BG64289B1 - М...'од за пол"-аван... на hmg-coa р...д"к'азни инхиби'ори ' ви'ока -и''о'а - Google Patents
М...'од за пол"-аван... на hmg-coa р...д"к'азни инхиби'ори ' ви'ока -и''о'а Download PDFInfo
- Publication number
- BG64289B1 BG64289B1 BG104696A BG10469600A BG64289B1 BG 64289 B1 BG64289 B1 BG 64289B1 BG 104696 A BG104696 A BG 104696A BG 10469600 A BG10469600 A BG 10469600A BG 64289 B1 BG64289 B1 BG 64289B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- water
- hmg
- coa reductase
- organic solvent
- reductase inhibitor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI9800046A SI9800046A (sl) | 1998-02-18 | 1998-02-18 | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti |
| PCT/IB1999/000808 WO1999042601A1 (en) | 1998-02-18 | 1999-02-17 | PROCESS FOR THE OBTAINING OF HMG-CoA REDUCTASE INHIBITORS OF HIGH PURITY |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG104696A BG104696A (en) | 2001-07-31 |
| BG64289B1 true BG64289B1 (bg) | 2004-08-31 |
Family
ID=20432203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG104696A BG64289B1 (bg) | 1998-02-18 | 2000-08-17 | М...'од за пол"-аван... на hmg-coa р...д"к'азни инхиби'ори ' ви'ока -и''о'а |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6825015B1 (cs) |
| EP (1) | EP1054993B1 (cs) |
| JP (2) | JP2002504345A (cs) |
| KR (1) | KR100582620B1 (cs) |
| CN (1) | CN1206363C (cs) |
| AT (1) | ATE296357T1 (cs) |
| AU (1) | AU743619B2 (cs) |
| BG (1) | BG64289B1 (cs) |
| CA (1) | CA2321052A1 (cs) |
| CZ (1) | CZ297093B6 (cs) |
| DE (1) | DE69925459T2 (cs) |
| HR (1) | HRP20000541A2 (cs) |
| HU (1) | HUP0100820A3 (cs) |
| IL (1) | IL137782A0 (cs) |
| PL (1) | PL193510B1 (cs) |
| RO (1) | RO120922B1 (cs) |
| RU (1) | RU2235130C2 (cs) |
| SI (2) | SI9800046A (cs) |
| SK (1) | SK285074B6 (cs) |
| WO (1) | WO1999042601A1 (cs) |
| YU (1) | YU50100A (cs) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60031447T2 (de) * | 1999-11-30 | 2007-08-30 | Teva Gyogyszergyar Zartköruen Muködo Reszvenytarsasag | Verfahren zur rückgewinnung von statinverbindungen aus einer fermentationsbrühe |
| PL364929A1 (en) | 1999-12-14 | 2004-12-27 | Biogal Gyogyszergyar Rt. | Novel forms of pravastatin sodium |
| HRP20020683A2 (en) * | 2000-02-24 | 2004-12-31 | Biogal Gyogyszergyar | Method of purifying a fermentation broth |
| TR200403001T3 (tr) | 2000-03-03 | 2005-02-21 | Plus Chemical, S.A. | Lovastatin ve simvastatinin, azaltılmış dimerik katışkı seviyelerine sahip olacak şekilde arıtılması için bir işlem |
| IN192861B (cs) * | 2000-06-30 | 2004-05-22 | Ranbaxy Lab Ltd | |
| US6936731B2 (en) * | 2000-10-05 | 2005-08-30 | TEVA Gyógyszergyár Részvénytársaság | Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same |
| JP3236282B1 (ja) | 2000-10-16 | 2001-12-10 | 三共株式会社 | プラバスタチンを精製する方法 |
| US6716615B2 (en) | 2002-02-27 | 2004-04-06 | Yung Shin Pharmaceutical Ind. Co., Ltd. | Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase |
| US20060019269A1 (en) * | 2002-10-17 | 2006-01-26 | Decode Genetics, Inc. | Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment |
| US20080293750A1 (en) * | 2002-10-17 | 2008-11-27 | Anna Helgadottir | Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment |
| RU2261901C2 (ru) * | 2003-10-17 | 2005-10-10 | Буяновский Эдуард Константинович | Штамм гриба aspergillus terreus № 44-62 - продуцент ловастатина, промышленный способ выделения ловастатина и способ лактонизации статинов |
| TWI319707B (en) | 2003-11-24 | 2010-01-21 | Method of purifying pravastatin | |
| US20100216863A1 (en) * | 2004-01-30 | 2010-08-26 | Decode Genetics Ehf. | Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment |
| US8158362B2 (en) * | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
| ES2239533B1 (es) * | 2004-03-01 | 2006-12-16 | Ercros Industrial, S.A. | Procedimiento para la obtencion de compactina. |
| CN102384955B (zh) * | 2010-09-01 | 2014-04-30 | 北京北大维信生物科技有限公司 | 人体血浆中HMG－CoA还原酶抑制剂的定量分析方法 |
| RU2585233C2 (ru) * | 2013-12-27 | 2016-05-27 | Открытое акционерное общество "Красфарма" | Промышленный способ получения компактина |
| RU2585234C2 (ru) * | 2013-12-27 | 2016-05-27 | Открытое акционерное общество "Красфарма" | Способ получения компактина |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4319039A (en) * | 1979-06-15 | 1982-03-09 | Merck & Co., Inc. | Preparation of ammonium salt of hypocholesteremic fermentation product |
| US4294846A (en) * | 1979-09-21 | 1981-10-13 | Merck & Co., Inc. | Hypocholesteremic fermentation products and products of preparation |
| PT85109A (en) | 1986-06-23 | 1987-07-01 | Merck & Co Inc | Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors |
| US4965200A (en) * | 1989-06-23 | 1990-10-23 | Merck & Co., Inc. | Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs |
| US5202029A (en) * | 1991-03-13 | 1993-04-13 | Caron Kabushiki Kaisha | Process for purification of hmg-coa reductase inhibitors |
| ES2145479T3 (es) * | 1995-08-03 | 2000-07-01 | Dsm Nv | Procedimiento mejorado de obtencion de lovastatina, compactina o pravastatina. |
| EA000954B1 (ru) | 1995-12-06 | 2000-08-28 | Балканфарма - Разград Ад | Способ получения ловастатина |
| HUP9902352A1 (hu) | 1999-07-12 | 2000-09-28 | Gyógyszerkutató Intézet Kft. | Eljárás pravasztatin mikrobiológiai előállítására |
-
1998
- 1998-02-18 SI SI9800046A patent/SI9800046A/sl not_active IP Right Cessation
-
1999
- 1999-02-17 RO ROA200000828A patent/RO120922B1/ro unknown
- 1999-02-17 HU HU0100820A patent/HUP0100820A3/hu unknown
- 1999-02-17 WO PCT/IB1999/000808 patent/WO1999042601A1/en active IP Right Grant
- 1999-02-17 YU YU50100A patent/YU50100A/sh unknown
- 1999-02-17 CN CNB998030805A patent/CN1206363C/zh not_active Expired - Fee Related
- 1999-02-17 AT AT99915976T patent/ATE296357T1/de active
- 1999-02-17 DE DE69925459T patent/DE69925459T2/de not_active Expired - Lifetime
- 1999-02-17 CZ CZ20002856A patent/CZ297093B6/cs not_active IP Right Cessation
- 1999-02-17 IL IL13778299A patent/IL137782A0/xx not_active IP Right Cessation
- 1999-02-17 PL PL99342513A patent/PL193510B1/pl unknown
- 1999-02-17 EP EP99915976A patent/EP1054993B1/en not_active Expired - Lifetime
- 1999-02-17 JP JP2000532541A patent/JP2002504345A/ja active Pending
- 1999-02-17 RU RU2000124064/13A patent/RU2235130C2/ru not_active IP Right Cessation
- 1999-02-17 HR HR20000541A patent/HRP20000541A2/xx not_active Application Discontinuation
- 1999-02-17 SI SI9930812T patent/SI1054993T1/xx unknown
- 1999-02-17 KR KR1020007009056A patent/KR100582620B1/ko not_active Expired - Fee Related
- 1999-02-17 US US09/600,566 patent/US6825015B1/en not_active Expired - Fee Related
- 1999-02-17 AU AU34384/99A patent/AU743619B2/en not_active Ceased
- 1999-02-17 SK SK1185-2000A patent/SK285074B6/sk not_active IP Right Cessation
- 1999-02-17 CA CA002321052A patent/CA2321052A1/en not_active Abandoned
-
2000
- 2000-08-17 BG BG104696A patent/BG64289B1/bg unknown
-
2004
- 2004-12-22 JP JP2004372018A patent/JP2005110693A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1206363C (zh) | 2005-06-15 |
| AU743619B2 (en) | 2002-01-31 |
| SI9800046A (sl) | 1999-08-31 |
| JP2002504345A (ja) | 2002-02-12 |
| PL342513A1 (en) | 2001-06-18 |
| BG104696A (en) | 2001-07-31 |
| DE69925459T2 (de) | 2006-04-27 |
| SK11852000A3 (sk) | 2001-05-10 |
| KR20010041024A (ko) | 2001-05-15 |
| CN1291238A (zh) | 2001-04-11 |
| US6825015B1 (en) | 2004-11-30 |
| CZ20002856A3 (cs) | 2000-11-15 |
| EP1054993B1 (en) | 2005-05-25 |
| PL193510B1 (pl) | 2007-02-28 |
| SI1054993T1 (en) | 2005-10-31 |
| RO120922B1 (ro) | 2006-09-29 |
| HUP0100820A3 (en) | 2003-07-28 |
| DE69925459D1 (de) | 2005-06-30 |
| WO1999042601A1 (en) | 1999-08-26 |
| JP2005110693A (ja) | 2005-04-28 |
| CA2321052A1 (en) | 1999-08-26 |
| EP1054993A1 (en) | 2000-11-29 |
| RU2235130C2 (ru) | 2004-08-27 |
| KR100582620B1 (ko) | 2006-05-23 |
| AU3438499A (en) | 1999-09-06 |
| ATE296357T1 (de) | 2005-06-15 |
| SK285074B6 (sk) | 2006-05-04 |
| CZ297093B6 (cs) | 2006-09-13 |
| YU50100A (sh) | 2003-07-07 |
| HUP0100820A2 (hu) | 2001-08-28 |
| HRP20000541A2 (en) | 2001-12-31 |
| IL137782A0 (en) | 2001-10-31 |
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