BE905796A - HUMAN MANGANESE SUPEROXIDE DISMUTASE DNA, ITS EXPRESSION IN BACTERIA, AND HUMAN MANGANESE SUPEROXIDE DISMUTASE RECOVERY METHOD. - Google Patents

HUMAN MANGANESE SUPEROXIDE DISMUTASE DNA, ITS EXPRESSION IN BACTERIA, AND HUMAN MANGANESE SUPEROXIDE DISMUTASE RECOVERY METHOD.

Info

Publication number
BE905796A
BE905796A BE0/217445A BE217445A BE905796A BE 905796 A BE905796 A BE 905796A BE 0/217445 A BE0/217445 A BE 0/217445A BE 217445 A BE217445 A BE 217445A BE 905796 A BE905796 A BE 905796A
Authority
BE
Belgium
Prior art keywords
superoxide dismutase
manganese superoxide
human manganese
bacteria
expression
Prior art date
Application number
BE0/217445A
Other languages
French (fr)
Original Assignee
Bio Technology General Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Technology General Corp filed Critical Bio Technology General Corp
Publication of BE905796A publication Critical patent/BE905796A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Molécule d'ADN à double brin qui comprend de l'ADN encodant de la superoxyde dismutase de manganèse humaine, ces molécules pouvant etre introduites dans des cellules procaryotiques, par exemple bactériennes, ou eucaryotiques, par exemple des levures ou des cellules de mammifères, les cellules résultantes étant cultivées sous des conditions appropriées de manière à produire de la superoxyde dismutase de manganèse humaine ou des analogues de celle-ci qui peuvent ensuite etre récupérés.Double-stranded DNA molecule which comprises DNA encoding human manganese superoxide dismutase, these molecules being able to be introduced into prokaryotic cells, for example bacterial, or eukaryotic cells, for example yeasts or mammalian cells, resulting cells being cultured under suitable conditions to produce human manganese superoxide dismutase or analogs thereof which can then be recovered.

BE0/217445A 1985-11-22 1986-11-20 HUMAN MANGANESE SUPEROXIDE DISMUTASE DNA, ITS EXPRESSION IN BACTERIA, AND HUMAN MANGANESE SUPEROXIDE DISMUTASE RECOVERY METHOD. BE905796A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80109085A 1985-11-22 1985-11-22
US90705186A 1986-09-12 1986-09-12

Publications (1)

Publication Number Publication Date
BE905796A true BE905796A (en) 1987-03-16

Family

ID=27122291

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/217445A BE905796A (en) 1985-11-22 1986-11-20 HUMAN MANGANESE SUPEROXIDE DISMUTASE DNA, ITS EXPRESSION IN BACTERIA, AND HUMAN MANGANESE SUPEROXIDE DISMUTASE RECOVERY METHOD.

Country Status (21)

Country Link
JP (2) JP2609449B2 (en)
AT (1) AT400443B (en)
AU (1) AU607897B2 (en)
BE (1) BE905796A (en)
CA (1) CA1341362C (en)
CH (1) CH676990A5 (en)
DE (1) DE3639725C2 (en)
DK (1) DK534686A (en)
ES (1) ES2003518A6 (en)
FI (1) FI90353C (en)
FR (1) FR2590591B1 (en)
GB (1) GB2183658B (en)
GR (1) GR862713B (en)
HK (1) HK75195A (en)
IE (1) IE59498B1 (en)
IL (2) IL106449A (en)
IT (1) IT1205418B (en)
LU (1) LU86676A1 (en)
NL (1) NL8602960A (en)
PT (1) PT83792B (en)
SE (1) SE8604884L (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0284105B1 (en) * 1987-03-27 1995-11-15 Bio-Technology General Corporation Human manganese superoxide dismutase and methods of treatment
EP0282899B1 (en) * 1987-03-14 1996-01-10 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Human manganese superoxide dismutase (hMn-SoD)
US5540911A (en) * 1985-11-22 1996-07-30 Bio-Technology General Corp. Methods of use of human manganese superoxide dismutase

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62215532A (en) * 1986-03-18 1987-09-22 Ube Ind Ltd Anti-inflammatory drug
JPH0643341B2 (en) * 1986-03-27 1994-06-08 宇部興産株式会社 Organ function improving agent
JPH0643340B2 (en) * 1986-09-03 1994-06-08 宇部興産株式会社 Ischemic heart disease drug
JPS6377822A (en) * 1986-09-18 1988-04-08 Ube Ind Ltd Organ function improver
US6326003B1 (en) 1986-10-14 2001-12-04 Chiron Corporation Manganese superoxide dismutase cloning and expression in microorganisms
US5260204A (en) * 1987-03-14 1993-11-09 Boehringer Ingelheim International Gmbh Human manganese superoxide dismutase (hMn-SOD)
JPH01233228A (en) * 1988-03-11 1989-09-19 Toyo Jozo Co Ltd Metastasis preventive of malignant tumor cells
US5772996A (en) * 1990-08-03 1998-06-30 Public Health Laboratory Service Board Pharmaceutical compositions containing superoxide dismutase from Bacillus Stearothermophilus and Bacillus Caldotenax
DE4038563A1 (en) * 1990-12-04 1992-06-11 Gruenenthal Gmbh USE OF SUPEROXIDE DISMUTASES FOR PROPHYLAXIS AND / OR TREATMENT OF ORGAN FAILURE IN RISK PATIENTS WITH POLYTRAUMA
ATE209928T1 (en) * 1992-09-09 2001-12-15 Bio Technology General Corp USE OF MANGANEOUS SUPEROXIDE DISMUTASE (MN-SOD) FOR THE PRODUCTION OF MEDICINAL PRODUCTS FOR THE TREATMENT OF DISEASES IN LOW DOSES
DE4239877C1 (en) * 1992-11-27 1994-03-17 Boehringer Ingelheim Int Stabilized superoxide dismutase (SOD) composition

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56102787A (en) * 1980-01-18 1981-08-17 Mamoru Sugiura Preparation of human placenta superoxide dismutase
BG49718A3 (en) * 1983-07-15 1992-01-15 Bio- Technology General Corp Method for preparing of polypeptid with superoxiddismutasne activitty
EP0138111B1 (en) * 1983-10-03 1991-11-21 Chiron Corporation Superoxide dismutase cloning and expression in microorganisms

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5540911A (en) * 1985-11-22 1996-07-30 Bio-Technology General Corp. Methods of use of human manganese superoxide dismutase
US6361772B1 (en) 1985-11-22 2002-03-26 Bio-Technology General Corp. Human manganese superoxide dismutase DNA, its expression and method of recovering human manganese superoxide dismutase
US6610520B1 (en) 1985-11-22 2003-08-26 Bio-Technology General Corp. Gene encoding human manganese superoxide dismutase and recombinant polypeptide encoded thereby
EP0282899B1 (en) * 1987-03-14 1996-01-10 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Human manganese superoxide dismutase (hMn-SoD)
EP0284105B1 (en) * 1987-03-27 1995-11-15 Bio-Technology General Corporation Human manganese superoxide dismutase and methods of treatment

Also Published As

Publication number Publication date
FI90353B (en) 1993-10-15
FI864756A (en) 1987-05-23
GB8627294D0 (en) 1986-12-17
IT1205418B (en) 1989-03-15
IT8667865A0 (en) 1986-11-21
FI90353C (en) 1994-01-25
IL80702A0 (en) 1987-02-27
IE862851L (en) 1987-05-22
DE3639725A1 (en) 1987-07-23
IL106449A (en) 1997-02-18
DK534686A (en) 1987-05-23
JP2967557B2 (en) 1999-10-25
HK75195A (en) 1995-05-26
FI864756A0 (en) 1986-11-21
NL8602960A (en) 1987-06-16
JP2609449B2 (en) 1997-05-14
GR862713B (en) 1987-03-24
AT400443B (en) 1995-12-27
AU607897B2 (en) 1991-03-21
IE59498B1 (en) 1994-03-09
ES2003518A6 (en) 1988-11-01
JPS62289187A (en) 1987-12-16
GB2183658B (en) 1990-04-25
CA1341362C (en) 2002-05-28
ATA308986A (en) 1995-05-15
LU86676A1 (en) 1987-05-04
FR2590591B1 (en) 1989-12-01
JPH08289792A (en) 1996-11-05
SE8604884D0 (en) 1986-11-14
DE3639725C2 (en) 1998-02-19
GB2183658A (en) 1987-06-10
IL106449A0 (en) 1993-11-15
SE8604884L (en) 1987-05-23
CH676990A5 (en) 1991-03-28
PT83792B (en) 1989-01-17
PT83792A (en) 1986-12-01
FR2590591A1 (en) 1987-05-29
DK534686D0 (en) 1986-11-07
AU6497586A (en) 1987-05-28

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: *BIO-TECHNOLOGY GENERAL CORP.

Effective date: 20021130