BG64484B1 - Аралкил и аралкилиден хетероциклени лактами и имиди - Google Patents
Аралкил и аралкилиден хетероциклени лактами и имиди Download PDFInfo
- Publication number
- BG64484B1 BG64484B1 BG103297A BG10329799A BG64484B1 BG 64484 B1 BG64484 B1 BG 64484B1 BG 103297 A BG103297 A BG 103297A BG 10329799 A BG10329799 A BG 10329799A BG 64484 B1 BG64484 B1 BG 64484B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- thiomorpholin
- benzylidene
- methylpiperazin
- dione
- dichlorophenyl
- Prior art date
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- -1 heterocyclic lactams Chemical class 0.000 title claims abstract description 186
- 125000003710 aryl alkyl group Chemical group 0.000 title abstract description 3
- 150000003949 imides Chemical class 0.000 title abstract description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 176
- 238000002360 preparation method Methods 0.000 claims abstract description 31
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 17
- 125000005842 heteroatom Chemical group 0.000 claims abstract description 14
- 125000004429 atom Chemical group 0.000 claims abstract description 12
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 10
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 122
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 76
- 150000003839 salts Chemical class 0.000 claims description 61
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- 239000003814 drug Substances 0.000 claims description 34
- 229910052739 hydrogen Inorganic materials 0.000 claims description 34
- 239000001257 hydrogen Substances 0.000 claims description 34
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 30
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 28
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- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 claims description 14
- 229910052717 sulfur Inorganic materials 0.000 claims description 14
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- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims description 11
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- 208000007777 paroxysmal Hemicrania Diseases 0.000 claims description 10
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 9
- 208000026331 Disruptive, Impulse Control, and Conduct disease Diseases 0.000 claims description 9
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- 125000003545 alkoxy group Chemical group 0.000 claims description 9
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- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 8
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- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims description 7
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims description 7
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 7
- 125000004076 pyridyl group Chemical group 0.000 claims description 7
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- 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 claims description 6
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- 125000004404 heteroalkyl group Chemical group 0.000 claims description 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 6
- LHYMPSWMHXUWSK-STZFKDTASA-N (2z)-4-(3,4-dichlorophenyl)-2-[[2-(4-methylpiperazin-1-yl)phenyl]methylidene]thiomorpholin-3-one Chemical compound C1CN(C)CCN1C1=CC=CC=C1\C=C/1C(=O)N(C=2C=C(Cl)C(Cl)=CC=2)CCS\1 LHYMPSWMHXUWSK-STZFKDTASA-N 0.000 claims description 5
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- HBDDRESWUAFAHY-UHFFFAOYSA-N thiomorpholin-3-one Chemical compound O=C1CSCCN1 HBDDRESWUAFAHY-UHFFFAOYSA-N 0.000 claims description 5
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims description 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 4
- HWEYWXTUEQAQPH-UHFFFAOYSA-N 2-[[2-(4-methylpiperazin-1-yl)phenyl]methylidene]thiomorpholin-3-one Chemical compound C1CN(C)CCN1C1=CC=CC=C1C=C1C(=O)NCCS1 HWEYWXTUEQAQPH-UHFFFAOYSA-N 0.000 claims description 4
- POXGWNNZSDNSDS-UHFFFAOYSA-N 4-(3,4-dichlorophenyl)-2-[[2-[3-(dimethylamino)pyrrolidin-1-yl]phenyl]methylidene]thiomorpholin-3-one Chemical compound C1C(N(C)C)CCN1C1=CC=CC=C1C=C1C(=O)N(C=2C=C(Cl)C(Cl)=CC=2)CCS1 POXGWNNZSDNSDS-UHFFFAOYSA-N 0.000 claims description 4
- 125000004193 piperazinyl group Chemical group 0.000 claims description 4
- 125000003386 piperidinyl group Chemical group 0.000 claims description 4
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims description 3
- JTDABAYCSTYVRE-UHFFFAOYSA-N 3-[(4-chlorophenyl)methyl]-5-[[2-(4-methylpiperazin-1-yl)phenyl]methylidene]imidazolidine-2,4-dione Chemical compound C1CN(C)CCN1C1=CC=CC=C1C=C1C(=O)N(CC=2C=CC(Cl)=CC=2)C(=O)N1 JTDABAYCSTYVRE-UHFFFAOYSA-N 0.000 claims description 3
- JEZUNFQLOXFHOC-UHFFFAOYSA-N 4-(3,4-dichlorophenyl)-2-[(2-piperazin-1-ylphenyl)methylidene]thiomorpholin-3-one Chemical compound C1=C(Cl)C(Cl)=CC=C1N(CCS1)C(=O)C1=CC1=CC=CC=C1N1CCNCC1 JEZUNFQLOXFHOC-UHFFFAOYSA-N 0.000 claims description 3
- REDYEYMWNNRSFN-UHFFFAOYSA-N 4-(3,4-dichlorophenyl)-2-[[2-(4-propan-2-ylpiperazin-1-yl)phenyl]methylidene]thiomorpholin-3-one Chemical compound C1CN(C(C)C)CCN1C1=CC=CC=C1C=C1C(=O)N(C=2C=C(Cl)C(Cl)=CC=2)CCS1 REDYEYMWNNRSFN-UHFFFAOYSA-N 0.000 claims description 3
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- NAZGUUFZBWIEQY-UHFFFAOYSA-N 2-[[2,4-dibromo-6-(4-methylpiperazin-1-yl)phenyl]-hydroxymethyl]-4-(3,4-dichlorophenyl)thiomorpholin-3-one Chemical compound C1CN(C)CCN1C1=CC(Br)=CC(Br)=C1C(O)C1C(=O)N(C=2C=C(Cl)C(Cl)=CC=2)CCS1 NAZGUUFZBWIEQY-UHFFFAOYSA-N 0.000 claims description 2
- QUDKCGONSFCDSG-UHFFFAOYSA-N 2-[[2-(4-cyclopropylpiperazin-1-yl)phenyl]methylidene]-4-(3,4-dichlorophenyl)thiomorpholin-3-one Chemical compound C1=C(Cl)C(Cl)=CC=C1N(CCS1)C(=O)C1=CC1=CC=CC=C1N1CCN(C2CC2)CC1 QUDKCGONSFCDSG-UHFFFAOYSA-N 0.000 claims description 2
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- OINZMMOQVNVXQQ-UHFFFAOYSA-N 2-[[2-(4-cyclopropylpiperazin-1-yl)phenyl]methylidene]-4-(3,5-dichlorophenyl)thiomorpholin-3-one Chemical compound ClC1=CC(Cl)=CC(N2C(C(=CC=3C(=CC=CC=3)N3CCN(CC3)C3CC3)SCC2)=O)=C1 OINZMMOQVNVXQQ-UHFFFAOYSA-N 0.000 claims description 2
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- XXBPFFVLNGPMIR-UHFFFAOYSA-N 2-[hydroxy-[2-(4-methylpiperazin-1-yl)phenyl]methyl]-4-[4-(trifluoromethyl)phenyl]thiomorpholin-3-one Chemical compound C1CN(C)CCN1C1=CC=CC=C1C(O)C1C(=O)N(C=2C=CC(=CC=2)C(F)(F)F)CCS1 XXBPFFVLNGPMIR-UHFFFAOYSA-N 0.000 claims description 2
- KICPBAVEBLIWTI-UHFFFAOYSA-N 2-[hydroxy-[2-(4-methylpiperazin-1-yl)phenyl]methyl]thiomorpholin-3-one Chemical compound C1CN(C)CCN1C1=CC=CC=C1C(O)C1C(=O)NCCS1 KICPBAVEBLIWTI-UHFFFAOYSA-N 0.000 claims description 2
- TZTFAKGBRFQVQD-UHFFFAOYSA-N 3-(3,4-dichlorophenyl)-5-[[2-(4-methylpiperazin-1-yl)phenyl]methylidene]-1,3-thiazolidin-4-one Chemical compound C1CN(C)CCN1C1=CC=CC=C1C=C1C(=O)N(C=2C=C(Cl)C(Cl)=CC=2)CS1 TZTFAKGBRFQVQD-UHFFFAOYSA-N 0.000 claims description 2
- IHPJZHGVCCTYLQ-UHFFFAOYSA-N 3-(4-chlorophenyl)-5-[[2-(4-methylpiperazin-1-yl)phenyl]methylidene]-1,3-thiazolidine-2,4-dione Chemical compound C1CN(C)CCN1C1=CC=CC=C1C=C1C(=O)N(C=2C=CC(Cl)=CC=2)C(=O)S1 IHPJZHGVCCTYLQ-UHFFFAOYSA-N 0.000 claims description 2
- MNTCAKAVQXYCQK-UHFFFAOYSA-N 3-(4-chlorophenyl)-5-[[2-(4-methylpiperazin-1-yl)phenyl]methylidene]imidazolidine-2,4-dione Chemical compound C1CN(C)CCN1C1=CC=CC=C1C=C1C(=O)N(C=2C=CC(Cl)=CC=2)C(=O)N1 MNTCAKAVQXYCQK-UHFFFAOYSA-N 0.000 claims description 2
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- ATLDPSAQFNYPEF-UHFFFAOYSA-N 4-(3,4-dichlorophenyl)-2-[(5-fluoro-2-piperazin-1-ylphenyl)methylidene]thiomorpholin-3-one Chemical compound S1CCN(C=2C=C(Cl)C(Cl)=CC=2)C(=O)C1=CC1=CC(F)=CC=C1N1CCNCC1 ATLDPSAQFNYPEF-UHFFFAOYSA-N 0.000 claims description 2
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- STARTPWBYOQRTM-UHFFFAOYSA-N 4-(3,4-dichlorophenyl)-2-[[2-fluoro-6-(4-methylpiperazin-1-yl)phenyl]methylidene]thiomorpholin-3-one Chemical compound C1CN(C)CCN1C1=CC=CC(F)=C1C=C1C(=O)N(C=2C=C(Cl)C(Cl)=CC=2)CCS1 STARTPWBYOQRTM-UHFFFAOYSA-N 0.000 claims description 2
- LCKQKNHLBUGERA-UHFFFAOYSA-N 4-(3,4-dichlorophenyl)-2-[[3-fluoro-2-(4-methylpiperazin-1-yl)phenyl]methylidene]thiomorpholin-3-one Chemical compound C1CN(C)CCN1C1=C(F)C=CC=C1C=C1C(=O)N(C=2C=C(Cl)C(Cl)=CC=2)CCS1 LCKQKNHLBUGERA-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07—ORGANIC CHEMISTRY
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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US2711196P | 1996-09-30 | 1996-09-30 |
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UA56185C2 (ru) * | 1996-09-30 | 2003-05-15 | Пфайзер Інк. | Аралкил- и аралкилиденгетероциклические лактамы и имиды, фармацевтическая композиция и способ лечения |
US6423708B1 (en) * | 1996-09-30 | 2002-07-23 | Pfizer Inc | Aralkyl and aralkylidene heterocyclic lactams and imides |
ATE273970T1 (de) * | 1998-04-16 | 2004-09-15 | Pfizer Prod Inc | N-acyl und n-aroyl aralkylamide |
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PT1041070E (pt) * | 1999-03-30 | 2004-12-31 | Pfizer Prod Inc | Processo para preparar tioamidas ciclicas |
DE10022661A1 (de) | 2000-05-10 | 2001-11-15 | Clariant Gmbh | Ortho-substituierte Benzaldehyde, Verfahren zu ihrer Herstellung und ihre Verwendung |
UA76130C2 (en) | 2000-11-20 | 2006-07-17 | Merck Patent Gmbh | Use of compounds combining properties of selective inhibitors of serotonin re-uptake and agonists of 5-ht1a receptor for treatment of irritable bowel syndrome |
WO2002078643A2 (en) * | 2001-03-30 | 2002-10-10 | Philadelphia Health And Education Corporation | Immunomodulation and effect on cell processes relating to serotonin family receptors |
EP1746091A1 (en) * | 2001-08-30 | 2007-01-24 | Pfizer Products Inc. | Process for the preparation of 2-substituted 2-[-(4-methylpiperazin-1-yl)-benzylidene]-thiomorpholin-3-one citrate |
PT1288208E (pt) * | 2001-08-30 | 2006-09-29 | Pfizer Prod Inc | Processo para preparacao de compostos de 2 - (4 - alquil - 1 - piperazinil) - benzaldeido e - benzilidenilo por substituicao necleofilica aromatica de 2 - fluorobenzaldeido com 4 - alquil - 1 - piperazina em agua como solvente |
DK1451166T3 (da) * | 2001-12-07 | 2005-11-14 | Pfizer Prod Inc | Citronsyresalt af en terapeutisk forbindelse og farmaceutiske kompositioner deraf |
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US7235573B2 (en) | 2002-09-30 | 2007-06-26 | The Regents Of The University Of California | Methods of treating secretory diarrhea using cystic fibrosis transmembrane conductance regulator protein inhibitors |
EA009847B1 (ru) * | 2002-09-30 | 2008-04-28 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния | Ингибиторы белка-регулятора трансмембранной проводимости при муковисцидозе и их применение |
AU2003282920A1 (en) * | 2002-10-04 | 2004-05-04 | Bristol-Myers Squibb Company | Hydantoin derivatives as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme (tace) |
ES2347152T3 (es) * | 2003-11-26 | 2010-10-26 | Pfizer Products Inc. | Derivados de aminopirazol como inhibidores de gsk-3. |
WO2005053701A1 (en) * | 2003-11-26 | 2005-06-16 | Pfizer Products Inc. | Combination of dopamine agonists and aralkyl and aralkylidene heterocyclic lactams and imides |
EP1697353A2 (en) * | 2003-12-15 | 2006-09-06 | Pfizer Products Incorporated | Aralkyl and aralkylidene heterocyclic lactams with affinity for 5-ht1 receptors |
US20050171095A1 (en) * | 2004-01-06 | 2005-08-04 | Pfizer Inc | Combination of CRF antagonists and 5-HT1B receptor antagonists |
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WO2005082372A1 (en) * | 2004-01-29 | 2005-09-09 | Pfizer Products Inc. | COMBINATION OF γ-AMINOBUTYRIC ACID MODULATORS AND 5-HT 1B RECEPTOR ANTAGONISTS |
EA200601461A1 (ru) | 2004-03-17 | 2007-02-27 | Пфайзер Продактс, Инк. | Новые производные бензил(иден)лактама |
AU2005238296A1 (en) | 2004-04-30 | 2005-11-10 | Warner-Lambert Company Llc | Substituted morpholine compounds for the treatment of central nervous system disorders |
JP2007537232A (ja) * | 2004-05-11 | 2007-12-20 | ファイザー・プロダクツ・インク | 非定型抗精神病薬と5−ht1b受容体拮抗薬の組合せ |
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WO2007026219A2 (en) * | 2005-08-31 | 2007-03-08 | Pfizer Products Inc. | Combinations of a 5-ht1b antagonist with a noradrenalin re-uptake inhibitor or a serotonin noradrenalin reutake inhibitor for treating cns conditions |
WO2007026224A2 (en) * | 2005-08-31 | 2007-03-08 | Pfizer Products Inc. | 5-ht1b antagonist composition for depression, anxiety and cognition |
WO2007057742A2 (en) * | 2005-11-18 | 2007-05-24 | Pfizer Products Inc. | Novel piperazinone derivatives |
GB0701970D0 (en) * | 2007-02-01 | 2007-03-14 | Wilson Stuart | Treatment of protein aggregation diseases |
CA2698808A1 (en) | 2007-09-13 | 2009-03-19 | Concert Pharmaceuticals, Inc. | Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof |
KR20100134063A (ko) * | 2008-03-25 | 2010-12-22 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 낭포성 섬유증 막투과 전도성 조절자의 수용성 소분자 억제제 |
TWI461423B (zh) | 2008-07-02 | 2014-11-21 | Astrazeneca Ab | 用於治療Pim激酶相關病狀及疾病之噻唑啶二酮化合物 |
KR102049534B1 (ko) * | 2011-10-03 | 2019-11-27 | 오게다 에스.에이. | 선택적 NK-3 수용체 길항제로서의 신규한 키랄 N-아실-5,6,7,(8-치환된)-테트라히드로-[1,2,4]트리아졸로[4,3-a]피라진, 의약 조성물, NK-3 수용체 매개 질환에 사용하는 방법 및 그의 키랄 합성법 |
JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
DE102013019618A1 (de) * | 2013-11-25 | 2015-05-28 | Avlen Georges | Tri- und Tetracyclische Verbindungen zur Behandlung von Inkontinenz |
WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
CN110054597B (zh) * | 2019-04-17 | 2022-11-08 | 温州大学 | 一种无金属催化剂条件下合成的噻唑烷-4-酮衍生物及其制备方法 |
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UA56185C2 (ru) * | 1996-09-30 | 2003-05-15 | Пфайзер Інк. | Аралкил- и аралкилиденгетероциклические лактамы и имиды, фармацевтическая композиция и способ лечения |
US6423708B1 (en) * | 1996-09-30 | 2002-07-23 | Pfizer Inc | Aralkyl and aralkylidene heterocyclic lactams and imides |
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1997
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- 1997-09-29 PA PA19978439101A patent/PA8439101A1/es unknown
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- 1997-09-29 SA SA05260293A patent/SA05260293B1/ar unknown
- 1997-09-29 TN TNTNSN97161A patent/TNSN97161A1/fr unknown
- 1997-09-29 ID IDP973316A patent/ID19833A/id unknown
- 1997-09-29 SA SA97180449A patent/SA97180449B1/ar unknown
- 1997-09-29 DZ DZ970171A patent/DZ2321A1/xx active
- 1997-09-29 GT GT199700107A patent/GT199700107A/es unknown
- 1997-09-30 HR HR970540A patent/HRP970540B1/xx not_active IP Right Cessation
- 1997-09-30 CO CO97056992A patent/CO4650135A1/es unknown
- 1997-11-23 HN HN1997000135A patent/HN1997000135A/es unknown
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1999
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- 1999-03-30 BG BG103297A patent/BG64484B1/bg unknown
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2000
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2001
- 2001-11-06 US US10/011,505 patent/US6403592B1/en not_active Expired - Fee Related
- 2001-11-06 US US10/011,568 patent/US6921760B2/en not_active Expired - Fee Related
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0666261A1 (en) * | 1994-02-04 | 1995-08-09 | Santen Pharmaceutical Co., Ltd. | Novel thiazine or thiomorpholine derivatives |
WO1995031988A1 (en) * | 1994-05-25 | 1995-11-30 | Smithkline Beecham P.L.C. | COMPOSITION CONTAINING 5HTIA and 5HTID ANTAGONISTS |
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