BG67494B1 - Nutritional supplement formulation - Google Patents

Abstract

The formulation according to this invention can be applied in the pharmaceutical industry since the enhanced potency of useful bacteria makes it a powerful probiotic in humans. The formulation can be used for the treatment of digestive disorders as it improves the environment in the digestive tract, enhances the body’s immune system and maintains the balance of gastrointestinal microflora. The nutritional supplement according to this invention contains (in per cent by weight): bentonite – from 30 to 75, probiotic or a combination of probiotics – from 5 to 50, magnesium oxide – from 3 to 6 and agar– agar – from 5 to 15. The probiotic is a blend of monocultures of Lactobacillus bulgaricus, Lactococcus lactis, Acetobacter pasteurianus, Leuconostoc mesenteroides, Streptococcus thermophilus, Bifidobacterium bifidum. The formulation according to this invention also provides for the magnesium requirements of the human body, in addition to which it produces a detoxication effect and helps maintain the pH balance of the body.

Description

Field of application

The composition according to the invention will find application in pharmacy as a powerful probiotic for people with improved vitality of beneficial bacteria, in case of digestive problems to improve the environment in the digestive tract, to increase the body's immune system, to maintain the balance of the gastrointestinal microflora.

Prior art

Bentonite clay has been used by various cultures throughout human history and people have been convinced of its therapeutic benefits. Due to its wide spread and accessibility, bentonite is gradually beginning to find its modern application as a support agent for a number of diseases.

Recent studies have shown that informed dietary intake of bentonite results in a 40-60% reduction in common illnesses in humans and animals. However, the main benefit of bentonite is in the prevention of many pre-clinical conditions caused by the modern lifestyle.

During the hydration process, bentonite can increase its volume 14 to 16 times. This property together with its non-toxicity make it a very valuable material in construction, food industry and pharmacy.

It is known from patent document CZ194 (A3) the use of a combination of at least one lyophilized anaerobic or facultative anaerobic strain of bacteria from the genera Lactobacterium, Lactococcus and Enterococcus, and bentonite and/or zeolite containing in 1 g 10-11 to 1010 vital bacteria, as a probiotic preparation to increase the used properties of feed and feed mixtures for farm animals.

From the patent document CN 102008016 (A) a probiotic powder and a method for its preparation are known. The probiotic powder contains a mixture of active probiotics and active zeolite in the following percentages by weight: 30 to 50% zeolite, 20 to 40% attapulgite clay and 10 to 30% bentonite. Probiotic (solid) powder provides a high-quality and low-cost alternative to antibiotics for animal husbandry; the probiotic /solid/ powder with 1 to 4 million CFU of live bacteria is added in each gram of feed, in which the growth rate of chickens, pigs and fish can be improved by 2.0 to 15.6%, the feed conversion rate can be improved by 1.1 to 9.3%, and the diarrhea rate and animal mortality can be reduced obviously.

Patent document CN 108936000 (A) relates to a method for obtaining a special feed for pigs at the end of pregnancy. The method includes the following stages: mixing corn flour with fish meal, soy mash and brewer's yeast; mixing xanthan gum with bentonite, monoglycerides and water, heating the mixture and stirring, adding corn starch, mixing, heating and pre-gelatinizing, lowering the temperature, adding soybean oil and xylooligosaccharide, stirring and spray drying to make the second mixture ; evenly mixing linoleic acid with calcium formate, complex vitamins, chromium methionine, complex of amino acids of iron compounds, taurine, thymol, probiotic preparation, mixing the second mixture with choline chloride to make the third mixture; evenly mixing the first with the third mixture, adding calcium hydrogen phosphate, table salt, rock powder, lysine, methionine, threonine, magnesium sulfate and composite trace elements, subsequent granulation and drying to obtain a special fodder for sows in late pregnancy.

Technical essence of the invention

The aim of the invention is to create a composition of a food supplement based on bentonite and probiotic/s, which will have a positive effect when applied to humans, provide increased vitality of probiotic bacteria, have a lasting health effect, and have an increased detoxification effect and no presence of synthetic polymers.

The goal is achieved with a food additive composition containing bentonite from 30 to 75, probiotic from 5 to 50, magnesium oxide from 3 to 6 and agar-agar from 5 to 15. According to an embodiment of the invention, the probiotic can be in a combination of probiotic.

Probiotics are Lactobacillus bulgaricus, Lactococcus lactis, Acetobacter pasteurianus, Leuconostoc mesenteroides, Streptococcus thermophilus, Bifidobacterium bifidum.

According to the invention, the bentonite is purified by methods known in the industry.

Probiotics are living microorganisms that, taken in sufficient quantity, have a healthy effect on the human body. One of the most important characteristics of probiotic bacteria is their ability to survive their passage through the upper parts of the gastrointestinal tract and reach the large intestine alive and in sufficient quantity, where they colonize and multiply. There they produce vital enzymes and cellular bioproducts. Probiotic bacteria are not a permanent inhabitant of the human microbial flora, therefore they must be taken with food continuously and over a long period of time in order to feel their health effects. The purpose of the probiotic is to strengthen the body's immune system, maintain the balance of the gastrointestinal microflora. Bentonite has a proven positive effect on digestive problems such as: acid reflux, bloating, gas, diarrhea, vomiting, etc. In addition, montmorillonite has antibacterial properties and bentonite modulates the body's immune response. Bentonite particles suppress the production of lipopolysaccharides by pathogenic bacteria and thus make them more susceptible to antibodies. Research shows that bentonite is very effective against antibiotic-resistant staph, as well as Escherichia coli and Salmonella. Bacteria cannot develop resistance to bentonite like they can to antibiotics.

The active ingredient in bentonite is montmorillonite.

Magnesium is important for all living organisms (including probiotic bacteria) due to its ability to bind to proteins or other molecules, transport ions, activate and mediate a number of biochemical reactions.

It is estimated that between 30% and 67% of magnesium intake is completely absorbed. The digestibility of magnesium as a dietary supplement depends to a large extent on the substance with which it is combined. According to the invention, magnesium oxide is included in the proposed composition. Unexpectedly, it was found that when combined with water, magnesium oxide forms a base that increases the pH in the body, an action that is close to that of montmorillonite. It has been established that the two ingredients of the composition according to the invention have a unidirectional effect, i.e. potentiation is achieved. At the same time, the magnesium oxide forms negative ions that bind to the positive ions of the montmorillonite and provide the possibility of its action in the digestive tract, rather than being absorbed through the small intestine. According to the invention, a prolongation of the positive effect of montmorillonite and magnesium oxide is achieved.

It is necessary to specify the nutritional supplement containing live bacteria of 2-5 billion in 1 g of product.

The dietary supplement is a dry powdery substance that is available as capsules.

The advantages provided by the composition according to the invention are:

Due to its high pH, bentonite improves the environment in the digestive tract and increases the viability of probiotic bacteria, while limiting the reproduction of other unwanted microflora such as e.g. helicobacter pylori, thanks to the alkaline environment it creates. This makes it possible to significantly reduce the content of bacteria in the capsules while maintaining the same therapeutic effect, or to significantly increase the action of the probiotic with the same amount of bacteria.

The composition is free of animal products. The vegetable agar-agar gel is a natural organic polymer that improves the viscosity of bentonite, unlike the currently used synthetic polymers. The organic polymer also provides a favorable nutrient environment for the probiotic bacteria.

The composition according to the invention is a powerful probiotic with improved vitality of beneficial bacteria and satisfies the need for magnesium in the human body. At the same time, it has a detoxifying effect and its use improves the pH balance in the body.

Examples of implementation of the invention

The given examples illustrate the invention without limiting it.

Example 1.

The food supplement contains:

Bentonite - 75 wt. h.

Lactobacillus bulgaricus - 6 wt. h.

Magnesium oxide - 4 wt. h.

Agar-agar - 15

Method of preparation:

At room temperature, the bentonite and magnesium oxide are mixed, the probiotic Lactobacillus bulgaricus, containing 5.0 x 10 ⁹ bact./g, is added, the mixture is homogenized for 40 min at a stirrer speed of 60 rpm. Next comes the filling of 1.3 mg capsules.

Example 2.

The food supplement contains:

Bentonite - 71.6 wt. h.

Lactococcus lactis - 10 wt. h.

Magnesium oxide - 5.4 wt. h.

Agar-agar - 13 wt. h.

The method of preparation of the supplement is as in example 1, Lactococcus lactis contains 4.4 x 10 ⁹ bact./g.

Example 3.

The food supplement contains:

Bentonite - 66.8 wt. h.

Acetobacter pasteurianus - 20 wt. h.

Magnesium oxide - 4.2 wt. h.

Agar-agar - 9

The method of preparation of the supplement is as in example 1, Acetobacter pasteurianus contains 3.2 x 10 ⁹ bact./g, the capsules are 1 mg.

Example 4.

The food supplement contains

Bentonite - 62 wt. h.

Leuconostoc mesenteroides - 30 wt. h.

Magnesium oxide - 3 wt. h.

Agar-agar - 5.

The method of preparation of the supplement is as in example 1, Leuconostoc mesenteroides contains 2.0 x 10 ⁹ bact./g.

Example 5.

The food supplement contains:

Bentonite - 64.4 wt. h.

Streptococcus thermophilus - 25 wt. h.

Magnesium oxide - 3.6 wt. h.

Agar-agar - 7.

The method of preparation of the supplement is as in example 1, Streptococcus thermophilus contains 2.6 x 10 ⁹ bact./g.

Example 6.

The food supplement contains:

Bentonite - 69.2 wt. h.

Bifidobacterium bifidum - 15 wt. h.

Magnesium oxide - 4.8 wt. h.

Agar-agar - 11.

The method of preparation of the supplement is as in example 1, Bifidobacterium bifidum contains 3.86 x 10 ⁹ bact./g.

Example 7.

The food supplement contains:

Bentonite - 30 wt. h.

Lactococcus lactis - 50 wt. h.

Magnesium oxide - 6 wt. h.

Agar-agar - 14.

The method of preparation of the supplement is as in example 1, Lactococcus lactis contains 4.4 x 10 ⁹ bact./g.

Example 8.

The food supplement contains:

Bentonite - 74 wt. h.

Lactobacillus bulgaricus - 5 wt. h.

Magnesium oxide - 6 wt. h.

Agar-agar - 15.

The method of preparation of the supplement is as in example 1.

Example 9.

The food supplement contains:

Bentonite - 47 wt. h.

Bifidobacterium bifidum - 8 wt. h.

Leuconostoc mesenteroides - 35 wt. h.

Magnesium oxide - 3 wt. h.

Agar-agar - 7.

The method of preparation of the supplement is as in example 1, Bifidobacterium bifidum contains 3.86 x 10 ⁹ bact./g, Leuconostoc mesenteroides contains 2.0 x 10 ⁹ bact./g.

Example 10.

The food supplement contains:

Bentonite - 60 wt. h.

Lactococcus lactis - 7 wt. h.

Streptococcus thermophilus - 15 wt. h.

Magnesium oxide - 5 wt. h.

Agar-agar - 13.

The method of preparation of the supplement is as in example 1, Lactococcus lactis contains 4.4 x 10 ⁹ bact./g, Streptococcus thermophilus contains 2.6 x 10 ⁹ bact./g.

Example 11.

The food supplement contains:

Bentonite - 65 wt. h.

Lactobacillus bulgaricus - 2 wt. h.

Acetobacter pasteurianus - 12 wt. h.

Magnesium oxide - 6 wt. h.

Agar-agar - 15.

The method of preparation of the supplement is as in example 1, Lactobacillus bulgaricus contains 5.0 x 10 ⁹ bact./g, Acetobacter pasteurianus contains 3.2 x 10 ⁹ bact./g.

Claims (2)

Patent claims 1. Composition of a food supplement containing bentonite and a probiotic, characterized in that it additionally contains /in wt. %/: magnesium oxide from 3 to 6 and agar-agar from 5 to 15, and the remaining components are bentonite, probiotic or a combination of two or more probiotics, in the following amounts bentonite from 30 to 75, probiotic from 5 to 50. 2. Food supplement composition according to claim 1, characterized in that the probiotic has a composition of the monocultures of Lactobacillus bulgaricus 5.0 x 10 ⁹ bact./g, Lactococcus lactis 4.4 x 10 ⁹ bact./g, Acetobacter pasteurianus 3 ,2 x 10 ⁹ bact./g, Leuconostoc mesenteroides 2.0 x 10 ⁹ bact./g, Streptococcus thermophilus 2.6 x 10 ⁹ bact./g, Bifidobacterium bifidum 3.86 x 10 ⁹ bact./g.