL342281A1 (pt)
SG (1) SG87146A1 (pt)
SK (1) SK12872000A3 (pt)
SV (1) SV2002000159A (pt)
TN (1) TNSN00177A1 (pt)
TR (1) TR200002529A2 (pt)
UY (1) UY26314A1 (pt)
ZA (1) ZA200004435B (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6669042B1 (en) * 2002-09-30 2003-12-30 Hewlett-Packard Development Company, L.P. Integrated positioning and locking device
EP1834953A1 (en) * 2006-03-14 2007-09-19 Ranbaxy Laboratories Limited Tetrahydropyrane derivatives as 5-lipoxygenase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063928A (en) * 1994-10-18 2000-05-16 Pfizer Inc 5-lipoxygenase inhibitors
US5883106A (en) * 1994-10-18 1999-03-16 Pfizer Inc. 5-lipoxygenase inhibitors
SK281577B6 (sk) 1994-10-18 2001-05-10 Pfizer Inc. Heterocyklické zlúčeniny a farmaceutický prostriedok na ich báze
US6239285B1 (en) * 1998-02-06 2001-05-29 Pfizer Inc Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems

Also Published As

Publication number Publication date
TR200002529A2 (tr) 2001-04-20
PE20010520A1 (es) 2001-04-28
BG104731A (en) 2001-09-28
HUP0003439A3 (en) 2002-08-28
SV2002000159A (es) 2002-01-23
IL138087A0 (en) 2001-10-31
CA2317097A1 (en) 2001-02-28
HU0003439D0 (en) 2000-08-30
SG87146A1 (en) 2002-03-19
OA11452A (en) 2003-12-08
SK12872000A3 (sk) 2001-11-06
CZ20003158A3 (cs) 2001-09-12
PA8499701A1 (es) 2001-12-14
GT200000142A (es) 2002-02-19
NO20004313L (no) 2001-03-01
MA26751A1 (fr) 2004-12-20
CN1286250A (zh) 2001-03-07
JP2001106682A (ja) 2001-04-17
US6346624B1 (en) 2002-02-12
EP1081143A1 (en) 2001-03-07
TNSN00177A1 (fr) 2005-11-10
AP2000001910A0 (en) 2000-09-30
HRP20000564A2 (en) 2001-12-31
ID27129A (id) 2001-03-01
HUP0003439A2 (hu) 2001-08-28
EA200000801A1 (ru) 2001-04-23
IS5603A (is) 2001-03-01
EE200000512A (et) 2001-04-16
UY26314A1 (es) 2001-04-30
KR20010050256A (ko) 2001-06-15
PL342281A1 (en) 2001-03-12
ZA200004435B (en) 2002-02-28
NO20004313D0 (no) 2000-08-30
NZ506632A (en) 2002-02-01
AU5360300A (en) 2001-03-08

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 3A, 4A, 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.