BG107013A - Il-8 рецепторни антагонисти - Google Patents
Il-8 рецепторни антагонисти Download PDFInfo
- Publication number
- BG107013A BG107013A BG107013A BG10701302A BG107013A BG 107013 A BG107013 A BG 107013A BG 107013 A BG107013 A BG 107013A BG 10701302 A BG10701302 A BG 10701302A BG 107013 A BG107013 A BG 107013A
- Authority
- BG
- Bulgaria
- Prior art keywords
- alkyl
- chloro
- hydroxy
- optionally substituted
- heterocyclyl
- Prior art date
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- 238000010189 synthetic method Methods 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- BSWOVOPHAZMAHS-UHFFFAOYSA-N tert-butyl 5-chloro-2-oxo-4-sulfamoyl-1,3-benzoxazole-3-carboxylate Chemical compound NS(=O)(=O)C1=C(C=CC2=C1N(C(O2)=O)C(=O)OC(C)(C)C)Cl BSWOVOPHAZMAHS-UHFFFAOYSA-N 0.000 description 1
- 150000003536 tetrazoles Chemical class 0.000 description 1
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical compound C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 description 1
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- 229930192474 thiophene Natural products 0.000 description 1
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- JLTRXTDYQLMHGR-UHFFFAOYSA-N trimethylaluminium Chemical compound C[Al](C)C JLTRXTDYQLMHGR-UHFFFAOYSA-N 0.000 description 1
- UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 210000003556 vascular endothelial cell Anatomy 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
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- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
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- C07C311/47—Y being a hetero atom
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- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
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- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
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- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
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Applications Claiming Priority (2)
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| US18984800P | 2000-03-16 | 2000-03-16 | |
| PCT/US2001/008672 WO2001068084A1 (en) | 2000-03-16 | 2001-03-16 | Il-8 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
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| BG107013A true BG107013A (bg) | 2003-05-30 |
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| BG107013A BG107013A (bg) | 2000-03-16 | 2002-08-20 | Il-8 рецепторни антагонисти |
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| AR030689A1 (es) * | 2000-03-14 | 2003-09-03 | Smithkline Beecham Corp | Compuestos de 3-aminosulfonil-2-hidroxifenil urea, composiciones farmaceuticas que los comprenden, y uso de dichos compuestos en la manufactura de medicamentos para tratar enfermedades mediadas por quimioquinas |
| US7326729B2 (en) | 2004-05-12 | 2008-02-05 | Schering Corporation | CXCR1 and CXCR2 chemokine antagonists |
| AU2007240364A1 (en) * | 2006-04-21 | 2007-11-01 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| BRPI0710232B8 (pt) * | 2006-04-21 | 2021-05-25 | Glaxosmithkline Llc | composto antagonista do receptor de il-8, composição farmacêutica que compreende o dito composto e uso do mesmo para o tratamento de uma doença mediada por quimiocina |
| CR20160557A (es) * | 2014-05-29 | 2017-01-20 | Glaxosmithkline Ip Dev Ltd | Compuestos derivados de 1-(ciclopent-2-en-1-il)-3-(2-hidroxi-3-(arilsulfonil)fenil)urea como inhibidores cxcr2 |
| BR112017002060A2 (pt) * | 2014-07-31 | 2017-12-26 | Glaxosmithkline Ip Dev Ltd | novo uso |
| JP7223764B2 (ja) * | 2018-01-11 | 2023-02-16 | シェンチェン オプティマム バイオロジカル テクノロジー カンパニー，リミティド | Ｃｘｃｒ２アンタゴニスト |
| CN114286819B (zh) * | 2019-07-11 | 2024-03-05 | 深圳嘉科生物科技有限公司 | 一种cxcr2拮抗剂的晶型及其应用 |
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| JPH11503110A (ja) * | 1995-02-17 | 1999-03-23 | スミスクライン・ビーチャム・コーポレイション | Ｉｌ−８受容体拮抗剤 |
| CA2258850A1 (en) * | 1996-06-27 | 1997-12-31 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| WO1998007418A1 (en) * | 1996-08-21 | 1998-02-26 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
| PT1115701E (pt) * | 1998-09-23 | 2003-09-30 | Tularik Inc | Ureias de arilsulfonanilida |
| UY25842A1 (es) * | 1998-12-16 | 2001-04-30 | Smithkline Beecham Corp | Antagonistas de receptores de il-8 |
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| OA12231A (en) | 2003-11-07 |
| MXPA02009094A (es) | 2003-03-12 |
| EP1263427A1 (en) | 2002-12-11 |
| NO20024367L (no) | 2002-10-22 |
| KR20020091130A (ko) | 2002-12-05 |
| WO2001068084A1 (en) | 2001-09-20 |
| NO20024367D0 (no) | 2002-09-12 |
| AP2002002606A0 (en) | 2002-09-30 |
| CA2403062A1 (en) | 2001-09-20 |
| PL366034A1 (en) | 2005-01-24 |
| AR031098A1 (es) | 2003-09-10 |
| HUP0300470A3 (en) | 2005-05-30 |
| JP2003526664A (ja) | 2003-09-09 |
| CN1424910A (zh) | 2003-06-18 |
| BR0108749A (pt) | 2004-06-29 |
| EP1263427A4 (en) | 2005-08-24 |
| SK13282002A3 (sk) | 2003-02-04 |
| ZA200207325B (en) | 2003-10-17 |
| CZ20023075A3 (cs) | 2003-05-14 |
| MA25659A1 (fr) | 2002-12-31 |
| HUP0300470A2 (hu) | 2003-06-28 |
| AU2001250873A1 (en) | 2001-09-24 |
| EA200200981A1 (ru) | 2003-02-27 |
| CO5280089A1 (es) | 2003-05-30 |
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