BG101582A - Piperazine derivatives, medicaments containing the same, their use and process for preparing the same - Google Patents

Piperazine derivatives, medicaments containing the same, their use and process for preparing the same

Info

Publication number
BG101582A
BG101582A BG101582A BG10158297A BG101582A BG 101582 A BG101582 A BG 101582A BG 101582 A BG101582 A BG 101582A BG 10158297 A BG10158297 A BG 10158297A BG 101582 A BG101582 A BG 101582A
Authority
BG
Bulgaria
Prior art keywords
same
preparing
piperazine derivatives
medicaments containing
salts
Prior art date
Application number
BG101582A
Other languages
Bulgarian (bg)
English (en)
Inventor
Helmut Pieper
Volkhard Austel
Frank Himmelsbach
Guenter Linz
Brian Guth
Johannes Weisenberger
Original Assignee
Dr. Karl Thomae Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19944446301 external-priority patent/DE4446301A1/de
Application filed by Dr. Karl Thomae Gmbh filed Critical Dr. Karl Thomae Gmbh
Publication of BG101582A publication Critical patent/BG101582A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
BG101582A 1994-12-23 1997-06-06 Piperazine derivatives, medicaments containing the same, their use and process for preparing the same BG101582A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19944446301 DE4446301A1 (de) 1994-12-23 1994-12-23 Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE19526678A DE19526678A1 (de) 1994-12-23 1995-07-21 Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
DE1995133639 DE19533639A1 (de) 1994-12-23 1995-09-12 Piperazinderivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
PCT/EP1995/005031 WO1996020173A1 (fr) 1994-12-23 1995-12-19 Derives de piperazine, medicaments contenant ces composes, leur utilisation et leur procede de preparation

Publications (1)

Publication Number Publication Date
BG101582A true BG101582A (en) 1998-01-30

Family

ID=27207101

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101582A BG101582A (en) 1994-12-23 1997-06-06 Piperazine derivatives, medicaments containing the same, their use and process for preparing the same

Country Status (20)

Country Link
US (1) US5922717A (fr)
EP (1) EP0799202A1 (fr)
JP (1) JPH10511374A (fr)
CN (1) CN1183770A (fr)
AR (1) AR002950A1 (fr)
AU (1) AU4432496A (fr)
BG (1) BG101582A (fr)
BR (1) BR9510360A (fr)
CA (1) CA2207618A1 (fr)
CZ (1) CZ189197A3 (fr)
EE (1) EE9700141A (fr)
FI (1) FI972646A (fr)
HR (1) HRP950609A2 (fr)
IL (1) IL116517A0 (fr)
MX (1) MX9704745A (fr)
NO (1) NO972881L (fr)
PL (1) PL321003A1 (fr)
SK (1) SK79797A3 (fr)
TR (1) TR199501634A2 (fr)
WO (1) WO1996020173A1 (fr)

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US6037343A (en) * 1994-12-22 2000-03-14 Smithkline Beecham Corporation Fibrinogen receptor antagonists
US5889006A (en) * 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
JPH11513382A (ja) * 1995-10-20 1999-11-16 ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング ５員複素環化合物、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
EP1070712A4 (fr) 1998-04-09 2005-01-05 Meiji Seika Kaisha Composes heterocycliques a base d'azote anti-agregation plaquettaire et leur utilisation medicale
EP1533310A1 (fr) * 1999-09-29 2005-05-25 Ortho-McNeil Pharmaceutical, Inc. isonipecotamides destinées au traitement de maladies provoquées par l'integrine
BR0007183A (pt) * 1999-09-29 2002-02-05 Ortho Mcneil Pharm Inc Isonipectoamidas para o tratamento de distúrbios mediados por integrina
GB9923748D0 (en) 1999-10-07 1999-12-08 Glaxo Group Ltd Chemical compounds
USRE39921E1 (en) 1999-10-07 2007-11-13 Smithkline Beecham Corporation Chemical compounds
GB0025354D0 (en) 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
US7081460B2 (en) * 2001-04-09 2006-07-25 Ortho-Mcneil Pharmaceutical, Inc. Quinazoline and quinazoline-like compounds for the treatment of integrin-mediated disorders
ES2376399T3 (es) 2001-08-24 2012-03-13 Yale University Compuestos de piperazinona como agentes antitumorales y anticancer�?genos.
FR2829766A1 (fr) * 2001-09-14 2003-03-21 Lipha Derives d'oxamates comportant un heterocycle azote diversement substitue
GB0203022D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
EP1472222A1 (fr) 2002-02-08 2004-11-03 Glaxo Group Limited Derives piperidylcarboxamide, et leur utilisation dans le traitement des maladies dont la mediation est assuree par les tachykinines
GB0203020D0 (en) 2002-02-08 2002-03-27 Glaxo Group Ltd Chemical compounds
CA2558585C (fr) * 2004-02-27 2010-10-12 Amgen Inc. Composes, compositions pharmaceutiques et procedes d'utilisation dans le traitement de troubles metaboliques
US7851474B2 (en) * 2005-08-02 2010-12-14 Neurogen Corporation Dipiperazinyl ketones and related analogues
WO2007053400A2 (fr) * 2005-10-28 2007-05-10 Merck & Co., Inc. Inhibiteurs de transporteurs de glycine de type pipéridine
CA2655159C (fr) 2006-06-28 2014-12-30 Amgen Inc. Inhibiteurs du transporteur 1 de la glycine
US9090604B2 (en) 2006-07-27 2015-07-28 E I Du Pont De Nemours And Company Fungicidal azocyclic amides
WO2008013622A2 (fr) * 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Amides azocycliques fongicides
PL2076506T3 (pl) * 2007-01-16 2011-03-31 Purdue Pharma Lp Heterocyklicznie podstawione piperydyny jako ligandy ORL-1
ES2920605T3 (es) * 2007-08-31 2022-08-05 Purdue Pharma Lp Intermedios de piperidina
WO2010081851A1 (fr) 2009-01-14 2010-07-22 Genoscience Pharma Composés de pipéridin-4-ylpipérazine pour le traitement d'une infection à vhc
EA201490152A1 (ru) 2011-06-24 2014-05-30 Эмджен Инк. Антагонисты trpm8 и их применение при лечении
AU2012272898A1 (en) 2011-06-24 2013-04-11 Amgen Inc. TRPM8 antagonists and their use in treatments
WO2013123511A1 (fr) * 2012-02-16 2013-08-22 New York University Contrôle de l'expression génique induite par l'hypoxie avec des mimétiques hélicoïdaux non peptidiques d'oligo-oxopipérazine
US8952009B2 (en) 2012-08-06 2015-02-10 Amgen Inc. Chroman derivatives as TRPM8 inhibitors
JP2016510327A (ja) 2013-01-19 2016-04-07 ニューヨーク・ユニバーシティ ｐ５３再活性化のためのオリゴオキソピペラジン
EP3145921A4 (fr) 2014-05-21 2017-11-08 New York University Mimétiques d'hélice d'oxopipérazine pour le contrôle de l'expression génétique inductible par hypoxie
WO2023122481A2 (fr) * 2021-12-20 2023-06-29 Sigma-Aldrich Co. Llc Lieurs chimiques

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
DE2926472A1 (de) * 1979-06-30 1981-01-15 Thomae Gmbh Dr K Neue benzoylderivate, deren herstellung und deren verwendung als arzneimittel
ZA825719B (en) * 1981-09-03 1983-06-29 Recordati Chem Pharm Alkanoylanilides
PH19166A (en) * 1982-09-04 1986-01-16 Pfizer Dihydropyridined,pharmaceutical compositions and method of use
US4895846A (en) * 1984-04-11 1990-01-23 Bristol-Myers Company Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moieties
US4778796A (en) * 1985-07-19 1988-10-18 Dainippon Pharmaceutical Co., Ltd. ω-(3-pyridyl)alkenamide derivatives and anti-allergenic pharmaceutical compositions containing same
DE4035961A1 (de) * 1990-11-02 1992-05-07 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE4213919A1 (de) * 1992-04-28 1993-11-04 Thomae Gmbh Dr K Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4332168A1 (de) * 1993-02-22 1995-03-23 Thomae Gmbh Dr K Cyclische Derivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
ZW4194A1 (en) * 1993-03-29 1994-12-21 Zeneca Ltd Heterocyclic compounds
DK0691959T3 (da) * 1993-03-29 1999-04-26 Zeneca Ltd Heterocykliske derivater som blodpladeaggregations-inhibitorer
DE4324580A1 (de) * 1993-07-22 1995-01-26 Thomae Gmbh Dr K Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4326344A1 (de) * 1993-08-05 1995-02-09 Thomae Gmbh Dr K Carbonamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
EP0721941A4 (fr) * 1994-07-15 1996-09-25 Meiji Seika Co Nouveaux composes ayant un effet inhibant l'agregation plaquettaire
IL115420A0 (en) * 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives

Also Published As

Publication number Publication date
TR199501634A2 (tr) 1996-07-21
JPH10511374A (ja) 1998-11-04
CA2207618A1 (fr) 1996-07-04
WO1996020173A1 (fr) 1996-07-04
CZ189197A3 (cs) 1998-01-14
BR9510360A (pt) 1997-12-23
EP0799202A1 (fr) 1997-10-08
MX9704745A (es) 1997-10-31
AU4432496A (en) 1996-07-19
US5922717A (en) 1999-07-13
IL116517A0 (en) 1996-03-31
NO972881D0 (no) 1997-06-20
FI972646A (fi) 1997-08-19
CN1183770A (zh) 1998-06-03
HRP950609A2 (en) 1997-10-31
EE9700141A (et) 1997-12-15
PL321003A1 (en) 1997-11-24
SK79797A3 (en) 1997-11-05
AR002950A1 (es) 1998-05-27
FI972646A0 (fi) 1997-06-19
NO972881L (no) 1997-06-20

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