BG106122A - Тиазолидиндионово производно и неговото използване като антидиабетично средство - Google Patents

Тиазолидиндионово производно и неговото използване като антидиабетично средство

Info

Publication number
BG106122A
BG106122A BG106122A BG10612201A BG106122A BG 106122 A BG106122 A BG 106122A BG 106122 A BG106122 A BG 106122A BG 10612201 A BG10612201 A BG 10612201A BG 106122 A BG106122 A BG 106122A
Authority
BG
Bulgaria
Prior art keywords
compound
spectrum containing
containing peaks
thiazolidinedion
antidiabetic
Prior art date
Application number
BG106122A
Other languages
English (en)
Other versions
BG65517B1 (bg
Inventor
Paul Blackler
Robert Giles
Stephen Moore
Michael Sasse
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9909471.6A external-priority patent/GB9909471D0/en
Priority claimed from GBGB9912195.6A external-priority patent/GB9912195D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of BG106122A publication Critical patent/BG106122A/bg
Publication of BG65517B1 publication Critical patent/BG65517B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Изобретението се отнася до полиморфна форма на 5-[4-[2-(N-метил-N-(2-пиридил) амино)етокси] бензил]тиазолидин-2,4-дион, сол на малеиновата киселина (полиморф) с инфрачервен спектър, съдържащ пикове при 1752, 1546, 1154, 621 и 602 cm-1, и/или Раманов спектър, съдържащ пикове при 1751, 1243 и 602 cm-1, и/или спектър на ядрения магнитен резонанс в твърдо състояние, съдържащ пикове при 111,9, 114,8,119,6, 129,2, 134,0, 138,0, 144,7, 153,2, 1571, 170,7, 172,0 и 175,0 ppm, и/или рентгенова прахова дифрактограма (XRPD), която дава изчислени разстояния на кристалната решетка 6,46, 5,39, 4,83, 4,68,3,71, 3,63, 3,58 и 3,48 А. Изобретението се отнася и до метод за получаване на това съединение, до фармацевтичен състав, който го съдържа и до използването му в медицината.
BG106122A 1999-04-23 2001-11-20 Тиазолидиндионово производно и неговото използване като антидиабетично средство BG65517B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9909471.6A GB9909471D0 (en) 1999-04-23 1999-04-23 Novel compounds
GBGB9912195.6A GB9912195D0 (en) 1999-05-25 1999-05-25 Novel pharmaceutical

Publications (2)

Publication Number Publication Date
BG106122A true BG106122A (bg) 2002-05-31
BG65517B1 BG65517B1 (bg) 2008-10-31

Family

ID=26315459

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106122A BG65517B1 (bg) 1999-04-23 2001-11-20 Тиазолидиндионово производно и неговото използване като антидиабетично средство

Country Status (36)

Country Link
EP (2) EP1277753A1 (bg)
JP (1) JP2002543076A (bg)
KR (1) KR100744361B1 (bg)
CN (1) CN1152878C (bg)
AP (1) AP1607A (bg)
AR (2) AR023560A1 (bg)
AU (2) AU4307200A (bg)
BG (1) BG65517B1 (bg)
BR (1) BR0009935A (bg)
CA (1) CA2370262A1 (bg)
CO (1) CO5170419A1 (bg)
CZ (1) CZ20013801A3 (bg)
DZ (1) DZ3164A1 (bg)
EA (1) EA003031B1 (bg)
EG (1) EG23937A (bg)
GC (1) GC0000250A (bg)
HK (1) HK1045152A1 (bg)
HR (1) HRP20010774A2 (bg)
HU (1) HUP0200937A3 (bg)
IL (1) IL146115A0 (bg)
MA (1) MA26786A1 (bg)
MX (1) MXPA01010822A (bg)
MY (1) MY138673A (bg)
NO (1) NO320587B1 (bg)
NZ (1) NZ515167A (bg)
OA (1) OA11873A (bg)
PE (1) PE20010045A1 (bg)
PL (1) PL351685A1 (bg)
SK (1) SK14932001A3 (bg)
TR (1) TR200103060T2 (bg)
TW (1) TWI288749B (bg)
UA (1) UA67845C2 (bg)
UY (1) UY26119A1 (bg)
WO (1) WO2000064893A2 (bg)
YU (1) YU75401A (bg)
ZA (1) ZA200108718B (bg)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9726568D0 (en) 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
US6664278B2 (en) 1997-12-16 2003-12-16 Smithkline Beecham P.L.C. Hydrate of 5-[4-[2-(N-methyl-N-(2-pyridil)amino)ethoxy]benzyl]thiazolidine-2,4-dione maleic acid salt
US20020137940A1 (en) 1997-12-16 2002-09-26 Smithkline Beecham P.L.C. 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
JP2002541785A (ja) * 1999-04-13 2002-12-10 アメリカ合衆国 クローン化ヌクレオチド配列からの弱毒化キメラ呼吸系発疹ウイルスワクチンの製造
ATE247653T1 (de) 1999-04-23 2003-09-15 Smithkline Beecham Plc Thiazolidindionderivat und seine verwendung als antidiabetikum
ATE246191T1 (de) 1999-04-23 2003-08-15 Smithkline Beecham Plc Polymorph von 5-(4-(2-(n-methyl-n-(2- pyrdyl)amino)äthoxy)benzyl)thiazolidin-2,4-dion maleinsäuresalz
GB0006133D0 (en) 2000-03-14 2000-05-03 Smithkline Beecham Plc Novel pharmaceutical
US7241895B2 (en) * 2000-09-26 2007-07-10 Dr. Reddy's Laboratories Limited Polymorphic forms of 5-[4-[2-[n-methyl-n-(2-pyridyl)amino[ethoxy]benzyl] thiazolidine-2,4-dione maleate and process for their preparation
WO2004062667A1 (en) * 2003-01-08 2004-07-29 Dr. Reddy's Laboratories Limited Amorphous form of rosiglitazone maleate and process for preparation thereof
GB0307259D0 (en) * 2003-03-28 2003-05-07 Glaxo Group Ltd Process
EP1468997A3 (en) * 2003-04-18 2004-11-03 CHEMI S.p.A. Polymorphous forms of rosiglitazone maleate
GB2405403A (en) * 2003-08-29 2005-03-02 Cipla Ltd Rosiglitazone maleate of particular polymorphic forms and methods of preparing rosiglitazone free base
ITMI20041537A1 (it) * 2004-07-28 2004-10-28 Chemi Spa Nuova forma polimorfa del rosiglitazone maleato
CZ298424B6 (cs) * 2005-05-24 2007-09-26 Zentiva, A. S. Zpusob krystalizace rosiglitazonu a jeho derivátuze smesných rozpouštedel
TW200838512A (en) * 2007-02-08 2008-10-01 Daiichi Sankyo Co Ltd Crystalline forms of a thiazolidinedione compound and manufacturing methods thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10199003I1 (de) * 1987-09-04 2003-06-12 Beecham Group Plc Substituierte Thiazolidinionderivate
GB9218830D0 (en) * 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
GB9726563D0 (en) * 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
GB9726568D0 (en) * 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
GB9726566D0 (en) * 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical

Also Published As

Publication number Publication date
NZ515167A (en) 2004-02-27
IL146115A0 (en) 2002-07-25
UY26119A1 (es) 2000-12-29
MA26786A1 (fr) 2004-12-20
CA2370262A1 (en) 2000-11-02
NO320587B1 (no) 2005-12-27
EG23937A (en) 2008-01-14
YU75401A (sh) 2004-09-03
PL351685A1 (en) 2003-06-02
HK1045152A1 (zh) 2002-11-15
EP1175418A2 (en) 2002-01-30
AR023560A1 (es) 2002-09-04
HUP0200937A3 (en) 2004-03-29
AU2755102A (en) 2002-05-16
AR023750A1 (es) 2002-09-04
EP1277753A1 (en) 2003-01-22
DZ3164A1 (fr) 2000-11-02
MY138673A (en) 2009-07-31
KR20010110804A (ko) 2001-12-13
KR100744361B1 (ko) 2007-07-30
GC0000250A (en) 2006-11-01
HRP20010774A2 (en) 2002-10-31
TWI288749B (en) 2007-10-21
EA200101122A1 (ru) 2002-04-25
CN1355800A (zh) 2002-06-26
TR200103060T2 (tr) 2002-05-21
OA11873A (en) 2006-03-27
AP2001002329A0 (en) 2001-12-31
NO20015148L (no) 2001-12-17
MXPA01010822A (es) 2002-06-04
BR0009935A (pt) 2002-04-16
NO20015148D0 (no) 2001-10-22
JP2002543076A (ja) 2002-12-17
ZA200108718B (en) 2002-12-03
AP1607A (en) 2006-05-03
AU771342B2 (en) 2004-03-18
BG65517B1 (bg) 2008-10-31
CN1152878C (zh) 2004-06-09
SK14932001A3 (sk) 2002-02-05
WO2000064893A3 (en) 2001-01-25
PE20010045A1 (es) 2001-03-10
AU4307200A (en) 2000-11-10
WO2000064893A2 (en) 2000-11-02
HUP0200937A2 (en) 2002-08-28
UA67845C2 (uk) 2004-07-15
EA003031B1 (ru) 2002-12-26
CZ20013801A3 (cs) 2002-07-17
CO5170419A1 (es) 2002-06-27

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