BG61687B1 - Метод за увеличаване на съотношението на алфа към бета васпартаминова купелуваща реакция - Google Patents

Метод за увеличаване на съотношението на алфа към бета васпартаминова купелуваща реакция Download PDF

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Publication number
BG61687B1
BG61687B1 BG95616A BG9561691A BG61687B1 BG 61687 B1 BG61687 B1 BG 61687B1 BG 95616 A BG95616 A BG 95616A BG 9561691 A BG9561691 A BG 9561691A BG 61687 B1 BG61687 B1 BG 61687B1
Authority
BG
Bulgaria
Prior art keywords
solvent
phenylalanine
lower alkyl
alkyl ester
ratio
Prior art date
Application number
BG95616A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG95616A (bg
Inventor
Yefim Gelman
Original Assignee
Nutrasweet Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrasweet Co filed Critical Nutrasweet Co
Publication of BG95616A publication Critical patent/BG95616A/bg
Publication of BG61687B1 publication Critical patent/BG61687B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Arrangement And Mounting Of Devices That Control Transmission Of Motive Force (AREA)
  • Mechanical Operated Clutches (AREA)
  • Seasonings (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Materials For Medical Uses (AREA)
  • Polyesters Or Polycarbonates (AREA)
BG95616A 1990-03-12 1991-12-11 Метод за увеличаване на съотношението на алфа към бета васпартаминова купелуваща реакция BG61687B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49252490A 1990-03-12 1990-03-12
PCT/US1991/001527 WO1991013860A1 (en) 1990-03-12 1991-03-06 Method for increasing the alpha to beta ratio in an aspartame coupling reaction

Publications (2)

Publication Number Publication Date
BG95616A BG95616A (bg) 1993-12-24
BG61687B1 true BG61687B1 (bg) 1998-03-31

Family

ID=23956610

Family Applications (1)

Application Number Title Priority Date Filing Date
BG95616A BG61687B1 (bg) 1990-03-12 1991-12-11 Метод за увеличаване на съотношението на алфа към бета васпартаминова купелуваща реакция

Country Status (21)

Country Link
EP (1) EP0471833B1 (no)
CN (1) CN1052490C (no)
AT (1) ATE123782T1 (no)
AU (1) AU650647B2 (no)
BG (1) BG61687B1 (no)
CA (1) CA2058932C (no)
CZ (1) CZ281204B6 (no)
DE (1) DE69110374T2 (no)
DK (1) DK0471833T3 (no)
ES (1) ES2073162T3 (no)
HR (1) HRP921061A2 (no)
HU (1) HU212897B (no)
IE (1) IE68315B1 (no)
NO (1) NO920158D0 (no)
PT (1) PT97021B (no)
RO (1) RO111571B1 (no)
SK (1) SK279939B6 (no)
TW (1) TW207991B (no)
WO (1) WO1991013860A1 (no)
YU (1) YU44291A (no)
ZA (1) ZA911810B (no)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104628819B (zh) * 2014-10-23 2019-05-21 常茂生物化学工程股份有限公司 一种偶合反应生成阿斯巴甜的工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3933781A (en) * 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
FR2516077A1 (fr) * 1981-11-06 1983-05-13 Human Pharm Sa Laboratoires Procede de preparation de l'ester-methylique de l'a-aspartyl phenylalanine
IT8419324A0 (it) * 1984-01-26 1984-01-26 Pierrel Spa Procedimento per la sintesi di derivati n-acilici dell'aspartame.
JPH07636B2 (ja) * 1984-12-17 1995-01-11 三井東圧化学株式会社 Ｎ−ホルミル−α−アスパルチルフエニルアラニンの製造法
JPH0680075B2 (ja) * 1985-12-24 1994-10-12 味の素株式会社 Ｎ―ホルミル―α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの製造法
DE3600731A1 (de) * 1986-01-13 1987-07-16 Green Cross Korea Verfahren zur herstellung von (alpha)-l-aspartyl-l-phenylalaninmethylester
JPH085912B2 (ja) * 1986-09-04 1996-01-24 味の素株式会社 Ｎ−ホルミルアスパルチル−フエニルアラニンまたはそのメチルエステルの製造方法
US4946988A (en) * 1988-07-14 1990-08-07 The Nutrasweet Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride

Also Published As

Publication number Publication date
HU212897B (en) 1996-12-30
RO111571B1 (ro) 1996-11-29
CN1052490C (zh) 2000-05-17
YU44291A (sh) 1994-05-10
PT97021A (pt) 1991-10-31
TW207991B (no) 1993-06-21
ATE123782T1 (de) 1995-06-15
IE910826A1 (en) 1991-09-25
BG95616A (bg) 1993-12-24
ES2073162T3 (es) 1995-08-01
AU7545291A (en) 1991-10-10
DK0471833T3 (da) 1995-09-25
WO1991013860A1 (en) 1991-09-19
NO920158L (no) 1992-01-13
DE69110374T2 (de) 1995-11-02
EP0471833B1 (en) 1995-06-14
NO920158D0 (no) 1992-01-13
CN1055539A (zh) 1991-10-23
HUT61268A (en) 1992-12-28
AU650647B2 (en) 1994-06-30
DE69110374D1 (de) 1995-07-20
PT97021B (pt) 1998-07-31
ZA911810B (en) 1992-01-29
SK279939B6 (sk) 1999-06-11
EP0471833A4 (en) 1993-06-16
CA2058932A1 (en) 1991-09-13
HRP921061A2 (en) 1996-02-29
CA2058932C (en) 1998-08-25
IE68315B1 (en) 1996-06-12
HU913775D0 (en) 1992-04-28
CS9100639A2 (en) 1991-12-17
EP0471833A1 (en) 1992-02-26
CZ281204B6 (cs) 1996-07-17

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