BG518Y1 - Preparation for pediculis humanis control - Google Patents

Abstract

The preparation is used in human medicine for the treatment and prevention against Pediculis humanis, in particular of head, pubic and body lice and their nits, imago and nymphs. The active component is O,O,O',O'-tetramethyl-O,O'-thiodi-p-phenylene-phosphorothioate. The remaining components are ethyl alcohol, softener, glycerin, propyleneglycol,polyethyleneglycol, sorbitol of mixtures thereof. 1 claim

Description

A useful model relates to a medicament used in human medicine for the treatment of Pediculis humanis in the treatment and prophylaxis, and in particular of combating head, pubic and aphids, their nits, imago and nymphs.

BACKGROUND OF THE INVENTION

A preparation for the control of Pediculis humanis, and in particular head, pubic and aphids, is known, which is an aqueous emulsion of the active components of the oil / water type / 1 /.

The active components are O, O, O ', O'-tetramethyl-O, O'-thio-p-phenylene-phosphorothioate and cetyltrimethylammonium chloride. Excipients such as emulsion stabilizers and preservatives, antiseptics, softeners and flavoring agents are also incorporated into the preparation. Cetyl alcohol, glycerin, citric acid, 2-bromo-2-nitro-1,3-propanediol and a variety of perfume compositions may be mentioned as such. Water has the highest proportion by weight, preferably drinking.

The preparation can be used in the form of lotion, conditioner, cream, spray, shampoo and more.

The technical nature of the utility model

The preparation for combating head, pubic and aphids, their nits, imago and nymphs contains the following components: O, O, O ', O'-tetramethyl-O, O'-thiodi-β-phenylene-phosphorothioate, ethyl alcohol, softener and perfume essence. The active ingredient is of formula

Qi ₃ 0 _h S $ osn ₃ ³ \ «» / ³

P - 0 - C _b H ₄ - s - C ^ i ₄ - 0 - P cn ₃ o ' ^xn ₃

Ethyl alcohol used is of high concentration - over 90 and preferably about 95.

The softener is glycerin, propylene glycol, polyethylene glycols (preferably with a molecular weight of 200 to 700), sorbitol or mixtures thereof.

The perfume essence is optional.

Because all the components are liquids, their amounts in the preparation of solutions, lotions or sprays are in volume percent.

The amount of O, O, O ', O-tetramethyl-O, O'thiodi-p-phenylene-phosphorothioate can range from 1 to 3% vol., Preferably about 2%. High grade ethyl alcohol can be present at 85 to 95% by volume, preferably about 90 to 93% by volume, and the softener by 3 to 8% by volume, preferably about 5% by volume. The perfume essence is in minimum quantities from 0.1 to 0.3% vol.

The preparation of the preparation is carried out by dissolving the active substance while stirring in ethanol, after which the softener is added and finally the perfume essence.

The method of administration is as follows. The preparation is applied to completely moisten the hair, rubbing it at the roots.

Examples of implementation

In a stirred reactor, with constant stirring of the active ingredient Ο, Ο, Ο ', Ο'tetramethyl-O, the O-thiodi-p-phenylene-phosphorothioate is dissolved in ethyl alcohol. They are then added to completely dissolve and homogenize the other components in the following order - softener and perfume essence. The table below shows sample recipes.

Components Volume percentages 1.0, Ο, ΟΌ'-tetramethyl- 1 2 3 2 2 Oh, O-thiods-p-phenylene- phosphorothioate 2. Ethyl alcohol 95 93,9 92,9 91,9 92,9 92,9 3. Glycerin - 5 - - 2.5 4. Propylene glycol 5 - - - - 5. Polyethylene glycol - - - 5 2.5 6. Sorbitol - - 5 - - 7. Perfume Essence 0.1 0.1 0.1 0.1 0.1

Application of utility model

The preparation has been tested in laboratory and practical conditions.

A. Laboratory testing 5

From infected persons, a strand of hair with nits, imago or nymphs is taken and treated with the preparation. The treated nits had a 100% mortality rate after 60 minutes in solution of the preparation. In lice and nymphs, mortality occurs by the 10th minute.

B. Practical conditions

20 children aged 8 to 15 years, infected to varying degrees with nits, imago or nymphs of head lice, are treated with hair. Nests and lice are taken from the infected ones before and after treatment to determine the ovicidal (on eggs) and imagocidal (on imago and nymphs) effects of the test preparation. All nymphs and imago die by 15 min after treatment at the latest, and rot after exposure for more than 6 h.

Claims

Claims (1)

1. A preparation for the control of Pediculis humanis, and in particular head, pubic and aphids and their nits, imago and nymphs, containing as active ingredient Ο, Ο, ΟΌ'-tetramethyl-O, O'-thiodi-β-phenylene -phosphorothioate of the formula <* 3 ° χ5 S AXIS ₃ P - 0 - C ₆ H ₄ - S - c ₆ n ₄ - 0 - P cn ₃ (D ^x base _3, characterized in that it includes ethyl alcohol and a softener, glycerin, propylene glycol, sorbitol or mixtures thereof.