BG103684A - Производни на 2,3-дихидрофуро/3,2-в/пиридин, метод за тяхното получаване и използването им в терапията - Google Patents

Производни на 2,3-дихидрофуро/3,2-в/пиридин, метод за тяхното получаване и използването им в терапията

Info

Publication number
BG103684A
BG103684A BG103684A BG10368499A BG103684A BG 103684 A BG103684 A BG 103684A BG 103684 A BG103684 A BG 103684A BG 10368499 A BG10368499 A BG 10368499A BG 103684 A BG103684 A BG 103684A
Authority
BG
Bulgaria
Prior art keywords
alkyl group
dihydrofluoro
pyridin
therapy
derivatives
Prior art date
Application number
BG103684A
Other languages
English (en)
Inventor
Alistair Lochead
Samir Jegham
Frederic Galli
Thierry Gallet
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of BG103684A publication Critical patent/BG103684A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Съединенията са мощни и селективни холинергични лиганди за никотиновите рецептори. Могат да бъдат използвани за лечение или предотвратяване на смущения, свързани с дисфункция на никотиновите рецептори, на ниво централна нервна система или на стомашно-чревната система. Те са с обща формула@@в която R1 означава водороден атом, (С1-С6) алкилова групаили фенил (С1-С4) алкилова група; R2 е водороден атом или (С1-С6) алкилова група и R3, R4 и R5 означават всеки независимо един от друг, водороден илихалогенен атом, или трифлуорометилова, циано, хидрокси, (С1-С6) алкилова или (С1-С6) алкоксигрупа.
BG103684A 1997-03-20 1999-08-24 Производни на 2,3-дихидрофуро/3,2-в/пиридин, метод за тяхното получаване и използването им в терапията BG103684A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9703395A FR2761072B1 (fr) 1997-03-20 1997-03-20 Derives de 2,3-dihydrofuro[3,2-b]pyridine, leur preparation et leur application en therapeutique
PCT/FR1998/000531 WO1998042713A1 (fr) 1997-03-20 1998-03-17 DERIVES DE 2,3-DIHYDROFURO[3,2-b]PYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (1)

Publication Number Publication Date
BG103684A true BG103684A (bg) 2000-06-30

Family

ID=9505006

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103684A BG103684A (bg) 1997-03-20 1999-08-24 Производни на 2,3-дихидрофуро/3,2-в/пиридин, метод за тяхното получаване и използването им в терапията

Country Status (22)

Country Link
US (1) US6143761A (bg)
EP (1) EP0971929A1 (bg)
JP (1) JP2001518099A (bg)
KR (1) KR20000076282A (bg)
CN (1) CN1251105A (bg)
AR (1) AR012097A1 (bg)
AU (1) AU6924298A (bg)
BG (1) BG103684A (bg)
BR (1) BR9808346A (bg)
CA (1) CA2282320A1 (bg)
CO (1) CO4940417A1 (bg)
EE (1) EE9900414A (bg)
FR (1) FR2761072B1 (bg)
HU (1) HUP0002335A3 (bg)
IL (1) IL131254A0 (bg)
NO (1) NO994527L (bg)
NZ (1) NZ337566A (bg)
PL (1) PL335759A1 (bg)
SK (1) SK127699A3 (bg)
TR (1) TR199902115T2 (bg)
WO (1) WO1998042713A1 (bg)
ZA (1) ZA982365B (bg)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790474B1 (fr) 1999-03-05 2001-04-06 Synthelabo Derives de pyridopyranoazepines, leur preparation et leur application en therapeutique
SE9902267D0 (sv) * 1999-06-16 1999-06-16 Astra Ab New compounds
JP2005104838A (ja) * 2003-01-09 2005-04-21 Tanabe Seiyaku Co Ltd 縮合フラン化合物
US7780981B2 (en) 2004-09-13 2010-08-24 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery
KR20110075044A (ko) 2007-04-02 2011-07-05 파킨슨즈 인스티튜트 처치 치료의 부작용을 감소시키기 위한 방법 및 조성물
CA2974324A1 (en) 2015-01-28 2016-08-04 Zita S. Netzel Drug delivery methods and systems
US9585867B2 (en) 2015-08-06 2017-03-07 Charles Everett Ankner Cannabinod formulation for the sedation of a human or animal
WO2018129304A1 (en) 2017-01-06 2018-07-12 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
US11596779B2 (en) 2018-05-29 2023-03-07 Morningside Venture Investments Limited Drug delivery methods and systems

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4176147B2 (ja) * 1995-07-28 2008-11-05 アボツト・ラボラトリーズ 化学的シナプス伝達の制御に有用なフロピリジン、チエノピリジン、ピロロピリジンおよび関連するピリミジン、ピリダジンおよびトリアジン化合物

Also Published As

Publication number Publication date
CA2282320A1 (en) 1998-10-01
FR2761072A1 (fr) 1998-09-25
PL335759A1 (en) 2000-05-22
TR199902115T2 (xx) 2000-01-21
KR20000076282A (ko) 2000-12-26
HUP0002335A2 (hu) 2001-05-28
JP2001518099A (ja) 2001-10-09
AR012097A1 (es) 2000-09-27
SK127699A3 (en) 2000-05-16
CN1251105A (zh) 2000-04-19
ZA982365B (en) 1998-09-23
NZ337566A (en) 2000-09-29
BR9808346A (pt) 2000-05-23
IL131254A0 (en) 2001-01-28
CO4940417A1 (es) 2000-07-24
NO994527L (no) 1999-11-18
US6143761A (en) 2000-11-07
EE9900414A (et) 2000-04-17
HUP0002335A3 (en) 2002-07-29
AU6924298A (en) 1998-10-20
WO1998042713A1 (fr) 1998-10-01
EP0971929A1 (fr) 2000-01-19
NO994527D0 (no) 1999-09-17
FR2761072B1 (fr) 1999-04-23

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