CN108836938B - Environment-friendly composite foam hoof bath lotion and preparation method thereof - Google Patents
Environment-friendly composite foam hoof bath lotion and preparation method thereof Download PDFInfo
- Publication number
- CN108836938B CN108836938B CN201811067302.5A CN201811067302A CN108836938B CN 108836938 B CN108836938 B CN 108836938B CN 201811067302 A CN201811067302 A CN 201811067302A CN 108836938 B CN108836938 B CN 108836938B
- Authority
- CN
- China
- Prior art keywords
- parts
- foam
- hoof
- environment
- hoof bath
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/11—Aldehydes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the technical field of animal medicated bath liquid, and particularly discloses environment-friendly composite foam hoof bath liquid and a preparation method thereof, wherein the environment-friendly composite foam hoof bath liquid comprises the following components: 1-20 parts of glutaraldehyde, 1-20 parts of quaternary ammonium salt, 0.1-0.3 part of nano silver, 1-15 parts of foaming agent, 0.5-5 parts of foam stabilizer, 8-10 parts of polyol, 0.1-0.6 part of pigment and 10-30 parts of deionized water; the prepared foam hoof bath lotion can keep stable and not freeze in a low-temperature environment, is beneficial to use and storage of the hoof bath lotion, contains bactericidal components which stay for a longer time in a diseased part, slowly permeates into the space between the toes of an animal hoof, and directly acts on the diseased part to effectively kill germs.
Description
Technical Field
The invention belongs to the technical field of animal medicated bath liquid, and particularly relates to animal hoof bath liquid, in particular to environment-friendly composite foam hoof bath liquid and a preparation method thereof.
Background
Hoof disease of the dairy cow is a main disease affecting the health of the dairy cow, is a general name of the four limbs and hoof disease of the dairy cow, and can cause pain, lameness and the like after the hoof disease of the dairy cow occurs, so that the milk yield is reduced; the suppuration of joints can be serious, the lying area cannot be raised, the healthy development of the dairy cows is influenced, even the dairy cows are eliminated, the huge economic loss is brought to the milk breeding industry, and the healthy development of the dairy cow industry is influenced. Therefore, the hoof bath is the best method for solving the hoof disease of the dairy cows at present, and the incidence rate of the hoof disease can be effectively reduced by the functions of cleaning and hoof disinfection.
Common hoof bath liquid in the market is still formaldehyde solution and copper sulfate solution, and the formaldehyde solution has high irritation and toxicity, has great influence on sick cows and has a tendency of gradually exiting the market; the copper sulfate solution has low bioavailability, is easy to inactivate when meeting organic matters, belongs to heavy metals and has serious environmental pollution.
With the development of animal husbandry and the enhancement of the control consciousness of cow hoof diseases, novel hoof bath liquid with the sterilization and disinfection functions and environmental friendliness also appears in the market. There are still some drawbacks: (1) when the cow hoof is used for hoof bath, the excrement and hoof dirt easily pollute the traditional Chinese medicine liquid in the pool, so that the hoof bath liquid is invalid, the effect on the affected part of the hoof disease is reduced, and the cost of the cow breeding industry is increased; (2) the liquid solution has limited adhesiveness and is easy to evaporate, the sterilization and disinfection action time is short, and the liquid medicine cannot penetrate into the affected part or dead corners of the cow hoofs; (3) the liquid medicine is easily taken out when the milk cow passes through the hoof bath pool, the ground is wet and slippery when the liquid medicine is wasted, the risk of slipping of the milk cow is increased, and then the milk cow breast is polluted or even polluted.
Disclosure of Invention
The invention discloses environment-friendly composite foam hoof bath lotion and a preparation method thereof.
In order to achieve the purpose, the technical scheme of the invention is as follows:
an environment-friendly composite foam hoof bath lotion is characterized in that: the environment-friendly composite foam hoof bath lotion is prepared from the following components in parts by weight:
1-20 parts of glutaraldehyde
1-20 parts of quaternary ammonium salt
0.1-0.3 part of nano silver simple substance
1-15 parts of foaming agent
0.5-5 parts of foam stabilizer
8-10 parts of polyol
0.1 to 0.6 portion of pigment
10-30 parts of deionized water
Wherein the quaternary ammonium salt is any one of benzalkonium bromide, benzalkonium chloride, dodecyl trimethyl ammonium chloride, polyquaternary ammonium salt or biquaternary ammonium salt or is formed by mixing any two of the benzalkonium bromide, the benzalkonium chloride, the dodecyl trimethyl ammonium chloride, the polyquaternary ammonium salt and the biquaternary ammonium salt according to the proportion of 1: 1-1: 3;
the foam stabilizer is one or a mixture of any two of guar gum and derivatives thereof, namely nonionic guar gum, cationic guar gum and zwitterionic guar gum, methyl cellulose ether and derivatives thereof, namely hydroxyethyl methyl cellulose ether, hydroxypropyl methyl cellulose ether, ethyl methyl cellulose ether and carboxymethyl methyl cellulose ether, ethyl cellulose ether and polyethylene glycol stearate, in a ratio of 1: 2-1: 10;
wherein the polyalcohol is any one of ethanol, ethylene glycol, propylene glycol, glycerol, butanediol and hexanediol or is prepared by mixing any two of the above components in any proportion.
Preferably, the foaming agent is any one of tea saponin, fatty alcohol-polyoxyethylene ether, lauryl alcohol-polyoxyethylene ether, fatty amide-polyoxyethylene ether, cocofatty acid diethanolamide, cocamidopropyl dimethyl betaine, cocamidopropyl hydroxysulfonic acid betaine, dodecyl dimethyl ammonium oxide and alkyl polyglycoside or is formed by mixing any two of the tea saponin, fatty alcohol-polyoxyethylene ether, lauryl alcohol-polyoxyethylene ether, fatty amide-polyoxyethylene ether, cocoamidopropyl dimethyl betaine, cocamidopropyl hydroxysulfonic acid betaine, dodecyl dimethyl ammonium oxide and alkyl polyglycoside according to the proportion of 1: 1-1: 5.
Preferably, the pigment is any one of brilliant blue, lake blue, sapphire blue, gardenia blue, normal blue, indigo blue or a combination thereof.
The preparation method of the environment-friendly composite foam hoof bath liquid comprises the following steps:
(1) weighing glutaraldehyde, quaternary ammonium salt, nano silver simple substance, foaming agent and foam stabilizer according to the weight parts, adding the weighed glutaraldehyde, quaternary ammonium salt, nano silver simple substance, foaming agent and foam stabilizer into the weighed polyol liquid according to the weight parts, and stirring for 1min to form a dispersion system;
(2) weighing the pigment and deionized water according to the weight parts, adding the pigment and the dispersion system prepared in the step (1) into the deionized water, stirring for 30min, and standing for 1h to obtain the environment-friendly composite foam hoof bath lotion.
The using method comprises the following steps: the prepared environment-friendly composite type foam hoof bath liquid is diluted according to the mass concentration of 2%, and then is foamed by a special foaming machine for use, can be used for hoof bath, and can also be directly sprayed on the affected parts of cattle hoofs.
The invention has the beneficial effects that:
(1) according to the invention, guar gum and derivatives thereof, methyl cellulose ether and derivatives thereof are used as foam stabilizers and are matched with foaming agents for use, so that the stability time of foam can be effectively prolonged, and the sterilization components contained in the hoof bath lotion can be retained in affected parts for a longer time and slowly permeate into the animal hoof and toe spaces to directly act on affected parts, thereby effectively killing germs; the foaming agent in the components can also generate a large amount of fine foam, so that the utilization rate and the stability of the sterilization components can be effectively improved;
(2) the polyhydric alcohol used in the invention can not only play a role of moistening skin, but also moisten the position of the animal hoof vegetable, and can pre-disperse powder substances contained in a bath solution system to prevent the powder substances from agglomerating and play a role of a dispersing agent; in addition, the use of the polyhydric alcohol can effectively reduce the freezing point of a bath solution system, so that the hoof bath solution can be kept stable and not frozen in a low-temperature environment, and the hoof bath solution is favorable for use and storage. In addition, the polyhydric alcohol in the system is matched with glutaraldehyde in the components for use, so that the stability of the glutaraldehyde in hoof bath liquid can be improved;
(3) in addition, the nano-silver monomer in the components has a spectrum antibacterial effect and strong bactericidal capability, and can be used in a hoof bath solution system in a compounding manner with glutaraldehyde and quaternary ammonium salt to enhance the bactericidal effect and play a synergistic role. The prepared foam hoof bath liquid has the advantages of fine, stable and lasting foam, high safety, convenient use, strong permeability, stable body system under the low temperature condition, difficult icing and easy storage.
Drawings
FIG. 1 is a foam form diagram of the environment-friendly composite foam hoof bath lotion prepared in example 1 after 10 times of foaming;
fig. 2 is a state diagram of a cow when it is hoof-bathing;
FIG. 3 is a diagram showing the initial state of a patient's cow hoof after a hoof bath;
FIG. 4 is a diagram of a cow hoof;
fig. 5 is a state diagram of a hoof bath of a cow in a patient 7 days later.
Detailed Description
The technical solution of the present invention is further explained by the following embodiments.
Example 1
An environment-friendly composite foam hoof bath lotion is characterized in that: the environment-friendly composite foam hoof bath lotion is prepared from the following components in parts by weight:
1 part of glutaraldehyde
Quaternary ammonium salt 1 part
0.1 part of nano silver simple substance
Foaming agent 1 part
Foam stabilizer 0.5 part
8 parts of polyol
0.1 portion of pigment
10 portions of deionized water
Wherein the quaternary ammonium salt is formed by mixing benzalkonium bromide and biquaternary ammonium salt according to the proportion of 1: 1;
the foam stabilizer is prepared by mixing guar gum and methyl cellulose ether according to the proportion of 1: 2;
wherein the polyalcohol is formed by mixing ethanol and hexanediol according to any proportion;
wherein the foaming agent is formed by mixing tea saponin and alkyl polyglycoside according to the proportion of 1: 1;
wherein the pigment is brilliant blue;
the preparation method of the environment-friendly composite foam hoof bath liquid comprises the following steps:
(1) weighing glutaraldehyde, benzalkonium bromide, biquaternary ammonium salt, nano silver simple substance, tea saponin, alkyl polyglycoside, guar gum and methyl cellulose ether according to the weight parts, adding the weighed materials into mixed liquid of ethanol and hexanediol, and stirring for 1min to form a dispersion system;
(2) weighing the bright blue pigment and deionized water according to the weight parts, adding the bright blue pigment and the dispersion system prepared in the step (1) into the deionized water, stirring for 30min, and standing for 1h to obtain the environment-friendly composite foam hoof bath lotion;
the using method comprises the following steps: diluting the prepared environment-friendly composite type foam hoof bath liquid according to the mass concentration of 2%, and then foaming the bath liquid by using a special foaming machine for use, and performing hoof bath or directly spraying the bath liquid on the affected parts of the cow hoofs;
the prepared composite foam hoof bath lotion can stay in a diseased part for a longer time, slowly permeates into the space between the toes of the animal hoofs, and directly acts on the diseased part to effectively kill germs; in addition, the hoof bath liquid is stable and free from icing in a low-temperature environment, and the hoof bath liquid is convenient to use and store.
Example 2
The environment-friendly composite foam hoof bath lotion is prepared from the following components in parts by weight:
20 parts of glutaraldehyde
20 parts of quaternary ammonium salt
0.3 part of nano silver simple substance
15 portions of foaming agent
5 parts of foam stabilizer
10 portions of polyol
0.6 part of pigment
30 portions of deionized water
Wherein the quaternary ammonium salt is formed by mixing benzalkonium chloride and dodecyl trimethyl ammonium chloride in a ratio of 1: 3;
the foam stabilizer is prepared by mixing nonionic guar gum and hydroxyethyl methyl cellulose ether according to the proportion of 1: 10;
wherein the polyalcohol is formed by mixing ethylene glycol and butanediol according to any proportion;
wherein the foaming agent is prepared by mixing saponin and dodecyl dimethyl ammonium oxide in a ratio of 1: 5;
wherein the pigment sapphire blue;
the preparation method of the environment-friendly composite foam hoof bath liquid comprises the following steps:
(1) weighing glutaraldehyde, benzalkonium chloride, dodecyl trimethyl ammonium chloride, nano silver simple substance, saponin, dodecyl dimethyl ammonium oxide, nonionic guar gum and hydroxyethyl methyl cellulose ether according to the weight parts, adding the weighed materials into a mixed liquid of ethylene glycol and butanediol, and stirring for 1min to form a dispersion system;
(2) weighing the sapphire blue pigment and deionized water according to the weight parts, adding the sapphire blue pigment and the dispersion system prepared in the step (1) into the deionized water, stirring for 30min, and standing for 1h to obtain the environment-friendly composite foam hoof bath lotion;
the using method comprises the following steps: the prepared environment-friendly composite type foam hoof bath liquid is diluted according to the mass concentration of 2%, and then is foamed by a special foaming machine for use, can be used for hoof bath, and can also be directly sprayed on the affected parts of cattle hoofs.
Example 3
The environment-friendly composite foam hoof bath lotion is prepared from the following components in parts by weight:
glutaraldehyde 10 parts
10 parts of quaternary ammonium salt
0.2 part of nano silver simple substance
Foaming agent 7 parts
Foam stabilizer 3.5 parts
9 parts of polyol
0.3 portion of pigment
20 portions of deionized water
Wherein the quaternary ammonium salt is polyquaternium;
the foam stabilizer is prepared by mixing zwitterionic guar gum and hydroxypropyl methyl cellulose ether according to the proportion of 1: 6;
wherein the polyalcohol is formed by mixing propylene glycol and glycerol according to any proportion;
wherein the foaming agent is formed by mixing fatty alcohol-polyoxyethylene ether and fatty amide-polyoxyethylene ether in a ratio of 1: 3;
wherein the pigment gardenia blue and the positive blue are combined;
the preparation method of the environment-friendly composite foam hoof bath liquid comprises the following steps:
(1) weighing glutaraldehyde, polyquaternium, nano silver simple substance, fatty alcohol-polyoxyethylene ether and fatty amide polyoxyethylene ether, zwitterionic guar gum and hydroxypropyl methyl cellulose ether according to the weight parts, adding the weighed mixture into the mixed liquid of propylene glycol and glycerol, and stirring for 1min to form a dispersion system;
(2) weighing gardenia blue, positive blue pigment and deionized water according to the weight parts, adding the gardenia blue, the positive blue pigment and the dispersion system prepared in the step (1) into the deionized water, stirring for 30min, and standing for 1h to obtain the environment-friendly composite foam hoof bath lotion;
the using method comprises the following steps: the prepared environment-friendly composite type foam hoof bath liquid is diluted according to the mass concentration of 2%, and then is foamed by a special foaming machine for use, can be used for hoof bath, and can also be directly sprayed on the affected parts of cattle hoofs.
Comparative test
(1) Freezing point comparison test of foam hoof bath
Experiment 1: example 1 the obtained environment-friendly composite foam hoof bath liquid is prepared;
experiment 2: example 2 the obtained environment-friendly composite foam hoof bath liquid is prepared;
experiment 3: example 3 the obtained environment-friendly composite foam hoof bath solution is prepared;
experiment 4: the prepared hoof bath liquid does not contain ethanol and hexanediol components, and the other components and the preparation process parameters are the same as those of the example 1, so that the obtained environment-friendly composite foam hoof bath liquid is prepared;
experiment 5: the prepared hoof bath lotion does not contain glycol and butanediol components, and the other components and the preparation process parameters thereof are the same as those in the example 2, so that the obtained environment-friendly composite foam hoof bath lotion is prepared;
experiment 6: the prepared hoof bath lotion does not contain propylene glycol and glycerol, and the other components and the preparation process parameters thereof are the same as those in example 3, so as to prepare the obtained environment-friendly composite foam hoof bath lotion;
the freezing point of the foam hoof bath liquid prepared in the experiments 1-6 is tested, and the test method comprises the following steps: aligning a refraction prism of the freezing point tester to the bright direction, adjusting the ocular diopter ring until the marked line is clear, and calibrating the tester to ensure that the blue-white boundary in the ocular visual field coincides with the reference line. During testing, 3 drops of the sample to be tested are dropped on the dioptric prism, the cover plate is covered and slightly pressed, and the scale corresponding to the blue-white boundary is read out to obtain the measurement result. The results are shown in table 1:
from the test results, the hoof bath liquid prepared in experiments 1-3 has a low freezing point which can reach-13 ℃ at the lowest, compared with the hoof bath liquid prepared in experiments 4-6 which does not contain a polyol component, the freezing point is high, and the hoof bath liquid begins to freeze at a temperature lower than-1 ℃ and the system is unstable. Therefore, the polyol component added in the preparation of the foam hoof bath liquid can reduce the freezing point of the system, so that the foam hoof bath liquid can still keep stable at a lower temperature;
(2) foam stability comparative test for foam hoof bath
Experiment 1: example 1 the obtained environment-friendly composite foam hoof bath liquid is prepared;
experiment 2: example 2 the obtained environment-friendly composite foam hoof bath liquid is prepared;
experiment 3: example 3 the obtained environment-friendly composite foam hoof bath solution is prepared;
experiment 4: replacing guar gum and methyl cellulose ether in example 1 with polyacrylamide, and preparing the obtained foam hoof bath solution with the other components and the preparation method parameters as in example 1;
experiment 5: replacing the nonionic guar gum and the hydroxyethyl methyl cellulose ether in the example 2 with polyvinyl alcohol, and preparing the foam hoof bath solution with the rest components and the preparation method parameters of the foam hoof bath solution in the example 2;
experiment 6: the zwitterionic guar gum and the hydroxypropyl methyl cellulose ether in the example 3 are replaced by polyethylene oxide, and the other components and the preparation method parameters thereof are the same as those of the foam hoof bath liquid prepared in the example 3;
an experimental instrument: stopwatches, electronic balances, high-speed stirrers, measuring cylinders (mL), beakers, droppers and other required reagents;
the experimental method comprises the following steps: at room temperature, 5g of the sample was taken from the beaker, diluted to 100g, stirred with a high-speed stirrer for 1 minute, the foam was quickly poured into a measuring cylinder, observed on standing, the initial volume of the foam was recorded, and the half-life of the foam was recorded with a stopwatch. The foaming performance of the foaming agent was measured by the foaming volume of 100g of the solution stirred at high speed for 1min, and the stability of the foam was measured by the foam half-life. The results of the experiment are shown in table 2:
as can be seen from the data in table 2, the foam volume and the foam half-life period of the hoof bath liquid prepared in experiments 1 to 3 are both greatly improved compared with those of experiments 4 to 6, wherein the hoof bath liquid prepared in experiment 2 has a long foam half-life period, i.e., the foam is lasting and stable, and the hoof bath liquid prepared in experiment 3 has a large foam volume, i.e., the sample in experiment 3 can generate a better bubble effect;
the foam stabilizers taken in experiments 4-6 are respectively polyacrylamide, polyvinyl alcohol and polyethylene oxide, the viscosity of the foam stabilizers is high, the liquid discharge speed of a liquid film is reduced mainly by increasing the liquid phase viscosity in the system, the gas exchange speed among bubbles is also reduced, the viscosity increasing range is large, the foaming volume of a foam system can be reduced, and the foam stabilizing effect is poor; the foam stabilizer selected in experiments 1-3 can increase the liquid phase viscosity, and has important characteristics in structure, so that the toughness, compressibility and service life of the bubbles are obviously higher than those of foams formed by common water films;
(3) foam hoof bath adhesion determination
Experimental samples:
sample 1: example 1 the resulting foam hoof bath was prepared;
sample 2: replacing guar gum and methyl cellulose ether in example 1 with polyacrylamide, and preparing the obtained foam hoof bath solution with the other components and the preparation method parameters as in example 1;
selecting a pasture as an experimental object, and actually measuring the local surface temperature to be 32 ℃. The foam hoof baths of samples 1 and 2 were foamed in 10 volumes through a foaming device to fill the cow hoof baths with foam. Randomly selecting 100 cows in the pasture as test objects, randomly dividing the test objects into 2 groups, wherein each group comprises 50 cows, enabling the two groups of cows to respectively walk through hoof baths filled with experimental samples 1 and 2, and observing and recording the adhesion effect of foam on cow hooves and the foam retention time. The results of the experiment are shown in table 3:
as can be seen from the data in Table 3, the foam hoof bath prepared in example 1 of the present invention has a longer stay on cow hooves, i.e., has a better adhesion ability.
Examples of the invention
In order to prove the clinical efficacy of the environment-friendly foam hoof bath liquid, 510 cases of cow hoof diseases are selected in five pastures in northwest, wherein 150 cases of wart dermatitis, 105 cases of interphalangeal hyperplasia, 105 cases of hoof bottom ulcer, 75 cases of foot rot and 75 cases of other types of hoof diseases are selected; randomly dividing the 510 cows into A, B, C3 groups of 170 cows each;
case selection criteria: obvious claudication symptom, groveling and lying, difficult standing or short standing time; the affected limb has weak weight bearing or the feet and limbs have alternate weight bearing; the temperature of the palpated affected limb and hoof is increased, and the pain is sensitive during the palpation. Sick cattle show depressed spirit, inappetence, decreased milk production, sometimes elevated body temperature, sometimes up to 40 ℃ or more. If the disease condition is aggravated, individual sick cows show some general symptoms, and the affected parts of the severe cows are red and swollen and cannot lie on the ground;
thoroughly cleaning the hoof of the cattle to ensure that no excrement is left in gaps between the hoof and the toes so as to ensure that the hoof and the toes are clean;
experimental groups: selecting the foam hoof bath liquid prepared in the example 2, preparing the foam hoof bath liquid into the bath liquid with the mass concentration of 5%, and foaming by using foaming equipment to fill the bath pool with foams;
control group 1: CuSO with the mass concentration of 5 percent is selected4Solution of 5% CuSO4Directly pouring the solution into a hoof bath;
control group 2: the nonionic guar gum and the hydroxyethyl methyl cellulose ether in the embodiment 2 are replaced by polyvinyl alcohol, no nano silver simple substance is contained, and the polyol is replaced by CuSO4Preparing the solution, the rest components and the preparation method parameters of the solution as those of the foam hoof bath liquid prepared in the example 2 into the bath liquid with the mass concentration of 5%, and foaming by using foaming equipment to fill the bath pool with foams;
the experimental method comprises the following steps: respectively treating the hoofs of the milk cows of A, B, C three groups in the morning and evening with bath liquid of an experimental group, a control group 1 and a control group 2, continuously bathing for 16 days in the morning and evening, taking 4 days as a cycle, observing and recording; symptoms of sick cattle were observed on days 7 and 14 after hoof bath;
the therapeutic effect judgment standard is as follows: the lameness of the dairy cows of the patients disappears, the pain disappears, the swelling subsides, and the wound surface is healed; pain is significantly reduced, swelling is reduced, and lameness is reduced or not significantly effective; pain does not disappear, swelling does not disappear, lameness does not disappear, and dyskinesia is ineffective;
the experimental results are shown in tables 4 and 5:
as can be seen from the experimental data in tables 4 and 5, the foam hoof bath lotion obtained by the invention can effectively cure the hoof diseases of dairy cows, and has better treatment effect and higher cure rate on warty skin, toe hyperplasia, hoof bottom ulcer, foot rot and other types of hoof diseases. The invention has the advantages that the synergistic effect is generated among the polyol, the foam stabilizer, the nano-silver monomer and other components which are added in the preparation of the foam hoof bath liquid, so that the drug effect of the bath liquid is enhanced;
fig. 4 shows the sick cow hoof, fig. 5 shows an example of cow hoof after 7 days of hoof bath in the experimental group, and comparison of fig. 4 and 5 shows that the sick cow hoof is obviously improved and the hair color is recovered to be normal.
Claims (3)
1. An environment-friendly composite foam hoof bath lotion is characterized in that: the environment-friendly composite foam hoof bath lotion is prepared from the following components in parts by weight:
1-20 parts of glutaraldehyde
1-20 parts of quaternary ammonium salt
0.1-0.3 part of nano silver simple substance
1-15 parts of foaming agent
0.5-5 parts of foam stabilizer
8-10 parts of polyol
0.1 to 0.6 portion of pigment
10-30 parts of deionized water
Wherein the quaternary ammonium salt is any one of benzalkonium bromide, benzalkonium chloride, dodecyl trimethyl ammonium chloride, polyquaternary ammonium salt or biquaternary ammonium salt or is formed by mixing any two of the benzalkonium bromide, the benzalkonium chloride, the dodecyl trimethyl ammonium chloride, the polyquaternary ammonium salt and the biquaternary ammonium salt according to the proportion of 1: 1-1: 3;
the foam stabilizer is prepared by mixing any one of nonionic guar gum, cationic guar gum and zwitterionic guar gum with any one of methyl cellulose ether and derivatives thereof, namely hydroxyethyl methyl cellulose ether, hydroxypropyl methyl cellulose ether, ethyl methyl cellulose ether, carboxymethyl methyl cellulose ether and ethyl cellulose ether according to the proportion of 1: 2-1: 10;
wherein the polyalcohol is any one of ethanol, ethylene glycol, propylene glycol, glycerol, butanediol and hexanediol or is formed by mixing any two of the ethanol, the ethylene glycol, the propylene glycol, the glycerol, the butanediol and the hexanediol according to any proportion;
the foaming agent is one of or a mixture of any two of tea saponin, fatty alcohol-polyoxyethylene ether, lauryl alcohol-polyoxyethylene ether, fatty amide-polyoxyethylene ether, coconut fatty acid diethanolamide, cocamidopropyl dimethyl betaine, cocamidopropyl hydroxysulfonic acid betaine, dodecyl dimethyl ammonium oxide and alkyl polyglycoside in a ratio of 1: 1-1: 5.
2. The environment-friendly composite foam hoof bath liquid according to claim 1, wherein: the pigment is any one or combination of brilliant blue, lake blue, sapphire blue, gardenia blue, normal blue and indigo blue.
3. The environment-friendly composite foam hoof bath liquid according to any one of claims 1-2, wherein: the preparation method of the environment-friendly composite foam hoof bath liquid comprises the following steps:
(1) weighing glutaraldehyde, quaternary ammonium salt, nano silver simple substance, foaming agent and foam stabilizer according to the weight parts, adding the weighed glutaraldehyde, quaternary ammonium salt, nano silver simple substance, foaming agent and foam stabilizer into the weighed polyol liquid according to the weight parts, and stirring for 1min to form a dispersion system;
(2) weighing the pigment and deionized water according to the weight parts, adding the pigment and the dispersion system prepared in the step (1) into the deionized water, stirring for 30min, and standing for 1h to obtain the environment-friendly composite foam hoof bath lotion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811067302.5A CN108836938B (en) | 2018-09-13 | 2018-09-13 | Environment-friendly composite foam hoof bath lotion and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811067302.5A CN108836938B (en) | 2018-09-13 | 2018-09-13 | Environment-friendly composite foam hoof bath lotion and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108836938A CN108836938A (en) | 2018-11-20 |
| CN108836938B true CN108836938B (en) | 2021-08-13 |
Family
ID=64189345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811067302.5A Active CN108836938B (en) | 2018-09-13 | 2018-09-13 | Environment-friendly composite foam hoof bath lotion and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108836938B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109481395A (en) * | 2018-12-24 | 2019-03-19 | 刘长德 | A kind of foam filling paste and application for preventing and treating domestic animal hoof disease |
| CN110079402B (en) * | 2019-05-30 | 2021-03-19 | 陕西汉隆清洁消毒产品有限公司 | Environment-friendly composite alkaline foam cleaning agent and preparation method thereof |
| CN110507748A (en) * | 2019-09-09 | 2019-11-29 | 郑州百瑞动物药业有限公司 | A kind of milk cow hoof bath foam and preparation method thereof |
| CN115737611B (en) * | 2022-12-01 | 2024-05-14 | 成都科宏达科技有限公司 | Animal medicated bath lotion with low temperature stability |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107485606A (en) * | 2017-07-19 | 2017-12-19 | 上海康臣生物科技有限公司 | A kind of foam type preventing and treating milk cow hoof body lotion, preparation method and applications |
-
2018
- 2018-09-13 CN CN201811067302.5A patent/CN108836938B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107485606A (en) * | 2017-07-19 | 2017-12-19 | 上海康臣生物科技有限公司 | A kind of foam type preventing and treating milk cow hoof body lotion, preparation method and applications |
Non-Patent Citations (1)
| Title |
|---|
| "护蹄I号";西安汉隆化工科技有限公司;《http://www.xianhanlong.com/product/?110_795.html》;20161015;1-3 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108836938A (en) | 2018-11-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108836938B (en) | Environment-friendly composite foam hoof bath lotion and preparation method thereof | |
| ES2623909T3 (en) | Antimicrobial compositions and methods of use | |
| CN104586653B (en) | Shampoo used also as bath lotion suitable for infant and preparation method thereof | |
| CN111110577B (en) | Mild mite-removing itching-relieving shower gel and preparation method thereof | |
| CN104042558B (en) | A kind of feature feminine care wet tissue and preparation method | |
| CN107137299A (en) | A kind of women special care wet tissue and preparation method thereof | |
| CN109528523A (en) | A kind of amino acid cleansing cream | |
| CN107998028A (en) | A kind of shower cream and preparation method thereof | |
| CN107485606A (en) | A kind of foam type preventing and treating milk cow hoof body lotion, preparation method and applications | |
| CN105342882A (en) | Multi-efficiency compound moisturizing essence and application method thereof | |
| CN110755331B (en) | Antibacterial infant washing and caring preparation and application thereof | |
| CN110029026A (en) | A kind of sterilizing and itch-relieving medicated soap and preparation method thereof | |
| CN114432170A (en) | Mild shower gel for pets and preparation process thereof | |
| CN106265259A (en) | A kind of whitening type bath gel and preparation method thereof | |
| RU2537143C1 (en) | Preparation for treatment and prevention of mastitis in cows | |
| CN116898777A (en) | Moisturizing and soothing effect facial cleanser aiming at sensitive muscles and preparation method thereof | |
| CN106267329B (en) | A kind of plants essential oil gel dressing and its preparation method and application | |
| CN106692397A (en) | Compound eprinomectin preparation as well as preparation method and application of compound eprinomectin preparation | |
| CN106581051A (en) | Nano microemulsion iodine and preparation method thereof | |
| KR102646763B1 (en) | Bath slime and method for manufacturing the same | |
| WO2020097982A1 (en) | Essential oil composition for scalp care and use | |
| CN102552317B (en) | Iodine glycerol nipple infusion and preparation method thereof | |
| KR20110054940A (en) | Kitchen detergent composition using herb medicine materials,and preparation thereof | |
| CN108186440A (en) | Can antibiotic skin-care Chinese medicinal plant shower cream and its preparation method and application | |
| Lestari et al. | Effectiveness Test of Natural Detoxification Facial Wash Gel Activated Charcoal Palm Shells Using Habatussaudah Scrub |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: Room 1001, unit 2, building 2, No.82, Keji Road, high tech Zone, Xi'an City, Shaanxi Province, 710077 Applicant after: SHAANXI HANLONG CLEANING DISINFECTION PRODUCT Co.,Ltd. Address before: 710077 room 11006, unit 1, building 1, No. 82, Keji Road, high tech Zone, Xi'an City, Shaanxi Province Applicant before: SHAANXI HANLONG CLEANING DISINFECTION PRODUCT Co.,Ltd. |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant |