BG104122A - 2-{3-[4-(2-tret.-butyl-6-trifluoromethylpyrimidin-4-yl)piperazin-1 -yl]propylmercapto}pyrimidin-4-ol fumarate - Google Patents
2-{3-[4-(2-tret.-butyl-6-trifluoromethylpyrimidin-4-yl)piperazin-1 -yl]propylmercapto}pyrimidin-4-ol fumarateInfo
- Publication number
- BG104122A BG104122A BG104122A BG10412200A BG104122A BG 104122 A BG104122 A BG 104122A BG 104122 A BG104122 A BG 104122A BG 10412200 A BG10412200 A BG 10412200A BG 104122 A BG104122 A BG 104122A
- Authority
- BG
- Bulgaria
- Prior art keywords
- propylmercapto
- trifluoromethylpyrimidin
- tret
- piperazin
- pyrimidin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19735410A DE19735410A1 (de) | 1997-08-14 | 1997-08-14 | 2-{3-[4-(2-t-Butyl-6-trifluormethylpyrimidin-4-yl)piperazin-1-yl]propylmercapto}pyrimidin-4-ol-fumarat |
PCT/EP1998/005178 WO1999009015A1 (de) | 1997-08-14 | 1998-08-14 | 2-{3-[4-(2-t-butyl-6- trifluormethylpyrimidin-4-yl) piperrazin-1-yl] propylmercapto} pyrimidin-4-ol-fumarat |
Publications (1)
Publication Number | Publication Date |
---|---|
BG104122A true BG104122A (en) | 2000-11-30 |
Family
ID=7839072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG104122A BG104122A (en) | 1997-08-14 | 2000-02-03 | 2-{3-[4-(2-tret.-butyl-6-trifluoromethylpyrimidin-4-yl)piperazin-1 -yl]propylmercapto}pyrimidin-4-ol fumarate |
Country Status (25)
Country | Link |
---|---|
US (1) | US20010020022A1 (ko) |
EP (2) | EP2272833A1 (ko) |
JP (1) | JP4444492B2 (ko) |
KR (1) | KR100571945B1 (ko) |
CN (1) | CN1267286A (ko) |
AR (1) | AR016605A1 (ko) |
AT (1) | ATE525362T1 (ko) |
AU (1) | AU749575B2 (ko) |
BG (1) | BG104122A (ko) |
BR (1) | BR9811177A (ko) |
CA (1) | CA2301297A1 (ko) |
CO (1) | CO4960663A1 (ko) |
DE (1) | DE19735410A1 (ko) |
ES (1) | ES2374156T3 (ko) |
HU (1) | HUP0003710A3 (ko) |
ID (1) | ID24639A (ko) |
IL (1) | IL134246A (ko) |
NO (1) | NO314935B1 (ko) |
NZ (1) | NZ502675A (ko) |
PL (1) | PL201927B1 (ko) |
SK (1) | SK1182000A3 (ko) |
TR (1) | TR200000406T2 (ko) |
TW (1) | TW467912B (ko) |
WO (1) | WO1999009015A1 (ko) |
ZA (1) | ZA987239B (ko) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001250404A1 (en) * | 2000-03-27 | 2001-10-08 | Basf Aktiengesellschaft | Use of dopamine-d3 receptor ligands for the treatment of diseases of the central nervous system |
DE102004027358A1 (de) | 2004-06-04 | 2005-12-29 | Abbott Gmbh & Co. Kg | Pyrimidinverbindungen und ihre Verwendung |
MX2007001530A (es) * | 2004-08-09 | 2007-04-23 | Abbott Gmbh & Co Kg | Compuestos de 4-piperazinil-pirimidina adecuados para tratar trastornos que responde a la modulacion del receptor dopamina d3. |
CN102887860B (zh) * | 2012-09-29 | 2015-07-01 | 上海泰坦科技有限公司 | 4-氯-6-三氟甲基嘧啶类化合物的制备方法 |
ES2734268T3 (es) | 2012-10-11 | 2019-12-05 | Southern Res Inst | Derivados de urea y amida de aminoalquilpiperazinas y uso de los mismos |
US9376396B2 (en) | 2012-10-22 | 2016-06-28 | AbbVie Deutschland GmbH & Co. KG | Acylaminocycloalkyl compounds suitable for treating disorders that respond to modulation of dopamine D3 receptor |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4425143A1 (de) | 1994-07-15 | 1996-01-18 | Basf Ag | Substituierte Pyrimidinverbindungen und deren Verwendung |
-
1997
- 1997-08-14 DE DE19735410A patent/DE19735410A1/de not_active Withdrawn
-
1998
- 1998-08-12 TW TW087113230A patent/TW467912B/zh not_active IP Right Cessation
- 1998-08-12 AR ARP980103980A patent/AR016605A1/es not_active Application Discontinuation
- 1998-08-13 ZA ZA9807239A patent/ZA987239B/xx unknown
- 1998-08-13 CO CO98046527A patent/CO4960663A1/es unknown
- 1998-08-14 EP EP10179278A patent/EP2272833A1/de not_active Withdrawn
- 1998-08-14 HU HU0003710A patent/HUP0003710A3/hu unknown
- 1998-08-14 BR BR9811177-9A patent/BR9811177A/pt not_active IP Right Cessation
- 1998-08-14 US US09/485,460 patent/US20010020022A1/en not_active Abandoned
- 1998-08-14 KR KR1020007001435A patent/KR100571945B1/ko not_active IP Right Cessation
- 1998-08-14 ID IDW20000266A patent/ID24639A/id unknown
- 1998-08-14 AT AT98946343T patent/ATE525362T1/de active
- 1998-08-14 NZ NZ502675A patent/NZ502675A/en not_active IP Right Cessation
- 1998-08-14 PL PL338603A patent/PL201927B1/pl unknown
- 1998-08-14 WO PCT/EP1998/005178 patent/WO1999009015A1/de not_active Application Discontinuation
- 1998-08-14 CA CA002301297A patent/CA2301297A1/en not_active Abandoned
- 1998-08-14 TR TR2000/00406T patent/TR200000406T2/xx unknown
- 1998-08-14 SK SK118-2000A patent/SK1182000A3/sk unknown
- 1998-08-14 AU AU93426/98A patent/AU749575B2/en not_active Ceased
- 1998-08-14 IL IL13424698A patent/IL134246A/en not_active IP Right Cessation
- 1998-08-14 EP EP98946343A patent/EP1003728B1/de not_active Expired - Lifetime
- 1998-08-14 JP JP2000509698A patent/JP4444492B2/ja not_active Expired - Lifetime
- 1998-08-14 CN CN98808156A patent/CN1267286A/zh active Pending
- 1998-08-14 ES ES98946343T patent/ES2374156T3/es not_active Expired - Lifetime
-
2000
- 2000-02-03 BG BG104122A patent/BG104122A/xx unknown
- 2000-02-10 NO NO20000665A patent/NO314935B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
DE19735410A1 (de) | 1999-02-18 |
ID24639A (id) | 2000-07-27 |
CA2301297A1 (en) | 1999-02-25 |
NZ502675A (en) | 2001-06-29 |
JP4444492B2 (ja) | 2010-03-31 |
IL134246A0 (en) | 2001-04-30 |
HUP0003710A2 (hu) | 2001-10-28 |
KR100571945B1 (ko) | 2006-04-18 |
AU749575B2 (en) | 2002-06-27 |
CN1267286A (zh) | 2000-09-20 |
NO20000665D0 (no) | 2000-02-10 |
ES2374156T3 (es) | 2012-02-14 |
WO1999009015A1 (de) | 1999-02-25 |
TR200000406T2 (tr) | 2000-05-22 |
US20010020022A1 (en) | 2001-09-06 |
HUP0003710A3 (en) | 2002-01-28 |
SK1182000A3 (en) | 2000-09-12 |
ZA987239B (en) | 2000-02-14 |
KR20010022833A (ko) | 2001-03-26 |
PL338603A1 (en) | 2000-11-06 |
AU9342698A (en) | 1999-03-08 |
EP1003728B1 (de) | 2011-09-21 |
CO4960663A1 (es) | 2000-09-25 |
AR016605A1 (es) | 2001-07-25 |
JP2001515070A (ja) | 2001-09-18 |
NO314935B1 (no) | 2003-06-16 |
BR9811177A (pt) | 2000-07-25 |
EP2272833A1 (de) | 2011-01-12 |
IL134246A (en) | 2002-11-10 |
TW467912B (en) | 2001-12-11 |
ATE525362T1 (de) | 2011-10-15 |
EP1003728A1 (de) | 2000-05-31 |
NO20000665L (no) | 2000-02-10 |
PL201927B1 (pl) | 2009-05-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1024232A1 (en) | Therapeutically active levorotatory and dextrorotatory 1-((4-chlorophenyl)phenylmethyl)piperazines | |
NO995006L (no) | Nye forbindelser | |
MX9605128A (es) | Nuevos derivados de aminoacidos, procedimientos para su preparacion y composiciones farmaceuticas que contienen estos compuestos. | |
IL118889A0 (en) | N-(aroyl) glycine hydroxamic acid derivatives and related compounds | |
TR200000129T2 (tr) | Yepyeni spiroazabisiklik heterosiklik bileşikler. | |
MY114389A (en) | Aqueous risperidone formulations | |
ZA200102105B (en) | Stable concentrated insulin preparations for pulmonary. | |
CA2004747A1 (en) | Substituted phenylpyrimidines useful in the treatment of cns disorders | |
SE9301830D0 (sv) | New compounds | |
WO2002000209A3 (en) | Gabapentin analogues for sleep disorders | |
HRP20010584B1 (en) | N-[2-hydroxy-3-(1-piperidinyl)propoxy]pyridine-1-oxide-3-carboximidoyl chloride and its use in the treatment of insulin resistance | |
TW223061B (en) | 9-(3-cyanophenyl)-3,4,6,7,9,10-hexahydro-1,8-(2h,5h)-acridinedione and pharmaceutical compositions containing same | |
BG104122A (en) | 2-{3-[4-(2-tret.-butyl-6-trifluoromethylpyrimidin-4-yl)piperazin-1 -yl]propylmercapto}pyrimidin-4-ol fumarate | |
WO2003031447A3 (de) | Pyrimidinderivate mit pde-v hemmender wirkung | |
ES2108595A1 (es) | Derivados de la 3(2h)-piridacinona y procedimiento para su preparacion. | |
IL162314A0 (en) | Use of pyridine-2,4-dicarboxylic acid diamides andof pyrimidine-4,6-dicarboxylic acid diamides for selective collagenase inhibition | |
MY103210A (en) | Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds. | |
MX9701996A (es) | Utlizacion de 3-oxo de 2, 4-diamino-pirimidina o una de sus sales en el tratamiento de desordenes dela maduracion y de la estructuracion del colageno. | |
AU3523295A (en) | Quinoxaline derivatives useful in therapy | |
TR199801184T2 (xx) | Analjezik tesirli yeni bile�ikler. | |
TW349864B (en) | Use of N-(pyridinyl)-1H-indol-a-amines for the preparation of a medicament for the treatment of obsessive-compulsive disorders | |
GB0112494D0 (en) | New therapeutic use | |
ATE44875T1 (de) | 4-amino-2-(imidazolidin-2-on-l-yl)-pyrimidin-5carbons|ure-(n-(3-trifluormethyl-phenyl)-amide) zur antithrombotischen prophylaxe und behandlung sowie ihre verwendung zur herstellung von antithrombotisch wirksamen arzneimitteln. | |
GR3023896T3 (en) | 2,3,4,5-tetrahydro-1h-3-benzazepines and pharmaceutically acceptable acid addition salts thereof. | |
CA2283083A1 (en) | Use of 2,3,4,5-tetrahydro-1h-3-benzazepines for the manufacture of a pharmaceutical composition for the treatment of sleep disorders |