BE903463A - Procede pour la microencapsulation par separation de phases de substances medicamenteuses hydrosolubles - Google Patents
Procede pour la microencapsulation par separation de phases de substances medicamenteuses hydrosolublesInfo
- Publication number
- BE903463A BE903463A BE0/215739A BE215739A BE903463A BE 903463 A BE903463 A BE 903463A BE 0/215739 A BE0/215739 A BE 0/215739A BE 215739 A BE215739 A BE 215739A BE 903463 A BE903463 A BE 903463A
- Authority
- BE
- Belgium
- Prior art keywords
- microencapsulation
- solvent
- water
- soluble drug
- drug substances
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/20—After-treatment of capsule walls, e.g. hardening
- B01J13/206—Hardening; drying
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2989—Microcapsule with solid core [includes liposome]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
On procède à la microencapsulation par séparation de phases de substances médicamenteuses hydrosolubles. Les opérations de l'étape de durcissement se déroulent à une température comprise entre env. 0 et env. 25 degrés C, le non-solvant utilisé lors de cette étape étant un hydrocarbure aliphatique fluoré ou fluorohalogéné ou un mélange de tels hydrocarbures. Le non-solvant est en outre utilisé en excès par rapport au volume de solvant et non-solvant provenant de l'étape de séparation de phases.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH4979/84A CH660302A5 (fr) | 1984-10-17 | 1984-10-17 | Procede de micro-encapsulation en phase heterogene de substances medicamenteuses hydrosolubles. |
Publications (1)
Publication Number | Publication Date |
---|---|
BE903463A true BE903463A (fr) | 1986-02-17 |
Family
ID=4285848
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE0/215739A BE903463A (fr) | 1984-10-17 | 1985-10-17 | Procede pour la microencapsulation par separation de phases de substances medicamenteuses hydrosolubles |
Country Status (15)
Country | Link |
---|---|
US (1) | US4673595A (fr) |
JP (1) | JPS6197216A (fr) |
AT (1) | AT392586B (fr) |
BE (1) | BE903463A (fr) |
CA (1) | CA1259567A (fr) |
CH (1) | CH660302A5 (fr) |
DE (1) | DE3536902A1 (fr) |
DK (1) | DK165355C (fr) |
ES (1) | ES8701495A1 (fr) |
FR (1) | FR2571617B1 (fr) |
GB (1) | GB2165517B (fr) |
IE (1) | IE58245B1 (fr) |
IT (2) | IT1187226B (fr) |
NL (1) | NL192249C (fr) |
SE (1) | SE462780B (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4832686A (en) * | 1986-06-24 | 1989-05-23 | Anderson Mark E | Method for administering interleukin-2 |
US5000886A (en) * | 1987-05-26 | 1991-03-19 | American Cyanamid Company | Silicone-hardened pharmaceutical microcapsules and process of making the same |
GB2209937B (en) * | 1987-09-21 | 1991-07-03 | Depiopharm S A | Water insoluble polypeptides |
WO1989003678A1 (fr) * | 1987-10-30 | 1989-05-05 | Stolle Research & Development Corporation | Microspheres a faible solvant residuaire et procede de microencapsulage |
US6056992A (en) * | 1988-06-02 | 2000-05-02 | Campbell Soup Company | Encapsulated additives |
IL92344A0 (en) * | 1989-01-04 | 1990-07-26 | Gist Brocades Nv | Microencapsulation of bioactive substances in biocompatible polymers,microcapsules obtained and pharmaceutical preparation comprising said microcapsules |
HU221294B1 (en) * | 1989-07-07 | 2002-09-28 | Novartis Ag | Process for producing retarde compositions containing the active ingredient in a polymeric carrier |
DE4223169C1 (de) | 1992-07-10 | 1993-11-25 | Ferring Arzneimittel Gmbh | Verfahren zur Mikroverkapselung wasserlöslicher Wirkstoffe |
FR2693905B1 (fr) * | 1992-07-27 | 1994-09-02 | Rhone Merieux | Procédé de préparation de microsphères pour la libération prolongée de l'hormone LHRH et ses analogues, microsphères et formulations obtenues. |
SE512663C2 (sv) | 1997-10-23 | 2000-04-17 | Biogram Ab | Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer |
US20030180368A1 (en) * | 1998-03-14 | 2003-09-25 | Cenes Drug Delivery Limited | Production of microparticles |
KR100321854B1 (ko) * | 1998-12-30 | 2002-08-28 | 동국제약 주식회사 | 루테이나이징 호르몬 릴리싱 호르몬 동족체를 함유하는 장기 서방출성 미립구 및 그의 제조방법 |
US6833191B2 (en) * | 2001-11-20 | 2004-12-21 | Encap Technologies, Llc | Microencapsulated particles and process for manufacturing same |
KR100722607B1 (ko) * | 2006-05-11 | 2007-05-28 | 주식회사 펩트론 | 분산성 및 주사 투여능이 향상된 서방성 미립구의 제조방법 |
KR101411349B1 (ko) | 2010-12-24 | 2014-06-25 | 주식회사 삼양바이오팜 | 생리활성 펩타이드를 포함하는 마이크로입자 및 그의 제조방법, 및 그를 포함하는 약제학적 조성물 |
JP2016527308A (ja) | 2013-08-06 | 2016-09-08 | ドン クック ファーマシューティカル カンパニー リミテッド | エンテカビル微小球及びこれを含む非経口投与用医薬組成物 |
WO2019066649A1 (fr) | 2017-09-26 | 2019-04-04 | Nanomi B.V. | Procédé de préparation de microparticules par une technique de double émulsion |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3173878A (en) * | 1960-02-26 | 1965-03-16 | Ibm | Process of making microcapsules |
JPS5134879A (en) * | 1974-09-19 | 1976-03-24 | Eisai Co Ltd | Bishochukuryushinoseizoho |
US4166800A (en) * | 1977-08-25 | 1979-09-04 | Sandoz, Inc. | Processes for preparation of microspheres |
CH649217A5 (de) * | 1977-08-25 | 1985-05-15 | Sandoz Ag | Bromocriptin enthaltende mikrokapseln. |
PH19942A (en) * | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
-
1984
- 1984-10-17 CH CH4979/84A patent/CH660302A5/fr not_active IP Right Cessation
-
1985
- 1985-10-07 IE IE245985A patent/IE58245B1/en not_active IP Right Cessation
- 1985-10-11 NL NL8502787A patent/NL192249C/nl not_active IP Right Cessation
- 1985-10-11 CA CA000492804A patent/CA1259567A/fr not_active Expired
- 1985-10-15 IT IT05236/85A patent/IT1187226B/it active
- 1985-10-15 GB GB08525398A patent/GB2165517B/en not_active Expired
- 1985-10-15 IT IT1985A05236A patent/IT8505236A1/it unknown
- 1985-10-15 US US06/787,249 patent/US4673595A/en not_active Expired - Lifetime
- 1985-10-16 SE SE8504835A patent/SE462780B/sv not_active IP Right Cessation
- 1985-10-16 DK DK474585A patent/DK165355C/da not_active IP Right Cessation
- 1985-10-16 FR FR8515356A patent/FR2571617B1/fr not_active Expired
- 1985-10-16 DE DE19853536902 patent/DE3536902A1/de active Granted
- 1985-10-16 ES ES547915A patent/ES8701495A1/es not_active Expired
- 1985-10-17 JP JP60234390A patent/JPS6197216A/ja active Pending
- 1985-10-17 BE BE0/215739A patent/BE903463A/fr not_active IP Right Cessation
- 1985-10-17 AT AT3011/85A patent/AT392586B/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US4673595A (en) | 1987-06-16 |
IT8505236A0 (it) | 1985-10-15 |
ATA301185A (de) | 1990-10-15 |
AT392586B (de) | 1991-04-25 |
NL192249B (nl) | 1996-12-02 |
IE58245B1 (en) | 1993-08-11 |
FR2571617B1 (fr) | 1988-08-19 |
ES547915A0 (es) | 1986-12-16 |
SE462780B (sv) | 1990-09-03 |
IT8505236A1 (it) | 1987-04-15 |
CH660302A5 (fr) | 1987-04-15 |
JPS6197216A (ja) | 1986-05-15 |
DE3536902A1 (de) | 1986-04-17 |
GB8525398D0 (en) | 1985-11-20 |
CA1259567A (fr) | 1989-09-19 |
GB2165517B (en) | 1988-08-10 |
IE852459L (en) | 1986-04-17 |
IT1187226B (it) | 1987-12-16 |
NL8502787A (nl) | 1986-05-16 |
DE3536902C2 (fr) | 1991-08-01 |
NL192249C (nl) | 1997-04-03 |
ES8701495A1 (es) | 1986-12-16 |
GB2165517A (en) | 1986-04-16 |
SE8504835D0 (sv) | 1985-10-16 |
FR2571617A1 (fr) | 1986-04-18 |
DK474585A (da) | 1986-04-18 |
DK474585D0 (da) | 1985-10-16 |
DK165355C (da) | 1993-04-05 |
DK165355B (da) | 1992-11-16 |
SE8504835L (sv) | 1986-04-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Effective date: 20041031 |
|
RE | Patent lapsed |
Effective date: 20041031 |