BG108087A - Увеличено възстановяване на активни протеини - Google Patents

Увеличено възстановяване на активни протеини Download PDF

Info

Publication number
BG108087A
BG108087A BG108087A BG10808703A BG108087A BG 108087 A BG108087 A BG 108087A BG 108087 A BG108087 A BG 108087A BG 10808703 A BG10808703 A BG 10808703A BG 108087 A BG108087 A BG 108087A
Authority
BG
Bulgaria
Prior art keywords
protein
recombinant protein
receptor
fraction
soluble
Prior art date
Application number
BG108087A
Other languages
Bulgarian (bg)
English (en)
Inventor
Helmut Sassenfeld
Richard Remmele
Rebecca McCOY
Original Assignee
Immunex Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunex Corporation filed Critical Immunex Corporation
Publication of BG108087A publication Critical patent/BG108087A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measurement Of Radiation (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
BG108087A 2001-02-23 2003-08-13 Увеличено възстановяване на активни протеини BG108087A (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27103301P 2001-02-23 2001-02-23

Publications (1)

Publication Number Publication Date
BG108087A true BG108087A (bg) 2005-04-30

Family

ID=23033913

Family Applications (1)

Application Number Title Priority Date Filing Date
BG108087A BG108087A (bg) 2001-02-23 2003-08-13 Увеличено възстановяване на активни протеини

Country Status (21)

Country Link
US (2) US7157557B2 (fr)
EP (1) EP1366062B1 (fr)
JP (1) JP2005505494A (fr)
KR (1) KR20040052481A (fr)
CN (1) CN1547586A (fr)
AT (1) ATE517909T1 (fr)
AU (1) AU2002255600B2 (fr)
BG (1) BG108087A (fr)
CA (1) CA2438094C (fr)
CZ (1) CZ20032208A3 (fr)
EE (1) EE200300408A (fr)
ES (1) ES2370235T3 (fr)
HK (1) HK1059267A1 (fr)
HU (1) HUP0303246A2 (fr)
IL (1) IL157446A0 (fr)
MX (1) MXPA03007563A (fr)
PL (1) PL374045A1 (fr)
RU (1) RU2316563C2 (fr)
SK (1) SK10472003A3 (fr)
WO (1) WO2002068455A2 (fr)
ZA (1) ZA200305909B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ20032208A3 (cs) * 2001-02-23 2004-01-14 Immunex Corporation Zvýšený výtěžek aktivních proteinů
WO2005019434A2 (fr) 2003-08-26 2005-03-03 The Regents Of The University Of Colorado, A Body Corporate Inhibiteurs de l'activite de la protease serine et leurs utilisations dans des methodes et preparations de traitement d'infections bacteriennes
NZ554520A (en) 2004-10-22 2010-03-26 Amgen Inc Methods for refolding of recombinant antibodies
CA2584137A1 (fr) * 2004-10-22 2006-06-08 Amgen Inc. Methodes de repliement de polypeptides
EP1844069A4 (fr) * 2005-01-28 2009-05-20 Apollo Life Sciences Ltd Molécules et leurs molécules chimériques
MX2007014148A (es) 2005-05-19 2008-01-11 Amgen Inc Composiciones y metodos para incrementar la estabilidad de anticuerpos.
WO2006138181A2 (fr) 2005-06-14 2006-12-28 Amgen Inc. Preparations de proteines a tamponnage spontane
JP5335422B2 (ja) * 2005-06-17 2013-11-06 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 少なくとも１つの非天然のシステインを含んでいる操作されたタンパク質の選択的な還元および誘導体化
DE602007012412D1 (de) 2005-12-22 2011-03-24 Genentech Inc Rekombinante produktion heparinbindender proteine
WO2007102946A2 (fr) 2006-01-23 2007-09-13 Amgen Inc. Polypeptides cristallins
JP5566104B2 (ja) 2006-07-14 2014-08-06 ジェネンテック， インコーポレイテッド 組み換えタンパク質の再折り畳み
JP5623743B2 (ja) 2006-10-20 2014-11-12 アムジエン・インコーポレーテツド 安定なポリペプチド製剤
ES2751022T3 (es) 2007-07-09 2020-03-30 Genentech Inc Prevención de la reducción de enlaces disulfuro durante la producción recombinante de polipéptidos
EP2197911A2 (fr) * 2007-09-14 2010-06-23 Amgen Inc. Populations d'anticorps homogènes
MX2011013898A (es) 2009-06-22 2012-05-22 Amgen Inc Proteínas replegadas que usan un estado de oxido-reduccion quimicamente controlado.
JP2012531428A (ja) 2009-06-25 2012-12-10 アムジエン・インコーポレーテツド 哺乳類以外の系で発現されるタンパク質の捕獲精製プロセス
US9005926B2 (en) 2009-10-02 2015-04-14 Biogen Idec Ma Inc. Methods of preventing and removing trisulfide bonds
US8722615B2 (en) * 2009-12-02 2014-05-13 Acceleron Pharma, Inc. Compositions and methods for increasing serum half-life
HUE042314T2 (hu) 2011-02-07 2019-06-28 Cerenis Therapeutics Holding Sa Lipoprotein komplexek és azok gyártása és alkalmazásai
WO2012170938A1 (fr) 2011-06-08 2012-12-13 Acceleron Pharma Inc. Compositions et procédés pour augmenter la demi-vie sérique
WO2012178102A2 (fr) 2011-06-24 2012-12-27 The Regents Of The Unversity Of Colorado, A Body Corporate Compositions, procédés et utilisations de molécules de fusion de l'alpha-1 antitrypsine
EP2802653A4 (fr) 2012-01-10 2015-09-02 Univ Colorado Regents Compositions de molécules de fusion de l'alpha-1 antitrypsine, procédés et utilisations associés
US9353165B2 (en) * 2012-07-25 2016-05-31 Grifols, S.A. Purification of cell culture derived alpha1 protease inhibitor
KR20150037959A (ko) 2012-08-02 2015-04-08 에프. 호프만-라 로슈 아게 단량체 및 다량체 분자의 제조 방법 및 이의 용도
CN104902914B (zh) 2012-09-11 2019-01-01 科荣生生物科学公司 高纯度和优异产量的正确折叠的依那西普
WO2014137903A2 (fr) 2013-03-08 2014-09-12 Genzyme Corporation Fabrication continue intégrée de substances de médicament de protéine thérapeutique
TWI671312B (zh) 2014-01-17 2019-09-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
AR103172A1 (es) * 2014-12-22 2017-04-19 Novartis Ag Reducción selectiva de residuos de cisteina en anticuerpos il-17
EP3528787A4 (fr) 2016-10-21 2020-05-06 Amgen Inc. Formulations pharmaceutiques et leurs procédés de préparation
CN112638488A (zh) 2018-08-31 2021-04-09 建新公司 灭菌的层析树脂及其在制造工艺中的用途
AU2019356564A1 (en) 2018-10-11 2021-04-29 Amgen Inc. Downstream processing of bispecific antibody constructs
EP4267717A1 (fr) 2020-12-22 2023-11-01 Amgen Inc. Procédé de culture cellulaire

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5453363A (en) * 1985-10-23 1995-09-26 Boehringer Mannheim Gmbh Process for the activation of t-PA or Ing after genetic expression in prokaryotes
US4766205A (en) * 1985-11-13 1988-08-23 Beatrice Companies, Inc. Method for isolation of recombinant polypeptides in biologically active forms
EP0293785A3 (fr) 1987-05-29 1990-05-02 Oncogen Limited Partnership Clonage et expression du facteur de croissance transformant simien SS-1
US4970067A (en) * 1988-12-12 1990-11-13 Helene Curtis, Inc. Method and composition to condition hair and impart semi-permanent hair set retention properties
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
AU648214B2 (en) * 1991-12-31 1994-04-14 Lucky Limited Recombinant gene coding for human alpha interferon and expression vector thereof, etc.
US5447851B1 (en) * 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
AU685835B2 (en) * 1993-08-04 1998-01-29 Novartis Ag High molecular weight desulphatohirudin
US6310185B1 (en) * 1994-03-08 2001-10-30 Memorial Sloan Kettering Cancer Center Recombinant human anti-Lewis Y antibodies
WO1995032216A1 (fr) * 1994-05-25 1995-11-30 University Of Nebraska Board Of Regents Hormones glycoproteiques biologiquement actives produites dans des cellules procaryotes
CA2195665A1 (fr) 1994-07-22 1996-02-08 Robert Frederick Geoffrey Booth Compositions pharmaceutiques comprenant une proteine chimere liant le facteur de necrose tumorale
US5879673A (en) * 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US5935824A (en) * 1996-01-31 1999-08-10 Technologene, Inc. Protein expression system
US6808902B1 (en) 1999-11-12 2004-10-26 Amgen Inc. Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
FR2803303B1 (fr) * 2000-01-04 2002-05-10 Aventis Pasteur Glycoproteine d'enveloppe du vih modifiee chimiquement
CZ20032208A3 (cs) * 2001-02-23 2004-01-14 Immunex Corporation Zvýšený výtěžek aktivních proteinů

Also Published As

Publication number Publication date
RU2003127830A (ru) 2005-04-10
WO2002068455A2 (fr) 2002-09-06
MXPA03007563A (es) 2003-12-11
ES2370235T3 (es) 2011-12-13
CZ20032208A3 (cs) 2004-01-14
CA2438094C (fr) 2011-10-11
ZA200305909B (en) 2004-06-04
HUP0303246A2 (hu) 2003-12-29
US20070270577A1 (en) 2007-11-22
SK10472003A3 (sk) 2004-03-02
WO2002068455A3 (fr) 2003-09-18
IL157446A0 (en) 2004-03-28
KR20040052481A (ko) 2004-06-23
CN1547586A (zh) 2004-11-17
JP2005505494A (ja) 2005-02-24
EP1366062A2 (fr) 2003-12-03
US7157557B2 (en) 2007-01-02
US20020182665A1 (en) 2002-12-05
EP1366062B1 (fr) 2011-07-27
ATE517909T1 (de) 2011-08-15
CA2438094A1 (fr) 2002-09-06
EE200300408A (et) 2003-12-15
RU2316563C2 (ru) 2008-02-10
US7544784B2 (en) 2009-06-09
HK1059267A1 (en) 2004-06-25
PL374045A1 (en) 2005-09-19
AU2002255600B2 (en) 2008-01-24

Similar Documents

Publication Publication Date Title
BG108087A (bg) Увеличено възстановяване на активни протеини
AU2002255600A1 (en) Efficient recovery of correctly refolded proteins
US7928205B2 (en) Methods for refolding of recombinant antibodies
JP4414472B2 (ja) ポリペプチド産生を増加させる方法
US20080167450A1 (en) Methods of purifying proteins
JP2005527503A (ja) ポリペプチド製剤
MX2007014148A (es) Composiciones y metodos para incrementar la estabilidad de anticuerpos.
US10023608B1 (en) Protein purification methods to remove impurities
US8273707B2 (en) Process for purifying proteins
WO2006060083A1 (fr) Methodes de repliement de polypeptides
ZA200703280B (en) Methods for refolding of recombinant antibodies