BG61121B1 - Съединения,производни на индана,метод за получаване и междинни продукти при получаването,тяхното приложение като лекарствени средства и съдържащите ги фармацевтични състави - Google Patents
Съединения,производни на индана,метод за получаване и междинни продукти при получаването,тяхното приложение като лекарствени средства и съдържащите ги фармацевтични съставиInfo
- Publication number
- BG61121B1 BG61121B1 BG098525A BG9852594A BG61121B1 BG 61121 B1 BG61121 B1 BG 61121B1 BG 098525 A BG098525 A BG 098525A BG 9852594 A BG9852594 A BG 9852594A BG 61121 B1 BG61121 B1 BG 61121B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- carbon atoms
- group
- hydrogen atom
- atom
- alkyl radical
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 239000013067 intermediate product Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- -1 nitro, amino Chemical group 0.000 abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 239000011593 sulfur Substances 0.000 abstract 2
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 2
- CGFORRLIKRTSLT-UHFFFAOYSA-N 2-(3,4-dichlorophenyl)-n-methylacetamide Chemical compound CNC(=O)CC1=CC=C(Cl)C(Cl)=C1 CGFORRLIKRTSLT-UHFFFAOYSA-N 0.000 abstract 1
- XKWULHLBNUUMKR-UHFFFAOYSA-N 3,5-ditert-butyl-4-hydroxy-n-methylbenzamide Chemical compound CNC(=O)C1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 XKWULHLBNUUMKR-UHFFFAOYSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- AOZUATNZXGQECR-UHFFFAOYSA-N n-methyl-2-(3-nitrophenyl)acetamide Chemical compound CNC(=O)CC1=CC=CC([N+]([O-])=O)=C1 AOZUATNZXGQECR-UHFFFAOYSA-N 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical group NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
Abstract
Изобретението се отнася до съединения с формула в която r1 и r2, еднакви или различни, означават водороден атом или алкилов радикал, съдържащ от 1 до 5 въглеродни атома, или r1 и r2 образуват заедно с въглеродния атом, до който са свързани, циклоалкил, съдържащ между 3 и 6 въглеродни атома, и могат да съдържат евентуално хетероатом като кислороден, серен или азотен; и r6 и r7, еднакви или различни, означават халогенен атом, алкилов радикал или алкокси, съдържащ от 1 до 5 въглеродни атома, а и в са такива, че един от тях е от групата с формула в която r означава водороден атом или алкилна група с 1 до 5 въглеродни атома; z е линейна алкиленова верига-(сн2)n; n е число, което може да се изменя от 0 до 5, или разклонена алкиленова верига с 2 до 8 въглеродни атома или групата -сн2-0, х, х' и х'', еднакви или различни, означават водороден атом, алкилов радикал или алкокси, съдържащ от 1 до 4 въглеродни атома, халогенен атом, хидроксилов радикал, трифлуорметил, нитро, амино, моноалкил или диалкиламино или сулфоаминова група, а другите от субституентите а или в са избрани от групата с формулав която r3 и r4, еднакви или различни, означават водороден атом или алкилов радикал с 1 до 5 въглеродни атома или r3 и r4 образуват заедно с азотния атом, към който са свързани, хетероцикъл с 5 или 6 звена, който в дадения случай съдържа друг хетероатом като кислород, азот или сяра, при което азотният атом е заместен евентуално с алкилов радикал с 1 до 4 въглеродни атома; или r6 и r7 означават водороден атом; или в означава пиролидинов радикал и а означава групата 3,5-бис-(1,1-диметилетил)-4-хидрокси-n-метилбензамид, n-метил-3-нитробензолацетамид, или 3,4-дихлор-n-метилбензолацетамид, при което последните два продукта при необходимост могат да бъдат под формата на енантиомери; или а означава радикал 3,4-дихлор-n-метилбензолацетамид, и в означава метил-(2-фенилетил)-аминогрупа или (2-фурилметил)-метиламиногрупа или 4-(2-метоксифен
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR888816605A FR2640625B2 (fr) | 1986-08-21 | 1988-12-16 | Nouveaux composes optiquement actifs derives de l'indane, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG61121B1 true BG61121B1 (bg) | 1996-11-29 |
| BG61121B2 BG61121B2 (bg) | 1996-11-29 |
Family
ID=9373020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG98525A BG61121B2 (bg) | 1988-12-16 | 1994-02-23 | Съединения,производни на индана,метод за получаване и междинни продукти при получаването,тяхното приложение като лекарствени средства и съдържащите ги фармацевтични състави |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5436244A (bg) |
| EP (1) | EP0374054B1 (bg) |
| JP (1) | JP2753591B2 (bg) |
| AT (1) | ATE95517T1 (bg) |
| AU (1) | AU630136B2 (bg) |
| BG (1) | BG61121B2 (bg) |
| CA (1) | CA2005626A1 (bg) |
| DE (1) | DE68909757T2 (bg) |
| DK (1) | DK626889A (bg) |
| ES (1) | ES2059805T3 (bg) |
| HU (2) | HU219446B (bg) |
| IE (1) | IE65151B1 (bg) |
| ZA (1) | ZA899616B (bg) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5646151A (en) * | 1996-03-08 | 1997-07-08 | Adolor Corporation | Kappa agonist compounds and pharmaceutical formulations thereof |
| US5763445A (en) | 1996-03-08 | 1998-06-09 | Adolor Corporation | Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith |
| DE19929076A1 (de) | 1999-06-25 | 2000-12-28 | Aventis Pharma Gmbh | Indanylsubstituierte Benzolcarbonamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| AU2016258192B2 (en) | 2015-05-06 | 2021-07-29 | Leidos Biomedical Research, Inc. | K-Ras modulators |
| GB201601301D0 (en) * | 2016-01-25 | 2016-03-09 | Takeda Pharmaceutical | Novel compounds |
| WO2018195439A2 (en) | 2017-04-20 | 2018-10-25 | The Regents Of The University Of California | K-ras modulators |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1109080A (en) * | 1978-05-30 | 1981-09-15 | Hideo Kato | Indanamine derivatives |
| US4359476A (en) * | 1981-04-09 | 1982-11-16 | The Upjohn Company | Adjacently substituted cycloalkane-amide analgesics |
| US4460600A (en) * | 1981-04-09 | 1984-07-17 | The Upjohn Company | Adjacently substituted ketal derivatives of cycloalkane-amide analgesics |
| US4466977A (en) * | 1981-04-09 | 1984-08-21 | The Upjohn Company | N-[2-Amino(oxy- or thia- group-substituted-cycloaliphatic)]benzeneacetamides and -benzamide analgesics |
| US4360531A (en) * | 1981-04-09 | 1982-11-23 | The Upjohn Company | Substituted cycloalkanes |
| GB2096607B (en) * | 1981-04-09 | 1985-02-27 | Upjohn Co | Aminocycloalkyl amides |
| DE3781627T2 (de) * | 1986-08-21 | 1993-05-06 | Roussel Uclaf | Indanderivate, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel, diese enthaltende pharmazeutische zusammensetzungen und erhaltene zwischenprodukte. |
| US4876269A (en) * | 1986-09-10 | 1989-10-24 | E. I. Du Pont De Nemours And Company | Benoz-fused cycloalkane trans-1,2-diamine derivatives |
| FR2608598B1 (fr) * | 1986-12-23 | 1989-04-14 | Roussel Uclaf | Nouveaux derives de l'indane, leur procede de preparation et les nouveaux intermediaires ainsi obtenus, leur application comme medicaments et les compositions les renfermant |
-
1989
- 1989-12-12 DK DK626889A patent/DK626889A/da not_active Application Discontinuation
- 1989-12-14 JP JP1322788A patent/JP2753591B2/ja not_active Expired - Fee Related
- 1989-12-15 CA CA002005626A patent/CA2005626A1/fr not_active Abandoned
- 1989-12-15 AT AT89403506T patent/ATE95517T1/de not_active IP Right Cessation
- 1989-12-15 ES ES89403506T patent/ES2059805T3/es not_active Expired - Lifetime
- 1989-12-15 ZA ZA899616A patent/ZA899616B/xx unknown
- 1989-12-15 IE IE402789A patent/IE65151B1/en not_active IP Right Cessation
- 1989-12-15 EP EP89403506A patent/EP0374054B1/fr not_active Expired - Lifetime
- 1989-12-15 HU HU631/89A patent/HU219446B/hu not_active IP Right Cessation
- 1989-12-15 AU AU46802/89A patent/AU630136B2/en not_active Ceased
- 1989-12-15 DE DE89403506T patent/DE68909757T2/de not_active Expired - Fee Related
-
1993
- 1993-07-22 US US08/096,034 patent/US5436244A/en not_active Expired - Fee Related
-
1994
- 1994-02-23 BG BG98525A patent/BG61121B2/bg unknown
-
1995
- 1995-06-30 HU HU95P/P00668P patent/HU211609A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0374054A1 (fr) | 1990-06-20 |
| DE68909757D1 (de) | 1993-11-11 |
| IE65151B1 (en) | 1995-10-04 |
| CA2005626A1 (fr) | 1990-06-16 |
| BG61121B2 (bg) | 1996-11-29 |
| DE68909757T2 (de) | 1994-03-31 |
| IE894027L (en) | 1990-06-16 |
| HU896631D0 (en) | 1990-02-28 |
| DK626889D0 (da) | 1989-12-12 |
| EP0374054B1 (fr) | 1993-10-06 |
| ATE95517T1 (de) | 1993-10-15 |
| US5436244A (en) | 1995-07-25 |
| AU630136B2 (en) | 1992-10-22 |
| HU219446B (hu) | 2001-04-28 |
| AU4680289A (en) | 1990-06-21 |
| HUT53094A (en) | 1990-09-28 |
| HU211609A9 (en) | 1995-12-28 |
| JP2753591B2 (ja) | 1998-05-20 |
| ZA899616B (en) | 1991-02-27 |
| JPH02218653A (ja) | 1990-08-31 |
| ES2059805T3 (es) | 1994-11-16 |
| DK626889A (da) | 1990-06-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2102478T3 (es) | Complejos de vanadio, su preparacion y composiciones farmaceuticas que los contienen. | |
| ATE40122T1 (de) | N-(2-nitrophenyl)-2-aminopyrimidin-derivate, deren herstellung und verwendung. | |
| TR200002671T2 (tr) | Bisiklo(2.2.1)Heptanlar ve ilgili bileşikler | |
| ES544463A0 (es) | Procedimiento para la preparacion de derivados de n-(2-ni- trofenil)-2-aminopirimidina | |
| ATE16805T1 (de) | Trifluoromethylphenyltetrahydropyridine mit appetithemmender wirkung, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen. | |
| ATE277049T1 (de) | Substituierte aminoalkylverbindungen | |
| KR880007085A (ko) | 고지질혈증 치료용의 약학 조성물 | |
| BG61121B1 (bg) | Съединения,производни на индана,метод за получаване и междинни продукти при получаването,тяхното приложение като лекарствени средства и съдържащите ги фармацевтични състави | |
| YU38399A (sh) | Supstituisani derivati 1,3-bis(cikloheksilmetil)-1,2,3,6-tetrahidro-2,6-diokso-9h-purin-8-il)fenila,njihovo dobijanje i upotreba za proizvodnju medikamenata za lečenje inflamatornih stanja i imuno poremećaja | |
| DE3778508D1 (de) | Substituierte triazinderivate. | |
| FR2713085B1 (fr) | Composition tinctoriale contenant des p-phénylènediamines soufrées et procédés de teinture correspondants, nouvelles p-phénylènediamines soufrées et leur procédé de préparation. | |
| ES8205756A1 (es) | Procedimiento de preparacion de una composicion cosmetica destinada a ser utilizada para el tratamiento de materias queratinicas | |
| ES2057802T3 (es) | Nuevos derivados de 3-amino-cromano, procedimiento de preparacion y composiciones farmaceuticas que los contienen. | |
| SE8303913D0 (sv) | Heterocykliska foreningar | |
| ES2032501T3 (es) | Un procedimiento de preparacion de derivados de urileno-2,4,6-triamino-3-oxido. | |
| IL74324A (en) | 3-phenyl-2-propeneamine derivatives,their preparation and pharmaceutical compositions containing them | |
| EA199900460A1 (ru) | Производные бензолсульфоамида и лекарственные средства, содержащие упомянутые производные | |
| PT90815A (pt) | Processo de preparacao de derivados da fenotiazina | |
| DE3865656D1 (de) | Trizyklische derivate, agonistn von cholinergetischen rezeptoren und diese enthaltende arzneimittel. | |
| DK0434560T3 (da) | Hidtil ukendte substituerede aminosyrederivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende dem | |
| GB1317598A (en) | Pesticidal adducts of thiophosphorus acids and n-vinyl compounds and process of preparing same | |
| FR2603035A1 (fr) | Nouveaux derives de l'indane, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant | |
| KR890014483A (ko) | 치환 벤젠 유도체, 그의 제조방법 및 이 화합물을 함유하는 항암성 조성물 |