BG104328A - Изохинолини като инхибитори на урокиназа - Google Patents
Изохинолини като инхибитори на урокиназа Download PDFInfo
- Publication number
- BG104328A BG104328A BG104328A BG10432800A BG104328A BG 104328 A BG104328 A BG 104328A BG 104328 A BG104328 A BG 104328A BG 10432800 A BG10432800 A BG 10432800A BG 104328 A BG104328 A BG 104328A
- Authority
- BG
- Bulgaria
- Prior art keywords
- optionally substituted
- alkylene
- compound
- halogen
- halogen atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9721964.6A GB9721964D0 (en) | 1997-10-16 | 1997-10-16 | Isoquinolines |
| PCT/EP1998/006353 WO1999020608A1 (en) | 1997-10-16 | 1998-10-05 | Isoquinolines as urokinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG104328A true BG104328A (bg) | 2000-12-29 |
Family
ID=10820680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG104328A BG104328A (bg) | 1997-10-16 | 2000-04-11 | Изохинолини като инхибитори на урокиназа |
Country Status (41)
| Country | Link |
|---|---|
| US (1) | US6248738B1 (pt) |
| EP (1) | EP1023268B1 (pt) |
| JP (1) | JP3600794B2 (pt) |
| KR (1) | KR20010031163A (pt) |
| CN (1) | CN1275979A (pt) |
| AP (1) | AP959A (pt) |
| AR (1) | AR015964A1 (pt) |
| AT (1) | ATE240943T1 (pt) |
| AU (1) | AU727315B2 (pt) |
| BG (1) | BG104328A (pt) |
| BR (1) | BR9812922A (pt) |
| CA (1) | CA2306782C (pt) |
| CO (1) | CO4990959A1 (pt) |
| DE (1) | DE69814894T2 (pt) |
| DK (1) | DK1023268T3 (pt) |
| DZ (1) | DZ2624A1 (pt) |
| EA (1) | EA002632B1 (pt) |
| ES (1) | ES2197514T3 (pt) |
| GB (1) | GB9721964D0 (pt) |
| GT (1) | GT199800159A (pt) |
| HN (1) | HN1998000158A (pt) |
| HR (1) | HRP20000217A2 (pt) |
| HU (1) | HUP0004491A3 (pt) |
| ID (1) | ID23913A (pt) |
| IL (1) | IL135122A0 (pt) |
| IS (1) | IS5412A (pt) |
| MA (1) | MA26552A1 (pt) |
| NO (1) | NO20001924L (pt) |
| NZ (1) | NZ503390A (pt) |
| OA (1) | OA11348A (pt) |
| PA (1) | PA8461601A1 (pt) |
| PE (1) | PE121299A1 (pt) |
| PL (1) | PL340035A1 (pt) |
| PT (1) | PT1023268E (pt) |
| SK (1) | SK4872000A3 (pt) |
| TN (1) | TNSN98185A1 (pt) |
| TR (1) | TR200001010T2 (pt) |
| UY (2) | UY25211A1 (pt) |
| WO (1) | WO1999020608A1 (pt) |
| YU (1) | YU21100A (pt) |
| ZA (1) | ZA989412B (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000005214A2 (en) * | 1998-07-24 | 2000-02-03 | Pfizer Inc. | Isoquinolines as urokinase inhibitors |
| DE19940389A1 (de) * | 1999-08-25 | 2001-03-01 | Wilex Biotechnology Gmbh | Selektive Inhibitoren des Urokinase-Plasminogen Aktivators |
| ES2172376B1 (es) * | 2000-01-28 | 2003-11-16 | Servier Lab | Nuevos derivados de isoquinoleinas, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen. |
| DE10013715A1 (de) | 2000-03-20 | 2001-09-27 | Wilex Biotechnology Gmbh | Hochselektive Inhibitoren des Urokinase-Plasminogenaktivators |
| GB0026490D0 (en) * | 2000-10-30 | 2000-12-13 | Pfizer Ltd | Process |
| ATE415162T1 (de) * | 2001-06-11 | 2008-12-15 | Vertex Pharma | Isochinolin-inhibitoren von p38 |
| BR0311419A (pt) | 2002-05-28 | 2005-04-05 | Dimensional Pharm Inc | Amidinas de tiofeno suas composições e métodos de tratamento de doenças e condições mediadas por complemento |
| DK1564210T5 (da) * | 2002-11-20 | 2010-05-03 | Japan Tobacco Inc | 4-Oxoquinolinforbindelser og anvendelse deraf som HIV-integraseinhibitorer |
| GB0326964D0 (en) * | 2003-11-19 | 2003-12-24 | Glaxo Group Ltd | Chemical compounds |
| MY134672A (en) * | 2004-05-20 | 2007-12-31 | Japan Tobacco Inc | Stable crystal of 4-oxoquinoline compound |
| US7531554B2 (en) * | 2004-05-20 | 2009-05-12 | Japan Tobacco Inc. | 4-oxoquinoline compound and use thereof as HIV integrase inhibitor |
| EP1852421B1 (en) * | 2005-02-25 | 2011-05-04 | Kowa Company, Ltd. | Process for production of 4-fluoroisoquinoline-5-sulfonyl halide or salt thereof |
| RU2410087C2 (ru) | 2005-06-24 | 2011-01-27 | Вилекс Аг | Применение ингибиторов урокиназы для лечения и/или предупреждения невропатологических заболеваний |
| AU2007223260C1 (en) * | 2006-03-06 | 2011-02-03 | Japan Tobacco Inc. | Method for producing 4-oxoquinoline compound |
| TWI795381B (zh) * | 2016-12-21 | 2023-03-11 | 比利時商健生藥品公司 | 作為ｍａｌｔ１抑制劑之吡唑衍生物 |
| CN106831575B (zh) * | 2017-02-13 | 2019-04-16 | 北京六合宁远科技有限公司 | 一种1-氨基异喹啉-6-甲醇的制备方法 |
| CN113877483B (zh) * | 2021-07-20 | 2023-11-24 | 烟台宁远药业有限公司 | 医药中间体卤代异喹啉类硼酸的低温连续合成装置与方法 |
| CN115286573A (zh) * | 2022-08-04 | 2022-11-04 | 常州工程职业技术学院 | 一种1-烷氧基异喹啉化合物的绿色合成方法 |
-
1997
- 1997-10-16 GB GBGB9721964.6A patent/GB9721964D0/en not_active Ceased
-
1998
- 1998-10-05 KR KR1020007004083A patent/KR20010031163A/ko active IP Right Grant
- 1998-10-05 TR TR2000/01010T patent/TR200001010T2/xx unknown
- 1998-10-05 DK DK98954357T patent/DK1023268T3/da active
- 1998-10-05 NZ NZ503390A patent/NZ503390A/en unknown
- 1998-10-05 BR BR9812922-8A patent/BR9812922A/pt not_active Application Discontinuation
- 1998-10-05 HU HU0004491A patent/HUP0004491A3/hu unknown
- 1998-10-05 IL IL13512298A patent/IL135122A0/xx unknown
- 1998-10-05 WO PCT/EP1998/006353 patent/WO1999020608A1/en not_active Application Discontinuation
- 1998-10-05 PL PL98340035A patent/PL340035A1/xx unknown
- 1998-10-05 DE DE69814894T patent/DE69814894T2/de not_active Expired - Fee Related
- 1998-10-05 CN CN98810108A patent/CN1275979A/zh active Pending
- 1998-10-05 SK SK487-2000A patent/SK4872000A3/sk unknown
- 1998-10-05 US US09/424,497 patent/US6248738B1/en not_active Expired - Fee Related
- 1998-10-05 EP EP98954357A patent/EP1023268B1/en not_active Expired - Lifetime
- 1998-10-05 CA CA002306782A patent/CA2306782C/en not_active Expired - Fee Related
- 1998-10-05 AU AU11508/99A patent/AU727315B2/en not_active Ceased
- 1998-10-05 YU YU21100A patent/YU21100A/sh unknown
- 1998-10-05 ES ES98954357T patent/ES2197514T3/es not_active Expired - Lifetime
- 1998-10-05 AT AT98954357T patent/ATE240943T1/de not_active IP Right Cessation
- 1998-10-05 PT PT98954357T patent/PT1023268E/pt unknown
- 1998-10-05 EA EA200000320A patent/EA002632B1/ru not_active IP Right Cessation
- 1998-10-05 ID IDW20000691A patent/ID23913A/id unknown
- 1998-10-05 JP JP2000516950A patent/JP3600794B2/ja not_active Expired - Fee Related
- 1998-10-08 HN HN1998000158A patent/HN1998000158A/es unknown
- 1998-10-09 GT GT199800159A patent/GT199800159A/es unknown
- 1998-10-12 PA PA19988461601A patent/PA8461601A1/es unknown
- 1998-10-14 MA MA25298A patent/MA26552A1/fr unknown
- 1998-10-14 TN TNTNSN98185A patent/TNSN98185A1/fr unknown
- 1998-10-14 DZ DZ980234A patent/DZ2624A1/xx active
- 1998-10-14 AR ARP980105113A patent/AR015964A1/es not_active Application Discontinuation
- 1998-10-15 ZA ZA9809412A patent/ZA989412B/xx unknown
- 1998-10-15 UY UY25211A patent/UY25211A1/es unknown
- 1998-10-15 PE PE1998000973A patent/PE121299A1/es not_active Application Discontinuation
- 1998-10-16 CO CO98060365A patent/CO4990959A1/es unknown
- 1998-10-19 AP APAP/P/1998/001366A patent/AP959A/en active
- 1998-12-08 UY UY25291A patent/UY25291A1/es not_active IP Right Cessation
-
2000
- 2000-03-21 IS IS5412A patent/IS5412A/is unknown
- 2000-04-07 OA OA1200000102A patent/OA11348A/en unknown
- 2000-04-11 BG BG104328A patent/BG104328A/bg unknown
- 2000-04-13 NO NO20001924A patent/NO20001924L/no unknown
- 2000-04-14 HR HR20000217A patent/HRP20000217A2/hr not_active Application Discontinuation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BG104328A (bg) | Изохинолини като инхибитори на урокиназа | |
| US6025367A (en) | Sulfonamide derivatives as 5HT7 receptor antagonists | |
| EP1044967B1 (en) | 2-Pyridinylguanidine urokinase inhibitors | |
| KR100567649B1 (ko) | 혈관 내피 성장 인자와 같은 성장 인자의 효과를 억제하는 퀴놀린 유도체 | |
| US7087602B2 (en) | Cinnoline derivatives and use as medicine | |
| US6294532B1 (en) | Oxindolylquinazoline derivatives as angiogenesis inhibitors | |
| US6716841B2 (en) | Nitrogen containing heterobicycles as factor Xa inhibitors | |
| EP2915806B1 (en) | Quinoline compound and use thereof | |
| AU2008345681A1 (en) | Imidazo [1,2-a] pyridine compounds | |
| JP2000510115A (ja) | オキシインドール誘導体 | |
| WO2003055866A1 (en) | Quinazoline and quinoline derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents | |
| US6949578B2 (en) | Cycloalkyl alkanoic acids as integrin receptor antagonists | |
| JP2002527436A (ja) | キナゾリン誘導体 | |
| CA2294240A1 (en) | Antithrombotic agents | |
| SK285141B6 (sk) | Použitie chinazolínového derivátu, chinazolínový derivát, spôsob jeho prípravy a farmaceutická kompozícia, ktorá ho obsahuje | |
| EP1268437A1 (en) | Inhibitors of protein kinases | |
| AU2008345696A1 (en) | Benzimidazole compounds | |
| JPH06228092A (ja) | キノリンおよびインドリンのアミノカルボニル（チオカルボニル）およびシアノグアニジン誘導体 | |
| CA2304117A1 (en) | Integrin receptor antagonists | |
| CZ20001340A3 (cs) | Isochinoliny jako inhibitory urokinázy | |
| US20040043988A1 (en) | Cycloalkyl alkanoic acids as intergrin receptor antagonists | |
| MXPA00003715A (es) | Isoquinolinas | |
| MXPA00003589A (en) | 2-pyridinylguanidine urokinase inhibitors |