TR200000406T2 - 2-{3-[4-(2-T-Butil-6-Triflormetilpirimidin-4-il) piperazin-1-il] propilmerkapto} pirimidin-4-ol-fümerat. - Google Patents

2-{3-[4-(2-T-Butil-6-Triflormetilpirimidin-4-il) piperazin-1-il] propilmerkapto} pirimidin-4-ol-fümerat.

Info

Publication number
TR200000406T2
TR200000406T2 TR2000/00406T TR200000406T TR200000406T2 TR 200000406 T2 TR200000406 T2 TR 200000406T2 TR 2000/00406 T TR2000/00406 T TR 2000/00406T TR 200000406 T TR200000406 T TR 200000406T TR 200000406 T2 TR200000406 T2 TR 200000406T2
Authority
TR
Turkey
Prior art keywords
propylmercapto
trifluoromethylpyrimidin
piperazin
pyrimidin
butyl
Prior art date
Application number
TR2000/00406T
Other languages
English (en)
Inventor
Blank Stefan
Starck Dorothea
Treiber Hans-Jorg
Koser Stefan
Schafer Bernd
Thyes Marco
H�Ger Thomas
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of TR200000406T2 publication Critical patent/TR200000406T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Eldeki bulus 2-{3-[4-(2-t-butil-6-triflormetilpirimidin-4-il) piperazin-1-il]propilmerkapto} pirimidin-4-ol' ün fümerik asit tuzunu ve bu tuzu içeren farmasötik maddeleri kapsamaktadir. Bu tuz dopamin-D3-ligantlarina tepki veren hastaliklarin tedavisi açisindan yararlidir. Düsük pH altinda yüksek bir saglamliga sahiptir ve bu nedenle özellikle oral uygulama için uygundur.
TR2000/00406T 1997-08-14 1998-08-14 2-{3-[4-(2-T-Butil-6-Triflormetilpirimidin-4-il) piperazin-1-il] propilmerkapto} pirimidin-4-ol-fümerat. TR200000406T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19735410A DE19735410A1 (de) 1997-08-14 1997-08-14 2-{3-[4-(2-t-Butyl-6-trifluormethylpyrimidin-4-yl)piperazin-1-yl]propylmercapto}pyrimidin-4-ol-fumarat

Publications (1)

Publication Number Publication Date
TR200000406T2 true TR200000406T2 (tr) 2000-05-22

Family

ID=7839072

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00406T TR200000406T2 (tr) 1997-08-14 1998-08-14 2-{3-[4-(2-T-Butil-6-Triflormetilpirimidin-4-il) piperazin-1-il] propilmerkapto} pirimidin-4-ol-fümerat.

Country Status (25)

Country Link
US (1) US20010020022A1 (tr)
EP (2) EP2272833A1 (tr)
JP (1) JP4444492B2 (tr)
KR (1) KR100571945B1 (tr)
CN (1) CN1267286A (tr)
AR (1) AR016605A1 (tr)
AT (1) ATE525362T1 (tr)
AU (1) AU749575B2 (tr)
BG (1) BG104122A (tr)
BR (1) BR9811177A (tr)
CA (1) CA2301297A1 (tr)
CO (1) CO4960663A1 (tr)
DE (1) DE19735410A1 (tr)
ES (1) ES2374156T3 (tr)
HU (1) HUP0003710A3 (tr)
ID (1) ID24639A (tr)
IL (1) IL134246A (tr)
NO (1) NO314935B1 (tr)
NZ (1) NZ502675A (tr)
PL (1) PL201927B1 (tr)
SK (1) SK1182000A3 (tr)
TR (1) TR200000406T2 (tr)
TW (1) TW467912B (tr)
WO (1) WO1999009015A1 (tr)
ZA (1) ZA987239B (tr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001072306A1 (de) * 2000-03-27 2001-10-04 Basf Aktiengesellschaft Verwendung von dopamin-d3-rezeptor-liganden zur behandlung von erkrankungen des zentralen nervensystems
DE102004027358A1 (de) 2004-06-04 2005-12-29 Abbott Gmbh & Co. Kg Pyrimidinverbindungen und ihre Verwendung
MX2007001530A (es) * 2004-08-09 2007-04-23 Abbott Gmbh & Co Kg Compuestos de 4-piperazinil-pirimidina adecuados para tratar trastornos que responde a la modulacion del receptor dopamina d3.
CN102887860B (zh) * 2012-09-29 2015-07-01 上海泰坦科技有限公司 4-氯-6-三氟甲基嘧啶类化合物的制备方法
EA029054B1 (ru) 2012-10-11 2018-02-28 Саузерн Рисерч Инститьют Мочевинные и амидные производные аминоалкилпиперазинов и их применение
US9376396B2 (en) 2012-10-22 2016-06-28 AbbVie Deutschland GmbH & Co. KG Acylaminocycloalkyl compounds suitable for treating disorders that respond to modulation of dopamine D3 receptor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4425143A1 (de) * 1994-07-15 1996-01-18 Basf Ag Substituierte Pyrimidinverbindungen und deren Verwendung

Also Published As

Publication number Publication date
NZ502675A (en) 2001-06-29
HUP0003710A3 (en) 2002-01-28
WO1999009015A1 (de) 1999-02-25
NO20000665L (no) 2000-02-10
BG104122A (en) 2000-11-30
TW467912B (en) 2001-12-11
AR016605A1 (es) 2001-07-25
ATE525362T1 (de) 2011-10-15
US20010020022A1 (en) 2001-09-06
KR20010022833A (ko) 2001-03-26
CO4960663A1 (es) 2000-09-25
NO314935B1 (no) 2003-06-16
IL134246A (en) 2002-11-10
PL338603A1 (en) 2000-11-06
ZA987239B (en) 2000-02-14
SK1182000A3 (en) 2000-09-12
JP2001515070A (ja) 2001-09-18
ES2374156T3 (es) 2012-02-14
BR9811177A (pt) 2000-07-25
NO20000665D0 (no) 2000-02-10
KR100571945B1 (ko) 2006-04-18
HUP0003710A2 (hu) 2001-10-28
AU749575B2 (en) 2002-06-27
PL201927B1 (pl) 2009-05-29
DE19735410A1 (de) 1999-02-18
EP1003728A1 (de) 2000-05-31
AU9342698A (en) 1999-03-08
CN1267286A (zh) 2000-09-20
JP4444492B2 (ja) 2010-03-31
CA2301297A1 (en) 1999-02-25
IL134246A0 (en) 2001-04-30
EP1003728B1 (de) 2011-09-21
EP2272833A1 (de) 2011-01-12
ID24639A (id) 2000-07-27

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