BG60832B2 - Фармацевтичен състав с аналгетична активност - Google Patents
Фармацевтичен състав с аналгетична активност Download PDFInfo
- Publication number
- BG60832B2 BG60832B2 BG098593A BG9859394A BG60832B2 BG 60832 B2 BG60832 B2 BG 60832B2 BG 098593 A BG098593 A BG 098593A BG 9859394 A BG9859394 A BG 9859394A BG 60832 B2 BG60832 B2 BG 60832B2
- Authority
- BG
- Bulgaria
- Prior art keywords
- ibuprofen
- arginine
- sodium bicarbonate
- pharmaceutical composition
- granulate
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 12
- 230000000202 analgesic effect Effects 0.000 title claims description 8
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract description 46
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims abstract description 24
- 235000017557 sodium bicarbonate Nutrition 0.000 claims abstract description 24
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims abstract description 18
- 229930064664 L-arginine Natural products 0.000 claims abstract description 18
- 235000014852 L-arginine Nutrition 0.000 claims abstract description 18
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract description 8
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims description 52
- 229960001680 ibuprofen Drugs 0.000 claims description 50
- 239000008187 granular material Substances 0.000 claims description 39
- 239000000203 mixture Substances 0.000 claims description 38
- 229930006000 Sucrose Natural products 0.000 claims description 11
- 239000005720 sucrose Substances 0.000 claims description 11
- 108010011485 Aspartame Proteins 0.000 claims description 10
- 239000000605 aspartame Substances 0.000 claims description 10
- 235000010357 aspartame Nutrition 0.000 claims description 10
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 10
- 229960003438 aspartame Drugs 0.000 claims description 10
- 235000003599 food sweetener Nutrition 0.000 claims description 10
- 239000003765 sweetening agent Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 8
- 239000000796 flavoring agent Substances 0.000 claims description 6
- 235000019634 flavors Nutrition 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- GCCOJNYCFNSJII-VWMHFEHESA-N [n'-[(4s)-4-amino-4-carboxybutyl]carbamimidoyl]azanium;2-[4-(2-methylpropyl)phenyl]propanoate Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N.CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 GCCOJNYCFNSJII-VWMHFEHESA-N 0.000 claims description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- 239000000975 dye Substances 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 239000005715 Fructose Substances 0.000 claims description 2
- 229930091371 Fructose Natural products 0.000 claims description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 2
- 229940109275 cyclamate Drugs 0.000 claims description 2
- 239000008101 lactose Substances 0.000 claims description 2
- 229940081974 saccharin Drugs 0.000 claims description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical group C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 claims description 2
- 235000019204 saccharin Nutrition 0.000 claims description 2
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 125000000185 sucrose group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 description 12
- 235000006679 Mentha X verticillata Nutrition 0.000 description 11
- 235000002899 Mentha suaveolens Nutrition 0.000 description 11
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 11
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical class OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 10
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 10
- 229940079593 drug Drugs 0.000 description 10
- 239000000945 filler Substances 0.000 description 10
- 239000000243 solution Substances 0.000 description 9
- 239000003826 tablet Substances 0.000 description 9
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 238000010521 absorption reaction Methods 0.000 description 5
- 239000013543 active substance Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 230000036470 plasma concentration Effects 0.000 description 5
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 4
- 238000013103 analytical ultracentrifugation Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 235000007265 Myrrhis odorata Nutrition 0.000 description 3
- 240000004760 Pimpinella anisum Species 0.000 description 3
- 235000012550 Pimpinella anisum Nutrition 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 229960001230 asparagine Drugs 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 210000004400 mucous membrane Anatomy 0.000 description 3
- 239000004475 Arginine Substances 0.000 description 2
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
- 235000009697 arginine Nutrition 0.000 description 2
- 235000009582 asparagine Nutrition 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- 239000000829 suppository Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- VDZOOKBUILJEDG-UHFFFAOYSA-M tetrabutylammonium hydroxide Chemical compound [OH-].CCCC[N+](CCCC)(CCCC)CCCC VDZOOKBUILJEDG-UHFFFAOYSA-M 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- DIDYGLSKVUKRRP-UHFFFAOYSA-N 2-(diethylamino)ethyl 2,2-diphenylpropanoate Chemical compound C=1C=CC=CC=1C(C)(C(=O)OCCN(CC)CC)C1=CC=CC=C1 DIDYGLSKVUKRRP-UHFFFAOYSA-N 0.000 description 1
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical compound [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
- 206010053155 Epigastric discomfort Diseases 0.000 description 1
- WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 1
- 244000290333 Vanilla fragrans Species 0.000 description 1
- 235000009499 Vanilla fragrans Nutrition 0.000 description 1
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229940035676 analgesics Drugs 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 239000008122 artificial sweetener Substances 0.000 description 1
- 235000021311 artificial sweeteners Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 1
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 1
- 229940043351 ethyl-p-hydroxybenzoate Drugs 0.000 description 1
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000002489 hematologic effect Effects 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 229940082170 ibuprofen 200 mg Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 235000021096 natural sweeteners Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21358/86A IT1197038B (it) | 1986-08-01 | 1986-08-01 | Composizione farmaceutica ad attivita' analgesica |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG60832B2 true BG60832B2 (bg) | 1996-04-30 |
Family
ID=11180633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG098593A BG60832B2 (bg) | 1986-08-01 | 1994-02-25 | Фармацевтичен състав с аналгетична активност |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4834966A (cs) |
| JP (1) | JP2585005B2 (cs) |
| AT (1) | AT394945B (cs) |
| AU (1) | AU595342B2 (cs) |
| BE (1) | BE1002109A3 (cs) |
| BG (1) | BG60832B2 (cs) |
| CA (1) | CA1286992C (cs) |
| CH (1) | CH673394A5 (cs) |
| DE (1) | DE3725176C2 (cs) |
| FR (1) | FR2602141B1 (cs) |
| GB (1) | GB2193093B (cs) |
| GR (1) | GR871197B (cs) |
| IE (1) | IE60276B1 (cs) |
| IT (1) | IT1197038B (cs) |
| MX (1) | MX9203167A (cs) |
| NL (1) | NL194031C (cs) |
| ZA (1) | ZA875397B (cs) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4861797A (en) * | 1987-10-15 | 1989-08-29 | Oratech Pharmaceutical Development Corporation | Liquid ibuprofen compositions and methods of making them |
| JPH0256416A (ja) * | 1988-08-19 | 1990-02-26 | Daikyo Yakuhin Kogyo Kk | 苦味を抑えた顆粒剤 |
| DE3922441A1 (de) * | 1989-07-07 | 1991-01-17 | Pharmatrans Sanaq Ag | Ibuprofen- und s-(+)-ibuprofen-zubereitungen und verfahren zu ihrer herstellung |
| GB8920693D0 (en) * | 1989-09-13 | 1989-10-25 | Nicholas Kiwi Pty Ltd | Non-effervescent ibuprofen compositions |
| US5262179A (en) * | 1989-09-13 | 1993-11-16 | Nicholas Kiwi Pty Ltd. | Non-effervescent ibuprofen compositions |
| IT1245890B (it) * | 1991-04-12 | 1994-10-25 | Alfa Wassermann Spa | Formulazioni farmaceutiche per uso orale gastroresistenti contenenti acidi biliari. |
| IT1272149B (it) * | 1993-03-26 | 1997-06-11 | Zambon Spa | Composizione farmeceutiche ad attivita' analgesica |
| IT1264857B1 (it) | 1993-06-21 | 1996-10-17 | Zambon Spa | Composizione farmaceutica liquida per uso orale contenente acido 2-(4-isobutilfenil) propionico |
| IT1264856B1 (it) * | 1993-06-21 | 1996-10-17 | Zambon Spa | Composizione farmaceutica ad attivita' analgesica |
| IT1264855B1 (it) * | 1993-06-21 | 1996-10-17 | Zambon Spa | Composizioni farmaceutiche contenenti sali dell'acido s(+)-2-(4-isobutilfenil) propionico con amminoacidi basici |
| IT1266583B1 (it) * | 1993-07-30 | 1997-01-09 | Zambon Spa | Processo per la preparazione di sali dell'acido 2-(4-isobutilfenil)- propionico |
| DE19502789A1 (de) * | 1995-01-28 | 1996-08-01 | Dirk Krischenowski | Arzneimittel |
| DE19606151C2 (de) * | 1996-02-20 | 1999-05-12 | Losan Pharma Gmbh | Ibuprofen-Brausezubereitung sowie Verfahren zur Herstellung derselben |
| DE19800812C2 (de) * | 1998-01-12 | 2000-05-11 | Juergen C Froelich | Verbesserte orale Darreichungsformen von L-Arginin-HCl |
| IT1301966B1 (it) * | 1998-07-30 | 2000-07-20 | Zambon Spa | Composizioni farmaceutiche ad attivita' analgesica |
| CA2386312A1 (en) * | 1999-09-29 | 2001-04-05 | R.P. Scherer Technologies, Inc. | Hydrolyzed cellulose granulations of salts of drugs |
| AU2001288938A1 (en) * | 2000-09-07 | 2002-03-22 | Akpharma Inc. | Edible candy compositions and methods of using the same |
| US20020099037A1 (en) * | 2001-01-19 | 2002-07-25 | Akpharma, Inc. | Method for alleviating syndromes and conditions of discomfort of the mammalian intestinal and genito-urinary tracts |
| WO2002069936A2 (en) * | 2001-03-02 | 2002-09-12 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical composition of ibuprofen |
| CA2455274A1 (en) * | 2001-04-10 | 2002-10-24 | Zagros Pharma Limited | Animal model for evaluating analgesics |
| US6727286B2 (en) | 2001-11-02 | 2004-04-27 | Cumberland Pharmaceuticals Inc. | Pharmaceutical composition of 2-(4-isobutylphenyl) propionic acid |
| MXPA05010070A (es) * | 2003-04-11 | 2005-11-23 | Pfizer | Combinacion farmaceutica. |
| JP4913359B2 (ja) * | 2004-05-07 | 2012-04-11 | 第一三共ヘルスケア株式会社 | イブプロフェン含有医薬組成物 |
| WO2005115345A1 (en) | 2004-05-28 | 2005-12-08 | Imaginot Pty Ltd | Oral therapeutic compound delivery system |
| US8216610B2 (en) * | 2004-05-28 | 2012-07-10 | Imaginot Pty Ltd. | Oral paracetamol formulations |
| EP1800667A1 (en) | 2005-12-23 | 2007-06-27 | Losan Pharma GmbH | Rapidly solubilizing ibuprofen granulate |
| JP2008534477A (ja) * | 2005-03-22 | 2008-08-28 | ロザン ファルマ ゲゼルシャフトミットベシュレンクテルハフツンク | 可溶化イブプロフェン |
| JP2009517346A (ja) | 2005-11-28 | 2009-04-30 | イメイジノット ピーティーワイ エルティーディー | 治療用化合物の経口送達系 |
| ES2303468B1 (es) * | 2007-01-22 | 2009-06-08 | Masterfarm, S.L | "una composicion farmaceutica pulverulenta que comprende ibuprofeno". |
| NZ628603A (en) * | 2009-06-22 | 2016-04-29 | Wyeth Llc | Sodium ibuprofen tablets and methods of manufacturing pharmaceutical compositions including sodium ibuprofen |
| ES2353541B1 (es) | 2009-07-30 | 2011-09-20 | Farmalider, S.A. | Combinacion de ingredientes activos cosmeticos y composicion cosmetica obtenida a partir de la misma, y su utilizacion. |
| CN101810568A (zh) * | 2010-03-29 | 2010-08-25 | 南京泛太化工医药研究所 | 含有布洛芬的注射剂及其制备方法 |
| MX2010004974A (es) * | 2010-05-04 | 2011-11-23 | Senosiain S A De C V Lab | Combinacion de un aine y un aminoacido. |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2036890B1 (cs) * | 1969-04-15 | 1973-01-12 | Orsymonde | |
| GB1497044A (en) * | 1974-03-07 | 1978-01-05 | Prodotti Antibiotici Spa | Salts of phenyl-alkanoic acids |
| US4294819A (en) * | 1980-08-18 | 1981-10-13 | Bristol-Myers Company | Alkaline analgesic capsule |
| DE3328401A1 (de) * | 1983-08-05 | 1985-02-21 | Merckle GmbH, 7902 Blaubeuren | Injizierbare loesung zur behandlung von entzuendungen |
| US4609675A (en) * | 1984-08-17 | 1986-09-02 | The Upjohn Company | Stable, high dose, high bulk density ibuprofen granulations for tablet and capsule manufacturing |
| US4569937A (en) * | 1985-02-11 | 1986-02-11 | E. I. Du Pont De Nemours And Company | Analgesic mixture of oxycodone and ibuprofen |
| IT1209667B (it) * | 1985-11-12 | 1989-08-30 | Zambon Spa | Composizione effeverscente adattivita' analgesica. |
| GB8528195D0 (en) * | 1985-11-15 | 1985-12-18 | Boots Co Plc | Therapeutic compositions |
-
1986
- 1986-08-01 IT IT21358/86A patent/IT1197038B/it active
-
1987
- 1987-06-30 IE IE174587A patent/IE60276B1/en not_active IP Right Cessation
- 1987-07-10 AU AU75540/87A patent/AU595342B2/en not_active Expired
- 1987-07-10 GB GB8716301A patent/GB2193093B/en not_active Expired - Lifetime
- 1987-07-15 CH CH2701/87A patent/CH673394A5/it not_active IP Right Cessation
- 1987-07-20 JP JP62180899A patent/JP2585005B2/ja not_active Expired - Lifetime
- 1987-07-22 ZA ZA875397A patent/ZA875397B/xx unknown
- 1987-07-22 FR FR878710366A patent/FR2602141B1/fr not_active Expired - Lifetime
- 1987-07-22 US US07/076,547 patent/US4834966A/en not_active Expired - Lifetime
- 1987-07-22 NL NL8701729A patent/NL194031C/nl not_active IP Right Cessation
- 1987-07-23 AT AT0187887A patent/AT394945B/de not_active IP Right Cessation
- 1987-07-24 GR GR871197A patent/GR871197B/el unknown
- 1987-07-24 BE BE8700823A patent/BE1002109A3/fr not_active IP Right Cessation
- 1987-07-29 DE DE3725176A patent/DE3725176C2/de not_active Expired - Lifetime
- 1987-07-31 CA CA000543512A patent/CA1286992C/en not_active Expired - Lifetime
-
1992
- 1992-06-23 MX MX9203167A patent/MX9203167A/es unknown
-
1994
- 1994-02-25 BG BG098593A patent/BG60832B2/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU7554087A (en) | 1988-02-04 |
| GB8716301D0 (en) | 1987-08-19 |
| BE1002109A3 (fr) | 1990-07-10 |
| DE3725176A1 (de) | 1988-02-04 |
| IT8621358A0 (it) | 1986-08-01 |
| FR2602141A1 (fr) | 1988-02-05 |
| GB2193093B (en) | 1990-03-28 |
| JPS6341420A (ja) | 1988-02-22 |
| GB2193093A (en) | 1988-02-03 |
| AT394945B (de) | 1992-07-27 |
| IE60276B1 (en) | 1994-06-29 |
| JP2585005B2 (ja) | 1997-02-26 |
| NL8701729A (nl) | 1988-03-01 |
| IT8621358A1 (it) | 1988-02-01 |
| DE3725176C2 (de) | 1995-06-14 |
| US4834966A (en) | 1989-05-30 |
| AU595342B2 (en) | 1990-03-29 |
| FR2602141B1 (fr) | 1990-11-30 |
| ZA875397B (en) | 1988-02-01 |
| MX9203167A (es) | 1992-07-01 |
| NL194031C (nl) | 2001-05-03 |
| IE871745L (en) | 1988-02-01 |
| CH673394A5 (cs) | 1990-03-15 |
| IT1197038B (it) | 1988-11-25 |
| NL194031B (nl) | 2001-01-02 |
| CA1286992C (en) | 1991-07-30 |
| ATA187887A (de) | 1992-01-15 |
| GR871197B (en) | 1987-12-04 |
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