BG64534B1 - Полипептиди, способни да формират антиген свързващи структури със специфичност към резус d антигените, кодиращата ги днк и метод за тяхното получаване и приложение - Google Patents

Полипептиди, способни да формират антиген свързващи структури със специфичност към резус d антигените, кодиращата ги днк и метод за тяхното получаване и приложение Download PDF

Info

Publication number
BG64534B1
BG64534B1 BG103016A BG10301698A BG64534B1 BG 64534 B1 BG64534 B1 BG 64534B1 BG 103016 A BG103016 A BG 103016A BG 10301698 A BG10301698 A BG 10301698A BG 64534 B1 BG64534 B1 BG 64534B1
Authority
BG
Bulgaria
Prior art keywords
rhesus
fia
base pairs
fab
cdr3
Prior art date
Application number
BG103016A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG103016A (en
Inventor
Sylvia Miescher
Monique Vogel
Beda Stadler
Andreas Morell
Martin Imboden
Hanspeter Amstutz
Original Assignee
Rotkreuzstiftung Zentrallaboratorium Blutspendedienst Srp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotkreuzstiftung Zentrallaboratorium Blutspendedienst Srp filed Critical Rotkreuzstiftung Zentrallaboratorium Blutspendedienst Srp
Publication of BG103016A publication Critical patent/BG103016A/xx
Publication of BG64534B1 publication Critical patent/BG64534B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/34—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood group antigens
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/80—Antibody or fragment thereof whose amino acid sequence is disclosed in whole or in part
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
BG103016A 1996-06-24 1998-12-15 Полипептиди, способни да формират антиген свързващи структури със специфичност към резус d антигените, кодиращата ги днк и метод за тяхното получаване и приложение BG64534B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96810421 1996-06-24

Publications (2)

Publication Number Publication Date
BG103016A BG103016A (en) 1999-08-31
BG64534B1 true BG64534B1 (bg) 2005-06-30

Family

ID=8225636

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103016A BG64534B1 (bg) 1996-06-24 1998-12-15 Полипептиди, способни да формират антиген свързващи структури със специфичност към резус d антигените, кодиращата ги днк и метод за тяхното получаване и приложение

Country Status (23)

Country Link
US (3) US7038020B1 (cs)
EP (1) EP0920509B1 (cs)
JP (1) JP3841360B2 (cs)
KR (1) KR100361449B1 (cs)
AT (1) ATE272116T1 (cs)
AU (1) AU722127B2 (cs)
BG (1) BG64534B1 (cs)
BR (1) BR9709958A (cs)
CA (1) CA2258494C (cs)
CZ (1) CZ296807B6 (cs)
DE (1) DE69730031T2 (cs)
DK (1) DK0920509T3 (cs)
ES (1) ES2224255T3 (cs)
HU (1) HUP9902605A3 (cs)
IL (1) IL127595A (cs)
IS (1) IS2220B (cs)
NO (1) NO327947B1 (cs)
NZ (1) NZ333329A (cs)
PL (1) PL186019B1 (cs)
RU (1) RU2204602C2 (cs)
SK (1) SK284879B6 (cs)
TR (1) TR199802692T2 (cs)
WO (1) WO1997049809A1 (cs)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000029583A2 (en) * 1998-11-19 2000-05-25 Incyte Pharmaceuticals, Inc. Immunoglobulin superfamily proteins
EP1106625A1 (en) * 1999-11-17 2001-06-13 ZLB Bioplasma AG Rhesus D specific peptide sequences
FR2807767B1 (fr) * 2000-04-12 2005-01-14 Lab Francais Du Fractionnement Anticorps monoclonaux anti-d
WO2001079481A2 (en) 2000-04-17 2001-10-25 Dyax Corp. Methods of constructing display libraries of genetic packages for members of a diverse family of peptides
US8288322B2 (en) 2000-04-17 2012-10-16 Dyax Corp. Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
AU2002226049A1 (en) * 2000-12-05 2002-06-18 Alexion Pharmaceuticals, Inc. Engineered plasmids and their use for in situ production of genes
AU2002249854B2 (en) 2000-12-18 2007-09-20 Dyax Corp. Focused libraries of genetic packages
AU2016225923B2 (en) * 2001-04-17 2018-07-05 Takeda Pharmaceutical Company Limited Novel Methods of Constructing Libraries Comprising Displayed and/or Expressed Members of a Diverse Family of Peptides, Polypeptides or Proteins and the Novel Libraries
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
PL1787126T3 (pl) 2004-07-20 2010-03-31 Symphogen As Sposób charakteryzowania poliklonalnej linii komórkowej
EA014182B1 (ru) 2004-07-20 2010-10-29 Симфоген А/С КОМПОЗИЦИЯ ПОЛИКЛОНАЛЬНЫХ АНТИ-RhD АНТИТЕЛ, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ КОМПОЗИЦИИ
GB0706558D0 (en) * 2007-04-03 2007-05-09 Common Services Agency For The Diagnostic assay
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
CA3187687A1 (en) 2007-09-14 2009-03-19 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US20090093004A1 (en) 2007-10-04 2009-04-09 Symphogen A/S Potency assay
WO2009114815A1 (en) 2008-03-13 2009-09-17 Dyax Corp Libraries of genetic packages comprising novel hc cdr3 designs
CA3049612C (en) 2008-04-24 2023-01-10 Dyax Corp. Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs
DK2593594T3 (en) 2010-07-16 2017-12-11 Adimab Llc ANTIBODY LIBRARIES
JP2015535005A (ja) * 2012-11-06 2015-12-07 メディミューン，エルエルシー 抗シュードモナス属（Ｐｓｅｕｄｏｍｏｎａｓ）ＰｓｌおよびＰｃｒＶ結合分子を用いた併用治療

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2127434A (en) 1982-09-17 1984-04-11 Univ London A human monoclonal antibody against Rhesus D antigen
GB8925590D0 (en) 1989-11-13 1990-01-04 Central Blood Lab Authority Monoclonal antibodies

Also Published As

Publication number Publication date
NO986088D0 (no) 1998-12-23
US20050266013A1 (en) 2005-12-01
CZ395998A3 (cs) 1999-05-12
KR20000022530A (ko) 2000-04-25
CA2258494A1 (en) 1997-12-31
RU2204602C2 (ru) 2003-05-20
AU722127B2 (en) 2000-07-20
NO986088L (no) 1999-02-24
CZ296807B6 (cs) 2006-06-14
PL330794A1 (en) 1999-06-07
CA2258494C (en) 2008-05-27
IL127595A (en) 2005-09-25
EP0920509B1 (en) 2004-07-28
HUP9902605A3 (en) 2001-11-28
IS2220B (is) 2007-03-15
US7038020B1 (en) 2006-05-02
DE69730031T2 (de) 2005-06-16
KR100361449B1 (ko) 2003-01-24
AU3342397A (en) 1998-01-14
SK284879B6 (sk) 2006-01-05
US7399471B2 (en) 2008-07-15
BR9709958A (pt) 1999-08-10
HUP9902605A2 (hu) 1999-11-29
US20060165694A1 (en) 2006-07-27
PL186019B1 (pl) 2003-09-30
ES2224255T3 (es) 2005-03-01
WO1997049809A1 (en) 1997-12-31
BG103016A (en) 1999-08-31
EP0920509A1 (en) 1999-06-09
IL127595A0 (en) 1999-10-28
NZ333329A (en) 2000-07-28
DK0920509T3 (da) 2004-12-06
DE69730031D1 (de) 2004-09-02
IS4922A (is) 1998-12-11
TR199802692T2 (xx) 1999-03-22
NO327947B1 (no) 2009-10-26
JP3841360B2 (ja) 2006-11-01
SK176198A3 (en) 1999-07-12
JP2000515732A (ja) 2000-11-28
ATE272116T1 (de) 2004-08-15
US7429647B2 (en) 2008-09-30

Similar Documents

Publication Publication Date Title
US7429647B2 (en) Polypeptides capable of forming antigen binding structures with specificity for the Rhesus D antigens, the DNA encoding them and the process for their preparation and use
JP5192625B2 (ja) 抗ｄモノクローナル抗体
Persson et al. Generation of diverse high-affinity human monoclonal antibodies by repertoire cloning.
US5665356A (en) Human anti-Rh (D) monoclonal antibodies
Rekvig et al. Certain polyclonal antinuclear antibodies cross‐react with the surface membrane of human lymphocytes and granulocytes
Miescher et al. Sequence and specificity analysis of recombinant human Fab anti‐Rh D isolated by phage display
Fischer et al. Platelet‐reactive IgG antibodies cloned by phage display and panning with IVIG from three patients with autoimmune thrombocytopenia
JPS6344881A (ja) ヒト抗リ−サスｄ産生ヘテロハイブリド−マ
EP0378572A1 (en) HUMAN ANTI-Rh(D) MONOCLONAL ANTIBODIES
EP0383777B1 (en) HUMAN ANTI-Rh(D) MONOCLONAL ANTIBODIES
US5496548A (en) Human anti-RH(D) monoclonal antibodies, cell lines and methods of use of antibodies in immunoassays
AU622417B2 (en) Human anti-rh(d) monoclonal antibodies
JP2007527201A (ja) 抗インテグリン免疫グロブリン
Springer et al. Functional and structural interrelationships among the Mac-1, LFA-1 family of leukocyte adhesion glycoproteins, and their deficiency in a novel heritable disease
Olovnikova et al. Lymphocyte antibody-dependent cytotoxicity test for evaluation of clinical role of monoclonal anti-D-antibodies for prevention of rhesus sensitization
Pistillo et al. A novel approach to human anti-HLA mABs production: use of phage display libraries
KR20110047258A (ko) 저혈소판증의 치료 방법
De Leon Engineering antibodies against complex platelet antigens using phage display technology
MXPA99008621A (es) Peptidos de union a ctla-4, inmunoterapeuticos