BG60681B1 - Антивирусни тетрахидроимидазо [1,4] бензодиазепини - Google Patents

Антивирусни тетрахидроимидазо [1,4] бензодиазепини Download PDF

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Publication number
BG60681B1
BG60681B1 BG96041A BG9604192A BG60681B1 BG 60681 B1 BG60681 B1 BG 60681B1 BG 96041 A BG96041 A BG 96041A BG 9604192 A BG9604192 A BG 9604192A BG 60681 B1 BG60681 B1 BG 60681B1
Authority
BG
Bulgaria
Prior art keywords
formula
alkyl
hydrogen
compound
aryl
Prior art date
Application number
BG96041A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG96041A (bg
Inventor
Michael J Kukla
Henry J Breslin
Alfons H Raeymaekers
Gelder Josephus L Van
Paul A Janssen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BG96041A publication Critical patent/BG96041A/bg
Publication of BG60681B1 publication Critical patent/BG60681B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BG96041A 1989-09-13 1992-03-12 Антивирусни тетрахидроимидазо [1,4] бензодиазепини BG60681B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40662589A 1989-09-13 1989-09-13
PCT/EP1990/001546 WO1991004255A1 (fr) 1989-09-13 1990-09-06 Tetrahydroimidazo[1,4]benzodiazepines antivirales

Publications (2)

Publication Number Publication Date
BG96041A BG96041A (bg) 1993-12-24
BG60681B1 true BG60681B1 (bg) 1995-12-29

Family

ID=23608794

Family Applications (1)

Application Number Title Priority Date Filing Date
BG96041A BG60681B1 (bg) 1989-09-13 1992-03-12 Антивирусни тетрахидроимидазо [1,4] бензодиазепини

Country Status (30)

Country Link
EP (2) EP0417840B1 (fr)
JP (1) JPH05500053A (fr)
KR (1) KR927003596A (fr)
CN (1) CN1029971C (fr)
AP (1) AP174A (fr)
AT (1) ATE115144T1 (fr)
AU (1) AU635328B2 (fr)
BG (1) BG60681B1 (fr)
CA (1) CA2064782A1 (fr)
DE (1) DE69014784T2 (fr)
DK (1) DK0417840T3 (fr)
ES (1) ES2067652T3 (fr)
FI (1) FI98816C (fr)
GR (1) GR3015270T3 (fr)
HU (1) HUT62297A (fr)
IE (1) IE65357B1 (fr)
IL (3) IL108074A (fr)
MA (1) MA21948A1 (fr)
MY (1) MY106961A (fr)
NO (1) NO300328B1 (fr)
NZ (1) NZ235137A (fr)
OA (1) OA09565A (fr)
PT (1) PT95303B (fr)
RO (1) RO109199B1 (fr)
RU (1) RU2099341C1 (fr)
TN (1) TNSN90121A1 (fr)
TW (1) TW199160B (fr)
WO (1) WO1991004255A1 (fr)
YU (1) YU169090A (fr)
ZA (1) ZA907278B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ238664A (en) * 1990-07-06 1992-12-23 Janssen Pharmaceutica Nv Substituted tetrahydroimidazo(1,4)benzodiazepin-2-(thi)ones and pharmaceutical anti-viral compositions
GB9018601D0 (en) * 1990-08-24 1990-10-10 Fujisawa Pharmaceutical Co Tricyclic compounds
EP0475231A1 (fr) * 1990-09-10 1992-03-18 F. Hoffmann-La Roche Ag Benzodiazépines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4075206A (en) * 1977-02-25 1978-02-21 Eli Lilly And Company Substituted pyrroloquinoxalinones and diones
GB8806449D0 (en) * 1988-03-18 1988-04-20 Janssen Pharmaceutica Nv Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones
IL93136A (en) * 1989-02-23 1995-01-24 Janssen Pharmaceutica Nv History of tetrahydroimidazo [1,4] benzodiazepine-2-thione, their preparation and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
NO300328B1 (no) 1997-05-12
NO920505D0 (no) 1992-02-07
FI98816B (fi) 1997-05-15
AU6293490A (en) 1991-04-18
IL95638A (en) 1995-01-24
RO109199B1 (ro) 1994-12-30
PT95303A (pt) 1991-05-22
OA09565A (fr) 1993-01-31
WO1991004255A1 (fr) 1991-04-04
BG96041A (bg) 1993-12-24
IL95638A0 (en) 1991-06-30
KR927003596A (ko) 1992-12-18
TNSN90121A1 (fr) 1991-03-05
JPH05500053A (ja) 1993-01-14
EP0417840B1 (fr) 1994-12-07
AP9000205A0 (en) 1990-10-31
IL108074A (en) 1995-06-29
ES2067652T3 (es) 1995-04-01
CN1050192A (zh) 1991-03-27
TW199160B (fr) 1993-02-01
AU635328B2 (en) 1993-03-18
ZA907278B (en) 1992-05-27
IE903313A1 (en) 1991-04-10
YU169090A (sh) 1993-10-20
PT95303B (pt) 1997-06-30
EP0491751A1 (fr) 1992-07-01
GR3015270T3 (en) 1995-06-30
HUT62297A (en) 1993-04-28
ATE115144T1 (de) 1994-12-15
DE69014784D1 (de) 1995-01-19
MA21948A1 (fr) 1991-04-01
MY106961A (en) 1995-08-30
CN1029971C (zh) 1995-10-11
DK0417840T3 (da) 1995-02-13
NO920505L (no) 1992-02-07
FI98816C (fi) 1997-08-25
RU2099341C1 (ru) 1997-12-20
AP174A (en) 1992-03-16
NZ235137A (en) 1992-02-25
DE69014784T2 (de) 1995-04-13
IE65357B1 (en) 1995-10-18
IL108074A0 (en) 1994-04-12
CA2064782A1 (fr) 1991-03-14
EP0417840A1 (fr) 1991-03-20
FI921070A0 (fi) 1992-03-12

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BG60681B1 (bg) Антивирусни тетрахидроимидазо [1,4] бензодиазепини
EP0538297B9 (fr) Tetrahydroimidazo 1,4]benzodiazepine-2-(thio)ones antivirales
HU207322B (en) Process for producing imidazo-benzodiazepin-2/1h/-one derivatives and pharmaceutical compositions containing them