BG103414A - N-(имидазолилбутил) бензенсулфонамидни производни, метод за тяхното получаване и използването им като лекарствени средства - Google Patents

N-(имидазолилбутил) бензенсулфонамидни производни, метод за тяхното получаване и използването им като лекарствени средства

Info

Publication number
BG103414A
BG103414A BG103414A BG10341499A BG103414A BG 103414 A BG103414 A BG 103414A BG 103414 A BG103414 A BG 103414A BG 10341499 A BG10341499 A BG 10341499A BG 103414 A BG103414 A BG 103414A
Authority
BG
Bulgaria
Prior art keywords
group
alkyl
prepraration
imidazolylbutyl
medicaments
Prior art date
Application number
BG103414A
Other languages
English (en)
Inventor
Jean-Michel Altenburger
Gilbert Lassalle
Valerie Martin
Daniel Galtier
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo filed Critical Synthelabo
Publication of BG103414A publication Critical patent/BG103414A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Съединенията имат формула в която R1 и R'1 означават водород, халоген или (С1-С4)алкил, R2 означава пиперидин-1-ил, 1,2,3,6-тетрахидропиридин-1-ил, в даден случай заместени, хексахидро-1Н-азепин-1-ил, хептахидроазоцин-1-ил или октахидро-1Н-азонин-1-илова група, или групата, в която а-В е -СОNR", m има стойност 1 до 2, а р - от 1 до 2, в която Q е въглероден или азотен атом, D e (С1-С4)-алкил или -СН2CF2 и r има стойност 1 до 3,R3 е (С1-С5)-алкил или -СОR5, като R5 e (C1-C4)алкил, -(СН2)nOCH3, -CH20(C2H40)nCH3, -(CH2)nCF3 или-(CH2)nOH, като n има стойност 1 до 4; -SO2R6 група, -СОNHR6 група, или -SO2N(R6)2 група, като R6 e(С1-С4)алкил; R4 е водород или халоген и А е фенил или хетероциклил, в даден случай заместени, или цикло-(С5-С8)-алкилова група. Изобретението се отнася и до метод за получаване на посочените съединения и до приложението им като лекарствени средства.
BG103414A 1996-11-22 1999-05-19 N-(имидазолилбутил) бензенсулфонамидни производни, метод за тяхното получаване и използването им като лекарствени средства BG103414A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9614309A FR2756285B1 (fr) 1996-11-22 1996-11-22 Derives de n-(imidazolylbutyle)benzenesulfonamide, leur preparation et leur application en therapeutique
PCT/FR1997/002079 WO1998022443A1 (fr) 1996-11-22 1997-11-19 Derives de n-(imidazolylbutyle) benzenesulfonamide ayant une activite antithrombotique

Publications (1)

Publication Number Publication Date
BG103414A true BG103414A (bg) 2000-01-31

Family

ID=9497920

Family Applications (1)

Application Number Title Priority Date Filing Date
BG103414A BG103414A (bg) 1996-11-22 1999-05-19 N-(имидазолилбутил) бензенсулфонамидни производни, метод за тяхното получаване и използването им като лекарствени средства

Country Status (20)

Country Link
EP (1) EP0946517A1 (bg)
JP (1) JP2001504128A (bg)
KR (1) KR20000069063A (bg)
CN (1) CN1238765A (bg)
AR (1) AR009627A1 (bg)
AU (1) AU5226498A (bg)
BG (1) BG103414A (bg)
BR (1) BR9713291A (bg)
CA (1) CA2270478A1 (bg)
CO (1) CO4910158A1 (bg)
CZ (1) CZ178299A3 (bg)
EE (1) EE9900201A (bg)
FR (1) FR2756285B1 (bg)
HU (1) HUP9904599A2 (bg)
IL (1) IL129546A0 (bg)
NO (1) NO992436L (bg)
SK (1) SK66799A3 (bg)
TR (1) TR199901143T2 (bg)
WO (1) WO1998022443A1 (bg)
ZA (1) ZA9710515B (bg)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2783521B1 (fr) * 1998-09-18 2002-04-26 Synthelabo Derives de n-(arginyl) benzenesulfonamide, leur preparation et leur application en therapeutique
FR2806722B1 (fr) * 2000-03-23 2002-05-17 Sanofi Synthelabo Derives de n-(heterocyclylbutyl) benzene-ou pyridine sulfonamide, leur preparation et leur application en therapeutique
EP3201168B1 (en) 2014-09-29 2020-03-18 Cellix Bio Private Limited Compounds and compositions for the treatment of multiple sclerosis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2689130B1 (fr) * 1992-03-30 1994-05-27 Synthelabo Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique.
FR2710066B1 (fr) * 1993-09-14 1995-10-20 Synthelabo Dérivés de 1-[2-amino-5-[1-(triphénylméthyl-1H-imidazol-4-yl]-1-oxopentyl]piperidine, leur préparation et leur utilisation comme intermédiaires de synthèse.
FR2727410B1 (fr) * 1994-11-25 1996-12-20 Synthelabo Chlorures de sulfonyles, leur preparation et leur utilisation comme intermediaires de synthese
FR2728570B1 (fr) * 1994-12-23 1997-04-11 Synthelabo Derives de 1-oxo-2-(phenylsulfonylamino)pentylpiperidine, leur preparation et leur application en therapeutique
DE19548797A1 (de) * 1995-12-27 1997-07-03 Thomae Gmbh Dr K Substituierte 2-Amino-imidazole, ihre Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
ZA9710515B (en) 1998-06-10
NO992436D0 (no) 1999-05-20
WO1998022443A1 (fr) 1998-05-28
HUP9904599A2 (hu) 2000-06-28
SK66799A3 (en) 2000-02-14
NO992436L (no) 1999-07-22
CZ178299A3 (cs) 1999-08-11
TR199901143T2 (xx) 1999-08-23
AU5226498A (en) 1998-06-10
FR2756285A1 (fr) 1998-05-29
JP2001504128A (ja) 2001-03-27
CA2270478A1 (en) 1998-05-28
KR20000069063A (ko) 2000-11-25
AR009627A1 (es) 2000-04-26
IL129546A0 (en) 2000-02-29
CO4910158A1 (es) 2000-04-24
EE9900201A (et) 1999-12-15
EP0946517A1 (fr) 1999-10-06
CN1238765A (zh) 1999-12-15
FR2756285B1 (fr) 1998-12-18
BR9713291A (pt) 1999-10-26

Similar Documents

Publication Publication Date Title
GB9526245D0 (en) Chemical compounds
AU671933B2 (en) The administration of monoamine acridine in cholinergic neuronal deficit states
MXPA03007248A (es) Quinazolinas como inhibidores de mmp-13.
HUP0400837A2 (hu) 2-feniltiazol-származékok, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények
EP0703222A4 (en) 3-AMINOAZEPINE COMPOUND AND ITS PHARMACEUTICAL USE
NO996108L (no) 9-oksinerytromycinderivater
MX9707053A (es) Nuevos derivados de arilglicinamida, procedimiento para su preparacion, y composiciones farmaceuticas que contienen estos compuestos.
NO961000L (no) Piperidinderivater, fremgangsmåte for fremstilling derav og medikament og preparat inneholdende slike
HUP0002853A2 (hu) 6,7-Helyzetben aszimmetrikusan diszubsztituált kinoxalinkarbonsav-származékok, és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
TW427982B (en) Polysubstituted 3-acylamino-5-phenyl-1,4-benzodiazepin-2-one derivatives, process for their preparation and the pharmaceutical compositions containing them
MY103348A (en) Heteroaryl 3-0x0-propanenitrile derivatives and process for their preparation
DK0424244T3 (da) 3-aryl-oxazolidinon-derivater, fremgangsmåde til fremstilling deraf og terapeutisk anvendelse deraf
ATE36151T1 (de) Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel.
BG103414A (bg) N-(имидазолилбутил) бензенсулфонамидни производни, метод за тяхното получаване и използването им като лекарствени средства
HUP0104224A2 (hu) Szubsztituált kaprolaktámok, azokat tartalmazó gyógyszerkészítmények és alkalmazásuk tumorok kezelésére
GB9426090D0 (en) Pharmaceutical compounds
GR3029428T3 (en) Novel bisoxadiazolidine derivative
ATE212227T1 (de) Verwendung von kompocedinderivaten zur inhibierung der bildung oder sekretion von beta- amyloid-protein
KR970009570B1 (en) Intermediates of aminobenzoic acid
CA2266565A1 (en) Azabicyclic rotomase inhibitors
HUP9900898A2 (hu) Eljárás benzo[b]tiofének előállítására
AU4713697A (en) Process for the preparation of N-(2-(dimethylamino)ethyl)acridine-4-carboxamide
ES2010225A6 (es) Procedimiento de preparacion de nuevos derivados de piperazina diona-2,6.
BR9812928A (pt) Novos derivados de 3-oxo-(2h) -1,2,4-triazina, processo de preparação de compostos quìmicos, e, composição farmacêutica
NO963307L (no) Karbamoylmetylureaderivater