BG50158A3 - Method for preparing derivatives of phenothiazine - Google Patents
Method for preparing derivatives of phenothiazineInfo
- Publication number
- BG50158A3 BG50158A3 BG088609A BG8860983A BG50158A3 BG 50158 A3 BG50158 A3 BG 50158A3 BG 088609 A BG088609 A BG 088609A BG 8860983 A BG8860983 A BG 8860983A BG 50158 A3 BG50158 A3 BG 50158A3
- Authority
- BG
- Bulgaria
- Prior art keywords
- alkylene
- phenothiazine
- general formula
- preparing derivatives
- drowsiness
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 125000001484 phenothiazinyl group Chemical class C1(=CC=CC=2SC3=CC=CC=C3NC12)* 0.000 title abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010041349 Somnolence Diseases 0.000 abstract 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000003266 anti-allergic effect Effects 0.000 abstract 1
- 230000003326 anti-histaminergic effect Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000002969 morbid Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940066767 systemic antihistamines phenothiazine derivative Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
- C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8234398 | 1982-12-02 | ||
| GB838318832A GB8318832D0 (en) | 1983-07-12 | 1983-07-12 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG50158A3 true BG50158A3 (en) | 1992-05-15 |
Family
ID=26284560
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG063286A BG47647A3 (en) | 1982-12-02 | 1983-12-01 | Method for preparing of phenothiazinic derivatives |
| BG088609A BG50158A3 (en) | 1982-12-02 | 1983-12-01 | Method for preparing derivatives of phenothiazine |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG063286A BG47647A3 (en) | 1982-12-02 | 1983-12-01 | Method for preparing of phenothiazinic derivatives |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0117302B1 (no) |
| JP (1) | JPH06767B2 (no) |
| KR (1) | KR890000638B1 (no) |
| AU (1) | AU572105B2 (no) |
| BG (2) | BG47647A3 (no) |
| CA (1) | CA1280749C (no) |
| DD (1) | DD213922A5 (no) |
| DE (1) | DE3381689D1 (no) |
| DK (1) | DK551283A (no) |
| ES (7) | ES527705A0 (no) |
| FI (1) | FI81788C (no) |
| GR (1) | GR81958B (no) |
| HU (1) | HU193274B (no) |
| IE (1) | IE56998B1 (no) |
| IL (2) | IL70359A0 (no) |
| MC (1) | MC1562A1 (no) |
| NO (1) | NO160203C (no) |
| NZ (1) | NZ206458A (no) |
| PH (1) | PH20433A (no) |
| PL (2) | PL145778B1 (no) |
| PT (1) | PT77766B (no) |
| YU (1) | YU44758B (no) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8413915D0 (en) * | 1984-05-31 | 1984-07-04 | Wellcome Found | Phenothiazine compounds |
| JPS6256489A (ja) * | 1985-09-04 | 1987-03-12 | Sanwa Kagaku Kenkyusho:Kk | 新規なピロリチジン化合物及びその塩、これらの製法並びにこれらを有効成分とする消化性潰瘍治療剤 |
| US6333322B1 (en) | 1996-03-13 | 2001-12-25 | Eisai Co., Ltd. | Nitrogen-containing tricyclic compounds and drugs containing the same |
| CN101896811B (zh) | 2007-12-10 | 2014-04-16 | 拜尔健康护理有限责任公司 | 制备3-苯基亚氨基-3h-吩噻嗪或3-苯基亚氨基-3h-吩噁嗪介体的方法 |
| EP2758403B1 (en) | 2011-09-21 | 2016-04-27 | Inception Orion, Inc. | Tricyclic compounds useful as neurogenic and neuroprotective agents |
| KR101646962B1 (ko) | 2014-09-29 | 2016-08-10 | 한국과학기술연구원 | CaM 저해활성을 가지는 페노싸이아진 유도체 |
| US10035795B1 (en) | 2017-04-06 | 2018-07-31 | Korea Institute Of Science And Technology | Phenothiazine derivatives having CaM inhibitory activity |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2956996A (en) * | 1960-10-18 | Alkylated phenotfflazenecarboxamede | ||
| NL97951C (no) * | 1955-11-15 | |||
| NL96990C (no) * | 1956-01-10 | |||
| NL58901C (no) * | 1957-02-07 | 1947-02-15 | ||
| NL273878A (no) * | 1961-01-24 | |||
| US3112310A (en) * | 1962-01-15 | 1963-11-26 | Searle & Co | 10-alkylaminoalkylphenothiazine-2-carboxamides |
-
1983
- 1983-12-01 IE IE2825/83A patent/IE56998B1/en not_active IP Right Cessation
- 1983-12-01 HU HU834128A patent/HU193274B/hu not_active IP Right Cessation
- 1983-12-01 DK DK551283A patent/DK551283A/da not_active Application Discontinuation
- 1983-12-01 PL PL1983252164A patent/PL145778B1/pl unknown
- 1983-12-01 BG BG063286A patent/BG47647A3/xx unknown
- 1983-12-01 NZ NZ206458A patent/NZ206458A/en unknown
- 1983-12-01 DE DE8383112101T patent/DE3381689D1/de not_active Expired - Fee Related
- 1983-12-01 CA CA000442325A patent/CA1280749C/en not_active Expired - Fee Related
- 1983-12-01 NO NO834424A patent/NO160203C/no unknown
- 1983-12-01 KR KR1019830005691A patent/KR890000638B1/ko not_active IP Right Cessation
- 1983-12-01 GR GR73129A patent/GR81958B/el unknown
- 1983-12-01 IL IL8370359A patent/IL70359A0/xx not_active IP Right Cessation
- 1983-12-01 ES ES527705A patent/ES527705A0/es active Granted
- 1983-12-01 JP JP58227775A patent/JPH06767B2/ja not_active Expired - Lifetime
- 1983-12-01 MC MC831675A patent/MC1562A1/xx unknown
- 1983-12-01 BG BG088609A patent/BG50158A3/xx unknown
- 1983-12-01 EP EP83112101A patent/EP0117302B1/en not_active Expired - Lifetime
- 1983-12-01 IL IL8370359Q patent/IL70359A/xx not_active IP Right Cessation
- 1983-12-01 FI FI834401A patent/FI81788C/fi not_active IP Right Cessation
- 1983-12-01 DD DD83257410A patent/DD213922A5/de not_active IP Right Cessation
- 1983-12-01 PH PH29907A patent/PH20433A/en unknown
- 1983-12-01 PL PL25216383A patent/PL252163A1/xx unknown
- 1983-12-01 YU YU2349/83A patent/YU44758B/xx unknown
- 1983-12-01 AU AU21900/83A patent/AU572105B2/en not_active Ceased
- 1983-12-02 PT PT77766A patent/PT77766B/pt not_active IP Right Cessation
-
1984
- 1984-07-16 ES ES534355A patent/ES8506674A1/es not_active Expired
- 1984-07-16 ES ES534358A patent/ES8506676A1/es not_active Expired
- 1984-07-16 ES ES534353A patent/ES534353A0/es active Granted
- 1984-07-16 ES ES534356A patent/ES534356A0/es active Granted
- 1984-07-16 ES ES534357A patent/ES8506675A1/es not_active Expired
- 1984-07-16 ES ES534354A patent/ES534354A0/es active Granted
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