BG104706A - Производни на 1,3,4-оксадиазолон - Google Patents

Производни на 1,3,4-оксадиазолон

Info

Publication number
BG104706A
BG104706A BG104706A BG10470600A BG104706A BG 104706 A BG104706 A BG 104706A BG 104706 A BG104706 A BG 104706A BG 10470600 A BG10470600 A BG 10470600A BG 104706 A BG104706 A BG 104706A
Authority
BG
Bulgaria
Prior art keywords
oxadiazolone
derivatives
solvate
disorders
responsive
Prior art date
Application number
BG104706A
Other languages
English (en)
Inventor
Piyasena Hewawasam
Min Ding
John STARRETT
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of BG104706A publication Critical patent/BG104706A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Съединенията се прилагат за лечение на заболявания в резултат от нарушено функциониране, поляризацията и проводимостта на клетъчните мембрани, лесно податливи на отварянето на високопроводящите, калцийактивируеми калиеви канали. Производните на 1,3,4-оксадиазолона или тяхна нетоксична фармацевтичноприемлива сол или солват имат обща формула@@в която А, В, D и R имат значенията, посочени в описанието.
BG104706A 1998-01-29 2000-08-22 Производни на 1,3,4-оксадиазолон BG104706A (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7296698P 1998-01-29 1998-01-29
US10227498P 1998-09-29 1998-09-29
PCT/US1999/000910 WO1999038510A1 (en) 1998-01-29 1999-01-15 Derivatives of 1,3,4-oxadiazolone

Publications (1)

Publication Number Publication Date
BG104706A true BG104706A (bg) 2001-04-30

Family

ID=26753969

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104706A BG104706A (bg) 1998-01-29 2000-08-22 Производни на 1,3,4-оксадиазолон

Country Status (27)

Country Link
US (1) US6034113A (bg)
EP (1) EP1051173A4 (bg)
JP (1) JP2002527352A (bg)
KR (1) KR20010077838A (bg)
CN (1) CN1150175C (bg)
AR (1) AR010712A1 (bg)
AU (1) AU735704B2 (bg)
BG (1) BG104706A (bg)
BR (1) BR9913010A (bg)
CA (1) CA2318830A1 (bg)
CO (1) CO5090837A1 (bg)
EE (1) EE04089B1 (bg)
GE (1) GEP20032914B (bg)
HU (1) HUP0102025A3 (bg)
ID (1) ID26909A (bg)
IL (1) IL137518A0 (bg)
LT (1) LT4838B (bg)
LV (1) LV12559B (bg)
NO (1) NO317102B1 (bg)
NZ (1) NZ505409A (bg)
PL (1) PL342060A1 (bg)
RU (1) RU2202548C2 (bg)
SK (1) SK10852000A3 (bg)
TR (1) TR200002019T2 (bg)
TW (1) TW550075B (bg)
UA (1) UA58579C2 (bg)
WO (1) WO1999038510A1 (bg)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU736599B2 (en) * 1998-01-29 2001-08-02 Bristol-Myers Squibb Company Amino acid derivatives of diaryl 1,3,4-oxadiazolone
US6297241B1 (en) 1999-01-29 2001-10-02 Bristol-Myers Squibb Company Carbamate derivatives of diaryl 1,3,4-oxadiazolone
ID29269A (id) * 1999-01-29 2001-08-16 Bristol Myers Squibb Co Turunan-turunan karbamat dari diaril 1,3,4,oksadiazolon
US6326388B1 (en) * 1999-12-21 2001-12-04 Celgene Corporation Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level
US6855829B2 (en) 2001-02-20 2005-02-15 Bristol-Myers Squibb Company 3-fluoro-2-oxindole modulators of KCNQ potassium channels and use thereof in treating migraine and mechanistically related disease
AU2002246397B2 (en) * 2001-04-16 2005-03-24 Tanabe Seiyaku Co., Ltd. Imidazole, thiazole and oxazole derivatives and their use for the manufacture of a medicament for the treatment and/or prevention of pollakiuria or urinary incontinence
US6909027B1 (en) * 2001-08-13 2005-06-21 Perry Robins Method of forming an in-situ film dressing and the composition of the film-forming material
US7119246B2 (en) * 2002-06-25 2006-10-10 Perry Robins Method of treating acne
WO2013170655A1 (en) 2012-05-16 2013-11-21 Techfields Pharma Co., Ltd. High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions
JP5855599B2 (ja) * 2013-04-30 2016-02-09 テックフィールズ バイオケム カンパニー リミテッド 非常に速い皮膚浸透率を有するアセトアミノフェン及び関連化合物の正荷電水溶性プロドラッグ
CN104710379B (zh) * 2015-03-09 2017-01-18 华南理工大学 一种bms‑191011的合成方法
JP6165816B2 (ja) * 2015-10-01 2017-07-19 テックフィールズ バイオケム カンパニー リミテッド 非常に速い皮膚浸透率を有するアセトアミノフェン及び関連化合物の正荷電水溶性プロドラッグ
MX2019009985A (es) * 2017-02-24 2019-10-09 Ovid Therapeutics Inc Metodos para tratar trastornos convulsivos.
CN110987847B (zh) * 2019-12-11 2021-02-19 苏州今蓝纳米科技有限公司 1,3,4-噁二唑衍生物在检测酸以及数据加密和储存中的应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH583213A5 (bg) * 1973-05-21 1976-12-31 Ciba Geigy Ag
IT1251488B (it) * 1991-09-17 1995-05-15 Mini Ricerca Scient Tecnolog Ossa(tia)diazol- e triazol-oni(tioni) ad attivita' acaricida ed insetticida
US5234947A (en) * 1991-11-07 1993-08-10 New York University Potassium channel activating compounds and methods of use thereof
US5547966A (en) * 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
TW467902B (en) * 1996-07-31 2001-12-11 Bristol Myers Squibb Co Diphenyl heterocycles as potassium channel modulators
AU736599B2 (en) * 1998-01-29 2001-08-02 Bristol-Myers Squibb Company Amino acid derivatives of diaryl 1,3,4-oxadiazolone

Also Published As

Publication number Publication date
TR200002019T2 (tr) 2000-11-21
GEP20032914B (en) 2003-03-25
NZ505409A (en) 2003-08-29
EE200000447A (et) 2001-12-17
UA58579C2 (uk) 2003-08-15
AU735704B2 (en) 2001-07-12
AR010712A1 (es) 2000-07-12
AU2230899A (en) 1999-08-16
IL137518A0 (en) 2001-07-24
JP2002527352A (ja) 2002-08-27
CO5090837A1 (es) 2001-10-30
HUP0102025A3 (en) 2002-01-28
CN1289249A (zh) 2001-03-28
NO317102B1 (no) 2004-08-09
HUP0102025A2 (hu) 2001-11-28
LV12559A (en) 2000-11-20
LT4838B (lt) 2001-08-27
LT2000068A (en) 2001-03-26
US6034113A (en) 2000-03-07
NO20003825L (no) 2000-07-26
LV12559B (en) 2001-04-20
WO1999038510A1 (en) 1999-08-05
KR20010077838A (ko) 2001-08-20
CA2318830A1 (en) 1999-08-05
SK10852000A3 (sk) 2002-02-05
EE04089B1 (et) 2003-08-15
NO20003825D0 (no) 2000-07-26
RU2202548C2 (ru) 2003-04-20
TW550075B (en) 2003-09-01
EP1051173A4 (en) 2002-07-31
CN1150175C (zh) 2004-05-19
EP1051173A1 (en) 2000-11-15
ID26909A (id) 2001-02-15
PL342060A1 (en) 2001-05-21
BR9913010A (pt) 2001-05-08

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