BG103414A - N-(имидазолилбутил) бензенсулфонамидни производни, метод за тяхното получаване и използването им като лекарствени средства - Google Patents
N-(имидазолилбутил) бензенсулфонамидни производни, метод за тяхното получаване и използването им като лекарствени средстваInfo
- Publication number
- BG103414A BG103414A BG103414A BG10341499A BG103414A BG 103414 A BG103414 A BG 103414A BG 103414 A BG103414 A BG 103414A BG 10341499 A BG10341499 A BG 10341499A BG 103414 A BG103414 A BG 103414A
- Authority
- BG
- Bulgaria
- Prior art keywords
- group
- alkyl
- prepraration
- imidazolylbutyl
- medicaments
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/68—Halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Съединенията имат формула в която R1 и R'1 означават водород, халоген или (С1-С4)алкил, R2 означава пиперидин-1-ил, 1,2,3,6-тетрахидропиридин-1-ил, в даден случай заместени, хексахидро-1Н-азепин-1-ил, хептахидроазоцин-1-ил или октахидро-1Н-азонин-1-илова група, или групата, в която а-В е -СОNR", m има стойност 1 до 2, а р - от 1 до 2, в която Q е въглероден или азотен атом, D e (С1-С4)-алкил или -СН2CF2 и r има стойност 1 до 3,R3 е (С1-С5)-алкил или -СОR5, като R5 e (C1-C4)алкил, -(СН2)nOCH3, -CH20(C2H40)nCH3, -(CH2)nCF3 или-(CH2)nOH, като n има стойност 1 до 4; -SO2R6 група, -СОNHR6 група, или -SO2N(R6)2 група, като R6 e(С1-С4)алкил; R4 е водород или халоген и А е фенил или хетероциклил, в даден случай заместени, или цикло-(С5-С8)-алкилова група. Изобретението се отнася и до метод за получаване на посочените съединения и до приложението им като лекарствени средства.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9614309A FR2756285B1 (fr) | 1996-11-22 | 1996-11-22 | Derives de n-(imidazolylbutyle)benzenesulfonamide, leur preparation et leur application en therapeutique |
PCT/FR1997/002079 WO1998022443A1 (fr) | 1996-11-22 | 1997-11-19 | Derives de n-(imidazolylbutyle) benzenesulfonamide ayant une activite antithrombotique |
Publications (1)
Publication Number | Publication Date |
---|---|
BG103414A true BG103414A (bg) | 2000-01-31 |
Family
ID=9497920
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG103414A BG103414A (bg) | 1996-11-22 | 1999-05-19 | N-(имидазолилбутил) бензенсулфонамидни производни, метод за тяхното получаване и използването им като лекарствени средства |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0946517A1 (bg) |
JP (1) | JP2001504128A (bg) |
KR (1) | KR20000069063A (bg) |
CN (1) | CN1238765A (bg) |
AR (1) | AR009627A1 (bg) |
AU (1) | AU5226498A (bg) |
BG (1) | BG103414A (bg) |
BR (1) | BR9713291A (bg) |
CA (1) | CA2270478A1 (bg) |
CO (1) | CO4910158A1 (bg) |
CZ (1) | CZ178299A3 (bg) |
EE (1) | EE9900201A (bg) |
FR (1) | FR2756285B1 (bg) |
HU (1) | HUP9904599A2 (bg) |
IL (1) | IL129546A0 (bg) |
NO (1) | NO992436L (bg) |
SK (1) | SK66799A3 (bg) |
TR (1) | TR199901143T2 (bg) |
WO (1) | WO1998022443A1 (bg) |
ZA (1) | ZA9710515B (bg) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2783521B1 (fr) * | 1998-09-18 | 2002-04-26 | Synthelabo | Derives de n-(arginyl) benzenesulfonamide, leur preparation et leur application en therapeutique |
FR2806722B1 (fr) * | 2000-03-23 | 2002-05-17 | Sanofi Synthelabo | Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique |
CN107207403A (zh) | 2014-09-29 | 2017-09-26 | 塞尔利克斯生物私人有限公司 | 用于治疗多发性硬化的组合物和方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2689130B1 (fr) * | 1992-03-30 | 1994-05-27 | Synthelabo | Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique. |
FR2710066B1 (fr) * | 1993-09-14 | 1995-10-20 | Synthelabo | Dérivés de 1-[2-amino-5-[1-(triphénylméthyl-1H-imidazol-4-yl]-1-oxopentyl]piperidine, leur préparation et leur utilisation comme intermédiaires de synthèse. |
FR2727410B1 (fr) * | 1994-11-25 | 1996-12-20 | Synthelabo | Chlorures de sulfonyles, leur preparation et leur utilisation comme intermediaires de synthese |
FR2728570B1 (fr) * | 1994-12-23 | 1997-04-11 | Synthelabo | Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique |
DE19548797A1 (de) * | 1995-12-27 | 1997-07-03 | Thomae Gmbh Dr K | Substituierte 2-Amino-imidazole, ihre Herstellung und ihre Verwendung als Arzneimittel |
-
1996
- 1996-11-22 FR FR9614309A patent/FR2756285B1/fr not_active Expired - Fee Related
-
1997
- 1997-11-19 BR BR9713291-8A patent/BR9713291A/pt not_active Application Discontinuation
- 1997-11-19 WO PCT/FR1997/002079 patent/WO1998022443A1/fr not_active Application Discontinuation
- 1997-11-19 SK SK667-99A patent/SK66799A3/sk unknown
- 1997-11-19 EE EEP199900201A patent/EE9900201A/xx unknown
- 1997-11-19 IL IL12954697A patent/IL129546A0/xx unknown
- 1997-11-19 CO CO97067574A patent/CO4910158A1/es unknown
- 1997-11-19 CZ CZ991782A patent/CZ178299A3/cs unknown
- 1997-11-19 AU AU52264/98A patent/AU5226498A/en not_active Abandoned
- 1997-11-19 KR KR1019997004485A patent/KR20000069063A/ko not_active Application Discontinuation
- 1997-11-19 CA CA002270478A patent/CA2270478A1/en not_active Abandoned
- 1997-11-19 CN CN97199986A patent/CN1238765A/zh active Pending
- 1997-11-19 EP EP97947089A patent/EP0946517A1/fr not_active Ceased
- 1997-11-19 TR TR1999/01143T patent/TR199901143T2/xx unknown
- 1997-11-19 HU HU9904599A patent/HUP9904599A2/hu unknown
- 1997-11-19 JP JP52328498A patent/JP2001504128A/ja active Pending
- 1997-11-21 ZA ZA9710515A patent/ZA9710515B/xx unknown
- 1997-11-21 AR ARP970105455A patent/AR009627A1/es unknown
-
1999
- 1999-05-19 BG BG103414A patent/BG103414A/bg unknown
- 1999-05-20 NO NO992436A patent/NO992436L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HUP9904599A2 (hu) | 2000-06-28 |
SK66799A3 (en) | 2000-02-14 |
NO992436D0 (no) | 1999-05-20 |
WO1998022443A1 (fr) | 1998-05-28 |
EP0946517A1 (fr) | 1999-10-06 |
CO4910158A1 (es) | 2000-04-24 |
CA2270478A1 (en) | 1998-05-28 |
EE9900201A (et) | 1999-12-15 |
NO992436L (no) | 1999-07-22 |
FR2756285B1 (fr) | 1998-12-18 |
CZ178299A3 (cs) | 1999-08-11 |
JP2001504128A (ja) | 2001-03-27 |
AR009627A1 (es) | 2000-04-26 |
ZA9710515B (en) | 1998-06-10 |
FR2756285A1 (fr) | 1998-05-29 |
CN1238765A (zh) | 1999-12-15 |
KR20000069063A (ko) | 2000-11-25 |
IL129546A0 (en) | 2000-02-29 |
BR9713291A (pt) | 1999-10-26 |
TR199901143T2 (xx) | 1999-08-23 |
AU5226498A (en) | 1998-06-10 |
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