BE901980A - Nouveaux derives de la cyclosporine, leur preparation et leur utilisation comme medicaments. - Google Patents

Nouveaux derives de la cyclosporine, leur preparation et leur utilisation comme medicaments.

Info

Publication number
BE901980A
BE901980A BE1/011217A BE1011217A BE901980A BE 901980 A BE901980 A BE 901980A BE 1/011217 A BE1/011217 A BE 1/011217A BE 1011217 A BE1011217 A BE 1011217A BE 901980 A BE901980 A BE 901980A
Authority
BE
Belgium
Prior art keywords
medicaments
preparation
cyclosporin derivatives
novel cyclosporin
novel
Prior art date
Application number
BE1/011217A
Other languages
English (en)
French (fr)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848407618A external-priority patent/GB8407618D0/en
Priority claimed from GB848411922A external-priority patent/GB8411922D0/en
Application filed by Sandoz Sa filed Critical Sandoz Sa
Publication of BE901980A publication Critical patent/BE901980A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/19—Antibiotic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
BE1/011217A 1984-03-23 1985-03-21 Nouveaux derives de la cyclosporine, leur preparation et leur utilisation comme medicaments. BE901980A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848407618A GB8407618D0 (en) 1984-03-23 1984-03-23 Organic compounds
GB848411922A GB8411922D0 (en) 1984-05-10 1984-05-10 Organic compounds

Publications (1)

Publication Number Publication Date
BE901980A true BE901980A (fr) 1985-09-23

Family

ID=26287502

Family Applications (1)

Application Number Title Priority Date Filing Date
BE1/011217A BE901980A (fr) 1984-03-23 1985-03-21 Nouveaux derives de la cyclosporine, leur preparation et leur utilisation comme medicaments.

Country Status (24)

Country Link
US (1) US4639434A (OSRAM)
JP (1) JPH08838B2 (OSRAM)
AT (1) AT388737B (OSRAM)
BE (1) BE901980A (OSRAM)
CA (1) CA1247546A (OSRAM)
CH (1) CH667274A5 (OSRAM)
CS (1) CS249542B2 (OSRAM)
DE (1) DE3509809A1 (OSRAM)
DK (1) DK128285A (OSRAM)
ES (1) ES8702926A1 (OSRAM)
FI (1) FI851120L (OSRAM)
FR (1) FR2561651B1 (OSRAM)
GB (1) GB2155936B (OSRAM)
GR (1) GR850716B (OSRAM)
HU (1) HU200786B (OSRAM)
IL (1) IL74681A (OSRAM)
IT (1) IT1199962B (OSRAM)
LU (1) LU85819A1 (OSRAM)
NL (1) NL8500828A (OSRAM)
NO (1) NO851160L (OSRAM)
NZ (1) NZ211526A (OSRAM)
PH (2) PH21868A (OSRAM)
PT (1) PT80149B (OSRAM)
SE (1) SE461334B (OSRAM)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0314862A1 (en) 1984-10-04 1989-05-10 Sandoz Ag Immunogenic conjugates comprising cyclosporins
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
ES2059558T3 (es) * 1987-06-17 1994-11-16 Sandoz Ag Ciclosporins y su uso como productos farmaceuticos.
EP0373260B1 (en) * 1987-06-22 1994-03-09 Merck & Co. Inc. Cyclosporin derivatives with modified "8-amino acid"
US5227467A (en) * 1987-08-03 1993-07-13 Merck & Co., Inc. Immunosuppressive fluorinated cyclosporin analogs
WO1989001772A1 (en) * 1987-09-03 1989-03-09 University Of Georgia Research Foundation, Inc. Ocular cyclosporin composition
US4839342A (en) * 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
US5089390A (en) * 1987-09-04 1992-02-18 Syntex (U.S.A.) Inc. 2-methyl-4-hexene- and 2-methyl-4-heptene-1,2-diol derivatives
US5236899A (en) * 1987-11-16 1993-08-17 Merck & Co., Inc. 6-position cyclosporin a analogs as modifiers of cytotoxic drug resistance
US4914188A (en) * 1987-11-16 1990-04-03 Merck & Co., Inc. Novel 6-position cyclosporin analogs as non-immunosuppressive antagonists of cyclosporin binding to cyclophilin
CH679119A5 (OSRAM) * 1988-05-13 1991-12-31 Sandoz Ag
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5540931A (en) * 1989-03-03 1996-07-30 Charles W. Hewitt Methods for inducing site-specific immunosuppression and compositions of site specific immunosuppressants
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US5122511A (en) * 1990-02-27 1992-06-16 Merck & Co., Inc. Immunosuppressive cyclosporin analogs with modified amino acids at position-8
US5202310A (en) * 1990-06-06 1993-04-13 Levy Gary A Cyclosporine metabolites
ES2095926T5 (es) * 1990-11-02 2001-02-16 Novartis Ag Cyclosporins.
ES2181734T3 (es) 1990-11-20 2003-03-01 Dade Behring Marburg Gmbh Ensayo inmunologico de ciclosporina.
US5747330A (en) * 1996-06-05 1998-05-05 Poli Industria Chimica Antibiotic producing microbe
RU2170741C2 (ru) * 1996-08-16 2001-07-20 Новартис Аг Способ получения циклоспорина
US20030220234A1 (en) * 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
KR100585348B1 (ko) 1997-10-08 2006-06-01 이소테크니카 인코포레이티드 중수소화된 시클로스포린 유사체 및 면역조절제로서 그의용도
US5990274A (en) 1997-11-25 1999-11-23 Dade Behring Inc. Cyclosporine derivatives and uses thereof
US7449544B2 (en) * 1999-11-30 2008-11-11 Cyclacel Limited p21 peptides
ES2330625T3 (es) * 2001-10-19 2009-12-14 Isotechnika Inc. Preconcentrados de microemulsion de analogos de ciclosporina novedosos.
NZ531944A (en) * 2001-10-19 2006-03-31 Isotechnika Inc Synthesis of cyclosporin analogs
AU2004222306A1 (en) * 2003-03-17 2004-09-30 Albany Molecular Research, Inc. Novel cyclosporins
EP1804823A4 (en) * 2004-09-29 2010-06-09 Amr Technology Inc NEW CYCLOSPORIN ANALOGUE AND ITS PHARMACEUTICAL APPLICATIONS
US7378391B2 (en) * 2004-09-29 2008-05-27 Amr Technology, Inc. Cyclosporin alkyne analogues and their pharmaceutical uses
EP1812037A4 (en) * 2004-10-06 2009-11-11 Amr Technology Inc ALKYNES OF CYCLOSPORINE AND THEIR USEFUL AS PHARMACEUTICAL AGENTS
US7696165B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) * 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7576057B2 (en) 2006-11-20 2009-08-18 Scynexis, Inc. Cyclic peptides
PT2651965T (pt) 2010-12-15 2019-01-28 Contravir Pharmaceuticals Inc Moléculas analógas de ciclosporinas modificadas ao nivel dos aminoácidos 1 e 3
ES2973062T3 (es) 2011-03-11 2024-06-18 Beth Israel Deaconess Medical Ct Inc Anticuerpos anti-CD40 y usos de los mismos
CN104877013B (zh) * 2015-06-03 2018-04-20 兰州大学 环孢菌素t及其制备方法和应用
EP3307322B1 (en) 2015-09-04 2021-02-17 Primatope Therapeutics Inc. Humanized anti-cd40 antibodies and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57140753A (en) * 1981-01-09 1982-08-31 Sandoz Ag Novel cyclosporine
DE3260468D1 (en) * 1981-01-09 1984-09-06 Sandoz Ag Novel cyclosporins

Also Published As

Publication number Publication date
PT80149A (en) 1985-04-01
IT8547852A1 (it) 1986-09-22
CH667274A5 (de) 1988-09-30
LU85819A1 (fr) 1985-12-12
GB2155936A (en) 1985-10-02
IL74681A (en) 1989-09-10
PT80149B (en) 1987-03-23
IT1199962B (it) 1989-01-05
FR2561651B1 (fr) 1990-03-09
SE8501392L (sv) 1985-09-24
SE8501392D0 (sv) 1985-03-21
JPS60215700A (ja) 1985-10-29
CS249542B2 (en) 1987-03-12
DK128285A (da) 1985-09-24
ES541465A0 (es) 1987-01-16
FI851120A7 (fi) 1985-09-24
NL8500828A (nl) 1985-10-16
FI851120A0 (fi) 1985-03-20
FR2561651A1 (fr) 1985-09-27
IT8547852A0 (it) 1985-03-22
PH23357A (en) 1989-07-14
PH21868A (en) 1988-03-25
DK128285D0 (da) 1985-03-21
GB2155936B (en) 1987-09-16
HUT38370A (en) 1986-05-28
AT388737B (de) 1989-08-25
NO851160L (no) 1985-09-24
US4639434A (en) 1987-01-27
IL74681A0 (en) 1985-06-30
NZ211526A (en) 1988-08-30
GR850716B (OSRAM) 1985-07-19
FI851120L (fi) 1985-09-24
GB8507270D0 (en) 1985-04-24
DE3509809A1 (de) 1986-01-09
HU200786B (en) 1990-08-28
JPH08838B2 (ja) 1996-01-10
SE461334B (sv) 1990-02-05
ATA86385A (de) 1989-01-15
CA1247546A (en) 1988-12-28
ES8702926A1 (es) 1987-01-16

Similar Documents

Publication Publication Date Title
BE901980A (fr) Nouveaux derives de la cyclosporine, leur preparation et leur utilisation comme medicaments.
AU588860B2 (en) Improvements in or relating to organic compounds
BE1003071A5 (fr) Nouveaux inhibiteurs de la renine, leur preparation et leur utilisation comme medicaments.
FR2432503A1 (fr) Nouveaux nonapeptides, leur procede de preparation et leur application comme medicaments
BE905954A (fr) Preparation pulverisable de dihydropyridine, son procede de production et son utilisation pharmaceutique.
HUP9900338A2 (hu) Sokfunkciós enzim
CA2331870A1 (fr) Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR930006027A (ko) 엔케팔리나제 및 안지오텐신 전환 효소(ace)의 억제제로서 유용한 2-치환 인단-2-메르캅토아세틸아미드 유도체
ATE72448T1 (de) 2-alkynyladenosine als aktive bestandteile enthaltende antihypertensive mittel.
FR2610947B1 (fr) Formulations liquides d'enzymes
KR970704710A (ko) 트리아졸 화합물 및 도파민 D₃리간드로서의 그의 용도(Triazole Compounds and Their Use as Dopamine-D₃-Ligands)
BE1002213A5 (fr) Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments.
BE904368A (fr) Nouveaux derives de pyridylmethoxy- et methylmercaptoanilines, utiles notamment comme antiasthmatiques, leur fabrication et medicaments les contenant.
IE861997L (en) Zwitterionic bicyclic compounds
BE1002663A4 (fr) Nouveaux derives de la somatostatine, leur preparation et leur utilisation comme medicaments.
BE901456A (fr) Nouvelles 8 alpha-acylaminoergolines, leur preparation et leur utilisation comme medicaments.
FR2391191A1 (fr) Nouveaux composes polypeptidiques, lyeptidiques, leur preparation et leur application comme medicaments
FR2608159B1 (fr) Nouveaux derives de l'acide furannuronique, leur preparation et leur utilisation comme medicaments
BE905790A (fr) Peptide de venin de serpent arretant la croissance.
EP0272174A3 (fr) Préparations d'adenyl cyclase purifiées, procédé d'obtention de ces préparations et leurs applications biologiques
ATE37369T1 (de) Eine thiazinverbindung, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
IE872239L (en) Pyridopyrimidinediones and quinazolines
FR2622446B1 (fr) Agent pour reduire la nephrotoxicite produite par l'administration de cyclosporine
CA2330351A1 (fr) Nouvelles urees lineaires ou cycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
BE899526A (fr) Nouveaux derives d'acylaminophenols, leur preparation et leur utilisation comme medicaments.

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: NOVARTIS A.G.

Effective date: 19990331