BG104138A - 2-аминопиридини, съдържащи заместители с кондензирани пръстени, като nоs инхибитори - Google Patents

2-аминопиридини, съдържащи заместители с кондензирани пръстени, като nоs инхибитори

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Publication number
BG104138A
BG104138A BG104138A BG10413800A BG104138A BG 104138 A BG104138 A BG 104138A BG 104138 A BG104138 A BG 104138A BG 10413800 A BG10413800 A BG 10413800A BG 104138 A BG104138 A BG 104138A
Authority
BG
Bulgaria
Prior art keywords
condensed rings
containing substituents
nos inhibitors
aminopyridines containing
relates
Prior art date
Application number
BG104138A
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English (en)
Inventor
John Adams Lowe
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of BG104138A publication Critical patent/BG104138A/bg

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    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/73Unsubstituted amino or imino radicals
    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00Antineoplastic agents
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
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    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Изобретението се отнася до 2-аминопиридинови производни с формула в която А, R1 и R2 са със значенията, посочени в описанието. Те показват активност като инхибитори на азотнооксидната синтеза (NOS). Изобретението се отнася същодо съдържащи ги фармацевтични състави и до използването им при лечение и профилактика на смущения вцентралната нервна система, възпалителни заболявания, септичен шок и други нарушения.
BG104138A 1997-08-27 2000-02-08 2-аминопиридини, съдържащи заместители с кондензирани пръстени, като nоs инхибитори BG104138A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5709497P 1997-08-27 1997-08-27
PCT/IB1998/001229 WO1999010339A1 (en) 1997-08-27 1998-08-11 2-aminopyridines containing fused ring substituents as nos inhibitors

Publications (1)

Publication Number Publication Date
BG104138A true BG104138A (bg) 2000-11-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BG104138A BG104138A (bg) 1997-08-27 2000-02-08 2-аминопиридини, съдържащи заместители с кондензирани пръстени, като nоs инхибитори

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EP (1) EP1007520B1 (bg)
JP (1) JP3411271B2 (bg)
KR (1) KR100367277B1 (bg)
CN (1) CN1268133A (bg)
AP (1) AP1213A (bg)
AR (1) AR014110A1 (bg)
AT (1) ATE248161T1 (bg)
AU (1) AU8458898A (bg)
BG (1) BG104138A (bg)
BR (1) BR9811555A (bg)
CA (1) CA2296313C (bg)
CO (1) CO4970728A1 (bg)
DE (1) DE69817584T2 (bg)
DK (1) DK1007520T3 (bg)
DZ (1) DZ2594A1 (bg)
EA (1) EA003839B1 (bg)
ES (1) ES2203976T3 (bg)
GT (1) GT199800128A (bg)
HN (1) HN1998000118A (bg)
HR (1) HRP980470A2 (bg)
HU (1) HUP0003700A3 (bg)
ID (1) ID24087A (bg)
IL (1) IL133958A0 (bg)
IS (1) IS5344A (bg)
MA (1) MA26537A1 (bg)
NO (1) NO20000958L (bg)
NZ (1) NZ502281A (bg)
OA (1) OA11288A (bg)
PA (1) PA8456901A1 (bg)
PE (1) PE106599A1 (bg)
PL (1) PL338987A1 (bg)
PT (1) PT1007520E (bg)
SK (1) SK1402000A3 (bg)
TN (1) TNSN98154A1 (bg)
TR (1) TR200000535T2 (bg)
UA (1) UA55461C2 (bg)
UY (1) UY25158A1 (bg)
WO (1) WO1999010339A1 (bg)
YU (1) YU10900A (bg)
ZA (1) ZA987726B (bg)

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GB0004153D0 (en) * 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel use
GB0004152D0 (en) 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel compounds
GB0004149D0 (en) 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel compounds
GB0004151D0 (en) * 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel use
FR2805818B1 (fr) * 2000-03-03 2002-04-26 Aventis Pharma Sa Derives d'azetidine, leur preparation et les compositions pharmaceutiques les contenant
BR0112939A (pt) * 2000-08-16 2005-11-01 Upjohn Co Compostos para o tratamento de distúrbios de dependência
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DE60318860T2 (de) * 2002-08-14 2008-05-21 Neurosearch A/S Chinucledin - derivate und deren verwendung
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AU2004325725A1 (en) * 2004-12-10 2006-06-22 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
WO2009029617A1 (en) * 2007-08-27 2009-03-05 Kalypsys, Inc. Diarylamine-substituted quinolones useful as inducible nitric oxide synthase inhibitors
TW200924772A (en) * 2007-08-27 2009-06-16 Kalypsys Inc Heterobicyclic-substituted quinolones useful as nitric oxide synthase inhibitors
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
DE102008054141A1 (de) 2008-10-31 2010-05-06 Merck Patent Gmbh Neue Materialien für organische Elektrolumineszenzvorrichtungen
DE102009033371A1 (de) 2009-07-16 2011-05-12 Merck Patent Gmbh Materialien für elektronische Vorrichtungen
US9120750B2 (en) 2013-03-07 2015-09-01 Northwestern University 2-Aminopyridine-based selective neuronal nitric oxide synthase inhibitors
CN104725249B (zh) * 2013-12-20 2019-02-12 广东东阳光药业有限公司 苄胺类衍生物及其在药物上的应用
US9951014B2 (en) 2014-11-04 2018-04-24 Northwestern University Mammalian and bacterial nitric oxide synthase inhibitors
US10759791B2 (en) 2014-11-04 2020-09-01 Northwestern University Mammalian and bacterial nitric oxide synthase inhibitors
CN106478376A (zh) * 2016-10-08 2017-03-08 贵州大学 一种4‑氟萘‑1‑醇的制备工艺
CN114560779A (zh) * 2022-01-25 2022-05-31 杭州华东医药集团浙江华义制药有限公司 一种米拉贝隆关键中间体的合成方法

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NZ502281A (en) 2002-09-27
KR20010022433A (ko) 2001-03-15
CA2296313A1 (en) 1999-03-04
OA11288A (en) 2003-08-22
YU10900A (sh) 2002-12-10
ZA987726B (en) 2000-02-28
EA200000171A1 (ru) 2000-10-30
SK1402000A3 (en) 2000-07-11
ES2203976T3 (es) 2004-04-16
EP1007520A1 (en) 2000-06-14
DE69817584D1 (de) 2003-10-02
PA8456901A1 (es) 2000-05-24
EA003839B1 (ru) 2003-10-30
CO4970728A1 (es) 2000-11-07
JP2001514176A (ja) 2001-09-11
ATE248161T1 (de) 2003-09-15
CN1268133A (zh) 2000-09-27
AP9801330A0 (en) 1998-09-30
PL338987A1 (en) 2000-12-04
AP1213A (en) 2003-10-07
UA55461C2 (uk) 2003-04-15
ID24087A (id) 2000-07-06
HUP0003700A3 (en) 2002-09-30
DZ2594A1 (fr) 2003-02-22
HUP0003700A2 (hu) 2001-10-28
DE69817584T2 (de) 2004-04-01
KR100367277B1 (ko) 2003-01-09
IL133958A0 (en) 2001-04-30
JP3411271B2 (ja) 2003-05-26
NO20000958L (no) 2000-04-14
PT1007520E (pt) 2003-12-31
NO20000958D0 (no) 2000-02-25
PE106599A1 (es) 1999-11-02
TR200000535T2 (tr) 2000-11-21
UY25158A1 (es) 2000-12-29
TNSN98154A1 (fr) 2005-03-15
GT199800128A (es) 2000-02-01
BR9811555A (pt) 2000-09-12
WO1999010339A1 (en) 1999-03-04
AU8458898A (en) 1999-03-16
DK1007520T3 (da) 2003-11-24
HRP980470A2 (en) 1999-06-30
HN1998000118A (es) 1999-02-09
IS5344A (is) 2000-01-14
EP1007520B1 (en) 2003-08-27
MA26537A1 (fr) 2004-12-20
AR014110A1 (es) 2001-02-07
CA2296313C (en) 2004-11-02

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