EA200000801A1 - Способ получения ингибиторов 5-липоксигеназы, включающих различные кольцевые гетероциклические системы - Google Patents
Способ получения ингибиторов 5-липоксигеназы, включающих различные кольцевые гетероциклические системыInfo
- Publication number
- EA200000801A1 EA200000801A1 EA200000801A EA200000801A EA200000801A1 EA 200000801 A1 EA200000801 A1 EA 200000801A1 EA 200000801 A EA200000801 A EA 200000801A EA 200000801 A EA200000801 A EA 200000801A EA 200000801 A1 EA200000801 A1 EA 200000801A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- obtaining
- including various
- inhibitors including
- lipoxygenase inhibitors
- heterocyclic systems
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Описан новый интермедиат, тетрагидро-4-[3-(4-фторфенил)тио]фенил-2H-пиран-4-карбоксамид формулытакже как и его использование в способе получения ингибиторов 5-липоксигеназы формулыкоторый заключается в образовании реакционной смеси, состоящей изэлектроно дефицитного моноциклического или бензоконденсированного бициклического N-гетероцикла, содержащего два атома азота, формулыв апротонном растворителе; в присутствии карбоната формулы: (M)-CO, где M - щелочной металл, элемент группы 1/Ia, выбранный из группы, состоящей из лития (Li), натрия (Na), калия (K), рубидия (Rb) и цезия (Cs), с последующим нагреванием указанной реакционной смеси в атмосфере азота; с получением целевого соединения вышеприведенной формулы.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15161599P | 1999-08-31 | 1999-08-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200000801A1 true EA200000801A1 (ru) | 2001-04-23 |
Family
ID=22539529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200000801A EA200000801A1 (ru) | 1999-08-31 | 2000-08-30 | Способ получения ингибиторов 5-липоксигеназы, включающих различные кольцевые гетероциклические системы |
Country Status (33)
Country | Link |
---|---|
US (1) | US6346624B1 (ru) |
EP (1) | EP1081143A1 (ru) |
JP (1) | JP2001106682A (ru) |
KR (1) | KR20010050256A (ru) |
CN (1) | CN1286250A (ru) |
AP (1) | AP2000001910A0 (ru) |
AU (1) | AU5360300A (ru) |
BG (1) | BG104731A (ru) |
BR (1) | BR0003945A (ru) |
CA (1) | CA2317097A1 (ru) |
CZ (1) | CZ20003158A3 (ru) |
EA (1) | EA200000801A1 (ru) |
EE (1) | EE200000512A (ru) |
GT (1) | GT200000142A (ru) |
HR (1) | HRP20000564A2 (ru) |
HU (1) | HUP0003439A3 (ru) |
ID (1) | ID27129A (ru) |
IL (1) | IL138087A0 (ru) |
IS (1) | IS5603A (ru) |
MA (1) | MA26751A1 (ru) |
NO (1) | NO20004313L (ru) |
NZ (1) | NZ506632A (ru) |
OA (1) | OA11452A (ru) |
PA (1) | PA8499701A1 (ru) |
PE (1) | PE20010520A1 (ru) |
PL (1) | PL342281A1 (ru) |
SG (1) | SG87146A1 (ru) |
SK (1) | SK12872000A3 (ru) |
SV (1) | SV2002000159A (ru) |
TN (1) | TNSN00177A1 (ru) |
TR (1) | TR200002529A2 (ru) |
UY (1) | UY26314A1 (ru) |
ZA (1) | ZA200004435B (ru) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6669042B1 (en) * | 2002-09-30 | 2003-12-30 | Hewlett-Packard Development Company, L.P. | Integrated positioning and locking device |
EP1834953A1 (en) * | 2006-03-14 | 2007-09-19 | Ranbaxy Laboratories Limited | Tetrahydropyrane derivatives as 5-lipoxygenase inhibitors |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6063928A (en) * | 1994-10-18 | 2000-05-16 | Pfizer Inc | 5-lipoxygenase inhibitors |
US5883106A (en) * | 1994-10-18 | 1999-03-16 | Pfizer Inc. | 5-lipoxygenase inhibitors |
SK281577B6 (sk) | 1994-10-18 | 2001-05-10 | Pfizer Inc. | Heterocyklické zlúčeniny a farmaceutický prostriedok na ich báze |
US6239285B1 (en) * | 1998-02-06 | 2001-05-29 | Pfizer Inc | Process for making 5-lipoxygenase inhibitors having varied heterocyclic ring systems |
-
2000
- 2000-06-29 US US09/607,011 patent/US6346624B1/en not_active Expired - Fee Related
- 2000-08-01 SG SG200004341A patent/SG87146A1/en unknown
- 2000-08-10 PA PA20008499701A patent/PA8499701A1/es unknown
- 2000-08-16 EP EP00307014A patent/EP1081143A1/en not_active Withdrawn
- 2000-08-18 OA OA1200000225A patent/OA11452A/en unknown
- 2000-08-24 IL IL13808700A patent/IL138087A0/xx unknown
- 2000-08-24 AU AU53603/00A patent/AU5360300A/en not_active Abandoned
- 2000-08-25 SK SK1287-2000A patent/SK12872000A3/sk unknown
- 2000-08-25 IS IS5603A patent/IS5603A/is unknown
- 2000-08-28 ZA ZA200004435A patent/ZA200004435B/xx unknown
- 2000-08-28 ID IDP20000711A patent/ID27129A/id unknown
- 2000-08-28 UY UY26314A patent/UY26314A1/es not_active Application Discontinuation
- 2000-08-28 GT GT200000142A patent/GT200000142A/es unknown
- 2000-08-29 BG BG104731A patent/BG104731A/xx unknown
- 2000-08-29 PE PE2000000885A patent/PE20010520A1/es not_active Application Discontinuation
- 2000-08-29 CA CA002317097A patent/CA2317097A1/en not_active Abandoned
- 2000-08-29 JP JP2000259063A patent/JP2001106682A/ja active Pending
- 2000-08-30 CZ CZ20003158A patent/CZ20003158A3/cs unknown
- 2000-08-30 MA MA26054A patent/MA26751A1/fr unknown
- 2000-08-30 EA EA200000801A patent/EA200000801A1/ru unknown
- 2000-08-30 SV SV2000000159A patent/SV2002000159A/es unknown
- 2000-08-30 HR HR20000564A patent/HRP20000564A2/hr not_active Application Discontinuation
- 2000-08-30 HU HU0003439A patent/HUP0003439A3/hu unknown
- 2000-08-30 NO NO20004313A patent/NO20004313L/no not_active Application Discontinuation
- 2000-08-30 TN TNTNSN00177A patent/TNSN00177A1/fr unknown
- 2000-08-30 CN CN00126408A patent/CN1286250A/zh active Pending
- 2000-08-30 NZ NZ506632A patent/NZ506632A/en unknown
- 2000-08-30 KR KR1020000050608A patent/KR20010050256A/ko active IP Right Grant
- 2000-08-31 BR BR0003945-4A patent/BR0003945A/pt not_active IP Right Cessation
- 2000-08-31 AP APAP/P/2000/001910A patent/AP2000001910A0/en unknown
- 2000-08-31 TR TR2000/02529A patent/TR200002529A2/xx unknown
- 2000-08-31 PL PL00342281A patent/PL342281A1/xx not_active Application Discontinuation
- 2000-08-31 EE EEP200000512A patent/EE200000512A/xx unknown
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