BG60834B2 - Фармацевтични състави на базата на фосфономравчена киселина и приложението им - Google Patents
Фармацевтични състави на базата на фосфономравчена киселина и приложението им Download PDFInfo
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- BG60834B2 BG60834B2 BG098492A BG9849294A BG60834B2 BG 60834 B2 BG60834 B2 BG 60834B2 BG 098492 A BG098492 A BG 098492A BG 9849294 A BG9849294 A BG 9849294A BG 60834 B2 BG60834 B2 BG 60834B2
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- Prior art keywords
- acid
- virus
- pharmaceutical composition
- inhibition
- salts
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- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 1
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- 150000002736 metal compounds Chemical class 0.000 description 1
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- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
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- 239000011736 potassium bicarbonate Substances 0.000 description 1
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- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
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- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
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- 239000008159 sesame oil Substances 0.000 description 1
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- 206010040872 skin infection Diseases 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- SRWFBFUYENBCGF-UHFFFAOYSA-M sodium;chloride;hydrochloride Chemical compound [Na+].Cl.[Cl-] SRWFBFUYENBCGF-UHFFFAOYSA-M 0.000 description 1
- 239000011973 solid acid Substances 0.000 description 1
- WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
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- 239000002511 suppository base Substances 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- DZLFLBLQUQXARW-UHFFFAOYSA-N tetrabutylammonium Chemical class CCCC[N+](CCCC)(CCCC)CCCC DZLFLBLQUQXARW-UHFFFAOYSA-N 0.000 description 1
- AYEKOFBPNLCAJY-UHFFFAOYSA-O thiamine pyrophosphate Chemical compound CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N AYEKOFBPNLCAJY-UHFFFAOYSA-O 0.000 description 1
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- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- JLEXUIVKURIPFI-UHFFFAOYSA-N tris phosphate Chemical compound OP(O)(O)=O.OCC(N)(CO)CO JLEXUIVKURIPFI-UHFFFAOYSA-N 0.000 description 1
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical class [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3886—Acids containing the structure -C(=X)-P(=X)(XH)2 or NC-P(=X)(XH)2, (X = O, S, Se)
- C07F9/3891—Acids containing the structure -C(=X)-P(=X)(XH)2, (X = O, S, Se)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Crystallography & Structural Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7607496A SE7607496L (sv) | 1976-07-01 | 1976-07-01 | Sett for bekempning av virusinfektioner |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG60834B2 true BG60834B2 (bg) | 1996-04-30 |
Family
ID=20328354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG098492A BG60834B2 (bg) | 1976-07-01 | 1994-02-18 | Фармацевтични състави на базата на фосфономравчена киселина и приложението им |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US4215113A (fi) |
| JP (1) | JPS536428A (fi) |
| AT (1) | AT369014B (fi) |
| AU (1) | AU510809B2 (fi) |
| BE (1) | BE856355A (fi) |
| BG (1) | BG60834B2 (fi) |
| CA (1) | CA1077848A (fi) |
| CH (1) | CH641471A5 (fi) |
| DE (1) | DE2728685C2 (fi) |
| DK (1) | DK288877A (fi) |
| FI (1) | FI772030A (fi) |
| FR (1) | FR2356424A1 (fi) |
| GB (1) | GB1585615A (fi) |
| HK (1) | HK28984A (fi) |
| IE (1) | IE45753B1 (fi) |
| LU (2) | LU77666A1 (fi) |
| MX (1) | MX9203635A (fi) |
| MY (1) | MY8500125A (fi) |
| NL (2) | NL180068C (fi) |
| NO (1) | NO772299L (fi) |
| SE (1) | SE7607496L (fi) |
| SG (1) | SG80383G (fi) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1140049A (en) * | 1977-12-22 | 1983-01-25 | Dke J.E. Helgstran | Pharmaceutical preparations from derivatives of hydroxycarbonylphosphonic acid |
| DK564378A (da) * | 1977-12-22 | 1979-06-23 | Astra Laekemedel Ab | Fremgangsmaade til fremstilling af amidderivater til bekaempelse af virusinfektioner |
| DE2926799A1 (de) * | 1979-07-03 | 1981-01-15 | Bayer Ag | Phosphonoameisensaeurehydrazide, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE2941384A1 (de) * | 1979-10-12 | 1981-04-23 | Bayer Ag, 5090 Leverkusen | Phosphono-hydroxy-essigsaeure, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE3127237A1 (de) * | 1981-07-10 | 1983-01-20 | Hoechst Ag, 6000 Frankfurt | Magenvertraegliche arzneiformen von xanthinderivaten und verfahren zu ihrer herstellung |
| MC1585A1 (fr) * | 1982-02-12 | 1985-02-22 | Ens Bio Logicals Inc | Procede de fabrication de compositions antivirales |
| US4902678A (en) * | 1982-02-12 | 1990-02-20 | Syntex (U.S.A.) Inc. | Anti-viral compositions |
| JPH0761814B2 (ja) * | 1984-09-10 | 1995-07-05 | 三菱化学株式会社 | 搬送装置 |
| JPS6194925A (ja) * | 1984-10-12 | 1986-05-13 | Mitsubishi Chem Ind Ltd | 搬送用装置 |
| JPS61217434A (ja) * | 1985-03-20 | 1986-09-27 | Mitsubishi Chem Ind Ltd | 搬送用装置 |
| GB8501374D0 (en) * | 1985-01-18 | 1985-02-20 | Wellcome Found | Treatment of aids |
| US4880619A (en) * | 1985-03-11 | 1989-11-14 | Colgate-Palmolive Company | Anticalculus oral composition |
| US4590064A (en) * | 1985-03-11 | 1986-05-20 | Colgate-Palmolive Company | Anticalculus oral composition |
| GB8512330D0 (en) * | 1985-05-15 | 1985-06-19 | Wellcome Found | Antiviral compounds |
| US4806532A (en) * | 1985-10-08 | 1989-02-21 | Mayo Foundation For Medical Education And Research | Inhibition of epithelial phosphate transport |
| EP0243352A1 (en) * | 1985-10-21 | 1987-11-04 | SERGIO, William | Method for reducing the risk or probability of infection from the aids virus (htlv-iii/lav/arv) |
| US6492352B1 (en) * | 1985-10-31 | 2002-12-10 | Astra Lakemedel Aktiebolag | Method for the control and treatment of acquired immunodeficiency syndrome (AIDS) |
| US5194654A (en) * | 1989-11-22 | 1993-03-16 | Vical, Inc. | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use |
| US5463092A (en) * | 1989-11-22 | 1995-10-31 | Vestar, Inc. | Lipid derivatives of phosphonacids for liposomal incorporation and method of use |
| US6110901A (en) * | 1990-07-03 | 2000-08-29 | American Cyanamid Company | Method for treating RNA viral infections by using RNA chain terminators |
| SE9403861D0 (sv) * | 1994-11-09 | 1994-11-09 | Astra Ab | Novel medicinal use |
| US5696277A (en) * | 1994-11-15 | 1997-12-09 | Karl Y. Hostetler | Antiviral prodrugs |
| EP0831842A4 (en) * | 1995-06-06 | 1998-08-19 | Univ Southern California | METHOD AND MEANS FOR INHIBITING PROPAGATION OF THE CYTOMEGALOVIRUS |
| US7517858B1 (en) | 1995-06-07 | 2009-04-14 | The Regents Of The University Of California | Prodrugs of pharmaceuticals with improved bioavailability |
| FI980216A0 (fi) * | 1998-01-30 | 1998-01-30 | Bene Pharma Oy | Medicin foer behandling av vaorfor |
| US20040002079A1 (en) * | 1998-02-11 | 2004-01-01 | Gunn Robert B. | Sodium-phosphate cotransporter in lithium therapy for the treatment of mental illness |
| DE19940748A1 (de) * | 1999-08-27 | 2001-03-01 | Hugo Seinfeld | Arzneimittel enthaltend xenogene Oligo- oder/und Polyribonukleotide |
| US20040131622A1 (en) * | 2002-07-15 | 2004-07-08 | Board Of Regents | Combinations and kits for treating viral infections using immunoconjugates to aminophospholipids |
| US7790159B2 (en) * | 2002-07-15 | 2010-09-07 | Board Of Regents, The University Of Texas System | Methods, combinations and kits for treating viral infections using immunoconjugates and antibodies to aminophospholipids |
| US7611704B2 (en) * | 2002-07-15 | 2009-11-03 | Board Of Regents, The University Of Texas System | Compositions and methods for treating viral infections using antibodies and immunoconjugates to aminophospholipids |
| US7906115B2 (en) | 2002-07-15 | 2011-03-15 | Thorpe Philip E | Combinations kits and methods for treating viral infections using antibodies and immunoconjugates to aminophospholipids |
| US7455833B2 (en) * | 2002-07-15 | 2008-11-25 | Board Of Regents, The University Of Texas System | Methods and compositions for treating viral infections using antibodies and immunoconjugates to aminophospholipids |
| US7132452B2 (en) * | 2003-03-10 | 2006-11-07 | Fang-Yu Lee | Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection |
| US20060166941A1 (en) * | 2003-03-14 | 2006-07-27 | Epistem Limited | Treatment and/or prevention of non-viral epithelial damage |
| US7424812B2 (en) | 2003-05-16 | 2008-09-16 | Stanton Concepts Inc. | Multiple function lock |
| WO2006119174A1 (en) * | 2005-04-30 | 2006-11-09 | Ocular Surface Center, P.A. | Method for treating ocular demodex |
| US20080045482A1 (en) * | 2006-01-27 | 2008-02-21 | Adventrx Pharmaceuticals, Inc. | Compositions and methods for the treatment of viral infections |
| US8128968B2 (en) | 2007-08-29 | 2012-03-06 | Tissuetech, Inc. | Compositions and methods for treating Demodex infestations |
| US9006219B2 (en) * | 2008-03-12 | 2015-04-14 | Nektar Therapeutics | Oligomer-foscarnet conjugates |
| ES2578902B1 (es) * | 2014-12-29 | 2017-07-07 | Agencia Pública Empresarial Sanitaria Costa Del Sol | Uso de análogos del ión pirofosfato para el tratamiento de la infección por VPH |
| WO2022153334A1 (en) * | 2021-01-15 | 2022-07-21 | Jubilant Generics Ltd | Transmucosal dosage forms of foscarnet |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3767795A (en) * | 1971-02-25 | 1973-10-23 | Abbott Lab | Method for combating certain virus infection |
| US3836650A (en) * | 1971-02-25 | 1974-09-17 | Abbott Lab | Method for combating marek's disease in poultry |
| DE2360797C2 (de) * | 1973-12-06 | 1985-05-23 | Henkel KGaA, 4000 Düsseldorf | Pharmazeutische Präparate |
-
1976
- 1976-07-01 SE SE7607496A patent/SE7607496L/xx unknown
-
1977
- 1977-06-20 US US05/807,783 patent/US4215113A/en not_active Expired - Lifetime
- 1977-06-25 DE DE2728685A patent/DE2728685C2/de not_active Expired
- 1977-06-27 AU AU26505/77A patent/AU510809B2/en not_active Expired
- 1977-06-27 IE IE1311/77A patent/IE45753B1/en not_active IP Right Cessation
- 1977-06-29 FI FI772030A patent/FI772030A/fi not_active Application Discontinuation
- 1977-06-29 NO NO772299A patent/NO772299L/no unknown
- 1977-06-29 NL NLAANVRAGE7707235,A patent/NL180068C/xx not_active IP Right Cessation
- 1977-06-29 DK DK288877A patent/DK288877A/da not_active Application Discontinuation
- 1977-06-30 FR FR7720100A patent/FR2356424A1/fr active Granted
- 1977-06-30 AT AT0465477A patent/AT369014B/de active Protection Beyond IP Right Term
- 1977-06-30 CH CH808577A patent/CH641471A5/de not_active IP Right Cessation
- 1977-06-30 CA CA281,863A patent/CA1077848A/en not_active Expired
- 1977-06-30 GB GB27464/77A patent/GB1585615A/en not_active Expired
- 1977-06-30 LU LU77666A patent/LU77666A1/xx unknown
- 1977-07-01 JP JP7797777A patent/JPS536428A/ja active Granted
- 1977-07-01 BE BE178982A patent/BE856355A/xx not_active IP Right Cessation
-
1978
- 1978-12-21 US US05/971,931 patent/US4339445A/en not_active Expired - Lifetime
-
1982
- 1982-08-02 US US06/404,295 patent/US4665062A/en not_active Expired - Lifetime
-
1983
- 1983-12-20 SG SG803/83A patent/SG80383G/en unknown
-
1984
- 1984-03-29 HK HK289/84A patent/HK28984A/xx unknown
-
1985
- 1985-10-31 US US06/793,575 patent/US4771041A/en not_active Expired - Fee Related
- 1985-12-30 MY MY125/85A patent/MY8500125A/xx unknown
-
1992
- 1992-06-26 MX MX9203635A patent/MX9203635A/es unknown
-
1993
- 1993-06-10 NL NL930053C patent/NL930053I2/nl unknown
- 1993-06-16 LU LU88310C patent/LU88310I2/fr unknown
-
1994
- 1994-02-18 BG BG098492A patent/BG60834B2/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2356424A1 (fr) | 1978-01-27 |
| BE856355A (fr) | 1978-01-02 |
| ATA465477A (de) | 1982-04-15 |
| DE2728685A1 (de) | 1978-01-12 |
| CH641471A5 (de) | 1984-02-29 |
| FI772030A (fi) | 1978-01-02 |
| NL180068C (nl) | 1987-01-02 |
| US4665062A (en) | 1987-05-12 |
| US4339445A (en) | 1982-07-13 |
| MX9203635A (es) | 1992-09-01 |
| LU77666A1 (fi) | 1977-10-07 |
| JPS536428A (en) | 1978-01-20 |
| LU88310I2 (fr) | 1994-05-04 |
| JPS562046B2 (fi) | 1981-01-17 |
| NL180068B (nl) | 1986-08-01 |
| AU510809B2 (en) | 1980-07-17 |
| CA1077848A (en) | 1980-05-20 |
| NL930053I2 (nl) | 1994-01-03 |
| IE45753B1 (en) | 1982-11-17 |
| MY8500125A (en) | 1985-12-31 |
| DE2728685C2 (de) | 1982-09-16 |
| US4771041A (en) | 1988-09-13 |
| HK28984A (en) | 1984-04-06 |
| IE45753L (en) | 1978-01-01 |
| SE7607496L (sv) | 1978-01-02 |
| NL930053I1 (nl) | 1993-09-01 |
| FR2356424B1 (fi) | 1980-04-18 |
| AT369014B (de) | 1982-11-25 |
| NL7707235A (nl) | 1978-01-03 |
| NO772299L (no) | 1978-04-25 |
| US4215113A (en) | 1980-07-29 |
| SG80383G (en) | 1984-08-03 |
| GB1585615A (en) | 1981-03-11 |
| AU2650577A (en) | 1979-01-04 |
| DK288877A (da) | 1978-01-02 |
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